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Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin. Erganzungsband最新文献

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Osmolality of nonionic contrast media. 非离子造影剂的渗透压。
Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin. Erganzungsband Pub Date : 1989-01-01
H Miklautz, K Fichte, K Wegscheider
{"title":"Osmolality of nonionic contrast media.","authors":"H Miklautz,&nbsp;K Fichte,&nbsp;K Wegscheider","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Solutions of different low osmolar contrast media (CM) obviously show clinically relevant differences in the osmolality despite equal iodine concentrations and similar molecular structure. To obtain precise and comparable data, the osmolality of five batches (usually) each of contrast media, iopamidol, iohexol, iopromide, and ioxaglate-all preparations commercially available-were measured by means of the vapor pressure method. The osmolality of the solutions of sodium meglumine ioxaglate with the same iodine concentration is lower than that of the nonionic CM examined. Iopromide showed the lowest osmolality and iohexol the highest value of the nonionic preparations. The differences are statistically significant as a rule. They are attributed to a varying association and hydration of the CM molecules in the solution.</p>","PeriodicalId":75861,"journal":{"name":"Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin. Erganzungsband","volume":"128 ","pages":"16-20"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13711617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Initial experience with a nonionic, dimeric contrast medium (iotrolan) in direct and indirect arteriography: a randomized, intraindividual double-blind study in 60 patients. 非离子型二聚体造影剂(iotrolan)在直接和间接动脉造影中的初步经验:一项随机、个体内双盲研究，60例患者。
Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin. Erganzungsband Pub Date : 1989-01-01
B Hagen, B I Wenzel-Hora
{"title":"Initial experience with a nonionic, dimeric contrast medium (iotrolan) in direct and indirect arteriography: a randomized, intraindividual double-blind study in 60 patients.","authors":"B Hagen,&nbsp;B I Wenzel-Hora","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The new isotonic contrast medium iotrolan has been compared with iopromide in aortofemoral arteriography, selective femoral arteriography, and intravenous digital substraction angiography (DSA). In each case a crossover study design has been chosen with special emphasis on patient comfort. Despite problems in the interpretation of results due to a \"hangover\" effect in selective peripheral arteriography, it may be concluded: (1) Iotrolan causes significantly less discomfort, such as the feeling of heat and most likely also pain, than iopromide. However, one patient reported slight pain after the injection of iotrolan even when no previous injection of iopromide had been performed; (2) in intravenous DSA contrast appeared 1 to 2 seconds later in the region of interest after the injection of iotrolan compared with iopromide, probably due to the slightly higher viscosity of the former agent; (3) otherwise, no differences between the two agents have been observed. No cardiovascular or other kind of side effects occurred with the exception of one slight allergy-like reaction in 60 patients.</p>","PeriodicalId":75861,"journal":{"name":"Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin. Erganzungsband","volume":"128 ","pages":"54-60"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13712012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Arthrography with iotrolan: double-blind comparison between nonionic, monomeric (iohexol 300) and nonionic, dimeric (iotrolan 300) contrast media. 碘曲兰关节造影术:双盲比较非离子、单体造影剂(碘己醇300)和非离子、二聚体造影剂(碘曲兰300)。
Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin. Erganzungsband Pub Date : 1989-01-01
M Schmidt, V Papassotiriou
{"title":"Arthrography with iotrolan: double-blind comparison between nonionic, monomeric (iohexol 300) and nonionic, dimeric (iotrolan 300) contrast media.","authors":"M Schmidt,&nbsp;V Papassotiriou","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Arthrography of the shoulder and knee joints is optimized by the new nonionic, dimer contrast medium iotrolan 300 in comparison to the nonionic, monomer iohexol 300. Detail recognition increases and is longer lasting. The contrast density remains good for more than 40 minutes, thus making repeated examinations due to diagnostic uncertainty superfluous.</p>","PeriodicalId":75861,"journal":{"name":"Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin. Erganzungsband","volume":"128 ","pages":"182-9"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13712282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Renal and hepatic tolerance of nonionic and ionic contrast media in intravenous digital subtraction angiography. 静脉数字减影血管造影中非离子和离子造影剂对肾脏和肝脏的耐受性。
Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin. Erganzungsband Pub Date : 1989-01-01
M Langer, W Junge, R Keysser, J Hasford, U A Jänicke
{"title":"Renal and hepatic tolerance of nonionic and ionic contrast media in intravenous digital subtraction angiography.","authors":"M Langer,&nbsp;W Junge,&nbsp;R Keysser,&nbsp;J Hasford,&nbsp;U A Jänicke","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The liver and kidney tolerance of iopromide 370 in comparison to that of sodium meglumine diatrizoate 370 or iopamidol 370 in doses of 2 ml/kg body weight was examined in two controlled double-blind studies with intravenous digital subtraction angiography on the basis of enzyme assays in serum and urine. In patients with normal kidney function no changes were observed in the levels of the liver enzymes GPT, GOT, and gamma glutamyl transpeptidase (GGT) serum up to 72 hours after injection of iopromide or sodium meglumine diatrizoate. Among the kidney-specific enzymes, the excretion of GGT in urine increased after injection of iopromide and iopamidol. The maximum increase of GGT excretion was, however, statistically significantly lower in the group treated with iopromide than in the iopamidol group. Within 72 hours, the activities had been returned to the initial values in both groups.</p>","PeriodicalId":75861,"journal":{"name":"Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin. Erganzungsband","volume":"128 ","pages":"95-100"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13712610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Renal excretion of iopromide and iopamidol after intravenous administration in digital subtraction angiography. 数字减影血管造影中静脉给药后碘丙胺和iopamidol的肾脏排泄。
Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin. Erganzungsband Pub Date : 1989-01-01
W Mützel, M Langer, R Keysser
{"title":"Renal excretion of iopromide and iopamidol after intravenous administration in digital subtraction angiography.","authors":"W Mützel,&nbsp;M Langer,&nbsp;R Keysser","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>After injection of iopromide or iopamidol into a central vein in 40 patients ages 57 +/- 14 years and 57 +/- 11 years, respectively, with normal renal function, iodine concentration and total iodine excretion were determined in pooled urine over 0 to 2 hours and 2 to 24 hours after injection. Iopromide excretion of 46.4 +/- 9.8% of the dose during the first 2 hours after injection was significantly (p less than 0.05) higher than that of iopamidol, which amounted to 41.4 +/- 10.5% of the dose. This is presumably due to the fact that iopromide has lower protein binding than iopamidol. Excretion of the two nonionic contrast media up to 2 hours after injection decreased constantly with increasing age. In the case of iopromide, a mean excretion of 55% of the dose in a patient 25 years old decreased to about 40% for a patient 90 years of age (p less than 0.05). The clinical relevance of the observed differences and correlations is discussed.</p>","PeriodicalId":75861,"journal":{"name":"Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin. Erganzungsband","volume":"128 ","pages":"101-4"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13711133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Iotrolan versus iopamidol: a controlled, multicenter, double-blind study of lumbar and direct cervical myelography. Iotrolan与iopamidol:一项腰椎和颈髓造影的对照、多中心、双盲研究。
Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin. Erganzungsband Pub Date : 1989-01-01
K Ringel, E Klotz, B I Wenzel-Hora
{"title":"Iotrolan versus iopamidol: a controlled, multicenter, double-blind study of lumbar and direct cervical myelography.","authors":"K Ringel,&nbsp;E Klotz,&nbsp;B I Wenzel-Hora","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Iotrolan is a new nonionic, dimeric contrast medium that is distinguished by its special physicochemical and low chemotoxic properties. It displays near isotonicity with blood and cerebrospinal fluid in all clinically used concentrations (190, 240, and 300 mg I/ml). The controlled, double-blind study of iotrolan versus iopamidol presented here shows that iotrolan is significantly superior to the monomeric contrast medium in lumbar and direct cervical myelography. Use of the dimeric contrast medium reduced not only the incidence of side effects, but also their severity and duration. The chemotoxicity of contrast media commonly used was significantly less with iotrolan in all neuroradiologic diagnostic studies of the spine. The diagnostic quality of lumbar and direct cervical myelography with iotrolan was high. In this randomized, double-blind study versus iopamidol, iotrolan proved to be the safer and better myelographic agent for contrast studies of the spinal canal.</p>","PeriodicalId":75861,"journal":{"name":"Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin. Erganzungsband","volume":"128 ","pages":"153-7"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13711615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical experience with iohexol versus iopromide in excretory urography. 碘己醇与碘丙胺在排泄性尿路造影中的临床应用。
Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin. Erganzungsband Pub Date : 1989-01-01
W Bischoff
{"title":"Clinical experience with iohexol versus iopromide in excretory urography.","authors":"W Bischoff","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In a controlled double-blind study the quality of the contrast produced by iopromide and iohexol was compared in two groups of 100 patients by excretory urography. The aim was to investigate whether iopromide or iohexol has any diagnostic advantages for the opacification of the kidneys, the renal pelves, and the ureters. The results show that there is no difference in contrast quality between the two substances (chi-square, p greater than 0.1). Moreover there is no difference in the frequency of concomitant symptoms (chi-square, p greater than 0.1). Both contrast media show the well-known excellent tolerance with only 1% side effects and the good contrast quality of the nonionic contrast media.</p>","PeriodicalId":75861,"journal":{"name":"Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin. Erganzungsband","volume":"128 ","pages":"108-10"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13711724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Elimination of the nonionic contrast medium iopromide in end-stage renal failure by hemodialysis. 血液透析消除非离子造影剂碘丙胺在终末期肾功能衰竭中的作用。
Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin. Erganzungsband Pub Date : 1989-01-01
H Kierdorf, J Kindler, R Winterscheid, H J Hollmann, D Vorwerk, U Speck
{"title":"Elimination of the nonionic contrast medium iopromide in end-stage renal failure by hemodialysis.","authors":"H Kierdorf,&nbsp;J Kindler,&nbsp;R Winterscheid,&nbsp;H J Hollmann,&nbsp;D Vorwerk,&nbsp;U Speck","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The increasing life-expectancy of patients with end-stage renal failure has led to a significant increase of diagnostic and interventional radiologic measures. The contrast media used in these procedures, however, are excreted only very slowly, due to the renal failure. We have therefore studied the elimination of the nonionic x-ray contrast medium iopromide (Ultravist) during dialysis in nine anuric patients with end-stage renal failure. All of the patients received 100 ml iopromide (30 g iodine) for the visualization of their Cimino-Brescia shunt. They were then dialyzed 30 minutes after the injection. The plasma iodine concentration declined from 1.7 to 0.7 mg I/ml plasma during the 3-hour dialysis treatment. The iopromide clearance was a constant 80 ml/min. This is the equivalent of a relative dialysance of 65% of the creatinine clearance. There were no incidences of side effects requiring therapy in this high-risk group of patients. The quality of the image was good in all cases. Iopromide proved itself to be an x-ray contrast medium with a low rate of side effects, which can be effectively eliminated from the body by means of conventional dialysis.</p>","PeriodicalId":75861,"journal":{"name":"Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin. Erganzungsband","volume":"128 ","pages":"119-23"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13711727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tolerance to iotrolan after subarachnoid injection in animals. 动物蛛网膜下腔注射后对碘曲兰的耐受性。
Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin. Erganzungsband Pub Date : 1989-01-01
W R Press, W Mützel, C Schöbel
{"title":"Tolerance to iotrolan after subarachnoid injection in animals.","authors":"W R Press,&nbsp;W Mützel,&nbsp;C Schöbel","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Neural tolerance after intracisternal administration of iotrolan was compared with that after iohexol, iopamidol, and metrizamide in mice, rats, and guinea pigs. Around the level of the ED50 (approximately two to four times the human dose) tolerance to iotrolan appeared to be much better than tolerance to the other agents. A study in rabbits comparing iotrolan with iohexol produced approximately the same result. High doses of iotrolan, iohexol, and iopamidol were almost equally well tolerated by rats, as were iotrolan and iohexol by rabbits. Tolerance to metrizamide by rats and to iopamidol by guinea pigs was vastly inferior. In support of this very good general tolerance histologic examinations of the spinal tract and of the brain did not reveal any substance-related changes in beagles after lumbar administration of a high dose. An investigation in rats using mannitol and sorbitol formulations with differing osmotic pressures indicates that contrast tolerance is influenced primarily by the chemotoxicity and not by increased osmotic pressure. As shown by the results of the preclinical investigations, iotrolan should be ideal for use in myelography and also appears highly suitable for the examination of other body cavities.</p>","PeriodicalId":75861,"journal":{"name":"Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin. Erganzungsband","volume":"128 ","pages":"126-33"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13711728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nonionic contrast media in gastrointestinal studies in newborns and small infants. 非离子造影剂在新生儿和小婴儿胃肠道研究中的应用。
Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin. Erganzungsband Pub Date : 1989-01-01
R Langer, H J Kaufmann
{"title":"Nonionic contrast media in gastrointestinal studies in newborns and small infants.","authors":"R Langer,&nbsp;H J Kaufmann","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Since January 1983, 431 patients were examined by oral or rectal application of nonionic contrast medium for gastrointestinal studies. The contrast medium was uniformly well tolerated, even by severely ill preterm babies and infants. We present a review of our experience and a list of indications for the use of nonionic contrast media in gastrointestinal studies. In addition, the urinary iodine concentration of eight patients was examined after oral application of nonionic contrast medium in order to evaluate the resorption of the substance.</p>","PeriodicalId":75861,"journal":{"name":"Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin. Erganzungsband","volume":"128 ","pages":"200-3"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13712286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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