硫丹对大鼠药物代谢酶及脂质过氧化的影响。

Journal of environmental science and health. Part C: Environmental health sciences Pub Date : 1978-01-01

D K Agarwal, P K Seth, P K Gupta

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引用次数: 0

摘要

本研究探讨了氯代烃杀虫剂硫丹对大鼠肝脏药物代谢酶和脂质过氧化的影响。两种剂量水平(2.5和5.0 mg/kg体重)的硫丹给药后，肝脏总重量显著增加，而不影响体重或9000 × g上清蛋白含量。氨基吡啶- n -去甲基化酶、苯胺羟化酶、酪氨酸氨基转移酶和自发脂质过氧化活性显著升高。在所有情况下，这种增加都是剂量依赖性的。

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Effect of endosulfan on drug metabolizing enzymes and lipid peroxidation in rat.

The influence of endosulfan, a chlorinated hydrocarbon insecticide, on rat hepatic drug metabolizing enzymes and lipid peroxidation has been explored in the present study. Total liver weight was significantly increased after endosulfan administration at both dose levels (2.5 and 5.0 mg/kg body weight) without affecting body weight or 9000 x g supernatant protein content. There was a marked increase in the activity of aminopyrine-N-demethylase, aniline hydroxylase, tyrosine amino-transferase and spontaneous lipid peroxidation. In all cases the increase was dose dependent.

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Journal of environmental science and health. Part C: Environmental health sciences

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