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The diagnostic value of bone marrow iron. 骨髓铁的诊断价值。
Folia haematologica (Leipzig, Germany : 1928) Pub Date : 1990-01-01
U Wulfhekel, J Düllmann
{"title":"The diagnostic value of bone marrow iron.","authors":"U Wulfhekel,&nbsp;J Düllmann","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The light and electronmicroscopic representation of non-haemiron in the bone-marrow provides the unique opportunity of extensively evaluating the iron metabolism. In the bone-marrow, macrophages represent the physiological place of iron storage. The iron in the cytoplasma is stored in them in the form of free ferritin molecules and lysomally as aggregated ferritin and/or haemosiderin in siderosomes. In an equal iron balance and unimpaired internal iron exchange only erythroblasts (sideroblasts) and erythrocytes (siderocytes) of the bone-marrow besides macrophages possess siderosomes. In addition to this physiological or orthotopic iron storage a heterotopic iron storage can be observed under pathological conditions, particularly with iron overloading of the organism, in the endothelial cells of sinusoids and plasma cells. In detail, the patterns of iron storage in the bone-marrow are described in the different stages of iron deficiency, disturbance of iron utilization in chronically inflammatory processes or tumour diseases, condition after intravenous iron administration, transfusion siderosis, hereditary haemochromatosis and sideroblastic anaemia.</p>","PeriodicalId":75853,"journal":{"name":"Folia haematologica (Leipzig, Germany : 1928)","volume":"117 3","pages":"419-34"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12867458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The evaluation of prognostic factors for achieving complete remission and survival in ANLL of adults. The proposition of a prognostic scale. 成人ANLL患者实现完全缓解和生存的预后因素评估。预测尺度的主张。
Folia haematologica (Leipzig, Germany : 1928) Pub Date : 1990-01-01
S Krzemien, J Holowiecki, K Jagoda, B Holowiecka
{"title":"The evaluation of prognostic factors for achieving complete remission and survival in ANLL of adults. The proposition of a prognostic scale.","authors":"S Krzemien,&nbsp;J Holowiecki,&nbsp;K Jagoda,&nbsp;B Holowiecka","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The retrospective analysis has concerned 323 patients with acute nonlymphocytic leukaemia (ANLL). The comparable patients groups were treated since 1981 according to protocols used by the Polish Acute Leukaemia Group (induction; modified TAD or Adriamycin plus Ara-C, maintenance; rotatingly changed polychemotherapy for 3 years). The prognostic value for achieving complete remission (CR) and survival of 67 pre-treatment factors (42 quantitative and 25 qualitative) was evaluated. The most important 9 parameters were scored according to the prognostic value as follows: age, proportion of blasts in bone marrow, blast count in peripheral blood, morphological subtype, percentage of granulocytes in bone marrow, proportion of blasts with CD-15 antigen, thrombocyte count, spleen/liver enlargement, protein concentration in cerebro-spinal fluid. The scoring system has been elaborated allowing selection of ANLL patients to standard risk group and a high risk group.</p>","PeriodicalId":75853,"journal":{"name":"Folia haematologica (Leipzig, Germany : 1928)","volume":"117 5","pages":"739-46"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12874048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of conditioned medium on recovery of circulating blood cells in irradiated mice. 条件培养基对辐照小鼠循环血细胞恢复的影响。
Folia haematologica (Leipzig, Germany : 1928) Pub Date : 1990-01-01
N Macková, P Fedorocko, P Brezáni
{"title":"Effect of conditioned medium on recovery of circulating blood cells in irradiated mice.","authors":"N Macková,&nbsp;P Fedorocko,&nbsp;P Brezáni","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effect of supernatant of thymus-cell conditioned medium (TCCM) on blood element recovery in peripheral blood was followed in mice exposed to a single whole body dose of 5.8 Gy of gamma radiation. As follows from our results. TCCM administered 18 h before irradiation accelerated the recovery of the reticulocyte and, in part, thrombocyte and granulocyte counts. However, no effect on the rate of lymphocyte recovery was found.</p>","PeriodicalId":75853,"journal":{"name":"Folia haematologica (Leipzig, Germany : 1928)","volume":"117 5","pages":"759-63"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12874050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Disturbances in iron utilization in acute leukemia and preleukemia]. [急性白血病和白血病前期铁利用紊乱]。
Folia haematologica (Leipzig, Germany : 1928) Pub Date : 1990-01-01
C Boewer
{"title":"[Disturbances in iron utilization in acute leukemia and preleukemia].","authors":"C Boewer","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>With Prussian blue reaction nonhaemoglobin iron in the erythroblasts is demonstrable. Three pathological sideroblast types are recorded separately: abnormal intermediate type I and II sideroblasts and ring sideroblasts, representing increasing levels of sideroachrestic disturbance. This permits the classification of sideroachrestic disturbances into four degrees of seriousness. The frequency of a sideroachrestic disturbance in 47 untreated patients with acute myeloid leukaemia was 87%. Among 11 patients with preleukaemic condition, 8 had a disturbance of iron utilisation. In both preleukaemia and leukaemia mainly intermediate sideroblasts were present. All patients with preleukaemia developed leukaemia within 1-20 months. In the course of preleukaemic condition a slight increase of iron misutilisation was obvious when terminating in overt leukaemia. This could be of prognostic importance. After treatment, pathological sideroblasts disappeared only in 2 out of 15 patients with complete remission. There was no correlation between effect of therapy and course of iron misutilisation.</p>","PeriodicalId":75853,"journal":{"name":"Folia haematologica (Leipzig, Germany : 1928)","volume":"117 6","pages":"805-10"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12878125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Arthrosonography--a modern method for morphologic and functional joint evaluation in hemophilia]. [关节超声-血友病关节形态和功能评估的现代方法]。
Folia haematologica (Leipzig, Germany : 1928) Pub Date : 1990-01-01
D Wiemann, V Aumann, U Mittler
{"title":"[Arthrosonography--a modern method for morphologic and functional joint evaluation in hemophilia].","authors":"D Wiemann,&nbsp;V Aumann,&nbsp;U Mittler","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The arthrosonography is a new depicting procedure for detection of destructing joint processes in haemophilia. A direct evaluation of the cartilage, of the border between cartilage and bone, of the synovial membrane with proliferative processes as well as the differentiation between soft-tissue bleeding and haemarthros are possible. An essential advantage is given by a combined morphological and functional joint evaluation. The diagnosis of joint instabilities can be recognized easier by sonography than by X-ray. Clinical findings are completed in an excellent manner and lesions of bone and cartilage are detected earlier by arthrosonography.</p>","PeriodicalId":75853,"journal":{"name":"Folia haematologica (Leipzig, Germany : 1928)","volume":"117 4","pages":"511-8"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12878783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Contribution to the mechanism of the "factor VIII bypassing activity" (FEIBA)-reaction]. [对“因子VIII旁路活性”(FEIBA)反应机制的贡献]。
Folia haematologica (Leipzig, Germany : 1928) Pub Date : 1990-01-01
W Sander, K Wilms
{"title":"[Contribution to the mechanism of the \"factor VIII bypassing activity\" (FEIBA)-reaction].","authors":"W Sander,&nbsp;K Wilms","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The principle of the FEIBactivity hadn't been defined in a sufficient manner up to now. Probably the factor VII or factor VIIa are playing a key role. According to own experiments the factor VII activity increases considerably in activated prothrombincomplex concentrates together with the quotient factor VIIa/VII. Factor VII should be administered in his activated form for bypassing. Fractions with limitation of the activation process to factor VII are of a low thrombogenicity. Among activated coagulation factors factor VIIa persists longest in the circulation and a bypass efficacy can be provoked only by this.</p>","PeriodicalId":75853,"journal":{"name":"Folia haematologica (Leipzig, Germany : 1928)","volume":"117 4","pages":"581-7"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12879268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Activated prothrombin complex preparations for the treatment of anticoagulant hemophilia. Preparation--method of operation--supply possibility]. 活化凝血酶原复合物制剂治疗抗凝血友病。准备-操作方法-供应可能性]。
Folia haematologica (Leipzig, Germany : 1928) Pub Date : 1990-01-01
K Wilms, W Sander
{"title":"[Activated prothrombin complex preparations for the treatment of anticoagulant hemophilia. Preparation--method of operation--supply possibility].","authors":"K Wilms,&nbsp;W Sander","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The mechanism of the bypass activity of prothrombin complex preparatives for treatment of haemophiliacs with circulating anticoagulants remains unclear up to now. The following parameters had been tested with preparatives produced in a different manner (absorption by DEAE-Sephadex A 50, Molselekt A 50, tricalcium phosphate or aluminium hydroxide): Coagulation factors II, VII, IX, X and XII, activated factors VIIa and Xa as well as the FEIB activity. The bypass activity is strongly correlated to the factor VIIa content of the preparatives, however. These results agree with the statements by HEDNER and KISIEL, which had used a factor VII a concentrate for treatment of haemophilia complicated by circulating anticoagulants with success. According to farther investigations factor VII is correlated with the lipid content of the starting plasma. This knowledge is important for optimizing the production procedure of prothrombin complex preparatives with bypassing activity.</p>","PeriodicalId":75853,"journal":{"name":"Folia haematologica (Leipzig, Germany : 1928)","volume":"117 4","pages":"589-93"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12879269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Thrombin/antithrombin III complex in patients with peripheral occlusive arterial disease. 凝血酶/抗凝血酶III复合物在外周动脉闭塞性疾病患者中的作用
Folia haematologica (Leipzig, Germany : 1928) Pub Date : 1990-01-01
D Rość, M Kotschy, M Rewakovicz, D Listopadzki
{"title":"Thrombin/antithrombin III complex in patients with peripheral occlusive arterial disease.","authors":"D Rość,&nbsp;M Kotschy,&nbsp;M Rewakovicz,&nbsp;D Listopadzki","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Determinations of thrombin/antithrombin III complex (TAT) in human plasma with the new enzyme immunoassay (Enzygnost-TAT) were performed. The study group consisted of 36 patients aged 36-79 years suffering from peripheral obliterative arterial disease (POAD) comparing to control group. In patients the elevation of TAT level was detected. The analysis of increased TAT level in the relation to clinical atherosclerotic complications, the kind of treatment, the stage of POAD, the age of patients and the period after operation was done. The highest TAT complex seemed to be correlated with the advance of atherosclerotic process, with additional diseases such as arterial hypertension, diabetes mellitus and performed operation. The \"Enzygnost-TAT\" assay can be useful for the detection of prethrombotic states without clinical symptoms of hypercoagulability and can be applied for clinical diagnosis.</p>","PeriodicalId":75853,"journal":{"name":"Folia haematologica (Leipzig, Germany : 1928)","volume":"117 3","pages":"405-11"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12867456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Deep vein thrombophlebitis of a leg in a young female with heterozygous protein C deficiency taking oral contraceptives. 杂合蛋白C缺乏症的年轻女性服用口服避孕药后发生下肢深静脉血栓性静脉炎。
Folia haematologica (Leipzig, Germany : 1928) Pub Date : 1990-01-01
P Simioni, A R Lazzaro, A Girolami
{"title":"Deep vein thrombophlebitis of a leg in a young female with heterozygous protein C deficiency taking oral contraceptives.","authors":"P Simioni,&nbsp;A R Lazzaro,&nbsp;A Girolami","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75853,"journal":{"name":"Folia haematologica (Leipzig, Germany : 1928)","volume":"117 3","pages":"443-5"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12867460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dose-reduced induction therapy for acute leukaemias decreases both the complete remission (CR) rate and the probability of leukaemia-free survival (LFS). 急性白血病的减剂量诱导治疗降低了完全缓解(CR)率和无白血病生存(LFS)的概率。
Folia haematologica (Leipzig, Germany : 1928) Pub Date : 1990-01-01
R Krahl, W Helbig, M Kubel
{"title":"Dose-reduced induction therapy for acute leukaemias decreases both the complete remission (CR) rate and the probability of leukaemia-free survival (LFS).","authors":"R Krahl,&nbsp;W Helbig,&nbsp;M Kubel","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Especially in AML but also in ALL a dose reduction during the induction therapy effected distinctly both a diminution of the CR rate and a shortening of the LFS. For these reason reduced treated patients are to exclude from final analysis of study in order to obtain a objective comparison of the four postremission treatment modalities. There was no difference concerning treatment related mortality between \"correct\" and \"reduced\" induction therapy.</p>","PeriodicalId":75853,"journal":{"name":"Folia haematologica (Leipzig, Germany : 1928)","volume":"117 6","pages":"783-6"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12878121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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