吸入硫酸气溶胶对小鼠和家兔的胚胎毒性。

Journal of environmental science and health. Part C: Environmental health sciences Pub Date : 1979-01-01

F J Murray, B A Schwetz, K D Nitschke, A A Crawford, J F Quast, R E Staples

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引用次数: 0

摘要

研究了吸入硫酸(H2SO4)对CF-1小鼠和新西兰大白兔胚胎和胎儿发育的影响。在主要器官发生期间，两种小鼠分别暴露于0、5或20 mg H2SO4/m3中7小时/天(小鼠，妊娠第6至15天;兔，妊娠第6 ~ 18天)。在暴露于H2SO4的小鼠或兔子的胎儿中，几乎没有发现毒性的证据。在H2SO4浓度为20 mg /m3时，两种动物均有轻微的母体毒性。暴露于H2SO4的小鼠和家兔均未发现致畸性。

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Embryotoxicity of inhaled sulfuric acid aerosol in mice and rabbits.

The effect of inhaled sulfuric acid (H2SO4) on embryonal and fetal development was assessed in CF-1 mice and in New Zealand white rabbits. Both species were exposed for 7 hr/day to 0, 5, or 20 mg H2SO4/m3 during the period of major organogenesis (mice, days 6 through 15 of gestation; rabbits, days 6 through 18 of gestation). Little evidence of toxicity was seen in the fetuses of mice or rabbits exposed to H2SO4. Slight maternal toxicity was seen at 20 mg H2SO4/m3 in both species. Teratogenicity was not observed in either mice or rabbits exposed to H2SO4.

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Journal of environmental science and health. Part C: Environmental health sciences

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