[Synthetic studies of substituted quinazolinone].

Abstract

We re-examined 2-methyl-3-(2-chlorophenyl)-6-ethoxycarbonyl-5,7-dimethyl-4 (3H)-quinazolinone to be hydroxymethylated by means of selenium oxide oxidation, followed by Ca (BH4)2 reduction. Chlorination reaction of 2-hydroxymethyl quinazolinone proceeded effectively by use of PCl5 in anhyd. benzene at room temperature. Thus, we prepared new compounds in respect of substituted quinazolinone.