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[Diagnosis and treatment of lymphogranulomatosis in children]. 【儿童淋巴肉芽肿病的诊断与治疗】。
Folia haematologica (Leipzig, Germany : 1928) Pub Date : 1990-01-01
L A Machonowa, B A Kolygin, H J Blau
{"title":"[Diagnosis and treatment of lymphogranulomatosis in children].","authors":"L A Machonowa,&nbsp;B A Kolygin,&nbsp;H J Blau","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Since more than 10 years there has been an informal pediatriconcological co-operation between Bulgaria, Hungary, Poland, GDR, CSFR, and USSR. In regular intervals an exchange was made for the coverage and care for oncologically affected children, on epidemiological, diagnostical and therapeutic results. Prospective co-operative therapy studies, however, could not be accomplished, with the exception of this retrospective analysis of M. Hodgkin covering 750 children, 465 boys and 285 girls according to age of disease, primary clinical division of stages, histological variant, applied treatment and their total findings. Thus, the demand for prospective studies of treatment is emphasized.</p>","PeriodicalId":75853,"journal":{"name":"Folia haematologica (Leipzig, Germany : 1928)","volume":"117 5","pages":"653-62"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12874165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Influence of cryopreservation on human leukaemic clonogenic cells (CFU-L). 低温保存对人白血病克隆细胞(CFU-L)的影响。
Folia haematologica (Leipzig, Germany : 1928) Pub Date : 1990-01-01
E Elstner, M Wächter, I W Blau
{"title":"Influence of cryopreservation on human leukaemic clonogenic cells (CFU-L).","authors":"E Elstner,&nbsp;M Wächter,&nbsp;I W Blau","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The biological and clinical significance of growth characteristics of leukaemic clonogenic cells (CFU-L) cultured from patients has been the subject of many studies. While some investigators collect leukaemic cells in large numbers from blood of untreated patients and store them in a frozen state before use in experiment, others study fresh cells. Since cryopreservation may alter the proliferation and differentiation of CFU-L, we have followed its influence and that of DMSO, used as protective agent and known to be an inducer of differentiation in leukaemic blasts, on the clonogenicity of peripheral blast cells from patients with AML and CML in blast crisis. Our data show that a short incubation with 7.5% DMSO (with or without cryopreservation) induced increase in the clonogenicity and proliferation rate of CFU-L (without morphological changes). The possible causes of these effects as well as the question of aggressivity of leukaemic blasts after the short incubation with 7.5% DMSO are discussed.</p>","PeriodicalId":75853,"journal":{"name":"Folia haematologica (Leipzig, Germany : 1928)","volume":"117 2","pages":"313-7"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12862320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lymphocyte function response to gammaglobulin infusion in common variable and sex-linked agammaglobulinaemia. 共同变量和性别连锁无球蛋白血症中淋巴细胞功能对丙种球蛋白输注的反应。
Folia haematologica (Leipzig, Germany : 1928) Pub Date : 1990-01-01
G Cascio, A Anania, M M Verney, C Cantamessa, R Barone, C Ricci
{"title":"Lymphocyte function response to gammaglobulin infusion in common variable and sex-linked agammaglobulinaemia.","authors":"G Cascio,&nbsp;A Anania,&nbsp;M M Verney,&nbsp;C Cantamessa,&nbsp;R Barone,&nbsp;C Ricci","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Lymphocyte electrophoretic mobility and natural killer cytotoxic activity are marked deranged in agammaglobulinaemia. These alterations can be normalised by correction of the serum Ig pattern. This suggests that Ig activity goes beyond specific antibody activity. I.v. Ig, in fact, exert several activities that also involve T-cell regulatory functions. It would thus be more correct to speak of \"immunotherapy\" of humoral immunodeficiencies with i.v. Ig, rather than simple \"immunosubstitution\".</p>","PeriodicalId":75853,"journal":{"name":"Folia haematologica (Leipzig, Germany : 1928)","volume":"117 2","pages":"283-90"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12862353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synoviorthesis with 198Au colloid gold in haemophilia patients. A preliminary report. 血友病患者用198Au胶体金滑膜成形术。初步报告。
Folia haematologica (Leipzig, Germany : 1928) Pub Date : 1990-01-01
G Ortonowski, J M Ziemski, W Kucharski, J Woy-Wojciechowski
{"title":"Synoviorthesis with 198Au colloid gold in haemophilia patients. A preliminary report.","authors":"G Ortonowski,&nbsp;J M Ziemski,&nbsp;W Kucharski,&nbsp;J Woy-Wojciechowski","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In 1988-1989 fifteen patients with severe haemophilia A and recurrent bleedings into the knee joint, aged from 19 to 44 years were treated by an intraarticular injection of 198Au colloid gold. So far 10 of them were assessed after 6 months follow-up. In 6 cases cesseation and in 2 cases reduction in number and volume of bleedings were observed. Only in 2 patients the frequency of haemarthroses remained unchanged. No significant difference in tracer uptake was observed between pretreatment 99mTc-pertechnate gamma scans of the knee joints and controls completed 6 months after the radiogold injections. It is worthy to stress the lower costs of the 198Au synoviorthesis as compared with surgical synovectomy of the knee joint. The radioisotope method is also much less traumatic to the patient than the surgical one.</p>","PeriodicalId":75853,"journal":{"name":"Folia haematologica (Leipzig, Germany : 1928)","volume":"117 4","pages":"505-10"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12878782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anti idiotypic recognition of auto and allo antibodies to factor VIII by immunoglobulin preparations from single blood donors and large plasma pool. 单个献血者和大血浆池的免疫球蛋白制剂对因子VIII自身抗体和容体抗体的抗独特型识别。
Folia haematologica (Leipzig, Germany : 1928) Pub Date : 1990-01-01
Y Sultan, F Rossi, M Kazatchkine
{"title":"Anti idiotypic recognition of auto and allo antibodies to factor VIII by immunoglobulin preparations from single blood donors and large plasma pool.","authors":"Y Sultan,&nbsp;F Rossi,&nbsp;M Kazatchkine","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Therapeutic immunoglobulins from commercial origin were administered to patients with allo and auto antibodies to factor VIII. The protocol used was similar to the prescription suggested for ITP, 0.4 g/kg body weight for five consecutive days. In patients with auto antibodies two kinds of effects were observed: A direct interaction between IVIg and the factor VIII inhibitor and long term interaction on antibody synthesis. The direct interaction observed in vivo was demonstrated to be mediated through Fab'2 fragments of both idiotypic interaction. This was also demonstrated using binding experiments and affinity chromatography experiments: Fab'2 fragments of IVIg were coupled to sepharose and Fab'2 fragments of patients IgG with allo and auto antibodies to Factor VIII were circulated through the column. The recovery of anti Factor VIII antibodies after elution was possible in 2 cases of allo antibodies out of 3 tested and 3 cases of auto antibodies out of 4. The question of anti idiotypes against factor VIII inhibitors in single individuals was investigated. IgG and Fab'2 fragments from single blood donors were isolated and tested for their inhibitory capacity against Fab'2 fragments of three different auto antibodies. The results did not show statistical differences between males and females however in the group of male blood donors, aging was a positive parameter for the presence of anti idiotypic antibodies against factor VIII inhibitors. Anti idiotypic antibodies against factor VIII inhibitors were present in 17.2% of the blood donor tested.</p>","PeriodicalId":75853,"journal":{"name":"Folia haematologica (Leipzig, Germany : 1928)","volume":"117 4","pages":"539-43"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12878787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Multivariate analysis for the understanding of typical diabetic hemostasis criteria. 3. Determination of a typical retinopathy parameter-constellation]. [多因素分析对典型糖尿病止血标准的理解。]3.典型视网膜病变参数群的确定[j]。
Folia haematologica (Leipzig, Germany : 1928) Pub Date : 1990-01-01
G Syrbe, H Schröder, E Keil, A Jütte
{"title":"[Multivariate analysis for the understanding of typical diabetic hemostasis criteria. 3. Determination of a typical retinopathy parameter-constellation].","authors":"G Syrbe,&nbsp;H Schröder,&nbsp;E Keil,&nbsp;A Jütte","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Features of metabolism and haemostasis which are different in diabetics of both types in comparison with normal subjects were covered by the statistical method of multivariance analysis depending on the severity of diabetic retinopathy. In 29 diabetics without retinopathy, 46 patients with stage I or II, and 36 patients with stage III the following parameters could be found as optimal criteria for characterizing the extent of vascular changes: blood sugar concentration, concentration of sialic acid and HDL cholesterol in the serum, serum protein, sialic acid per protein volume, total cholesterol in the serum and capillary fragility and number of large spreading forms of platelets features of hemostasis. Thus, diabetic retinopathy is characterized by a wide spectrum of different features containing the parameters of hemostasis. Thrombocytic vascular interactions are characterized by platelet spreading and capillary fragility which are significant for the development of diabetic retinopathy.</p>","PeriodicalId":75853,"journal":{"name":"Folia haematologica (Leipzig, Germany : 1928)","volume":"117 5","pages":"731-7"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12874047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Activity of some lysosomal enzymes in peritoneal macrophages of patients with end-stage renal failure treated by intermittent peritoneal dialysis. 间歇性腹膜透析治疗的终末期肾衰竭患者腹膜巨噬细胞中溶酶体酶活性的变化。
Folia haematologica (Leipzig, Germany : 1928) Pub Date : 1990-01-01
W Sułowicz
{"title":"Activity of some lysosomal enzymes in peritoneal macrophages of patients with end-stage renal failure treated by intermittent peritoneal dialysis.","authors":"W Sułowicz","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Acid phosphatase, beta-D-Glucuronidase and N-acetyl-beta-D-glucosaminidase were assessed cytochemically in peritoneal macrophages obtained from 50 patients with end-stage renal failure treated by intermittent peritoneal dialysis and from 30 control subjects with normal renal function. A statistically significant increase in beta-D-glucuronidase activity accompanied by a decrease in acid phosphatase activity were observed in peritoneal macrophages of dialysed patients, as compared with the control group. In patients with dialysis-associated peritonitis, the activity of N-acetyl-beta-D-glucosaminidase was significantly higher than that observed in the same patients during the complication-free period of the treatment.</p>","PeriodicalId":75853,"journal":{"name":"Folia haematologica (Leipzig, Germany : 1928)","volume":"117 5","pages":"663-7"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12874166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Platelet-tumor cell interaction. 血小板-肿瘤细胞相互作用。
Folia haematologica (Leipzig, Germany : 1928) Pub Date : 1990-01-01
U T Seyfert, W Hauck, H Berger, D Böhm, H Zankl, F W Albert
{"title":"Platelet-tumor cell interaction.","authors":"U T Seyfert,&nbsp;W Hauck,&nbsp;H Berger,&nbsp;D Böhm,&nbsp;H Zankl,&nbsp;F W Albert","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Several reports have appeared with regard to the potential role of platelets in tumor cells metastasis. Our in vitro studies with colon tumor cells in normals and in patients give some evidence against platelet aggregation as the determinant factor in tumor cell invasion and metastasis. Dimethylhydrazine induced colon tumors in Wistar rats demonstrate characteristic features of tumor cell dissociation in the invasion line and changes in intercellular adhesion.</p>","PeriodicalId":75853,"journal":{"name":"Folia haematologica (Leipzig, Germany : 1928)","volume":"117 5","pages":"685-97"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12874169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Characterization of T lymphocyte defects in patients with Hodgkin's disease using enzyme chemical markers]. [利用酶化学标记物表征霍奇金病患者T淋巴细胞缺陷]。
Folia haematologica (Leipzig, Germany : 1928) Pub Date : 1990-01-01
C Wendt, E Schön, B Gaede, A Franke, S Ansorge
{"title":"[Characterization of T lymphocyte defects in patients with Hodgkin's disease using enzyme chemical markers].","authors":"C Wendt,&nbsp;E Schön,&nbsp;B Gaede,&nbsp;A Franke,&nbsp;S Ansorge","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Patients suffering from lymphogranulomatosis were studied with respect to cellular immune deficiencies. For this purpose, mononuclear cells from venous blood were separated and subjected to analysis of lymphocyte markers. T-lymphocytes were enumerated by means of the sheep erythrocyte (SE) rosette test. T cell subpopulations were determined using enzyme cytochemical staining for dipeptidyl peptidase IV (DP IV) and unspecific acid alphanaphthylacetate esterase (ANAE). In 18 patients with M. Hodgkin a significant reduction in the T lymphocyte count in peripheral blood was found. This T cell defect is due to a selective decrease in the TM-subpopulation as identified by enzyme cytochemical markers DP IV and ANAE (focal reaction). From these results it is concluded that patients with lymphogranulomatosis have characteristic abnormalities in the immune system in the sense of a disturbed equilibrium of immune regulatory cells.</p>","PeriodicalId":75853,"journal":{"name":"Folia haematologica (Leipzig, Germany : 1928)","volume":"117 6","pages":"851-7"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12878094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[4th Haemoblastosis Symposium of the Society of Haematology and Blood Transfusion of the DDR]. 中华人民共和国血液学与输血学会第四届成血细胞病学术研讨会。
Folia haematologica (Leipzig, Germany : 1928) Pub Date : 1990-01-01
{"title":"[4th Haemoblastosis Symposium of the Society of Haematology and Blood Transfusion of the DDR].","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75853,"journal":{"name":"Folia haematologica (Leipzig, Germany : 1928)","volume":"117 6","pages":"765-915"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12878118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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