Russian Journal of Bioorganic Chemistry最新文献

{"title":"Flavonoids of the Far Eastern Species of the Genus Bupleurum L.","authors":"A. V. Myagchilov,&nbsp;P. G. Gorovoi,&nbsp;L. I. Sokolova","doi":"10.1134/S1068162024070227","DOIUrl":"10.1134/S1068162024070227","url":null,"abstract":"<p><b>Objective:</b> The aim of this study was to investigate the composition of flavonoids in <i>B. euphorbioides</i> Nakai., <i>B. triradiatum</i> Adam ex. Hoffm., <i>B. longiradiatum</i> Turcz., <i>B. scorzonerifolium</i> Willd., <i>B. komarovianum</i> Lincz., and <i>B. atargense</i> Gorovoi species of the genus <i>Bupleurum</i> L., growing in the Russian Far East (Primorskii krai, Magadan oblast). <b>Methods:</b> Compounds of the flavonoid class were isolated from six species of plants of the genus <i>Bupleurum</i> L., growing in the Russian Far East (Primorskii krai, Magadan oblast) by liquid extraction. Five compounds were identified by reversed-phase liquid chromatography: avicularin, rutin, narcissin, quercetin, and isorhamnetin. Avicularin was identified in <i>B. atargense</i> and <i>B. longiradiatum</i> plants for the first time. The structure of the compounds (avicularin, rutin, and narcissin) isolated by preparative column chromatography on Silica gel in the gradient elution mode using a mixture of solvents (carbon tetrachloride and ethanol) was proved by NMR-¹H, ¹³C, and ¹H, ¹³C-HMBC spectroscopy and by ESI mass spectrometry. Use of the differential spectrophotometry method allowed determining the content of total flavonoids in the aerial part of the six species of the genus <i>Bupleurum</i> L., whose mass fraction as calculated for absolutely dry raw material was found to vary from 0.58 to 2.92%. <b>Results and Discussion:</b> The highest content of flavonoids, 2.92 ± 0.58%, was detected in <i>B. euphoiroides</i>, and the lowest content, 0.58 ± 0.12%, in <i>B. longiradiatum</i>. <b>Conclusions:</b> A comparative analysis of individual flavonoids in the studied species of the genus <i>Bupleurum</i> L. revealed the features of their accumulation. The predominant flavonoid in the aerial part of <i>B. atargense</i> and <i>B. euphoiroides</i> was quercetin (1.14 ± 0.23 and 0.92 ± 0.18%, respectively), and that in <i>B. triradiatum</i>, <i>B. komarovianum</i>, <i>B. scorzonerifolium</i>, and <i>B. longiradiatum</i>, rutin (0.47 ± 0.09, 0.18 ± 0.04, 0.32 ± 0.08, and 0.13 ± 0.03%, respectively).</p>","PeriodicalId":758,"journal":{"name":"Russian Journal of Bioorganic Chemistry","volume":"50 7","pages":"2884 - 2889"},"PeriodicalIF":1.1,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142870425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antiradical Activity of Extractive Substances of Ledum polustre L., Growing in the Krasnoyarsk Territory","authors":"A. A. Efremov,&nbsp;E. E. Savelyeva,&nbsp;N. A. Bulgakova,&nbsp;R. K. Kunz,&nbsp;D. G. Slashchinin,&nbsp;T. A. Luneva,&nbsp;I. D. Zykova,&nbsp;D. V. Volkov","doi":"10.1134/S1068162024070161","DOIUrl":"10.1134/S1068162024070161","url":null,"abstract":"<p><b>Objective:</b> In model reactions with a free stable 2,2-diphenyl-1-picrylhydrazyl radical, the antiradical activity (ARA) of extractive substances of wild rosemary (<i>Ledum palustre</i> L.) growing in the Krasnoyarsk Territory was studied: aqueous-alcoholic extracts with an alcohol content of 20, 40, and 70%, water and alcohol extracts and essential oil. <b>Methods:</b> Whole essential oil obtained by exhaustive hydrosteam distillation for 8 h. The component composition of the essential oil was determined by chromato-mass spectrometry using a data bank on mass spectra and on the analysis of linear retention indices. <b>Results and Discussion:</b> At least 35 individual compounds were identified in the essential oil and their quantitative content was determined. The leaves of wild rosemary collected at the beginning of flowering in early June in the Partizansky district of the Krasnoyarsk Territory were used as raw materials. The extracts were obtained using a sample of air-dry raw materials in the amount of 1.00 g, the extraction hydromodule was 1 : 100, the extraction time was 1 h. The results of the DPPH test showed that the antiradical activity of the obtained extracts changes in the following order: essential oil &gt; 40% extract &gt; 70% extract &gt; 20% extract &gt; aqueous extract. Moreover, the essential oil of wild rosemary has an ARA value of 82.7% even when diluted 1 : 10. The obtained extracts were studied by electron spectroscopy in the UV region. It is shown that the extracts contain phenolic compounds represented by phenolcarboxylic acids and flavonoids. In the extracts obtained, the total content of phenolic compounds was determined (by reaction with the Folin–Ciocalteu reagent), which is 0.52–1.05 wt.% in terms of gallic acid. Moreover, this value passes through a maximum in the case of 40% alcohol extract. <b>Conclusions:</b> By reaction with aluminum chloride, the total content of flavonoids in the extracts was determined. It was found that the content of flavonoids in the extracts is 0.73–2.00 wt. % in terms of routine. The maximum content of flavonoids was found in 70% alcohol extract. It is shown that the ARA value correlates well with the total content of phenolic compounds - the correlation coefficient is 0.9512, and no correlation is observed with the total content of flavonoids.</p>","PeriodicalId":758,"journal":{"name":"Russian Journal of Bioorganic Chemistry","volume":"50 7","pages":"2853 - 2858"},"PeriodicalIF":1.1,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142870270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemical Composition of Volatile Components Pulicaria salviifolia and P. gnaphalodes and Their Insecticidal Activity","authors":"Sh. O. Melieva,&nbsp;S. M. Turaeva,&nbsp;R. P. Zakirova,&nbsp;K. A. Eshbakova","doi":"10.1134/S106816202407015X","DOIUrl":"10.1134/S106816202407015X","url":null,"abstract":"<p><b>Objective:</b> The aim of this work was to study the chemical composition of the volatile substances of gasoline fractions of <i>Pulicaria salviifolia</i> and <i>P. gnaphalodes</i> plants, collected on the territory of The Republic of Uzbekistan, and to study their comparative insecticidal activity against the number of insect pests. <b>Methods:</b> The composition of volatile substances in the ground parts of two species was studied for the first time, using the GC/MS method. <b>Results and Discussion:</b> It was revealed that the predominant substances of <i>P. salviifolia</i> are β-terpineol, isospatulenol, ledol, sabine hydrate, l-caryophyllene, terpinene-4-ol, d-kadinen, and α-amorphene. The volatile substances of <i>P. gnaphalodes</i> are dominated by calaminene, 2-phenylpyrazole-3-amine, 1,3,5-cycloheptatriene, 1,8-cineol, 2-hepten-1-ol, 2-methyl-6-(4-methylphenyl)-(<i>E</i>)-1-bromohomoadamantane, 7-acetyl-2-hydroxy-2-methyl-5-isopropylbicyclo[4.3.0]nonan. <b>Conclusions:</b> It was found that the biological efficiency of 1.0% concentrations of the studied plant species extracts against <i>Aphis pomi</i>, <i>Myzus persicae Sulzer</i>, and <i>Callosobruchus maculatus</i> after 24 h of exposure was 100%, as in the experiment with the use of the insecticide cypermethrin. When the dose was reduced to 0.1%, the toxicity of <i>P. gnaphalodes</i> extract was higher than that of <i>P. salviifolia</i>.</p>","PeriodicalId":758,"journal":{"name":"Russian Journal of Bioorganic Chemistry","volume":"50 7","pages":"2840 - 2846"},"PeriodicalIF":1.1,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142870284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial Properties of the Essential Oils of New Varieties of Origanum Vulgare L.","authors":"T. V. Sachivko,&nbsp;T. I. Akhramovich,&nbsp;N. A. Kovalenko,&nbsp;G. N. Supichenko,&nbsp;V. N. Bosak,&nbsp;V. N. Leont’ev","doi":"10.1134/S1068162024070045","DOIUrl":"10.1134/S1068162024070045","url":null,"abstract":"<p><b>Objective:</b> Oregano (<i>Origanum vulgare</i> L.) is widely used as a spicy-aromatic, essential-oil, and medicinal culture in various sectors of economy. <b>Methods:</b> The steam distillation method was used to obtain samples of essential oil of plants of new varieties of oregano, cultivated in the conditions of the Republic of Belarus. <b>Results and Discussion:</b> More than 20 components were identified in the essential oils of oregano, the main of which are sabinene, limonene, β-ocimene, and germacrene D. essential oils of oregano varieties Zavirukha and Aksamit showed antibacterial activity against gram-negative and gram-positive bacteria. The more pronounced antimicrobial properties of the essential oils from the oregano plants with white (Zavirukha variety) as compared to those with pink (Aksamit variety) corolla of the flower are due to the increased content of thymol and eugenol. <b>Conclusions:</b> The results obtained on the content and the component and the enantiomeric compositions of the essential oils, as well as on their antibacterial properties, allow more fully assessing the quality of oregano with a view to its use in various sectors of economy.</p>","PeriodicalId":758,"journal":{"name":"Russian Journal of Bioorganic Chemistry","volume":"50 7","pages":"2859 - 2865"},"PeriodicalIF":1.1,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142870468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Triterpene Glycosides as Plant Growth Regulators: Application Potential and Prospects (A Review)","authors":"E. S. Davidyants","doi":"10.1134/S1068162024070100","DOIUrl":"10.1134/S1068162024070100","url":null,"abstract":"<p>The increased interest in the growth-regulatory activity of triterpene glycosides (TGs) in recent years is largely explained by the need for new highly effective and environmentally friendly plant growth biostimulants, the use of which is considered as an important strategy in managing the productivity and stress resistance of agricultural crops. Тhe review summarizes the available published information on the phytoregulatory activity of TGs with emphasis on their growth-stimulating properties. The physiological effects of TGs in phytohormonal bioassays are considered. The auxin-, gibberellin-, and cytokinin-like effects of TGs on the growth and metabolism of the test plants (changes in the activity of enzymes: α-amylase, peroxidase, catalase, polyphenol oxidase, IAA oxidase, and nitrate reductase, as well as chlorophyll and protein contents) as a function of the structure of the TGs were demonstrated. Some aspects of the mechanism of the growth-stimulating action and the possible involvement of TGs and free triterpenes in physiological processes in plants are discussed. The relationships between the structure and phytoregulatory activity of TGs are analyzed. The effect of exogenous TGs and triterpenoids on plants under abiotic stresses, as well as the possibility to use TGs, extracts of saponin plant sources (<i>Сamellia</i> sp., <i>Silphium perfoliatum</i>, <i>Medicago sativa</i>,<i> Glycine max</i>,<i> Vigna radiata</i>,<i> Glycyrrhiza glabra</i>,<i> Moringa oleifera</i>,<i> Solidago gigantea</i>,<i> Centella asiatica</i>,<i> Eclipta alba</i>,<i> Quillaja saponaria</i>,<i> Bacopa monnieri</i>, et al.) and plant extracts containing triterpenoids (<i>Abies sibirica</i> and <i>Betula</i> sp.) in crop production as plant growth regulators, is considered.</p>","PeriodicalId":758,"journal":{"name":"Russian Journal of Bioorganic Chemistry","volume":"50 7","pages":"2730 - 2752"},"PeriodicalIF":1.1,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142870267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biologically Active Compounds and Antioxidant Activity of the Plants from the Mountain Altai of the Caragana Genus","authors":"E. P. Khramova,&nbsp;S. Ya. Syeva,&nbsp;T. A. Kukushkina,&nbsp;T. M. Shaldaeva","doi":"10.1134/S1068162024070173","DOIUrl":"10.1134/S1068162024070173","url":null,"abstract":"<p><b>Objective:</b> The article presents data on the content of biologically active compounds (BAC) and the total phenolic antioxidants activity (TPA) evaluated for aboveground organs of three species from the <i>Caragana</i> genus – <i>C. bungei</i>, <i>C. pygmaea</i>, and <i>C. spinosa</i>, growing in the Mountain Altai. <b>Methods:</b> The content of flavonols was determined by the spectrophotometric method on the SF-56 spectrophotometer in the presence of aluminum chloride, using CO rutin (Chemapol) as a reference substance. Phenolic compounds (flavonols, catechins, tannins), pectin substances (pectin and protopectin), pigments (carotenoids and chlorophylls) and the total content of phenolic antioxidants were analyzed in the aboveground organs of Caragana. <b>Results and Discussion:</b> It is shown that biologically active substances of a plant are synthesized differently depending on the species, habitat and organ of the plant. The highest level of flavonols (36.4 mg/g), tannins (117.2 mg/g), and carotenoids (0.56 mg/g) was registered in leaves of <i>C. spinosa</i>. Catechins predominantly accumulated in the leaves of <i>C. pygmaea</i> (up to 211.3 mg/100g) and inflorescences of <i>C. bungei</i> (up to 205 mg/g). The content of pectin substances was quite high, with the biggest share of protopectins. The highest level of protopectins was registered in inflorescences of <i>C. bungei</i> (5.81%) and leaves of <i>C. pygmaea</i> (3.58%). Pectins are synthesized more in the flowers of <i>C. bungei</i> (0.74%) and leaves of <i>C. spinosa</i> (0.49%). Differences in the content of photosynthetic pigments (chlorophylls and carotenoids) in the shoots of the studied Caraganas were revealed. The highest values of antioxidant activity were found in the water–ethanol extracts from the leaves of <i>C. spinosa</i> (1.61 mg/g), which is probably due to the increased content of flavonols and tannins. <b>Conclusions:</b> It was shown that the antioxidant activity of Caragana plants is 71% determined by the content of tannins, 62% by the content of flavonols and 41% by the content of carotenoids. <i>C. spinosa</i> is more promising for finding sources of antioxidants.</p>","PeriodicalId":758,"journal":{"name":"Russian Journal of Bioorganic Chemistry","volume":"50 7","pages":"2874 - 2883"},"PeriodicalIF":1.1,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142870286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obtaining and Rheological Properties of Pectin Isolated Using Microwave Radiation","authors":"L. B. Azimova,&nbsp;A. V. Filatova,&nbsp;M. Yu. Mukhamedzhanova,&nbsp;A. S. Turaev","doi":"10.1134/S1068162024070306","DOIUrl":"10.1134/S1068162024070306","url":null,"abstract":"<p><b>Objective:</b> А method has been developed for extracting modified pectin from plant raw materials by using microwave radiation at the stage of washing. <b>Methods:</b> The rheological properties of 5.0% aqueous solutions of apple pectin obtained by exposure to microwave radiation of various powers: 300, 450 and 600 W, as well as pectins obtained by the traditional method at temperatures of 25, 40, 55, 70°C were investigated. <b>Results and Discussion:</b> It is shown that the use of microwave radiation can improve the method of obtaining pectins by increasing the yield of pectins and regulating their structure and properties. The rheological properties of concentrated aqueous solutions of pectins obtained by exposure to microwave radiation of various powers have been studied. It is shown that all studied systems of pectin solutions are non-Newtonian fluids with a pseudoplastic type of viscous flow anomaly, determined by the values of the microwave energy. The values of the apparent activation energies of the viscous flow of solutions, which are an indirect characteristic of the strength of the structures of the system, have been estimated. Data was obtained on the structure and changes in the structure of their concentrated solutions under the action of external forces and temperature in the course of a viscous flow. <b>Conclusions:</b> It is shown that the power values оf microwave radiation are the main factor determining the structure of molecular matrices of pectins and the structure of their concentrated aqueous solutions.</p>","PeriodicalId":758,"journal":{"name":"Russian Journal of Bioorganic Chemistry","volume":"50 7","pages":"2922 - 2930"},"PeriodicalIF":1.1,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142870426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phenolic Compounds and Iridoids of the Aerial Part of Leonurus deminutus V. I. Krecz. (Lamiaceae)","authors":"Ya. V. Sokolova,&nbsp;V. M. Mirovich,&nbsp;D. N. Olennikov,&nbsp;L. V. Dudareva","doi":"10.1134/S1068162025070246","DOIUrl":"10.1134/S1068162025070246","url":null,"abstract":"<p><b>Objective:</b> The genus <i>Leonurus L.</i> comprises seven Siberian species, among which Leonurus deminutus V. I. Krecz. is widespread in Irkutsk oblast. This plant is used in folk medicine in the form of infusions, tinctures, and juices for treatment of anxiety disorders, irritability, insomnia, and hypertension and is a promising agent for introduction into pharmaceutical practice. In this regard, the aim of this study was to investigate the composition and content of the main biologically active substances (flavonoids, phenylpropanoids, and iridoids) of the aerial part of <i>L. deminutus</i>. <b>Methods:</b> HPLC-DAD-ESI-MS method was used for the analysis. The quantitative determination of the revealed phenolic compounds was carried out by the MC-HPLC-UV method. The iridoid profiling analysis of the aerial parts of <i>L. deminutus</i> was performed using the HPLC-DAD-ESI-MS method. <b>Results and Discussion:</b> The study revealed the presence of 20 phenolic compounds in the aerial organs of <i>L. deminutus</i>, of which 11 substances were isolated and identified for the first time: 4-<i>O</i>-caffeoylquinic acid, 5-<i>O</i>-caffeoylquinic acid, caffeoylmalic acid (isomer 9), rutin, nicotiflorin, isoquercitrin, leonosides A and B, astragalin, apigenin 5-<i>O</i>-glucoside, and genkwanin 5-<i>O</i>-glucoside. <b>Conclusions:</b> It was found that the aerial part of <i>L. deminutus</i> contained 13.76 mg/g total flavonoids and 75.4 mg/g total phenylpropanoids. The following iridoids were for the first time detected and identified in the aerial parts of <i>L. deminutus</i>: harpagide, ajugol isomer, 8-acetylharpagide, and ajugoside. According to the literature, these substances are characteristic of other representatives of the genus <i>Leonurus L.</i>, as confirmed by the present study <i>via</i> comparative analysis of the alcoholic extracts of <i>L. deminutus</i> and <i>L. cardiaca</i> by TLC.</p>","PeriodicalId":758,"journal":{"name":"Russian Journal of Bioorganic Chemistry","volume":"50 7","pages":"2897 - 2903"},"PeriodicalIF":1.1,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142870271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anthocyanins in Lilac Flowers Syringa vulgaris","authors":"I. P. Blinova,&nbsp;V. I. Deyneka,&nbsp;Ya. Yu. Salasina,&nbsp;E. Yu. Oleinits,&nbsp;L. A. Deineka","doi":"10.1134/S1068162024070069","DOIUrl":"10.1134/S1068162024070069","url":null,"abstract":"<p><b>Objective:</b> This study aims to determine the structure of anthocyanins of common lilac flowers (<i>Syringa vulgaris</i> L.) of various color intensities and shades of lilac color from nine samples purchased at the Belgorod market by investigation of solute retention regularities of the compounds, peculiarities of their electronic absorption spectra as well as mass-spectra fixtures. <b>Methods:</b> Reversed-phase HPLC with a diode array as well as mass spectra detection by electrospray ionization with partial fragmentation were used. <b>Results and Discussion:</b> It was found that in all the studied samples the main component was delphinidin-3-rutinoside (84–90% by peak areas in the chromatogram). The level of cyanidin-3-rutinoside biosynthesis was significantly lower (6–19.6%). Among the minor compounds, delphinidin-3-glucoside and petunidin-3-glucoside were found. Among the unusual compounds, pyranoanthocyanin, built on the basis of delphinidin-3-rutinoside due to condensation with pyruvic acid, was found in a number of studied samples, but the reasons for its appearance have not yet been established. The total content of anthocyanins in the samples was rather low in the region of 0.020–0.120 g per 100 g of fresh material (depending on the color intensity of the original plant material) expressed as cyanidin-3-glucoside. <b>Conclusions:</b> By drying flowers on a cut branch, air-dried material was obtained containing 0.100–0.300 per 100 g of anthocyanins.</p>","PeriodicalId":758,"journal":{"name":"Russian Journal of Bioorganic Chemistry","volume":"50 7","pages":"2813 - 2817"},"PeriodicalIF":1.1,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142870277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Component Composition and Antimicrobial Activity of Perovskia Angustifolia Essential Oil","authors":"O. K. Askarova,&nbsp;Kh. M. Bobakulov,&nbsp;S. A. Sasmakov,&nbsp;T. Kh. Sadullaev,&nbsp;E. Kh. Botirov","doi":"10.1134/S1068162024070082","DOIUrl":"10.1134/S1068162024070082","url":null,"abstract":"<p><b>Objective:</b> The component composition of the essential oil (EO) obtained by hydrodistillation from the air-dry and fresh aboveground parts of the plant <i>Perovskia angustifolia</i> Kudr., growing on the territory of the Namangan region of the Republic of Uzbekistan has been studied. <b>Methods:</b> By GC-MS, 57 compounds were identified in the composition of the EO from the air-dried plant, while 46 substances were found in the composition of the EO from the fresh plant, which is 94.0 and 96.2% of the total amount of EOs, respectively. <b>Results and Discussion:</b> The main EO components of both the air-dry and fresh aerial parts are 1,8-cineole, its content is 24.2, and 25.1%, respectively. EO from an air-dry plant contains camphor (8.6%), endoborneol (7.3%), bornyl acetate (6.2%), caryophyllene (4.4%), α-humulene (4.1%), δ-cadinene (3.8%) and other connections. The dominant components in the composition of EO from a fresh plant, in addition to 1,8-cineol, are camphor (13.8%), endoborneol (8.6%), bornyl acetate (7.0%), γ-terpinene (7.0%), m-cimene (5.2%), Δ-3-karen (4.5%), δ-kadinen (2.9%). The aerial part of <i>P. angustifolia</i> can serve as a rich source of 1,8-cineole, which is used in bronchitis, colds of the respiratory tract, chronic and inflammatory respiratory diseases. <b>Conclusions:</b> EO from the aerial part of the air-dry <i>P. angustifolia</i> exhibits a noticeable antimicrobial and antifungal effect against test strains of Gram-positive, Gram-negative bacteria, while gram-positive bacteria <i>Bacillus subtilis</i> and <i>Staphylococcus aureus</i> turned out to be the most sensitive to the effects of essential oil.</p>","PeriodicalId":758,"journal":{"name":"Russian Journal of Bioorganic Chemistry","volume":"50 7","pages":"2834 - 2839"},"PeriodicalIF":1.1,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142870352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}