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[Effect of ultraviolet light on the UV/VIS absorption spectrum of components of Eagle (MEM) cell culture medium]. [紫外光对Eagle (MEM)细胞培养基成分紫外/可见吸收光谱的影响]。
Folia haematologica (Leipzig, Germany : 1928) Pub Date : 1990-01-01
G Bollmann, K Redmann
{"title":"[Effect of ultraviolet light on the UV/VIS absorption spectrum of components of Eagle (MEM) cell culture medium].","authors":"G Bollmann,&nbsp;K Redmann","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The impact of ultraviolet light on uv/vis absorption spectra of selected individual components of the cell breeding medium according to Eagle (MEM) was investigated. The strongest alterations of light absorption were detected in L-phenylalanine, L-tyrosine and L-tryptophan. Thus, the absorption behaviour of the Eagle (MEM) medium changed post radiation may be attributed to spectrophotometric alterations of absorption in aromatic amino acids. The results are discussed with regard to the effect on the surface charge of erythrocytes.</p>","PeriodicalId":75853,"journal":{"name":"Folia haematologica (Leipzig, Germany : 1928)","volume":"117 1","pages":"201-7"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12859889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Striking feature of alpha-fetoprotein (AFP): stimulation of the phagocytic capabilities of human blood platelets. 甲胎蛋白(AFP)的显著特征:刺激人血小板的吞噬能力。
Folia haematologica (Leipzig, Germany : 1928) Pub Date : 1990-01-01
H Kemona, M Czokało, M Mantur, J Prokopowicz
{"title":"Striking feature of alpha-fetoprotein (AFP): stimulation of the phagocytic capabilities of human blood platelets.","authors":"H Kemona,&nbsp;M Czokało,&nbsp;M Mantur,&nbsp;J Prokopowicz","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In concentrations from 2.5 x 10(3) to 480 x 10(3) ng/ml AFP is able to increase the phagocytic index and the phagocytizing percentage of human blood platelets in vitro conditions. This effect is dependent on the dose of AFP and time of incubation.</p>","PeriodicalId":75853,"journal":{"name":"Folia haematologica (Leipzig, Germany : 1928)","volume":"117 1","pages":"161-5"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12859931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Thrombocytopenia after autologous bone marrow transplantation in in acute lymphatic leukemia]. 急性淋巴白血病自体骨髓移植后血小板减少的研究。
Folia haematologica (Leipzig, Germany : 1928) Pub Date : 1990-01-01
E Siegert, I Lauterbach, G Weissbach
{"title":"[Thrombocytopenia after autologous bone marrow transplantation in in acute lymphatic leukemia].","authors":"E Siegert,&nbsp;I Lauterbach,&nbsp;G Weissbach","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>There is reported about the treatment of refractory thrombocytopenia in a 9 years old boy following the autologous bone marrow transplantation for acute lymphoblastic leukaemia. The megakaryocytes were found diminished in the bone marrow smears. Controls of the thrombocyte count and the kinetics with radioactively labeled platelets of a donor spoke in favour of immunothrombocytopenia. Threatening bleeding complications challenged the use of all treatment possibilities. The irradiation of the spleen was without any success. After the splenectomy the thrombocyte count increased slowly, but after a remarkable lag phase, however. A diminished reproduction capacity of the bone marrow graft for special cell sorts has to be taken into account in such cases. The usual cytodynamics after splenectomy cannot be expected at all.</p>","PeriodicalId":75853,"journal":{"name":"Folia haematologica (Leipzig, Germany : 1928)","volume":"117 2","pages":"265-70"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12862350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inhibitor of granulopoiesis in human cyclic neutropenia. 人循环中性粒细胞减少症的颗粒生成抑制剂。
Folia haematologica (Leipzig, Germany : 1928) Pub Date : 1990-01-01
V Cukrová, H Klamová
{"title":"Inhibitor of granulopoiesis in human cyclic neutropenia.","authors":"V Cukrová,&nbsp;H Klamová","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Peripheral blood mononuclear cells of a patient with cyclic neutropenia release a high molecular weight substance (over 300,000) inhibiting normal CFU-GM cells to enter the S-phase of cell cycle. The inhibitor was released predominantly in the neutropenic phase of the disease, while in the period of normal granulocyte count the release was lower or undetectable. Also sensitivity of patient's bone marrow CFU-GM cells to similar high molecular weight inhibitor produced by ML-2 cell liner or to human placental ferritin varied within the disease cycle. CFU-GM in the normal granulocyte count period were sensitive to the inhibitors, but CFU-GM in the neutropenic phase were resistant.</p>","PeriodicalId":75853,"journal":{"name":"Folia haematologica (Leipzig, Germany : 1928)","volume":"117 5","pages":"647-52"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12873653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Malondialdehyde formation by platelets of hemophiliacs]. 血友病患者血小板中丙二醛的形成。
Folia haematologica (Leipzig, Germany : 1928) Pub Date : 1990-01-01
B Maak, F Marrouchieh
{"title":"[Malondialdehyde formation by platelets of hemophiliacs].","authors":"B Maak,&nbsp;F Marrouchieh","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The platelets of haemophilic patients produce after stimulation with thrombin (5 NIH-units) a significantly reduced amount of malondialdehyde in comparison to the platelets of healthy children of the same age. There is a positive correlation between the platelet count in citrated whole blood and malondialdehyde production in the group of healthy children, however the same correlation is negative in adults and strongly negative in haemophiliacs. Because of the 24 hour-intervals between the last substitution and investigation in the majority of haemophilic patients, the reduced MDA-production of their platelets seems to be the result of side effects of the administration of plasma fractions. On the other hand, the reduced capacity for the MDA-production of the platelets of haemophiliacs can be explained as the result of the release reaction of platelets after haemostasis activation following bleedings.</p>","PeriodicalId":75853,"journal":{"name":"Folia haematologica (Leipzig, Germany : 1928)","volume":"117 4","pages":"623-9"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12878623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Granulocytopoiesis in children with acute lymphoblastic leukaemia. 急性淋巴细胞白血病患儿的粒细胞生成。
Folia haematologica (Leipzig, Germany : 1928) Pub Date : 1990-01-01
E B Vladimirskaya, N S Shersheneva, S Sallam, N V Zamaraeva, S N Chukanin
{"title":"Granulocytopoiesis in children with acute lymphoblastic leukaemia.","authors":"E B Vladimirskaya,&nbsp;N S Shersheneva,&nbsp;S Sallam,&nbsp;N V Zamaraeva,&nbsp;S N Chukanin","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Numbers, proliferative potential, and differentiative capacity of bone marrow granulocyte-macrophage precursor cells were studied in 130 children with acute lymphoblastic leukaemia (ALL), including 77 children in an acute phase of the disease and 53 in remission. Bone marrow samples from 65 children without haematopoietic abnormalities were used as controls. The numbers of clonogenic precursors were found to be below normal in all phases of ALL, particularly during the acute period when the bone marrow was heavily infiltrated with leukaemic cells. It is shown that the decreases in the numbers and proliferative potential of the precursor cells during the acute phases was associated with the effects of leukaemic blast cells, but that in remission the observed reduction in the precursor cell pool was due to the cytostatic effect of therapy. The differentiative capacity of clonogenic granulocyte and macrophage precursors was not altered in children with ALL.</p>","PeriodicalId":75853,"journal":{"name":"Folia haematologica (Leipzig, Germany : 1928)","volume":"117 3","pages":"383-90"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12867453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Are our blood donors in danger of iron deficiency?]. 献血者是否有缺铁的危险?
Folia haematologica (Leipzig, Germany : 1928) Pub Date : 1990-01-01
L H Schmidt, W Gulich
{"title":"[Are our blood donors in danger of iron deficiency?].","authors":"L H Schmidt,&nbsp;W Gulich","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In blood donors the question arises for eventual endangering by iron deficiency. The results of this work show that ferritin determinations for blood donors will indicate a latent, in some cases a manifest iron deficiency. The examination of testing components such as PVC, MCH, Fe i. S., transferrin and transferrin saturation produced no special advantages concerning sensitivity and specificity, in terms of ferritin determination. It is indispensable, however, to know the ferritin value because the control of the Hb value prior to blood donation will usually characterize the blood donor's situation in a sufficient manner. For control purposes it is possible to use capillary or venous blood. It is only in general, but particularly in special clinical situations that you have to be aware of the blood donor's condition concerning his/her Fe-metabolism.</p>","PeriodicalId":75853,"journal":{"name":"Folia haematologica (Leipzig, Germany : 1928)","volume":"117 3","pages":"457-60"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12867924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[4th Haemophilia symposium of the German Democratic Republic with international participation. Dresden, 22-25 November 1989]. 第四届德意志民主共和国血友病国际研讨会。德累斯顿，1989年11月22-25日]。
Folia haematologica (Leipzig, Germany : 1928) Pub Date : 1990-01-01
{"title":"[4th Haemophilia symposium of the German Democratic Republic with international participation. Dresden, 22-25 November 1989].","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75853,"journal":{"name":"Folia haematologica (Leipzig, Germany : 1928)","volume":"117 4","pages":"489-641"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12879399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Antibodies to anticoagulants in rheumatic autoimmune diseases]. [风湿病自身免疫性疾病的抗凝血抗体]。
Folia haematologica (Leipzig, Germany : 1928) Pub Date : 1990-01-01
E Gromnica-Ihle, W Schössler, J Franz, S Ziemer, H Hüge, E Apostoloff
{"title":"[Antibodies to anticoagulants in rheumatic autoimmune diseases].","authors":"E Gromnica-Ihle,&nbsp;W Schössler,&nbsp;J Franz,&nbsp;S Ziemer,&nbsp;H Hüge,&nbsp;E Apostoloff","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The systemic lupus erythematosus (SLE) and the rheumatoid arthritis (RA) as the classic autoimmune diseases exhibit a great number of autoantibodies. Some of them are anticoagulants. Besides inactivating inhibitors against single coagulation factors interfering anticoagulants are known, belonging to the group of anti-phospholipid antibodies and detected as the lupus anticoagulants or anticardiolipin antibodies. Anti-phospholipid antibodies 184 patients with SLE or RA had been checked for. An enzyme immuno assay was used for detection of the anti-cardiolipin antibodies. The relations between occurrence of the anti-cardiolipin antibodies and vascular processes as well as other immunologic parameters had been tested for clinical relevancy.</p>","PeriodicalId":75853,"journal":{"name":"Folia haematologica (Leipzig, Germany : 1928)","volume":"117 4","pages":"549-56"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12879264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of wet pasteurization of a factor VIII concentrate produced by controlled-pore silica adsorption. 控制孔二氧化硅吸附生产的因子VIII浓缩物的湿法巴氏灭菌评价。
Folia haematologica (Leipzig, Germany : 1928) Pub Date : 1990-01-01
H Hiemstra, C E Nieuweboer, M A Idoe, J E Claassen, A H Vos, M Tersmette, P F Strengers, J Over, E P Mauser-Bunschoten, H Heijboer
{"title":"Evaluation of wet pasteurization of a factor VIII concentrate produced by controlled-pore silica adsorption.","authors":"H Hiemstra,&nbsp;C E Nieuweboer,&nbsp;M A Idoe,&nbsp;J E Claassen,&nbsp;A H Vos,&nbsp;M Tersmette,&nbsp;P F Strengers,&nbsp;J Over,&nbsp;E P Mauser-Bunschoten,&nbsp;H Heijboer","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In the routine production of a factor VIII concentrate (produced by adsorption of contaminating proteins in cryoprecipitate to controlled-pore silica and concentration of the factor VIII effluent by ultrafiltration) the terminal dry-heat treatment has been replaced by pasteurization in the liquid state. High effectivity of this procedure with respect to virus inactivation was demonstrated using a variety of both lipid- and protein-enveloped model viruses, including HIV. Pair-wise quality control of dry-heated and pasteurized product revealed no significant differences, except in the composition of the formulation buffer. In a clinical study in which 17 patients with haemophilia A participated the pasteurized product was well tolerated and in vivo recovery and half-life of factor VIII were in the same (normal) range as found for the dry-heated counterpart.</p>","PeriodicalId":75853,"journal":{"name":"Folia haematologica (Leipzig, Germany : 1928)","volume":"117 4","pages":"557-63"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12879265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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