Clinical and experimental pharmacology & physiology. Supplement最新文献_第8页

Increased Ca2+ influx in the resting state maintains the myogenic tone and activates charybdotoxin-sensitive K+ channels in femoral arteries from young SHR. 静息状态下增加的Ca2+内流维持了肌原性张力，并激活了年轻SHR的股动脉中对肉毒素敏感的K+通道。

Clinical and experimental pharmacology & physiology. Supplement Pub Date : 1995-12-01 DOI: 10.1111/j.1440-1681.1995.tb02892.x

M Asano, Y Nomura, M Hayakawa, K M Ito, K Ito, Y Uyama, Y Imaizumi, M Watanabe

{"title":"Increased Ca2+ influx in the resting state maintains the myogenic tone and activates charybdotoxin-sensitive K+ channels in femoral arteries from young SHR.","authors":"M Asano, Y Nomura, M Hayakawa, K M Ito, K Ito, Y Uyama, Y Imaizumi, M Watanabe","doi":"10.1111/j.1440-1681.1995.tb02892.x","DOIUrl":"https://doi.org/10.1111/j.1440-1681.1995.tb02892.x","url":null,"abstract":"1. To determine the possible role of voltage-dependent Ca2+ channels (VDCC) and Ca2+-activated K+ (KCa) channels in the regulation of resting tone of arteries from young spontaneously hypertensive rats (SHR), mechanical responses to the agents which interact with these channels were examined in endothelium-denuded strips of femoral arteries from 4 week old SHR and age-matched normotensive Wistar-Kyoto (WKY) rats. Systolic blood pressures at this age were not significantly different between SHR and WKY. 2. The strips from SHR, but not from WKY, maintained a myogenic tone; that is, the resting tone decreased when nifedipine was added. 3. Studies using 1 or 5 min pulse labelling of the strips with 45Ca showed that the basal Ca2+ influx was increased in SHR when compared with WKY, and this increase in SHR was abolished by nifedipine. Similar results were obtained when the cytoplasmic Ca2+ concentration ([Ca2+]i) in the resting state of the strips was measured by fura-PE3. 4. The addition of charybdotoxin (ChTX, a blocker of large conductance KCa channels) to the resting state caused a concentration-dependent contraction, which was much greater in SHR than in WKY. The ChTX-induced contraction in SHR was abolished by nifedipine. 5. In strips preloaded with 86Rb, the basal 86Rb efflux rate constant was significantly greater in SHR than in WKY. The increase in 86Rb efflux in SHR was abolished by nifedipine. 6. The results suggest that the Ca2+ influx via L-type VDCC was increased in the resting state of the femoral artery from 4 week old SHR, and therefore the myogenic tone was maintained and ChTX-sensitive K+ channels were highly activated.","PeriodicalId":75710,"journal":{"name":"Clinical and experimental pharmacology & physiology. Supplement","volume":"22 1","pages":"S225-7"},"PeriodicalIF":0.0,"publicationDate":"1995-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1440-1681.1995.tb02892.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20026507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Antihypertensive effects, determined by a telemetry method, of trichloromethiazide and 7-O-ethylfangchinoline, a derivative of tetrandrine, in spontaneously hypertensive rats. 用遥测法测定三氯噻嗪和粉防己碱衍生物7- o -乙基防己喹啉对自发性高血压大鼠的降压作用。

Clinical and experimental pharmacology & physiology. Supplement Pub Date : 1995-12-01 DOI: 10.1111/j.1440-1681.1995.tb02927.x

K Kawashima, T Negishi, H Amano, K Fujimoto, T Suzuki, T Fujii

{"title":"Antihypertensive effects, determined by a telemetry method, of trichloromethiazide and 7-O-ethylfangchinoline, a derivative of tetrandrine, in spontaneously hypertensive rats.","authors":"K Kawashima, T Negishi, H Amano, K Fujimoto, T Suzuki, T Fujii","doi":"10.1111/j.1440-1681.1995.tb02927.x","DOIUrl":"https://doi.org/10.1111/j.1440-1681.1995.tb02927.x","url":null,"abstract":"1. The antihypertensive effects of 10 mg/kg trichloromethiazide (TCM), 10 mg/kg 7-O-ethylfangchinoline (7-O-EFC) and the combination of these drugs given orally once daily for 2 weeks were investigated by measuring the blood pressure (BP), heart rate (HR) and activity in conscious, freely moving spontaneously hypertensive rats (SHR) fitted with a telemetry device. 2. Clear diurnal rhythms of the HR and activity in synchrony with the light/dark cycle were observed during therapy, whereas the BP rhythm was obscure. 3. Alone, TCM and 7-O-EFC produced slight and insignificant reductions of 24h mean BP, whereas in combination they produced an additive and significant BP reduction, compared with the vehicle-treated controls, from the third day of therapy. The BP reduction induced by the combination of these drugs during the dark phase was more marked than that during the light phase. 4. None of the drug therapies affected the HR and activity diurnal rhythms. 5. The results of the present study demonstrate that the telemetry method is useful for monitoring the antihypertensive effects of drugs in SHR under physiological conditions with minimal stress.","PeriodicalId":75710,"journal":{"name":"Clinical and experimental pharmacology & physiology. Supplement","volume":"22 1","pages":"S300-1"},"PeriodicalIF":0.0,"publicationDate":"1995-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1440-1681.1995.tb02927.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20026711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Effects of (-)-epigallocatechin-3-O-gallate (green tea tannin) on the life span of stroke-prone spontaneously hypertensive rats. (-)-表没食子儿茶素-3- 0 -没食子酸酯(绿茶单宁)对卒中易发自发性高血压大鼠寿命的影响。

Clinical and experimental pharmacology & physiology. Supplement Pub Date : 1995-12-01 DOI: 10.1111/j.1440-1681.1995.tb02928.x

S Uchida, M Ozaki, T Akashi, K Yamashita, M Niwa, K Taniyama

引用次数: 73

ETA and ETB receptors on vascular smooth muscle cells from mesenteric vessels of spontaneously hypertensive rats. 自发性高血压大鼠肠系膜血管平滑肌细胞上的ETA和ETB受体。

Clinical and experimental pharmacology & physiology. Supplement Pub Date : 1995-12-01 DOI: 10.1111/j.1440-1681.1995.tb02877.x

E L Schiffrin, R Lariviere, R M Touyz

引用次数: 11

Protective effect of nicardipine treatment on cerebrovascular microanatomical changes in spontaneously hypertensive rats. 尼卡地平治疗对自发性高血压大鼠脑血管显微解剖变化的保护作用。

Clinical and experimental pharmacology & physiology. Supplement Pub Date : 1995-12-01 DOI: 10.1111/j.1440-1681.1995.tb02941.x

F Amenta, F Ferrante, A Ricci, M Sabbatini

{"title":"Protective effect of nicardipine treatment on cerebrovascular microanatomical changes in spontaneously hypertensive rats.","authors":"F Amenta, F Ferrante, A Ricci, M Sabbatini","doi":"10.1111/j.1440-1681.1995.tb02941.x","DOIUrl":"https://doi.org/10.1111/j.1440-1681.1995.tb02941.x","url":null,"abstract":"1. The effect of long-term treatment with the dihydropyridine Ca2+ antagonist, nicardipine, on the morphology of different sized pial arteries was assessed in spontaneously hypertensive rats (SHR) using histological techniques associated with image analysis. 2. In control 20 week old SHR blood pressure values, the thickness of the tunica media, the media-to-lumen ratio and connective tissue content were significantly increased in comparison with reference normotensive Wistar-Kyoto (WKY) rats. 3. Treatment for 8 weeks with a daily dose of 3 mg/kg of nicardipine decreased blood pressure values in SHR and significantly reduced the area occupied by the tunica media and the media-to-lumen ratio. This effect was observed primarily in small sized pial arteries and to a lesser extent in medium sized pial arteries. Nicardipine administration was without effect on connective tissue content in the wall of cerebral arteries. 4. These results indicate that treatment with nicardipine reduces blood pressure elevation in SHR and exerts a protective effect on arteries controlling cerebrovascular resistance. The activity of the compound primarily on small sized pial arteries may protect the brain from generalized vasodilation which could cause cerebral hypoperfusion.","PeriodicalId":75710,"journal":{"name":"Clinical and experimental pharmacology & physiology. Supplement","volume":"22 1","pages":"S331-2"},"PeriodicalIF":0.0,"publicationDate":"1995-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1440-1681.1995.tb02941.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20027478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Effect of haemorrhage on the power of low frequency blood pressure fluctuations in young spontaneously hypertensive rats. 出血对年轻自发性高血压大鼠低频血压波动能力的影响。

Clinical and experimental pharmacology & physiology. Supplement Pub Date : 1995-12-01 DOI: 10.1111/j.1440-1681.1995.tb02843.x

S Eliash, O Oz, S Akselrod, S Cohen

{"title":"Effect of haemorrhage on the power of low frequency blood pressure fluctuations in young spontaneously hypertensive rats.","authors":"S Eliash, O Oz, S Akselrod, S Cohen","doi":"10.1111/j.1440-1681.1995.tb02843.x","DOIUrl":"https://doi.org/10.1111/j.1440-1681.1995.tb02843.x","url":null,"abstract":"1. Before the onset of hypertension low frequency (0.04-0.1 Hz) MAP fluctuations are reduced in SHR when compared to WKY. We studied the effect of haemorrhage under alpha1 blockade or angiotensin converting enzyme inhibition (CEI) on the power spectra (PS) of each strain. 2. MAP was recorded from the caudal artery in conscious, 1 month old SHR and WKY. Three groups of rats were studied. Group 1, acute 2 mL haemorrhage; groups 2 and 3, injection of prazosin (0.25-2.5 mg/kg) or captopril (0.5-4 mg/kg), followed by haemorrhage, as in group 1. The PS was divided into 3 frequency bands, 0.004-0.04, 0.04-0.07 and 0.07-0.1 Hz. 3. In SHR, although the baseline MAP levels were similar to those of WKY, the PS was significantly damped in each of the 3 frequency bands. 4. Haemorrhage induced a similar MAP fall in both strains accompanied by an increase in the slow MAP fluctuations. However, in SHR the PS response was significantly greater than in WKY. The biggest response was in the slowest (0.004-0.04 Hz) frequency band, 8.7 +/- 1.7 vs 1.5 +/- 0.4 times baseline levels, respectively. 5. The difference between the two strains in the PS response to haemorrhage was eliminated by alpha1 blockade. The exaggerated response observed in haemorrhaged, unblocked SHR was reduced in the 3 frequency bands. 6. Captopril reduced the PS response to haemorrhage in SHR to the level observed in WKY in all 3 frequency bands. 7. The enhanced amplification of the MAP fluctuations in haemorrhaged SHR may indicate that SHR requires greater recruitment of control mechanisms than WKY to maintain MAP at a similar level to WKY.","PeriodicalId":75710,"journal":{"name":"Clinical and experimental pharmacology & physiology. Supplement","volume":"22 1","pages":"S112-3"},"PeriodicalIF":0.0,"publicationDate":"1995-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1440-1681.1995.tb02843.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20027637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acceleration of renal disease in obese SHR by exacerbation of hypertension. 高血压加重对肥胖SHR患者肾脏疾病的加速作用

Clinical and experimental pharmacology & physiology. Supplement Pub Date : 1995-12-01 DOI: 10.1111/j.1440-1681.1995.tb02905.x

R J Koletsky, J Boccia, P Ernsberger

引用次数: 16

Altered uterine environment in the spontaneously hypertensive rat. 自发性高血压大鼠子宫环境的改变。

Clinical and experimental pharmacology & physiology. Supplement Pub Date : 1995-12-01 DOI: 10.1111/j.1440-1681.1995.tb02918.x

E Erkadius, T O Morgan, R Di Nicolantonio

{"title":"Altered uterine environment in the spontaneously hypertensive rat.","authors":"E Erkadius, T O Morgan, R Di Nicolantonio","doi":"10.1111/j.1440-1681.1995.tb02918.x","DOIUrl":"https://doi.org/10.1111/j.1440-1681.1995.tb02918.x","url":null,"abstract":"1. In order to determine the role of the uterine environment in the development of hypertension in the spontaneously hypertensive rat (SHR) we examined the patterns of fetal and placental growth and the composition of amniotic fluid of SHR and normotensive Wistar-Kyoto (WKY) rats during the final trimester of pregnancy. 2. SHR and WKY embryos and amniotic fluid were collected at days 15 and 20 of pregnancy, and fetal and placental weight and amniotic fluid volume were recorded. The sodium and potassium concentration of amniotic fluid was also measured. 3. Fetal and placental weights were significantly lower in SHR compared to WKY at 15 and 20 days of gestation. Amniotic fluid volume was significantly lower in SHR at 15 days, but significantly higher at 20 days. Amniotic fluid sodium concentration was significantly lower in SHR at 15 days but not different at 20 days when compared to WKY. Potassium concentration was lower in SHR at both ages. 4. Thus the reduced placental weight early in the gestational period of the SHR may play a role in its underdevelopment in utero and hence its reduced birthweight. The SHR foetus is also bathed in a hypokalaemic amniotic fluid of increased volume. How this might influence fetal development and later blood pressure is unclear. Also whether these changes are of maternal or fetal origin remain to be determined.","PeriodicalId":75710,"journal":{"name":"Clinical and experimental pharmacology & physiology. Supplement","volume":"22 1","pages":"S281-2"},"PeriodicalIF":0.0,"publicationDate":"1995-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1440-1681.1995.tb02918.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20027868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Vascular effects of selected antihypertensive drugs derived from traditional medicinal herbs. 中药降压药对血管的影响。

Clinical and experimental pharmacology & physiology. Supplement Pub Date : 1995-12-01 DOI: 10.1111/j.1440-1681.1995.tb02925.x

C Y Kwan

{"title":"Vascular effects of selected antihypertensive drugs derived from traditional medicinal herbs.","authors":"C Y Kwan","doi":"10.1111/j.1440-1681.1995.tb02925.x","DOIUrl":"https://doi.org/10.1111/j.1440-1681.1995.tb02925.x","url":null,"abstract":"1. The pharmacological actions of the active ingredients extracted or purified from two selected traditional Chinese medicinal plants on vascular smooth muscles are briefly reviewed. The active ingredients of these herbal drugs include tetrandrine (TET) and total ginseng saponins (TGS). These natural products have been clinically used in China for the treatment of cardiovascular diseases due to their vasodilatory and antihypertensive actions. 2. Studies from this laboratory have confirmed previously reported characteristics of these drugs as Ca2+ antagonists in vascular tissues. On the other hand, they also elicited inhibitory effects in response to a wide variety of receptor stimulations as indicated by contractility studies using isolated vascular tissues and radioligand binding studies using isolated subcellular membranes. 3. TET has been demonstrated as an effective but not very selective Ca2+ antagonist. Other than the vasodilatory action on arteries and veins, TET also shows a vasoconstrictive effect in veins. 4. TGS from panax notoginseng may be acting as a novel and selective Ca2+ antagonist that does not interact with the L-type Ca2+ channel (e.g. in KCl-induced contraction) but may interact with the putative receptor operated Ca2+ channel (e.g. in phenylephrine-induced contraction). TGS from panax quinquefolium, on the other hand, enhanced the vasoconstrictor effect produced by phenylephrine, but not KCl.","PeriodicalId":75710,"journal":{"name":"Clinical and experimental pharmacology & physiology. Supplement","volume":"22 1","pages":"S297-9"},"PeriodicalIF":0.0,"publicationDate":"1995-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1440-1681.1995.tb02925.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20027875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 43

alpha1-Adrenoceptor subtypes mediating the contraction of arteries in spontaneously hypertensive rats. α 1-肾上腺素能受体亚型介导自发性高血压大鼠动脉收缩。

Clinical and experimental pharmacology & physiology. Supplement Pub Date : 1995-12-01 DOI: 10.1111/j.1440-1681.1995.tb02983.x

S Fujimoto, K Sumi-Fujimoto

引用次数: 0