{"title":"Acute depression leading to a suicide attempt following successful cataract surgery that restored vision in a legally blind patient: A case report from Tanzania","authors":"Stephen Nyamsaya , Milka Mafwiri","doi":"10.1016/j.ajoc.2025.102405","DOIUrl":"10.1016/j.ajoc.2025.102405","url":null,"abstract":"<div><h3>Purpose</h3><div>Cataract surgery is a common and effective procedure for restoring vision, yet it can sometimes lead to unexpected psychological challenges, particularly in legally blind patients. This case report highlights the need for pre- and postoperative psychological assessment and support for some cataract patients to prevent potential mental health crises that may arise if they feel abandoned or unsupported after recovering vision.</div></div><div><h3>Observation</h3><div>We present a case of a legally blind 72-year-old male who, two weeks after a successful cataract surgery, developed acute depression that culminated in a suicide attempt. The psychological distress was possibly triggered by the sudden withdrawal of family support, leaving the patient feeling abandoned and overwhelmed by the abrupt expectation of independence.</div></div><div><h3>Conclusion</h3><div>Despite the success of cataract surgery in restoring vision, some patients may face significant emotional and psychological challenges. This case underscores the importance of holistic patient care, including mental health evaluations and psychosocial support, particularly for legally blind patients undergoing visual rehabilitation.</div></div>","PeriodicalId":7569,"journal":{"name":"American Journal of Ophthalmology Case Reports","volume":"39 ","pages":"Article 102405"},"PeriodicalIF":0.0,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144749633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Femtosecond laser-assisted half top hat penetrating keratoplasty for keratoglobus","authors":"Dahlia Palevski , Noa Reinhertz Marom , Eitan Livny , Yoav Nahum , Samuel Levinger , Irit Bahar","doi":"10.1016/j.ajoc.2025.102406","DOIUrl":"10.1016/j.ajoc.2025.102406","url":null,"abstract":"<div><h3>Purpose</h3><div>To describe a modified technique utilizing femtosecond laser-assisted penetrating keratoplasty for the surgical management of keratoglobus with an extremely thin peripheral cornea.</div></div><div><h3>Methods</h3><div>Two eyes of two patients with advanced keratoglobus underwent a modified, donor-only, top hat keratoplasty. Femtosecond laser-assisted top hat configuration was exclusively performed on the donor cornea (half top hat) and sutured under the recipient's cornea which underwent a regular full thickness trephination. Patients were followed up for 12–24 months after intervention. Visual acuity and anatomical results (measured using corneal tomography and anterior segment OCT) were evaluated after this intervention.</div></div><div><h3>Results</h3><div>Post-operatively, best corrected visual acuity improved from counting fingers in the first patient and 20/720 in the second to 20/30 in both. Keratometry values markedly decreased, and peripheral thickness was augmented in both cases. No complications during the follow-up period were noted.</div></div><div><h3>Conclusions</h3><div>Top hat configuration keratoplasty on donor cornea alone may be a unique surgical solution enabling the augmentation of the peripheral cornea in keratoglobus eyes, providing good visual outcomes as well as structural integrity.</div></div>","PeriodicalId":7569,"journal":{"name":"American Journal of Ophthalmology Case Reports","volume":"39 ","pages":"Article 102406"},"PeriodicalIF":0.0,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144749637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Implantation of a scleral fixated (Carlevale) EDOF IOL in aphakia","authors":"Petros Petrou, Spyridon Doumazos, Stylianos A. Kandarakis, Aikaterini Barlampa, Stergios Ntikos, Eirini Okoutsidou, Georgia Karageorgiou, Ilias Georgalas","doi":"10.1016/j.ajoc.2025.102391","DOIUrl":"10.1016/j.ajoc.2025.102391","url":null,"abstract":"<div><h3>Purpose</h3><div>To present a case of lens dislocation in which an Extended Depth of Focus (EDOF) scleral fixated (Carlevale) intraocular lens (IOL) was inserted after performing pars plana vitrectomy (PPV) and lens fragmentation.</div></div><div><h3>Case report</h3><div>A 68-year-old woman presented to our department with loss of vision in her right eye after a blunt trauma in the right eye. After clinical examination the patient was aphakic with a dropped nucleus in the vitreous cavity. Surgical plan involved PPV with lens fragmentation and insertion of an IOL. Due to patient circumstances, she requested spectacle independence as far as possible. In order to support her needs a custom made Carlevale EDOF scleral fixated IOL (FIL SSF EVOLVE) was successfully implanted in her right eye with excellent post operative results. Excellent distant visual acuity as well as good intermediate and near vision was achieved 3 months post-operative in our patient.</div></div><div><h3>Conclusion</h3><div>According to previous reports as well as from our own previous experience, achieving efficient scleral fixation using the Carlevale FIL SSF IOL seems like a promising option in cases of aphakia or zonular dehiscence. EDOF lens technology is widely used in routine cataract surgery for demanding patients who require a wider range of vision without glasses. Combining these two technologies lead to a lens design (Carlevale FIL SSF EVOLVE) that we used in this case and enabled us to help our patient and improve her quality of life.</div></div>","PeriodicalId":7569,"journal":{"name":"American Journal of Ophthalmology Case Reports","volume":"39 ","pages":"Article 102391"},"PeriodicalIF":0.0,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144713234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparative evaluation of anterior lens capsule electron microscopic pathology in a case undergoing simultaneous bilateral cataract surgery: A study of CAPSULaser and continuous curvilinear capsulorhexis","authors":"Thananop Pothikamjorn , Marisa Prasanpanich , Thanapong Somkijrungroj","doi":"10.1016/j.ajoc.2025.102400","DOIUrl":"10.1016/j.ajoc.2025.102400","url":null,"abstract":"<div><h3>Purpose</h3><div>To identify ultrastructural changes, such as thermal effects and lens cortex penetration, to assess the potential benefits of CAPSULaser for future use in patients with complex cataract conditions.</div></div><div><h3>Observation</h3><div>Histological examination of the CAPSULaser-treated tissue revealed sections of the anterior capsule, cuboidal epithelial cells, and lens cortex collagen fibers. The edges of the tissue were slightly bent toward the anterior side, displaying a thermal effect measuring 62.12 μm in width. The tissue strip showed irregular thickness, with a maximum lens cortex collagen fiber thickness of 237.1 μm. Under TEM, the capsular margins appeared fragmented, exhibiting bulbous edges and a bubbly appearance. In the cauterized areas, electron-dense materials obscured and distorted the attached epithelial cells and lens fibers, in contrast to the preserved central region. Conversely, light microscopy of the CCC specimen showed sharp, well-demarcated edges tapering from anterior to posterior, and it was thinner than the CAPSULaser specimen. Notably, the CCC specimen lacked lens cortex collagen fibers, consisting solely of the anterior capsule and cuboidal epithelial cells. Ultrastructurally, the CCC specimen's edges appeared angulated and well-dermacated.</div></div><div><h3>Conclusion and importance</h3><div>Our study indicates that the cauterized edges of the CAPSULaser specimen tend to fold toward the anterior side, emphasizing the role of collagen phase changes in enhancing tissue elasticity. This study reported both histopathological and TEM findings, particularly for CAPSULaser, offering valuable insights into the microscopic changes in the anterior capsule when comparing CCC and CAPSULaser.</div></div>","PeriodicalId":7569,"journal":{"name":"American Journal of Ophthalmology Case Reports","volume":"39 ","pages":"Article 102400"},"PeriodicalIF":0.0,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144766990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amit Narawane , Christian Viehland , Ryan Imperio , Du Tran-Viet , Shwetha Mangalesh , Joseph A. Izatt , Xi Chen , Cynthia A. Toth
{"title":"Handheld 400kHz optical coherence tomography angiography visualizes microvascular details in infants with advanced retinopathy of prematurity","authors":"Amit Narawane , Christian Viehland , Ryan Imperio , Du Tran-Viet , Shwetha Mangalesh , Joseph A. Izatt , Xi Chen , Cynthia A. Toth","doi":"10.1016/j.ajoc.2025.102401","DOIUrl":"10.1016/j.ajoc.2025.102401","url":null,"abstract":"<div><div>Clinical evaluation of the disease activity of retinopathy of prematurity (ROP) is routinely performed via indirect ophthalmoscopy and/or widefield fundus photography. Herein we report an infant with advanced ROP imaged with an investigational handheld 400kHz optical coherence tomography angiography system that visualized microvascular details not seen in fundus exam or photography.</div></div>","PeriodicalId":7569,"journal":{"name":"American Journal of Ophthalmology Case Reports","volume":"39 ","pages":"Article 102401"},"PeriodicalIF":0.0,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144713193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Colya N. Englisch , Philip Wakili , Clara E. Englisch , Karl T. Boden , Annekatrin Rickmann , Peter Szurman , André Messias
{"title":"Descemet membrane endothelial keratoplasty combined with secondary sulcus hydrophobic intraocular lens implantation","authors":"Colya N. Englisch , Philip Wakili , Clara E. Englisch , Karl T. Boden , Annekatrin Rickmann , Peter Szurman , André Messias","doi":"10.1016/j.ajoc.2025.102399","DOIUrl":"10.1016/j.ajoc.2025.102399","url":null,"abstract":"<div><h3>Purpose</h3><div>To report a case of combined Descemet membrane endothelial keratoplasty (DMEK) and secondary sulcus hydrophobic intraocular lens (IOL) implantation for hyperopic correction in a pseudophakic eye with Fuchs’ endothelial corneal dystrophy.</div></div><div><h3>Observation</h3><div>A 74-year-old woman with Fuchs’ dystrophy and a history of phacoemulsification with a hydrophilic IOL in her left eye (refraction: +5.25 D/–1.00 D × 68°; best corrected visual acuity [BCVA]: 20/40) underwent a preparatory yttrium aluminum garnet (YAG) iridotomy followed by implantation of a hydrophobic add-on +8 D IOL in the ciliary sulcus through a 2.4 mm incision. DMEK was performed using a 90 % fill of 10 % sulfur hexafluoride (SF<sub>6</sub>). Two months after surgery, refraction improved to −0.25 D/–1.75 D × 62° (BCVA: 20/25), with restored corneal clarity and an endothelial cell density of 1920 cells/mm<sup>2</sup>. At 10 months, refraction was +0.75 D/–1.25 D × 54°, and BCVA further improved to 20/20, with an endothelial density of 1778 cells/mm<sup>2</sup> and normalized corneal thickness. No IOL opacification was observed.</div></div><div><h3>Conclusion and importance</h3><div>This case indicates that combining DMEK with secondary sulcus hydrophobic IOL implantation can effectively correct hyperopia in pseudophakic eyes with Fuchs’ dystrophy.</div></div>","PeriodicalId":7569,"journal":{"name":"American Journal of Ophthalmology Case Reports","volume":"39 ","pages":"Article 102399"},"PeriodicalIF":0.0,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144749634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ocular post-transplant lymphoproliferative disorder after keratoplasty","authors":"Linna Liu, Xiangxi Chen, Jianhua Wu, Guohua Wang, Jing Yan, Rui Zhang","doi":"10.1016/j.ajoc.2025.102397","DOIUrl":"10.1016/j.ajoc.2025.102397","url":null,"abstract":"<div><h3>Purpose</h3><div>Epstein-Barr virus associated post-transplantation lymphoproliferative disorders (PTLD) is a common condition after solid-organ or allogeneic hematopoietic stem-cell transplants. But ocular involvement after keratoplasty remains a rare finding, and can be easily misdiagnosed.</div></div><div><h3>Observations</h3><div>We report a case of a 59-year-old man who presented with masquerade uveitis of right eye 4 months post penetrating keratoplasty and was ultimately diagnosed with ocular PTLD. The diagnosis relied on the presence of Epstein-Barr virus DNA in aqueous sample and iris specimens showed the presence of a B cell clone. The ocular condition was in complete remission after 15 intravitreal injections of methotrexate.</div></div><div><h3>Conclusions and Importance</h3><div>Local immunosuppression after keratoplasty can lead to ocular PTLD. Detection of Epstein-Barr virus DNA in intraocular fluid and tissue or cytological biopsy could help confirm the diagnosis.</div></div>","PeriodicalId":7569,"journal":{"name":"American Journal of Ophthalmology Case Reports","volume":"39 ","pages":"Article 102397"},"PeriodicalIF":0.0,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144749635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Angela C. Chen , Matthew Miller , Michael Kapamajian , Monica Khitri
{"title":"Delayed diagnosis of glaucoma in Coffin-Siris syndrome","authors":"Angela C. Chen , Matthew Miller , Michael Kapamajian , Monica Khitri","doi":"10.1016/j.ajoc.2025.102396","DOIUrl":"10.1016/j.ajoc.2025.102396","url":null,"abstract":"<div><h3>Purpose</h3><div>To report a case of delayed diagnosis of glaucoma in a patient with Coffin-Siris Syndrome (CSS) who did not have any other predisposing risk factors or typical anterior segment signs of congenital glaucoma.</div></div><div><h3>Observations</h3><div>A 27-year-old male with CSS was referred to the ophthalmology department for evaluation of strabismus. Past ocular history included a diagnosis of right morning glory anomaly and bilateral hyperopic astigmatism. Initial exam in the clinic was notable for visual acuity of 20/80 in the right eye and 20/40 in the left eye. Given difficulty with exam in the outpatient setting, the patient underwent exam under anesthesia. Intraocular pressures (IOPs) were 38 mmHg OD and 23 mmHg OS at induction and gonioscopy was significant for high iris insertion and prominent iris processes in both eyes. On dilated fundus exam, the right eye had a severely pallorous and cupped optic nerve; the left eye was also cupped but less so. Elevated IOPs and nerve cupping was consistent with a diagnosis of glaucoma.</div></div><div><h3>Conclusions and importance</h3><div>Patients with CSS may develop glaucoma and should be screened for this important ophthalmic association, even in the absence of external signs of pediatric glaucoma including an enlarged cornea, anterior segment dysgenesis, or other risk factors for glaucoma such as steroid use.</div></div>","PeriodicalId":7569,"journal":{"name":"American Journal of Ophthalmology Case Reports","volume":"39 ","pages":"Article 102396"},"PeriodicalIF":0.0,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144749632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Finger's continuous bipedicle conjunctival flap","authors":"Paul T. Finger","doi":"10.1016/j.ajoc.2025.102394","DOIUrl":"10.1016/j.ajoc.2025.102394","url":null,"abstract":"<div><h3>Purpose</h3><div>To describe a bipedicle conjunctival flap technique that offered symmetrical, thus structurally stabile, double-vascularized ocular surface reconstruction.</div></div><div><h3>Principal results</h3><div>A unilateral, inferior, severe corneal neovascularization with subepithelial fibrosis and partial limbal stem cell deficiency evolved over 1 year, covering 270 degrees of the cornea. There was no history of ocular trauma, chemical injury, pharmacologic drops, prior incisional conjunctival or retinal surgery. Ophthalmic oncology and uveitis evaluations were negative. Due to progressive covering of the visual axis, an excisional biopsy followed by a novel “bucket-handle” bipedicle conjunctival flap was performed. Superior bulbar conjunctiva was mobilized and advanced to cover the entire defect and sewn to the margin of conjunctival resection. Then, a central conjunctival corneal window was resected to expose the cornea and allow for vision. However, it also allowed for one continuous, vascularized conjunctival nasal to temporal pedicle flap.</div></div><div><h3>Major conclusion</h3><div>A “bucket-handle” conjunctival flap provided a continuous bipedicle, arcuate tissue replacement, and a structurally stable barrier to conjunctival regrowth.</div></div>","PeriodicalId":7569,"journal":{"name":"American Journal of Ophthalmology Case Reports","volume":"39 ","pages":"Article 102394"},"PeriodicalIF":0.0,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144721152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Naveen R. Ambati , Muhammad Hassan , Robert A. Sisk
{"title":"Bilateral tractional retinal detachments complicating hemolytic-uremic syndrome","authors":"Naveen R. Ambati , Muhammad Hassan , Robert A. Sisk","doi":"10.1016/j.ajoc.2025.102402","DOIUrl":"10.1016/j.ajoc.2025.102402","url":null,"abstract":"<div><h3>Purpose</h3><div>To present a case of bilateral retinal thrombotic microangiopathy and tractional retinal detachments in a pediatric patient with typical hemolytic uremic syndrome (HUS) weeks after resolution of systemic complications.</div></div><div><h3>Observations</h3><div>A 23-month-old female with a history of typical HUS requiring treatment with temporary peritoneal dialysis and eculizumab transfusions presents three months later with bilateral fovea involving tractional retinal detachments. Sequential surgical repair of both eyes with pars plana vitrectomy was only successful in reattaching the superior retina of the right eye despite careful bimanual dissection. Her vision remained bare light perception in both eyes. Given similarities to advanced familial exudative vitreoretinopathy (FEVR), the trio was examined further. Genetic testing did not identify a definitive cause. Clinically, her mother had zone 3 angiographic microvascular alterations and capillary dropout consistent with stage 1 FEVR.</div></div><div><h3>Conclusions and importance</h3><div>We report an unusual case of a pediatric patient with typical HUS who developed bilateral blindness from tractional retinal detachments despite treatment with eculizumab and complete resolution of systemic disease. FEVR may have contributed to the severity of her retinal disease in the setting of existing thrombotic microangiopathy secondary to HUS.</div></div>","PeriodicalId":7569,"journal":{"name":"American Journal of Ophthalmology Case Reports","volume":"39 ","pages":"Article 102402"},"PeriodicalIF":0.0,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144711040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}