American journal of nuclear medicine and molecular imaging最新文献

{"title":"Vascular age based on coronary calcium burden and carotid intima media thickness (a comparative study).","authors":"Maryam Moradi,&nbsp;Mahnaz Fosouli,&nbsp;Jalil Khataei","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Considering the importance of vascular age in the risk assessment of cardiovascular events and the presence of different methods for its estimation, this study aims to evaluate and compare vascular age according to coronary artery calcium scoring (CACS) and carotid ultrasonography.</p><p><strong>Methods: </strong>This study was conducted in Isfahan on patients who underwent CACS and carotid intima-media thickness (CIMT) assessments within 30 days. In patients who were candidates for CACS, calcium score was measured, then they were invited for carotid ultrasonography, and CIMT was measured. Vascular age was estimated based on these methods using available formulas.</p><p><strong>Results: </strong>In this study, 115 patients were enrolled. (Male 52.2%, female 47.8%). The mean chronological age was 59.08 ± 14.90 years old. The mean calcium score (CS) of patients was 48.23 ± 63.34. Mean CIMT was 0.73 ± 0.15 mm. The mean vascular age derived by CS and CIMT was 58.64 ± 12.63 and 53.99 ± 17.53 years, respectively. The vascular age obtained by CS was directly related to vascular age based on CIMT (<i>P</i>-value < 0.05).</p><p><strong>Conclusion: </strong>Calcium score is as helpful as CIMT for vascular age estimation.</p>","PeriodicalId":7572,"journal":{"name":"American journal of nuclear medicine and molecular imaging","volume":"12 3","pages":"86-90"},"PeriodicalIF":2.5,"publicationDate":"2022-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9301091/pdf/ajnmmi0012-0086.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40644838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of PSMA-based ¹⁸F-DCFPyL PET/CT and pelvic multiparametric MRI for lesion detection in the pelvis in patients with prostate cancer.","authors":"Trinh T Nguyen,&nbsp;Priya R Bhosale,&nbsp;Guofan Xu,&nbsp;Tinsu Pan,&nbsp;Peng Wei,&nbsp;Yang Lu","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>To directly compare the performance of pelvic mpMRI versus recently approved and increasingly used PSMA-based ¹⁸F-DCFPyL PET/CT in intermediate-high risk and biochemical recurrent prostate cancer patient cohort while exploring their potential differing applications in specific clinical scenarios.</p><p><strong>Methods: </strong>A retrospective analysis was performed on patients who had ¹⁸F-DCFPyL PET/CT and pelvic mpMRI done from September 2021 to January 2022 at a single institution. The inclusion criteria were paired exams within a 3-month interval. Exclusion criteria were intervening treatment between exams, a change in PSA by more than 50% and absolute difference more than 1 ng/mL, or concurrent history of other malignancy. Abnormal lesions on these 2 imaging exams were reviewed with the identification of concordant and discordant imaging findings. The findings were verified by pathology or other imaging techniques within minimal 5-month clinical follow-up.</p><p><strong>Results: </strong>A total of 57 patients with 57 paired exams were included. The rate of concordant exams was 43/57 or 75.4%. Lesion-based analyses of sensitivity, specificity, PPV and NPV for mpMRI and ¹⁸F-DCFPyL PET/CT in the prostate bed were 96%, 94%, 98%, 89% and 96%, 100%, 100%, 90% respectively. For pelvic lymph node metastases, the sensitivity, specificity, PPV and NPV for mpMRI and ¹⁸F-DCFPyL PET/CT were 52%, 100%, 100%, 55% and 100%, 100%, 100%, 100% respectively. For bone metastases, the sensitivity, specificity, PPV and NPV for mpMRI and ¹⁸F-DCFPyL PET/CT were 86%, 73%, 50%, 94% and 100%, 98%, 95%, 100% respectively. Exact McNemar's test for paired data suggested that in diagnostic performance between ¹⁸F-DCFPyL PET/CT and mpMRI was not statistically significant in prostate bed (<i>p</i>-value = 1.00), but significantly in pelvic lymph nodes (<i>p</i>-value < 0.0001) and bone lesions (<i>p</i>-value = 0.0026).</p><p><strong>Conclusion: </strong>Our study demonstrated that PSMA-based ¹⁸F-DCFPyL PET/CT and pelvic mpMRI have a good concordance rate in the detection of primary or recurrence prostate disease and can have complementary roles in the clinical assessment of the prostate bed lesions. However, there are key differences in their performance, with the notably superior performance of PSMA-based ¹⁸F-DCFPyL PET/CT in the detection of small metastatic nodal disease and bone metastases.</p>","PeriodicalId":7572,"journal":{"name":"American journal of nuclear medicine and molecular imaging","volume":"12 6","pages":"166-179"},"PeriodicalIF":2.5,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9831857/pdf/ajnmmi0012-0166.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9091780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidental findings on a Tc99m-SESTAMIBI parathyroid scan post COVID-19 vaccination.","authors":"Mitchel A Muhleman,&nbsp;Jorge D Oldan,&nbsp;Amir H Khandani","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We present a case of abnormal findings on a Tc99m-Sestamibi parathyroid scan, post COVID-19 vaccination. The patient is a 48-year-old female presenting for evaluation of hyperparathyroidism who received the mRNA-1273 Moderna (ModernaTX, Inc.) vaccine seven days prior to the scan. The patient is right hand dominant and reported no traumatic events, inflammation, infection, or extraneous use of the left arm. The patient did report \"soreness\" of the extremity starting approximately 24 hours post injection which continued to the time of the study.</p>","PeriodicalId":7572,"journal":{"name":"American journal of nuclear medicine and molecular imaging","volume":"12 2","pages":"71-73"},"PeriodicalIF":2.5,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9077171/pdf/ajnmmi0012-0071.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10251395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"¹⁸F-FDG PET/CT imaging of primary malignant melanoma of rectum with liver metastases mimicking rectum cancer: case report and literature review.","authors":"Yongkang Qiu,&nbsp;Hao Jiao,&nbsp;Wenpeng Huang,&nbsp;Zhao Chen,&nbsp;Qi Yang,&nbsp;Sitong Wu,&nbsp;Xinyao Sun,&nbsp;Lei Kang","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Malignant melanoma (MM) is an aggressive malignant tumor, which mostly occurs on the skin, uvea, etc. The mucosal MM accounts for a small proportion of all MM and can occur in the digestive tract. Primary MM of the digestive tract is rare and can be found in the middle and lower third of the esophagus and the rectum containing melanocytes. Primary rectal MM often occurs in middle-aged and elderly women, with rapid progress and strong invasion. We report a case of a 61-year-old man diagnosed with primary malignant melanoma of the rectum with liver metastases mimicking rectum cancer. ¹⁸F-FDG PET/CT showed the rectal wall was markedly thickened with a high metabolic level (SUVmax 10.6) and the boundary between the lesions and the prostate was unclear. In addition, increased FDG uptake were found in multiple lymph nodes, lung, liver, and bones, suggesting metastasis. In this case, ¹⁸F-FDG PET/CT shows the advantage of evaluating the whole-body situation and provides valuable information for the diagnosis, tumor stage, evaluation of treatment efficacy, and prognosis of MM.</p>","PeriodicalId":7572,"journal":{"name":"American journal of nuclear medicine and molecular imaging","volume":"12 6","pages":"188-194"},"PeriodicalIF":2.5,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9831859/pdf/ajnmmi0012-0188.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9091779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regional changes with global brain hypometabolism indicates a physiological triage phenomenon and can explain shared pathophysiological events in Alzheimer's & small vessel diseases and delirium.","authors":"Sandeep K Gupta,&nbsp;Natalie Rutherford,&nbsp;Xenia Dolja-Gore,&nbsp;Tahne Watson,&nbsp;Balakrishnan R Nair","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>While reduced global brain metabolism is known in aging, Alzheimer's disease (AD), small vessel disease (SVD) and delirium, explanation of regional brain metabolic (rBM) changes is a challenge. We hypothesized that this may be explained by \"triage phenomenon\", to preserve metabolic supply to vital brain areas. We studied changes in rBM in 69 patients with at least 5% decline in global brain metabolism during active lymphoma. There was significant decline in the rBM of the inferior parietal, precuneus, superior parietal, lateral occipital, primary visual cortices (P<0.001) and in the right lateral prefrontal cortex (P=0.01). Some areas showed no change; multiple areas had significantly increased rBM (e.g. medial prefrontal, anterior cingulate, pons, cerebellum and mesial temporal cortices; P<0.001). We conclude the existence of a physiological triage phenomenon and argue a new hypothetical model to explain the shared events in the pathophysiology of aging, AD, SVD and delirium.</p>","PeriodicalId":7572,"journal":{"name":"American journal of nuclear medicine and molecular imaging","volume":"11 6","pages":"492-506"},"PeriodicalIF":2.5,"publicationDate":"2021-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8727878/pdf/ajnmmi0011-0492.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39801102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implementation of level-2 biosafety for a macromolecular crystallography beamline at SSRF.","authors":"Huating Kong,&nbsp;Minjun Li,&nbsp;Qin Xu,&nbsp;Huan Zhou,&nbsp;Feng Yu,&nbsp;Qisheng Wang","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Macromolecular crystallography is commonly used to determine the structure of biological macromolecules. Currently the beamlines at synchrotron radiation facilities play an important role in macromolecular crystallography, and have produced an enormous number of molecular structures to help solve scientific questions and support applications. Structure information makes significant contributions to the virus-related research as well. However, it is mandatory to be protected the operators under a compatible biosafety infrastructure when a pathological agent is set up in a beamline. Here a level-2 biosafety protection for a macromolecular crystallography beamline at Shanghai Synchrotron Radiation Facility (SSRF) is introduced. To fulfill the biosafety in a radioactive environment, a dedicated design is implemented. Since the beamline will be opened to the external users from nationwide research units, the management process and experimental method are also drawn up.</p>","PeriodicalId":7572,"journal":{"name":"American journal of nuclear medicine and molecular imaging","volume":"11 6","pages":"529-536"},"PeriodicalIF":2.5,"publicationDate":"2021-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8727877/pdf/ajnmmi0011-0529.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39801105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review of advances in the last decade on targeted cancer therapy using ¹⁷⁷Lu: focusing on ¹⁷⁷Lu produced by the direct neutron activation route.","authors":"Rubel Chakravarty,&nbsp;Sudipta Chakraborty","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Lutetium-177 [T½ = 6.76 d; E_β (max) = 0.497 MeV; maximum tissue range ~2.5 mm; 208 keV γ-ray] is one of the most important theranostic radioisotope used for the management of various oncological and non-oncological disorders. The present review chronicles the advancement in the last decade in ¹⁷⁷Lu-radiopharmacy with a focus on ¹⁷⁷Lu produced via direct ¹⁷⁶Lu (n, γ) ¹⁷⁷Lu nuclear reaction in medium flux research reactors. The specific nuances of ¹⁷⁷Lu production by various routes are described and their pros and cons are discussed. Lutetium, is the last element in the lanthanide series. Its chemistry plays a vital role in the preparation of a wide variety of radiopharmaceuticals which demonstrate appreciable <i>in vivo</i> stability. Traditional bifunctional chelators (BFCs) that are used for ¹⁷⁷Lu-labeling are discussed and the upcoming ones are highlighted. Research efforts that resulted in the growth of various ¹⁷⁷Lu-based radiopharmaceuticals in preclinical and clinical settings are provided. This review also summarizes the results of clinical studies with potent ¹⁷⁷Lu-based radiopharmaceuticals that have been prepared using medium specific activity ¹⁷⁷Lu produced by direct neutron activation route in research reactors. Overall, the review amply demonstrates the practicality of the medium specific activity ¹⁷⁷Lu towards formulation of various clinically useful radiopharmaceuticals, especially for the benefit of millions of cancer patients in developing countries with limited reactor facilities.</p>","PeriodicalId":7572,"journal":{"name":"American journal of nuclear medicine and molecular imaging","volume":"11 6","pages":"443-475"},"PeriodicalIF":2.5,"publicationDate":"2021-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8727880/pdf/ajnmmi0011-0443.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39801101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimal timing for measuring cerebral blood flow after acetazolamide administration to detect preexisting cerebral hemodynamics and metabolism in patients with bilateral major cerebral artery steno-occlusive diseases: ¹⁵O positron emission tomography studies.","authors":"Masakazu Kobayashi,&nbsp;Suguru Igarashi,&nbsp;Tatsuhiko Takahashi,&nbsp;Shunrou Fujiwara,&nbsp;Kohei Chida,&nbsp;Kazunori Terasaki,&nbsp;Yoshitaka Kubo,&nbsp;Kuniaki Ogasawara","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The present study determined the optimal timing of scanning for measurement of cerebral blood flow (CBF) after acetazolamide (ACZ) administration for detection of preexisting cerebral hemodynamics and metabolism in bilateral major cerebral artery steno-occlusive diseases. Thirty three patients underwent ¹⁵O gas positron emission tomography (PET) and each parameter was obtained in the bilateral middle cerebral artery (MCA) territories. CBF was also obtained using H₂ ¹⁵O PET scanning performed at baseline and at 5, 15, and 30 min after ACZ administration. Relative CBF at each time point after ACZ administration to baseline CBF was calculated. For MCA territories with normal cerebral blood volume (CBV) and cerebral metabolic rate of oxygen (CMRO₂), CBF continued increasing until 15 min after ACZ administration. For MCA territories with abnormally increased CBV, CBF decreased 5 min after ACZ administration. After that, CBF continued increasing until 30 min after ACZ administration. For MCA territories with abnormally decreased CMRO₂, CBF did not change 5 min after ACZ administration. Ten min later, CBF increased. The accuracy to detect abnormally increased CBV was significantly greater for relative CBF₅ than for relative CBF₁₅. The accuracy to detect abnormally decreased CMRO₂ was significantly greater for relative CBF₅ or CBF₁₅ than for relative CBF₃₀. For detecting abnormally increased oxygen extraction fraction, the accuracy did not differ among each relative CBF. These findings suggested that CBF measurement at 5 min after ACZ administration is the optimal timing for detection of preexisting cerebral hemodynamics and metabolism in bilateral major cerebral artery steno-occlusive diseases.</p>","PeriodicalId":7572,"journal":{"name":"American journal of nuclear medicine and molecular imaging","volume":"11 6","pages":"507-518"},"PeriodicalIF":2.5,"publicationDate":"2021-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8727876/pdf/ajnmmi0011-0507.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39801103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fibroblast Activation Protein (FAP) targeting homodimeric FAP inhibitor radiotheranostics: a step to improve tumor uptake and retention time.","authors":"Euy Sung Moon,&nbsp;Sanjana Ballal,&nbsp;Madhav Prasad Yadav,&nbsp;Chandrasekhar Bal,&nbsp;Yentl Van Rymenant,&nbsp;Sarah Stephan,&nbsp;An Bracke,&nbsp;Pieter Van der Veken,&nbsp;Ingrid De Meester,&nbsp;Frank Roesch","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Several radiopharmaceuticals targeting fibroblast activation protein (FAP) based on the highly potent FAP inhibitor UAMC1110 are currently under investigation. Pre-clinical as well as clinical research exhibited the potential of these imaging agents. However, the monomeric small molecules seemed to have a short retention time in the tumor in combination with fast renal clearance. Therefore, our strategy was to develop homodimeric systems having two FAP inhibitors to improve residence time and tumor accumulation. The homodimers with two squaramide coupled FAP inhibitor conjugates DOTA.(SA.FAPi)₂ and DOTAGA.(SA.FAPi)₂ were synthesized and radiochemically evaluated with gallium-68. [⁶⁸Ga]Ga-DOTAGA.(SA.FAPi)₂ was tested for its <i>in vitro</i> stability, lipophilicity and affinity properties. In addition, human PET/CT scans were performed for [⁶⁸Ga]Ga-DOTAGA.(SA.FAPi)₂ with a head-to-head comparison with [⁶⁸Ga]Ga-DOTA.SA.FAPi and [¹⁸F]FDG. Labeling with gallium-68 demonstrated high radiochemical yields. Inhibition measurements revealed excellent affinity and selectivity with low nanomolar IC₅₀ values for FAP. In PET/CT human studies, significantly higher tumor uptake as well as longer tumor retention could be observed for [⁶⁸Ga]Ga-DOTAGA.(SA.FAPi)₂ compared to [⁶⁸Ga]Ga-DOTA.SA.FAPi. Therefore, the introduction of the dimer led to an advance in human PET imaging indicated by increased tumor accumulation and prolonged retention times <i>in vivo</i> and thus, the use of dimeric structures could be the next step towards prolonged uptake of FAP inhibitors resulting in radiotherapeutic analogs of FAP inhibitors.</p>","PeriodicalId":7572,"journal":{"name":"American journal of nuclear medicine and molecular imaging","volume":"11 6","pages":"476-491"},"PeriodicalIF":2.5,"publicationDate":"2021-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8727881/pdf/ajnmmi0011-0476.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39801100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The use of ⁶⁸Ga-EDTA PET allows detecting progressive decline of renal function in rats.","authors":"Andrea O Fontana,&nbsp;Mary Gonzalez Melo,&nbsp;Gilles Allenbach,&nbsp;Costa Georgantas,&nbsp;Ruijia Wang,&nbsp;Olivier Braissant,&nbsp;Frederic Barbey,&nbsp;John O Prior,&nbsp;Diana Ballhausen,&nbsp;David Viertl","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Evaluation of glomerular filtration rate is very important in both preclinical and clinical setting, especially in the context of chronic kidney disease. It is typically performed using ⁵¹Cr-EDTA or by imaging with ¹²³I-Hippuran scintigraphy, which has a significantly lower resolution and sensitivity as compared to PET. ⁶⁸Ga-EDTA represents a valid alternative due to its quick availability using a ⁶⁸Ge/⁶⁸Ga generator, while PET/CT enables both imaging of renal function and accurate quantitation of clearance of activity from both plasma and urine. Therefore, we aimed at investigating the use of ⁶⁸Ga-EDTA as a preclinical tracer for determining renal function in a knock-in rat model known to present progressive decline of renal function.</p><p><strong>Methods: </strong>⁶⁸Ga-EDTA was injected in 23 rats, either wild type (n=10) or knock-in (n=13). By applying a unidirectional, two-compartment model and Rutland-Patlak Plot linear regression analysis, split renal function was determined from the age of 6 weeks to 12 months.</p><p><strong>Results: </strong>Glomerular filtration ranged from 0.025±0.01 ml/min at 6 weeks to 0.049±0.05 ml/min at 6 months in wild type rats. Glomerular filtration was significantly lower in knock-in rats at 6 and 12 months (P<0.01). No significant difference was observed in renal volumes between knock-in and wild type animals, based on imaging-derived volume calculations.</p><p><strong>Conclusions: </strong>⁶⁸Ga-EDTA turned out to be a very promising PET/CT tracer for the evaluation of split renal function. This method allowed detection of progressive renal impairment in a knock-in rat model. Additional validation in a human cohort is warranted to further assess clinical utility in both, healthy individuals and patients with renal impairment.</p>","PeriodicalId":7572,"journal":{"name":"American journal of nuclear medicine and molecular imaging","volume":"11 6","pages":"519-528"},"PeriodicalIF":2.5,"publicationDate":"2021-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8727875/pdf/ajnmmi0011-0519.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39801104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}