Iyo Kizai Kenkyujo hokoku. Reports of the Institute for Medical and Dental Engineering, Tokyo Medical and Dental University最新文献

{"title":"[SEM observation of treated dentin surface].","authors":"A Watanabe,&nbsp;N Nakabayashi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Various pretreatments have been attempted to make a polymer bond strongly to dentin. The results of these pretreatments are generally evaluated by SEM or TEM observation. The SEM results sometimes do not lead to the exact evaluation of those pretreatment agents and methods, since artifact arisen during the preparation of SEM samples might conceal the effects of them. However, it could be useful for the discussion of treatments to appreciate the artifact. Thus, by SEM observation we investigated the fine structure of dentin affected by the different sample preparation method.</p>","PeriodicalId":75958,"journal":{"name":"Iyo Kizai Kenkyujo hokoku. Reports of the Institute for Medical and Dental Engineering, Tokyo Medical and Dental University","volume":"23 ","pages":"121-7"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13635640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flux growth and crystal structure of pyromorphite.","authors":"A Akao,&nbsp;H Aoki,&nbsp;Y Innami,&nbsp;S Minamikata,&nbsp;T Yamada","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Single crystals of pyromorphite, Pb5(PO4)3Cl, were grown by standard flux growth technique with excess lead chloride used as the flux. Pyromorphite was first prepared by heating an intimate mixture of lead hydrogen phosphate and lead chloride in the molar ratio 6:4 at 100 degrees C for 1 h. A mixture of 60 wt% of pyromorphite and 40 wt% of lead chloride was heated at 850 degrees C for 15 h and then cooled at the rate of 3.4 degrees C/h. Hexagonal prismatic crystals of length 1 mm were obtained. The chemical composition has close to the theoretical value. The crystal is hexagonal, space group P6(3)/m with a = 9.9981(8), c = 7.344(1) A and Z = 2. The structure was refined to R = 0.058 and Rw = 0.053 with 502 independent reflections. The structure is in principal the same as that of barium chlorapatite; the chlorine ions occupy the (0, 0, 0) position.</p>","PeriodicalId":75958,"journal":{"name":"Iyo Kizai Kenkyujo hokoku. Reports of the Institute for Medical and Dental Engineering, Tokyo Medical and Dental University","volume":"23 ","pages":"25-9"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13635641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HPLC quantitative analysis of plantaginin in Shazenso (Plantago asiatica L.) extracts and isolation of plantamajoside.","authors":"Y Komoda,&nbsp;H Chujo,&nbsp;S Ishihara,&nbsp;M Uchida","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Quantitative analytical method by means of high-performance liquid chromatography (HPLC) has been developed for the quality control of Shazenso (Plantago asiatica L.) extracts. Plantaginin (I) which is one of the known constituents of Shazenso, was selected as a standard compound of the analysis. A chemically labile component has been isolated from the methanol extract and identified to be plantamajoside (II). It was found that II was converted into III even in hot water.</p>","PeriodicalId":75958,"journal":{"name":"Iyo Kizai Kenkyujo hokoku. Reports of the Institute for Medical and Dental Engineering, Tokyo Medical and Dental University","volume":"23 ","pages":"81-5"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13634827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation and evaluation of the antiatherosclerotic activity of unsymmetrical pyridinolcarbamates.","authors":"S Ito,&nbsp;M Kobayashi,&nbsp;M Ishikawa","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>To discover a new and powerful antiathersclerotic agent which can regulate the transendotherial infiltration of very low density lipoprotein (VLDL), LDL, and another type of atherogenics, various kinds of unsymmetrical pyridinolcarbamate derivatives were prepared. The syntheses were started from partial reduction of diethyl dipicolinate with sodium borohydride. The resulted hydroxymethyl group was converted to N-methylcarbamate by a general procedure, and the remaining 6-ethoxycarbonyl group was modified to various kinds of structures. Most of the test compounds showed significant inhibition on edematous arterial reaction (EAR), which closely resembles to an early stage of atherosclerosis, in rabbit aorta in vivo. Among the compounds tested, we found the novel and most potent inhibitor, 2-methylaminomethyl-6-(N-methylcarbamoyloxymethyl) pyridine (13) coded as SHI-355, which inhibited the formation of edematous change on EAR less than 47%. This potency is much more efficient than those of pyridinolcarbamate (1) (83%) and phthalazinol (22) (64%). Furthermore, the morphological differences on the way of inhibition on edematous changes were not observed among the results of the test compounds.</p>","PeriodicalId":75958,"journal":{"name":"Iyo Kizai Kenkyujo hokoku. Reports of the Institute for Medical and Dental Engineering, Tokyo Medical and Dental University","volume":"23 ","pages":"49-58"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13635644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Some observations of the interface of metal bonding porcelain by the electron probe surface shape analyzer].","authors":"M Shiba,&nbsp;S Takase","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The metal bonding porcelain has been widely used for having the excellent qualities of color tone, corrosive resistance, abrasion proof and so on as the dental restorative material. And the many studies on its bonding mechanism have been done. However, there still remains some problems in operation of technical work. The Problems are how to choose polishing instruments for finishing cast metal before filled porcelain, and how to thin the part of dental neck as much as possible so that cast metal is not transmitted. So, as a clue to elucidate these problems, the appearance of metal/porcelain interface has been investigated by using the Electron Probe Surface Shape (EPSS) Analyzer. In this paper, two precious metals (KIK and HARD 2 on the market) and one nonprecious metal (TALLADIUM on the market) were used as base metal, and porcelain powder of two kinds, which were come onto the larket as VITA and DUCELAM, were used respectively. As polishing instruments, diamond point, carbide bur and pink point were used. The uneven images of metal/porcelain interface at parts of tooth top and neck, and middle part of those parts were observed respectively by EPSS analyzer, and the dimensional curves in section at three parts were also measured. The results obtained are as follows. VITA fused to two precious metals was observed to be fully bonded to the surfaces finished by any polishing instruments, and VITA was estimated to be able to get good bonding comparing with DUCERAM. But, in case of nonprecious metal, it was observed from the uneven images that metal/porcelain interfaces of both porcelains were clearly divided, and then this result might be evaluated as by way of the simply mechanical bonding predicted to be lower adhesive strength. The dimensional curves in section at metal/porcelain interface made by skilled and inexperienced dental technicians were distinctly characterized. That of skilled one suddenly varied when shifted from metal location to porcelain location. But, that of inexperienced one did not varied in any parts. Therefore, by measuring the dimensional curve in section using EPSS analyzer, the improvement of new technology in technical work is expected in future.</p>","PeriodicalId":75958,"journal":{"name":"Iyo Kizai Kenkyujo hokoku. Reports of the Institute for Medical and Dental Engineering, Tokyo Medical and Dental University","volume":"23 ","pages":"7-24"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13634825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolism of vitamin D in human promyelocytic leukemia cells (HL-60) II. Does the differentiation of the cells alter the metabolism?","authors":"Y Imae,&nbsp;M Shimizu,&nbsp;C Miyaura,&nbsp;T Suda,&nbsp;S Yamada","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The metabolism of 25-hydroxyvitamin D3 (25-OH-D3) in human promyelocytic leukemia cells (HL-60) which had been exposed to 1 alpha, 25-dihydroxyvitamin D3 (1,25-(OH)2D3) was compared with that in untreated cells. 8 alpha, 25-Dihydroxy-9,10-seco-4,6,10(19)-cholestatrien-3-one (8,25-(OH)2-3-oxoneo-D3) was the only major metabolite in untreated HL-60 cells but exposure of the cells to 1,25-(OH)2D3 for 1 day significantly changed the metabolism: 24R,25-dihydroxyvitamin D3 (24R,25-(OH)2D3) was produced as the major metabolite together with 8,25-(OH)2-3-oxoneo-D3 whose production was also increased. The 1,25-(OH)2D3 treatment did not stimulate the production of 25-hydroxyvitamin D3 26,23-lactone by the HL-60 cells. The metabolism of 25-OH-D3 by HL-60 cells was also significantly affected by fetal bovine serum added to the incubation medium: production of 24R,25-(OH)2D3 was significantly reduced and formation of 8,25-(OH)2-3-oxoneo-D3 was completely abolished.</p>","PeriodicalId":75958,"journal":{"name":"Iyo Kizai Kenkyujo hokoku. Reports of the Institute for Medical and Dental Engineering, Tokyo Medical and Dental University","volume":"23 ","pages":"73-80"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13634826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Experimental HFV apparatus utilizing a mechanical vibration].","authors":"K Takakuda,&nbsp;H Miyairi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We make an experimental HFV apparatus in which the mass-spring system is utilized as the vibration actuator. When this apparatus is operated near the characteristic frequency of the mechanical vibration system, the efficiency is quite good and trivial motor is enough to realize the vibrating flow for the experimental ventilator. In this paper we first investigate the flow-frequency relations and found that above the characteristic frequency of the mechanical vibration system the oscillating volume of flow is nearly constant. Next we check the gas exchange between model-lung and atmosphere and obtain the relations among pressure vs. flow rate, pressure vs. rate of gas exchange.</p>","PeriodicalId":75958,"journal":{"name":"Iyo Kizai Kenkyujo hokoku. Reports of the Institute for Medical and Dental Engineering, Tokyo Medical and Dental University","volume":"23 ","pages":"91-6"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13634829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Synthetic studies of substituted quinazolinone].","authors":"Y Eguchi,&nbsp;A Sugimoto,&nbsp;M Ishikawa","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We re-examined 2-methyl-3-(2-chlorophenyl)-6-ethoxycarbonyl-5,7-dimethyl-4 (3H)-quinazolinone to be hydroxymethylated by means of selenium oxide oxidation, followed by Ca (BH4)2 reduction. Chlorination reaction of 2-hydroxymethyl quinazolinone proceeded effectively by use of PCl5 in anhyd. benzene at room temperature. Thus, we prepared new compounds in respect of substituted quinazolinone.</p>","PeriodicalId":75958,"journal":{"name":"Iyo Kizai Kenkyujo hokoku. Reports of the Institute for Medical and Dental Engineering, Tokyo Medical and Dental University","volume":"23 ","pages":"65-72"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13635646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Interaction of platelets and cultured cells with polymers containing phospholipid polar groups].","authors":"A Watanabe,&nbsp;M Kojima,&nbsp;K Ishihara,&nbsp;N Nakabayashi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>To apply a polymer as biomaterials in a variety of medical field, the evaluations of its adaptability to various kinds of cells are necessary. Therefore, the present paper describes not only the interaction between new polymer materials having phospholipid moiety (MPC) and human epithelial cell (Ca. 9.22) but also the change of platelet function in contact with the material for a prolonged period. In many examples few cells are able to adhere or grow on the surface of high water content gels, similar phenomena are observed in the case of high MPC content copolymers. This result indicates that MPC copolymer tends to offer insufficient liquid structure on which cells are able to adhere and grow. Since the suspended cells which did not adhere on these MPC copolymers survive for prolonged incubation period, it is evident that the MPC copolymer has good compatibility to the cells, and is inadequate for the cell attachment. As the polymers containing polar head group of phospholipids suppress attachment or adhesion of platelets and Ca. 9.22 cells, the polymers are potentially useful for the nonthrombogenic materials and the coating of biosensor which is inserted and retained in the human body.</p>","PeriodicalId":75958,"journal":{"name":"Iyo Kizai Kenkyujo hokoku. Reports of the Institute for Medical and Dental Engineering, Tokyo Medical and Dental University","volume":"23 ","pages":"31-9"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13635642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Problems on the determination of intracellular free calcium concentration when measured by fura-2/AM in mast cells].","authors":"T Ohashi,&nbsp;H Azuma","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>When rat peritoneal mast cells which had been loaded with fluorescent Ca2+ indicator fura-2/AM were exposed to compound 48/80, fura-2 fluorescence was increased in the presence of 1mM extracellular Ca2+, but remained unchanged in the Ca2(+)-eliminated medium. Only in the presence of 1mM extracellular Ca2+, both fura-2 fluorescence and histamine release were increased in response to compound 48/80, depending on the concentration of the stimulant. Both of these responses were attenuated in the same degree by such release inhibitors as disodium cromoglycate and HSR-6071. Fluorescent microscopic observation of fura-2/AM-loaded mast cells revealed that fura-2 fluorescence was densely localized in the granules and the nucleus, but less in the cytoplasm. All these results strongly suggest that increase in the fura-2 fluorescence might not result from the increase in cytoplasmic free Ca2+ concentration, but from binding of fura-2, which had been released together with chemical mediators from granules following stimulation, to extracellular Ca2+. Therefore, it seems likely that the fura-2/AM loading method is inadequate to investigate whether or not the increase in cytoplasmic free Ca2+ concentration triggers release of chemical mediators from mast cells.</p>","PeriodicalId":75958,"journal":{"name":"Iyo Kizai Kenkyujo hokoku. Reports of the Institute for Medical and Dental Engineering, Tokyo Medical and Dental University","volume":"23 ","pages":"59-64"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13635645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}