American Journal of Ophthalmology Case Reports最新文献

A case of atypical retinopathy of prematurity with coexisting occlusive vasculitis 早产儿非典型视网膜病变合并闭塞性血管炎1例

American Journal of Ophthalmology Case Reports Pub Date : 2025-09-29 DOI: 10.1016/j.ajoc.2025.102444

Ji Hye Jang

{"title":"A case of atypical retinopathy of prematurity with coexisting occlusive vasculitis","authors":"Ji Hye Jang","doi":"10.1016/j.ajoc.2025.102444","DOIUrl":"10.1016/j.ajoc.2025.102444","url":null,"abstract":"<div><h3>Purpose</h3><div>To report an atypical case of retinopathy of prematurity (ROP) presenting with severe retinal vascular changes in a preterm infant who did not meet conventional criteria for aggressive ROP.</div></div><div><h3>Observations</h3><div>A male infant, born at 32 weeks and 6 days of gestation with a birth weight of 1400 g, developed significant retinal changes by 4 weeks of postnatal age. Fundus examination revealed bilateral severe plus disease, flat neovascularization, multiple retinal hemorrhages, severe vascular sheathing, extensive perivascular deposits, and arteriovenous shunting within zone I. These findings were atypical and resembled occlusive vasculitis, differing from classical aggressive ROP. During hospitalization, he received non-invasive oxygen therapy for 13 days, with oxygen saturation in the target range of 90–94 %. Although his general condition remained stable and there were no signs of infection, serum interleukin-6 levels were elevated at birth, suggesting possible perinatal inflammation. Intravitreal ranibizumab (0.2 mg) was administered on the day of diagnosis. Retinal vascular abnormalities gradually resolved over 4 weeks following treatment. No recurrence or complications were observed up to a postmenstrual age of 70 weeks.</div></div><div><h3>Conclusions and importance</h3><div>This case shows that severe and unusual retinal changes can develop even in premature infants who are not considered high risk for aggressive ROP based on gestational age or birth weight.</div><div>Fluctuations in oxygen levels and inflammation may play a role in these unusual forms of ROP, and further research is needed to better understand these causes.</div></div>","PeriodicalId":7569,"journal":{"name":"American Journal of Ophthalmology Case Reports","volume":"40 ","pages":"Article 102444"},"PeriodicalIF":0.0,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145217261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nd:YAG laser treatment for pupillary block secondary to toxic anterior segment syndrome after hole implantable collamer lens surgery Nd:YAG激光治疗孔型人工晶状体术后毒性前段综合征继发瞳孔阻滞

American Journal of Ophthalmology Case Reports Pub Date : 2025-09-29 DOI: 10.1016/j.ajoc.2025.102445

Ryuichi Shimada , Satoshi Katagiri , Tadashi Nakano , Yoshihiro Kitazawa

{"title":"Nd:YAG laser treatment for pupillary block secondary to toxic anterior segment syndrome after hole implantable collamer lens surgery","authors":"Ryuichi Shimada , Satoshi Katagiri , Tadashi Nakano , Yoshihiro Kitazawa","doi":"10.1016/j.ajoc.2025.102445","DOIUrl":"10.1016/j.ajoc.2025.102445","url":null,"abstract":"<div><h3>Purpose</h3><div>To report the clinical course of pupillary block by fibrin in the central hole of an implantable collamer lens (ICL).</div></div><div><h3>Observations</h3><div>A 24 year old male with high myopia and astigmatism underwent EVO ICL (V5; STAAR Surgical, Monrovia, CA) implantation. The surgery was completed without any complications. The following day, the patient complained of blurry vision in the right eye and headache. The decimal uncorrected distance visual acuity was 1.5 in both eyes. Slit-lamp examination of the right eye revealed fibrin in the central hole of the ICL with a few cells in the anterior chamber. The intraocular pressure (IOP) and vault were increased to 33 mmHg and 1396 μm, respectively. A single shot of the Nd:YAG laser swept away the fibrin, and the reopening of the central hole was confirmed through the aqueous humor flow. The pupillary block was completely relieved 30 min later and the IOP and vault recovered to the normal range. One week postoperatively, the inflammatory reaction disappeared with topical eye drops including steroids. The uncorrected distance visual acuity was 1.5 in both eyes one year postoperatively. Ophthalmic examinations revealed unremarkable findings. We diagnosed the cause of the inflammatory reaction in the right eye as TASS because of the lack of severe pain in the eye, early occurrence, and favorable response to steroid therapy.</div></div><div><h3>Conclusions and importance</h3><div>Pupillary block by fibrin in the central hole may rarely occur following ICL implantation. In such cases, direct fibrin removal using Nd:YAG laser may be an effective treatment.</div></div>","PeriodicalId":7569,"journal":{"name":"American Journal of Ophthalmology Case Reports","volume":"40 ","pages":"Article 102445"},"PeriodicalIF":0.0,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145217258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic interpretation of corneal tomography using a multimodal large language model (ChatGPT) 使用多模态大语言模型（ChatGPT）的角膜断层扫描诊断解释

American Journal of Ophthalmology Case Reports Pub Date : 2025-09-27 DOI: 10.1016/j.ajoc.2025.102441

Jeremy C.K. Tan, Minas T. Coroneo

{"title":"Diagnostic interpretation of corneal tomography using a multimodal large language model (ChatGPT)","authors":"Jeremy C.K. Tan, Minas T. Coroneo","doi":"10.1016/j.ajoc.2025.102441","DOIUrl":"10.1016/j.ajoc.2025.102441","url":null,"abstract":"<div><h3>Purpose</h3><div>To describe the use of a commercially available general large language model (LLM) in extracting and interpreting several key metrics from entire raw corneal tomography (Pentacam) reports for the diagnosis of corneal disorders.</div></div><div><h3>Observation</h3><div>Anonymized corneal tomography biometry reports of 50 eyes of 50 patients with healthy corneas (n = 28), keratoconus (n = 20) and post-surgical ectasia (n = 2) were analyzed by a multimodal general LLM. System prompts were used to extract flat and steep keratometry values (K1 and K2, respectively), astigmatism, pachymetry values and provide an overall diagnosis. Accuracy of data extraction was 100 % across all metrics and the model provided a diagnosis in agreement with the two observers in all eyes. Pachymetry and maximum keratometry values were the most common metric used to formulate the diagnosis and was cited in all eyes. This was followed by specifically citing the highest elevation map values (88 %) and degree of astigmatism (74 %).</div></div><div><h3>Conclusion and importance</h3><div>In this proof-of-concept study, a commercially available multimodal LLM was able to extract data from raw corneal tomography reports with high accuracy and with retention of spatial context, and formulated correct diagnoses with excellent proficiency. This study demonstrates the use of emerging LLMs as diagnostic adjuncts through the synthesis of multimodal data.</div></div>","PeriodicalId":7569,"journal":{"name":"American Journal of Ophthalmology Case Reports","volume":"40 ","pages":"Article 102441"},"PeriodicalIF":0.0,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145217263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recurrence of solitary extramedullary plasmacytoma affecting both optic nerves: a case report 影响双侧视神经的单发髓外浆细胞瘤复发1例

American Journal of Ophthalmology Case Reports Pub Date : 2025-09-27 DOI: 10.1016/j.ajoc.2025.102438

Pablo Ballester Dolz , Dimitrios Gkretsis , Marita Andersson Grönlund

{"title":"Recurrence of solitary extramedullary plasmacytoma affecting both optic nerves: a case report","authors":"Pablo Ballester Dolz , Dimitrios Gkretsis , Marita Andersson Grönlund","doi":"10.1016/j.ajoc.2025.102438","DOIUrl":"10.1016/j.ajoc.2025.102438","url":null,"abstract":"<div><h3>Purpose</h3><div>To present a case of atypically located plasmacytoma recurrence with bilateral involvement of the optic nerves.</div></div><div><h3>Observations</h3><div>A 73-year-old man with diabetes, essential hypertension, and primary hypercholesterolemia presented to our clinic with subjective visual loss in his left eye. The patient had a previous history of solitary extramedullary plasmacytoma in the spinal cord, which was treated with resection surgery at the thoracic T6-T12 levels and curative radiotherapy two years prior. The ophthalmological examination indicated best-corrected visual acuity of 20/50 (0.4 logMAR) in both the right eye (OD) and left eye (OS). Intraocular pressure was normal and fundus examination of the eyes showed edema in the left optic nerve, but no other findings. Magnetic resonance imaging of the brain and orbits showed enhancement in both optic nerves, as in other parts of the central nervous system (CNS).</div></div><div><h3>Conclusions and importance</h3><div>Plasmacytoma represents a rare form of plasma cell neoplasm. When the condition progresses and affects different sites within the CNS, it is essential to re-evaluate and exclude progression to multiple myeloma and/or other plasma cell neoplasms. Individuals diagnosed with plasmacytoma who complain of visual disturbances should undergo ophthalmologic evaluation.</div></div>","PeriodicalId":7569,"journal":{"name":"American Journal of Ophthalmology Case Reports","volume":"40 ","pages":"Article 102438"},"PeriodicalIF":0.0,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145217262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bilateral methanol-induced optic neuropathy following hand sanitizer ingestion 摄入洗手液后双侧甲醇引起的视神经病变

American Journal of Ophthalmology Case Reports Pub Date : 2025-09-26 DOI: 10.1016/j.ajoc.2025.102439

Caroline Simon Sherman , Julius T. Oatts , Danielle Sarlo

{"title":"Bilateral methanol-induced optic neuropathy following hand sanitizer ingestion","authors":"Caroline Simon Sherman , Julius T. Oatts , Danielle Sarlo","doi":"10.1016/j.ajoc.2025.102439","DOIUrl":"10.1016/j.ajoc.2025.102439","url":null,"abstract":"<div><h3>Purpose</h3><div>We report a case of a child with bilateral methanol-induced optic neuropathy highlighting the importance of early recognition and possible treatment options.</div></div><div><h3>Observations</h3><div>An 11-year-old female with history of autism spectrum disorder (ASD) and pica presented with a few hours of bilateral “spotty” vision and dizziness. Several hours prior to presentation, the patient ingested an unknown amount of recalled hand sanitizer. The child had normal vision, but dilated exam was notable for mild bilateral optic disc edema. Optical coherence tomography (OCT) of the retinal nerve fiber layer (RNFL) showed global thickening in both eyes. Given these findings of end-organ toxicity, the patient was urgently started on hemodialysis.</div></div><div><h3>Conclusions and importance</h3><div>Pediatric patients with ASD often have co-morbid eating disorders such as pica or avoidant/restrictive food intake disorder (ARFID). This population of patients is especially susceptible to toxic optic neuropathies related to restricted nutritional intake and toxic ingestion. A high clinical suspicion and early recognition is key to prompt treatment and visual recovery.</div></div>","PeriodicalId":7569,"journal":{"name":"American Journal of Ophthalmology Case Reports","volume":"40 ","pages":"Article 102439"},"PeriodicalIF":0.0,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145217356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Successful treatment of glaucoma in Sturge–Weber syndrome using PreserFlo™ microshunt with intraluminal stenting: a case report PreserFlo™微分流器联合腔内支架成功治疗斯特奇-韦伯综合征青光眼1例

American Journal of Ophthalmology Case Reports Pub Date : 2025-09-26 DOI: 10.1016/j.ajoc.2025.102440

Hidekazu Inami , Ryo Tomita , Kenya Yuki

{"title":"Successful treatment of glaucoma in Sturge–Weber syndrome using PreserFlo™ microshunt with intraluminal stenting: a case report","authors":"Hidekazu Inami , Ryo Tomita , Kenya Yuki","doi":"10.1016/j.ajoc.2025.102440","DOIUrl":"10.1016/j.ajoc.2025.102440","url":null,"abstract":"<div><h3>Purpose</h3><div>We report a case of glaucoma associated with Sturge–Weber syndrome (SWS) that was successfully managed with PreserFlo™ microshunt (PFM) insertion combined with two intraluminal 10-0 nylon suture stents.</div></div><div><h3>Observations</h3><div>A 27-year-old female patient with SWS and persistently elevated intraocular pressure (IOP) in the right eye was referred to our hospital for surgical treatment. The patient was diagnosed with bilateral SWS-related glaucoma. She first underwent a right trabeculotomy at the age of 11, followed by a trabeculectomy on the same eye. At the age of 13, a trabeculectomy was performed on the left eye. At the time of presentation, her right eye IOP was 28 mmHg. A PFM with two 10-0 nylon intraluminal sutures was implanted. On postoperative day 1, IOP decreased to 16 mmHg. The shunt was well positioned without complications. On day 17, IOP rose to 20 mmHg, leading to the removal of one suture. On day 22, IOP dropped to 18 mmHg, and the second suture was removed.</div></div><div><h3>Conclusions</h3><div>Herein, we successfully executed PFM insertion with intraluminal stenting in a patient with SWS, resulting in effective IOP reduction without any serious postoperative complications. These findings suggest that PFM insertion with stenting could be a viable treatment option for glaucoma associated with SWS.</div></div>","PeriodicalId":7569,"journal":{"name":"American Journal of Ophthalmology Case Reports","volume":"40 ","pages":"Article 102440"},"PeriodicalIF":0.0,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145217260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Iris mammillations in Cri-du-chat syndrome Cri-du-chat综合征的虹膜乳头状突起

American Journal of Ophthalmology Case Reports Pub Date : 2025-09-26 DOI: 10.1016/j.ajoc.2025.102442

Renée S. Landzberg , Julius T. Oatts , Neel D. Pasricha

引用次数: 0

High-resolution optical coherence tomography in pathology of the vitreomacular interface 高分辨率光学相干断层扫描在玻璃体黄斑界面病理学中的应用

American Journal of Ophthalmology Case Reports Pub Date : 2025-09-18 DOI: 10.1016/j.ajoc.2025.102432

Lorenzo Ferro Desideri , Karin Paschon , Ines Schumacher , Nicola Sagurski , Yousif Subhi , Janice Roth , Martin Zinkernagel , Rodrigo Anguita

{"title":"High-resolution optical coherence tomography in pathology of the vitreomacular interface","authors":"Lorenzo Ferro Desideri , Karin Paschon , Ines Schumacher , Nicola Sagurski , Yousif Subhi , Janice Roth , Martin Zinkernagel , Rodrigo Anguita","doi":"10.1016/j.ajoc.2025.102432","DOIUrl":"10.1016/j.ajoc.2025.102432","url":null,"abstract":"<div><h3>Aim</h3><div>This study investigates the diagnostic capabilities of high-resolution optical coherence tomography (HR-OCT) compared to spectral domain optical coherence tomography (SD-OCT) in detecting detailed microstructural changes in vitreomacular pathology.</div></div><div><h3>Methods</h3><div>This was a prospective cross-sectional study of eyes with vitreomacular interface disease. We included patients with epiretinal membrane (ERM), macular hole (MH), lamellar hole (LH), and vitreomacular traction (VMT). Each patient underwent a comprehensive ophthalmic exam followed by retinal imaging with both SD-OCT and HR-OCT. Images were analyzed for the presence of key biomarkers and the two OCT modalities were compared.</div></div><div><h3>Results</h3><div>The study cohort consisted of 18 patients with a mean age of 66 years (SD 8.9) and (61.1 %) had biological male sex. HR-OCT provided a superior subcellular view, including superior identification of rod cell nuclei in the outer nuclear layer (ONL) and ganglion cell layer (GCL) and enhanced visualization of biomarkers such as the “cotton ball sign” coupled with IZ disruption (33.3 % vs 5.6 % for HR-OCT and SD-OCT groups, respectively, p = 0.0042). Hyporeflective dots in the ONL, indicative of rod cell nuclei, were seen in 88.9 % of HR-OCT cases but were completely undetectable with SD-OCT (p < 0.0001). Inter-grader reliability was strong, with Cohen's Kappa values for most biomarkers ranging from 0.78 to 0.89.</div></div><div><h3>Conclusions</h3><div>HR-OCT significantly improves the detection of subcellular features and biomarkers in vitreomacular interface disorders. This device could enhance early diagnosis and monitoring of vitreomacular diseases, with potential correlations to functional outcomes.</div></div>","PeriodicalId":7569,"journal":{"name":"American Journal of Ophthalmology Case Reports","volume":"40 ","pages":"Article 102432"},"PeriodicalIF":0.0,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145118289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute-onset endophthalmitis caused by Staphylococcus warneri 由韦氏葡萄球菌引起的急性眼内炎

American Journal of Ophthalmology Case Reports Pub Date : 2025-09-18 DOI: 10.1016/j.ajoc.2025.102436

Michael Y. Zhao, Justin A. Chen, Lauren C. Kiryakoza, Landon J. Rohowetz, Darlene Miller, Harry W. Flynn Jr.

{"title":"Acute-onset endophthalmitis caused by Staphylococcus warneri","authors":"Michael Y. Zhao, Justin A. Chen, Lauren C. Kiryakoza, Landon J. Rohowetz, Darlene Miller, Harry W. Flynn Jr.","doi":"10.1016/j.ajoc.2025.102436","DOIUrl":"10.1016/j.ajoc.2025.102436","url":null,"abstract":"<div><h3>Purpose</h3><div>To report a series of patients with acute-onset bacterial endophthalmitis caused by culture proven <em>Staphylococcus warneri</em>, and to characterize clinical outcomes and microbiologic susceptibilities of this organism.</div></div><div><h3>Observations</h3><div>This study included 8 eyes of 8 patients. The etiologies included intravitreal injection (4), anterior segment surgery (3), and glaucoma surgery (1). All isolates (100 %) of <em>S. warneri</em> demonstrated sensitivity to vancomycin with minimal inhibitory concentration (MIC) values ranging from <0.5 to 1, and to gentamycin with MIC values ranging from <0.5 to 4 mcg/ml. All isolates (100 %) were also sensitive to a beta-lactam with MIC values reported as ≤ 0.25 mcg/ml and to fluroquinolones with MIC values ranging from 0.12 to 0.5 mcg/ml. After initial treatment with intravitreal antibiotics, 6 of 7 (85.7 %) patients subsequently underwent pars plana vitrectomy. Best-corrected visual acuity at last follow-up was ≤5/200 in 5/7 (71.4 %) of patients, and was ≥20/150 in 2/7 (28.6 %) of patients.</div></div><div><h3>Conclusion and importance</h3><div>Acute-onset endophthalmitis due to <em>Staphylococcus warneri</em> is associated with a range of intraocular procedures. After initial treatment with intravitreal antibiotics, additional treatments are often necessary. Vancomycin, amikacin, and ceftazidime remain consistent options, providing coverage against <em>S. warneri</em> in acute-onset endophthalmitis.</div></div>","PeriodicalId":7569,"journal":{"name":"American Journal of Ophthalmology Case Reports","volume":"40 ","pages":"Article 102436"},"PeriodicalIF":0.0,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145106168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Salmonella-associated endophthalmitis in healthy infants: Two case reports and a review of the literature 健康婴儿沙门氏菌相关性眼内炎：两例报告和文献综述

American Journal of Ophthalmology Case Reports Pub Date : 2025-09-17 DOI: 10.1016/j.ajoc.2025.102435

Asrar Alhejaili , Anas Alsaif , Firas Madani , Rawan N. Althaqib , Valmore Semidey , Rafaa Babgi , Hamad M. Alsulaiman

{"title":"Salmonella-associated endophthalmitis in healthy infants: Two case reports and a review of the literature","authors":"Asrar Alhejaili , Anas Alsaif , Firas Madani , Rawan N. Althaqib , Valmore Semidey , Rafaa Babgi , Hamad M. Alsulaiman","doi":"10.1016/j.ajoc.2025.102435","DOIUrl":"10.1016/j.ajoc.2025.102435","url":null,"abstract":"<div><h3>Purpose</h3><div>To report two cases of endophthalmitis caused by Salmonella species in healthy male infants.</div></div><div><h3>Background</h3><div>Endogenous endophthalmitis is a rare but severe intraocular infection, often associated with systemic risk factors such as diabetes mellitus, malignancies, or immunosuppression. However, <em>Salmonella</em> species as a causative agent in immunocompetent neonates remains exceedingly rare, with only a handful of cases documented.</div></div><div><h3>Observations</h3><div>We present two cases of previously healthy male infants diagnosed with Salmonella-associated endogenous endophthalmitis (SAEE). The first patient, a 2-month-old male, presented with fever, left upper eyelid swelling, and decreased activity, and was found to have intraocular cultures that confirmed Salmonella species. Despite aggressive intravenous and intravitreal antibiotic therapy, the patient developed progressive intraocular inflammation, necessitating left eye evisceration.</div><div>The second patient, a 5-month-old male, presented with fever and right eye inflammation. Examination revealed a hypopyon, hyphema, and dense vitritis in the right eye. Blood and vitreous cultures confirmed Salmonella infection, and magnetic resonance imaging (MRI) showed right peribulbar abscess formation. Due to poor response to medical therapy, right eye enucleation was performed.</div></div><div><h3>Conclusion and importance</h3><div><em>Salmonella</em>-associated endogenous endophthalmitis is a rare but aggressive intraocular infection that can rapidly progress to irreversible visual loss, even in immunocompetent neonates. Early recognition, aggressive antimicrobial therapy, and timely surgical intervention remain critical to optimizing outcomes.</div></div>","PeriodicalId":7569,"journal":{"name":"American Journal of Ophthalmology Case Reports","volume":"40 ","pages":"Article 102435"},"PeriodicalIF":0.0,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145217259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0