American journal of nuclear medicine and molecular imaging最新文献

{"title":"Rare pulmonary metastases of atypical meningioma diagnosed on total-body ¹⁸F-FDG PET/CT.","authors":"Qing Wang,&nbsp;Weijun Wei,&nbsp;Min Cao","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Here we reported a 59-year-old male who had undergone brain surgery three times and the pathological results showed atypical meningioma (2015, WHO grade I; 2018, WHO grade II; 2019, WHO grade II-III), with multiple pulmonary nodules, which arose during follow-up. A total-body ¹⁸F-FDG PET/CT showed multiple solid nodules with increased ¹⁸F-FDG metabolism (SUVmax = 8.6). The patient underwent a CT-guided lung biopsy and the histopathological study showed positive staining of epithelial membrane antigen (EMA), vimentin (VIM), SSTR2, Ki67 (20%), and negative staining of CK, TTF-1, CD34, SY, PR, P40, respectively. Based on the history and immunohistology results, multiple pulmonary metastases from atypical meningioma were finally diagnosed, since double positive staining of EMA and VIM supported the diagnosis of meningioma and negative staining excluded primary lung cancers. The patient has given up any treatment because of personal reasons. Pulmonary metastasis from meningioma is rare, accurate diagnosis should be based on medical history, imaging characteristics, and histopathological findings.</p>","PeriodicalId":7572,"journal":{"name":"American journal of nuclear medicine and molecular imaging","volume":"12 5","pages":"163-165"},"PeriodicalIF":2.5,"publicationDate":"2022-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9677137/pdf/ajnmmi0012-0163.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40721586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[⁶⁸Ga]Ga-DOTATATE-avid tumor volume, uptake and inflammation-based index correlate with survival in neuroendocrine tumor patients treated with [¹⁷⁷Lu]Lu-DOTATATE PRRT.","authors":"Elin Pauwels,&nbsp;Jeroen Dekervel,&nbsp;Chris Verslype,&nbsp;Paul M Clement,&nbsp;Christophe Dooms,&nbsp;Kristof Baete,&nbsp;Karolien Goffin,&nbsp;Sander Jentjens,&nbsp;Koen Van Laere,&nbsp;Eric Van Cutsem,&nbsp;Christophe M Deroose","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>To meet the increasing demand for PRRT in the treatment of patients with inoperable/disseminated well-differentiated neuroendocrine tumors (NETs) and to guide optimization strategies, adequate and accessible predictive tools that allow to stratify patients who will benefit from treatment from those who will not are becoming indispensable. Previously, we have investigated the role of baseline [⁶⁸Ga]Ga-DOTATOC PET tumor uptake and volumetric parameters and a blood-derived inflammatory biomarker, the inflammation-based index (IBI), for outcome prediction in NET patients treated with [⁹⁰Y]Y-DOTATOC. In this retrospective study in 83 NET patients treated with [¹⁷⁷Lu]Lu-DOTATATE in a routine clinical setting, we aimed to evaluate the generalizability of our previous findings to [¹⁷⁷Lu]Lu-DOTATATE treatment combined with a pre-therapeutic [⁶⁸Ga]Ga-DOTATATE PET. A semi-automatic customized SUV threshold-based approach was used for tumor delineation. The previously identified SUV_mean cut-off of 13.7 for better survival could not be applied to this patient cohort. Instead, a more optimal cut-off could be identified: an SUV_mean lower or equal than 11.2 was associated with worse overall survival (OS) (hazard ratio (HR) 2.28; P = 0.008). Also in line with our previous study, a [⁶⁸Ga]Ga-DOTATATE-avid tumor volume (TV) higher than 672 mL and an elevated baseline IBI were correlated with worse OS (HR 3.13 (P = 0.0001) and HR 2.00 (P = 0.034), respectively). Multivariate analysis confirmed independent associations between OS and baseline IBI (P = 0.032), SUV_mean (P = 0.027) and [⁶⁸Ga]Ga-DOTATATE-avid TV (P = 0.001). Taking baseline IBI, [⁶⁸Ga]Ga-DOTATATE-avid TV and [⁶⁸Ga]Ga-DOTATATE uptake into account may help guide PRRT treatment decisions.</p>","PeriodicalId":7572,"journal":{"name":"American journal of nuclear medicine and molecular imaging","volume":"12 5","pages":"152-162"},"PeriodicalIF":2.5,"publicationDate":"2022-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9677135/pdf/ajnmmi0012-0152.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40721584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fluorescent intraoperative navigation: trends and beyond.","authors":"Lixia Feng, Dawei Jiang","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7572,"journal":{"name":"American journal of nuclear medicine and molecular imaging","volume":"12 4","pages":"138-142"},"PeriodicalIF":2.0,"publicationDate":"2022-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441924/pdf/ajnmmi0012-0138.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33448968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare B-cell type chronic active Epstein-Barr virus infection patient mimicking lymphoma on ¹⁸F-FDG PET/CT and literature review.","authors":"Hao Jiao,&nbsp;Yongbai Zhang,&nbsp;Zhao Chen,&nbsp;Xueqi Chen,&nbsp;Yongkang Qiu,&nbsp;Wenpeng Huang,&nbsp;Lin Nong,&nbsp;Lei Kang","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A 13-year-old girl suffered from worsen snoring and persistent bilateral nasal congestion for one year. Paranasal sinus computed tomography (CT) and magnetic resonance imaging (MRI) found nasopharyngeal passages and sinus were occupied with soft tissues and bilateral neck enlarged lymph nodes 6 months ago. Tumor markers were normal. The titers of anti-Epstein-Barr virus (EBV) IgM, anti-EBV IgG, early antigen (EA) IgG, and Epstein-Barr nuclear antigen (EBNA) IgG increased. 2-Deoxy-2-[fluorine-18]-fluoro-D-glucose (¹⁸F-FDG) positron emission tomography combined with CT (PET/CT) revealed thickened soft tissues in nasopharynx and oropharynx, enlarged multiple lymph nodes in the neck, bilateral armpits, abdominal cavity and retroperitoneum, and pelvic cavity, diffuse thickening of the gastric wall of the antrum with hypermetabolism. According to the age, situation, regions, and abnormal FDG uptake, an initial diagnosis of EBV-related lymphoma was made. However, the pathological results of the nasopharyngeal mass and the abdominal lymph node confirmed the final diagnosis of a B-cell type chronic active Epstein-Barr virus disease (CAEBV), a rare type of EBV associated lymphoproliferative disorder (LPD). After receiving adoptive immune cells therapy, the EBV load decreased. At present, the patient is being followed up.</p>","PeriodicalId":7572,"journal":{"name":"American journal of nuclear medicine and molecular imaging","volume":"12 4","pages":"129-137"},"PeriodicalIF":2.5,"publicationDate":"2022-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441925/pdf/ajnmmi0012-0129.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33448966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imaging ligands targeting glypican-3 receptor expression in hepatocellular carcinoma.","authors":"Shaun D Grega,&nbsp;David X Zheng,&nbsp;Qi-Huang Zheng","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Hepatocellular carcinoma (HCC) is the third leading cause of cancer mortality. Early detection of HCC is important since potentially curative therapies exist in the initial stages of HCC; no curative therapies exist for late-stage HCC. However, the initial detection of HCC remains challenging due to the lack of symptoms during the early stage of the disease. Other methods of screening and detecting HCC, including blood serum tests and conventional imaging methods, remain inadequate due to genetic differences between patients and the high background activity of liver tissues. Thus, there is a need for an accurate imaging agent for the diagnosis, staging, and prognosis of HCC. Glypican-3 (GPC3) is an oncofetal receptor responsible for regulating cell division, growth, and survival. GPC3 is a clinically relevant biomarker for imaging and therapeutics, as its expression is HCC tumor-specific and absent from normal and other pathological liver tissues. The development of novel GPC3-targeting imaging agents has encompassed three classes of biomolecules: peptides, antibodies, and aptamers. These biomolecules serve as constructs for diagnostic imaging (demonstrating potential as positron emission tomography [PET], single-photon emission tomography [SPECT], and optical imaging agents) and HCC treatment delivery. More than 20 unique ligands have been identified in the literature as showing specificity for the GPC3 receptor. Although several ligands are currently under clinical investigation as therapies for HCC, clinical translation of GPC3-targeting ligands as imaging agents is lacking. This review highlights the current landscape of ligands targeting GPC3 and describes their promising possibilities as imaging agents for HCC.</p>","PeriodicalId":7572,"journal":{"name":"American journal of nuclear medicine and molecular imaging","volume":"12 4","pages":"113-121"},"PeriodicalIF":2.5,"publicationDate":"2022-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441927/pdf/ajnmmi0012-0113.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33448964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multimodal treatment and imaging of primary pulmonary artery sarcoma: a case report.","authors":"Wenpeng Huang,&nbsp;Yuhan Zhou,&nbsp;Ge Gao,&nbsp;Qi Yang,&nbsp;Zhao Chen,&nbsp;Yongkang Qiu,&nbsp;Lele Song,&nbsp;Lei Kang","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Primary pulmonary artery sarcoma (PAS) is a malignant neoplasm of the pulmonary vascular system originating from the intima, with clinical and imaging manifestations similar to those of pulmonary thromboembolism (PTE), and is often misdiagnosed. Spectral CT and PET/CT can clearly show the extent and metastasis of PAS and are valuable in visualizing adjacent structures such as lungs, bronchi, and mediastinum, providing a strong imaging basis for the diagnosis and differentiation of PAS, allowing treatment monitoring and follow-up.</p>","PeriodicalId":7572,"journal":{"name":"American journal of nuclear medicine and molecular imaging","volume":"12 4","pages":"122-128"},"PeriodicalIF":2.5,"publicationDate":"2022-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441926/pdf/ajnmmi0012-0122.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33448965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biodistribution of intravenous [^99mTc]Tc-phytate in mouse models of chemically and foreign-body induced sterile inflammation.","authors":"Maria Papachristou,&nbsp;Dimitrios Priftakis,&nbsp;Stavros Xanthopoulos,&nbsp;Ioannis Datseris,&nbsp;Penelope Bouziotis","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>When injected intravenously, [^99mTc]Tc-phytate forms particles in the nanometer range. This size can favor its extravasation into tumor and inflammation through pores of the vasculature. The aim of this work is the evaluation of the use of [^99mTc]Tc-phytate to assess sterile inflammation in mouse models. Biodistribution studies of [^99mTc]Tc-phytate were performed in two groups of male Swiss Albino mice. Sterile inflammation was induced after intramuscular injection of turpentine in the first group (chemically induced sterile inflammation model) and after implantation of sterile metal bolts in the second group (foreign-body induced sterile inflammation model). [^99mTc]Tc-phytate was intravenously injected after the development of inflammation in both groups and <i>ex vivo</i> biodistribution of the radiolabelled complex followed at different time-points. Biodistribution was expressed as percent injected dose per gram (%ID/g). Target-to-background ratios were also recorded. For the chemically induced sterile inflammation model, <i>ex vivo</i> biodistribution evaluation measurements revealed a pronounced uptake in the inflamed muscle when compared to uptake in the control/non-inflamed muscle. Moreover, as expected, there is a high uptake in the liver and spleen. For the foreign-body induced sterile inflammation model, a significantly higher uptake was observed in the inflamed muscle post [^99mTc]Tc-phytate injection, both for the 24 hours post-bolt implantation and for the 7 days post-bolt implantation groups. The nanoparticle properties of [^99mTc]Tc-phytate are potentially useful in the imaging of different types of sterile inflammation with translational potential clinical SPECT (single photon emission computed tomography) imaging applications in humans.</p>","PeriodicalId":7572,"journal":{"name":"American journal of nuclear medicine and molecular imaging","volume":"12 3","pages":"91-98"},"PeriodicalIF":2.5,"publicationDate":"2022-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9301090/pdf/ajnmmi0012-0091.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40644836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spontaneous intracerebral hemorrhage, initial computed tomography (CT) scan findings, clinical manifestations and possible risk factors.","authors":"Mahshid Bahrami,&nbsp;Majid Keyhanifard,&nbsp;Mahdieh Afzali","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Intracerebral hemorrhage is one of the types of stroke in patients with risk factors. In this study, we aimed to evaluate the initial computed tomography (CT) scan findings, clinical manifestations and possible risk factors of patients with intracerebral hemorrhage. This is a cross-sectional study that was performed in 2015-2022 on 900 patients with definite diagnosis of intracerebral hemorrhage. Data of patients were evaluated for patient's age, gender, clinical manifestations, primary radiologic signs in CT scan and possible risks factors for stroke. Lobar hemorrhage was the most common site of involvement (324 patients, 36%) followed by lenticular (putamen) (294 patients, 32.7%) and thalamus (135 patients, 15%). Among patients, 543 patients (60.3%) had hypertension, 81 patients (9%) had histories of anticoagulant. Hemorrhages in putamen were significantly more common in patients with hypertension (P<0.001) and lobar hemorrhages were significantly more common in patients with the use of anticoagulant drugs (P=0.033). The most common presentation of hemorrhagic stroke was decreased consciousness level (428 patients, 47.5%) followed by headache (343 patients, 38.1%), coma (81 patients, 9%) and seizure (48 patients, 5.4%). Evaluation of the relationships between patient's main symptoms and sites of involvement showed that patients with decreased consciousness as their most common symptom had more frequently diagnosed with lobar hemorrhage (54%) and putamen hemorrhage (30.4%) (P<0.001). Hypertension was the most common past medical history that was significantly related to hemorrhage in basal nuclei. Hemorrhages in putamen were common in hypertensive patients and lobar hemorrhages were common in patients with anticoagulant use.</p>","PeriodicalId":7572,"journal":{"name":"American journal of nuclear medicine and molecular imaging","volume":"12 3","pages":"106-112"},"PeriodicalIF":2.5,"publicationDate":"2022-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9301088/pdf/ajnmmi0012-0106.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40644837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidental renal masses on SPECT/CT and PET/CT.","authors":"Jorge D Oldan,&nbsp;Amir H Khandani","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>While the presence of incidental breast and lung masses on cardiac scans is well known, renal masses are often incidentally discovered as well on cardiac examinations, some of which are malignant. We searched the electronic medical record system over the past 18 years, since the system was installed, for patients with a cardiac rubidium-82 (⁸²Rb) rubidium PET/CT or technetium-99m (^99mTc) sestamibi SPECT/CT performed within 1 year of a renal-protocol CT or MR. Each PET/CT or SPECT/CT was examined for presence of a renal lesion on the attenuation-correction CT images. We found 43 SPECT/CT and 18 PET/CT studies which fit the desired criteria. Of these, 7 SPECT/CT studies and 2 PET/CT studies demonstrated the renal mass on at least one of the two sets of CT images (rest or stress); if not visible, most commonly the tumor was either out of the field of view or had already been removed. Of these, 6 SPECT/CT and 2 PET/CT studies demonstrated a malignancy. Cardiac SPECT/CT and PET/CT images demonstrate incidental renal masses with a non-negligible frequency, and CT images should be carefully examined.</p>","PeriodicalId":7572,"journal":{"name":"American journal of nuclear medicine and molecular imaging","volume":"12 3","pages":"81-85"},"PeriodicalIF":2.5,"publicationDate":"2022-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9301087/pdf/ajnmmi0012-0081.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40644839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between body mass index and external exposure in hyperthyroid patients treated with iodine-131.","authors":"Ghazal Yazdanpanah,&nbsp;Mohammad Nematdar,&nbsp;Hoda Talebian,&nbsp;Ali Shabestani Monfared","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We performed this study to evaluate the correlation between Body Mass Index (BMI) and Exposure Rate (ER) of hyperthyroid patients treated with iodine-131 so that in case of any relationship, we can improve the prescribed dose for the treatment of hyperthyroid patients and its side effects on the body and the environment. In this analytical and cross-sectional study, 30 patients with hyperthyroidism treated with liquid iodine-131 were randomly selected. We recorded demographic indicators (age, height, and weight) and ER. Patients were treated with the activity of 8-29 mCi (mean 14.4 mCi) oral I-131. The external radiation of patients was measured from a distance of one meter parallel to the patient's thyroid gland at intervals of 6 to 24 hours post-iodine-131 administration. ER measurements and other acquired data were statistically analyzed by R software and its methods. Data were normalized using the Shapiro method, and due to the non-normality of the data in the correlation test, the Spearman method was used. The measurements of this study represent two main findings: 1. There is a significant relationship between ER and iodine-131 activity because the observed significance level (<i>P</i>-value =0.002) is smaller than the predicted error value (0.01). 2. There is no significant relationship between ER and BMI because the observed significance level (<i>P</i>-value =0.082) is greater than the predicted error value (0.05). The present study's findings show a negative relationship between BMI and ER. Still, since the <i>P</i>-value is more than 0.05, this relationship is not statistically significant.</p>","PeriodicalId":7572,"journal":{"name":"American journal of nuclear medicine and molecular imaging","volume":"12 3","pages":"99-105"},"PeriodicalIF":2.5,"publicationDate":"2022-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9301089/pdf/ajnmmi0012-0099.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40644835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}