American Journal of Ophthalmology Case Reports最新文献

{"title":"Tay-Sachs disease in a child of indigenous Guatemalan-Mayan origin with macular brown spots and perifoveal whitening","authors":"Mya Abousy ,&nbsp;Lauren Hucko ,&nbsp;Audina Berrocal ,&nbsp;Erick Vinicio Saenz","doi":"10.1016/j.ajoc.2025.102381","DOIUrl":"10.1016/j.ajoc.2025.102381","url":null,"abstract":"<div><h3>Purpose</h3><div>This report describes an unusual macular presentation of Tay-Sachs disease in a two-year-old female of Guatemalan-Mayan origin. This case serves to build upon the very limited literature regarding ophthalmic manifestations of Tay-Sachs disease in the non-Caucasian population.</div></div><div><h3>Observations</h3><div>The patient and family presented with concern for poor visual acuity and hyperacusis. A brown macular spot with perifoveal whitening was identified in both eyes on fundus examination. Laboratory studies revealed low hexosaminidase A levels, which confirmed the diagnosis of Tay-Sachs disease.</div></div><div><h3>Conclusions and importance</h3><div>This is an extremely rare case of Tay-Sachs disease in a patient of Guatemalan-Mayan origin diagnosed by enzyme studies and fundus examination. Further, it is one of the few documented cases of “brown spots” appreciated in association with Tay-Sachs disease, as opposed to the classic “cherry red spot”. This case presentation challenges the nomenclature of the “cherry red spot” to account for the variations in the fundus that may occur in different racial and ethnic groups that present with Tay-Sachs disease.</div></div>","PeriodicalId":7569,"journal":{"name":"American Journal of Ophthalmology Case Reports","volume":"39 ","pages":"Article 102381"},"PeriodicalIF":0.0,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144611927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pigmented perivascular epithelioid cell tumors of the orbit with NONO::TFE3 fusion: Molecular evaluation and literature review","authors":"Naoko Takeda-Miyata ,&nbsp;Ken-ichi Yoshida ,&nbsp;Miho Shirono ,&nbsp;Akihide Watanabe ,&nbsp;Yoji Kukita ,&nbsp;Chie Sotozono ,&nbsp;Eiichi Konishi","doi":"10.1016/j.ajoc.2025.102378","DOIUrl":"10.1016/j.ajoc.2025.102378","url":null,"abstract":"<div><h3>Purpose</h3><div>To elucidate the clinical characteristics of rare orbital pigmented perivascular epithelioid cell tumors (PEComa) with <em>transcription factor E3</em> (<em>TFE3</em>) rearrangement through a literature review.</div></div><div><h3>Observations</h3><div>A 49-year-old female was referred to our hospital with a mass measuring 16 × 14 mm in the extraconal space of the right orbit. Suspecting hemangioma or distended hematoma clinically, the tumor was completely excised through the right nasal conjunctiva. Although initial histological evaluation raised the suspicion of malignant melanoma, subsequent immunohistochemistry and molecular analyses led to a diagnosis of <em>TFE3</em>-rearranged PEComa with the <em>NONO</em>::<em>TFE3</em> fusion gene. The patient's visual function was preserved 14 months postoperatively, with no evidence of recurrence.</div></div><div><h3>Conclusions and importance</h3><div>Although rare, <em>TFE3-</em>rearranged PEComa should be considered in the differential diagnosis of pigmented orbital tumors.</div></div>","PeriodicalId":7569,"journal":{"name":"American Journal of Ophthalmology Case Reports","volume":"39 ","pages":"Article 102378"},"PeriodicalIF":0.0,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144611580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidental detection of retinal nerve fiber layer thinning with slowed progression following optic nerve-carotid artery decompression: A case report","authors":"Hidenori Takahashi ,&nbsp;Keisuke Ohtani ,&nbsp;Takeshi Hara ,&nbsp;Kensuke Kawai","doi":"10.1016/j.ajoc.2025.102376","DOIUrl":"10.1016/j.ajoc.2025.102376","url":null,"abstract":"<div><h3>Purpose</h3><div>This report aims to present a case of the retinal nerve fiber layer (NFL) thinning, in which the progression of thinning was slowed following optic nerve-carotid artery decompression surgery.</div></div><div><h3>Observations</h3><div>A 41-year-old ophthalmologist incidentally noticed a generalized thinning of NFL in his left eye using optical coherence tomography (OCT). Five years earlier, the OCT showed only mild thinning. While visual acuity and visual fields were normal, the patient reported a blurriness. The MRI revealed an ectatic and tortuous left internal carotid artery compressing the left optic nerve. Due to the lack of reports on the correlation between NFL thickness and visual acuity, an internal review was conducted. We searched for cases with a progression from healthy visual acuity to blindness, and in the only case identified, we investigated the correlation between NFL thickness and visual acuity. Applying this correlation, it was predicted that the patient would lose vision by age 48. As a result, the patient decided to receive decompression surgery. Following the surgery, the rate of NFL thinning significantly slowed from −1.9 μm/year to −0.57 μm/year (p &lt; .0001). At the current age of 48, the patient's corrected visual acuity is 20/16, and visual field remains normal. The predicted onset of blindness has been postponed by 10 years.</div></div><div><h3>Conclusions and importance</h3><div>We report a case in which compression of the optic nerve by the internal carotid artery was observed in a patient with retinal nerve fiber layer (NFL) thinning. A slowing of NFL thinning was noted following surgical decompression.</div></div>","PeriodicalId":7569,"journal":{"name":"American Journal of Ophthalmology Case Reports","volume":"39 ","pages":"Article 102376"},"PeriodicalIF":0.0,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144632826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drainage of subconjunctival hemorrhage through conjunctival lymphatic pathways","authors":"Ashton Zheng-Boon Lau ,&nbsp;Grace YF. Tang ,&nbsp;William H. Morgan ,&nbsp;Geoffrey ZP. Chan","doi":"10.1016/j.ajoc.2025.102368","DOIUrl":"10.1016/j.ajoc.2025.102368","url":null,"abstract":"<div><h3>Purpose</h3><div>To demonstrate the role of ocular lymphatic involvement in aiding the drainage and resolution of subconjunctival hemorrhage.</div></div><div><h3>Methods</h3><div>We present the case of a 63-year-old Caucasian female who developed a subconjunctival hemorrhage following the administration of a subconjunctival anesthetic during cataract surgery. Intraoperative optical coherence tomography was utilized to image these structures within the deep and middle conjunctival-Tenon's space.</div></div><div><h3>Results</h3><div>Subconjunctival hemorrhage was visualized and saccular blood-filled structures developed adjacent to sites of hemorrhage. Intraoperative optical coherence tomography confirmed the presence of blood within structures containing partitions reminiscent of valvular leaflets, indicating their lymphatic origin. Rapid resolution of the subconjunctival hemorrhage was noted during the immediate postoperative period.</div></div><div><h3>Conclusion</h3><div>Subconjunctival hemorrhage may have its resolution assisted by conjunctival lymphatic vessels. Our findings confirm that lymphatic structures may play an under-appreciated role in assisting the clearance of macromolecules from the subconjunctival space.</div></div>","PeriodicalId":7569,"journal":{"name":"American Journal of Ophthalmology Case Reports","volume":"39 ","pages":"Article 102368"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144572697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Late onset bilateral annular subepithelial corneal haze after LASIK","authors":"Michelle Y. Ko ,&nbsp;Ben J. Glasgow ,&nbsp;Reza Ghaffari","doi":"10.1016/j.ajoc.2025.102371","DOIUrl":"10.1016/j.ajoc.2025.102371","url":null,"abstract":"<div><h3>Purpose</h3><div>Corneal haze is uncommon after laser assisted in situ keratomileusis (LASIK). Post-LASIK haze and scarring can develop due to different conditions such as infectious keratitis, LASIK flap complications, diffuse lamellar keratitis (DLK), corneal photo disruption and damage to the basement membrane due to effects of femtosecond laser, or unknown causes such as in central toxic keratopathy (CTK). In this report, we describe a patient with bilateral late onset annular subepithelial corneal haze which presented more than 20 years after LASIK.</div></div><div><h3>Observations</h3><div>A 65-year-old woman who presented with decreased vision in both eyes (Best corrected visual acuity [BCVA] 20/80 in right eye and 20/300 in the left eye) over 20 years after LASIK. The patient had history of gout, chromic kidney disease, dry eyes, and chronic cigarette smoking. Clinical examination and anterior segment optical coherence tomography revealed bilateral annular subepithelial corneal haze in the paracentral and midperipheral zone in an annular pattern. Following superficial keratectomy and mitomycin-C application, the uncorrected corrected visual acuity improved to 20/60 in the right eye at 7 months but the final BCVA decreased to 20/300 at 11 months after the surgery due to recurrence of subepithelial haze. The postoperative BCVA improved to 20/30 in the left eye 7 months after the surgery. Histologic examination of the excised corneal tissue revealed presence of subepithelial fibrous tissue and epithelial basement membrane thickening.</div></div><div><h3>Conclusions and importance</h3><div>Although uncommon, delayed onset bilateral annular subepithelial haze and scarring can develop after LASIK. Although the reason for this clinical presentation is unknown, it is possible that chronic ocular surface breakdown due to a combination of systemic and local factors such as gout, chronic kidney disease, dry eyes, and chronic cigarette smoking contributed to development of subepithelial haze in this patient.</div></div>","PeriodicalId":7569,"journal":{"name":"American Journal of Ophthalmology Case Reports","volume":"39 ","pages":"Article 102371"},"PeriodicalIF":0.0,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144548826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pyrenochaeta unguis-hominis-associated fungal keratitis: A rare case report with in vivo confocal microscopy findings","authors":"Andreas Guttmann,&nbsp;Paul Wintersteller,&nbsp;Nora Woltsche,&nbsp;Astrid Heidinger,&nbsp;Nika Medic Ajdnik,&nbsp;Karin Pekovits,&nbsp;Ingrid Boldin,&nbsp;Haleh Aminfar,&nbsp;Jutta Horwath-Winter","doi":"10.1016/j.ajoc.2025.102373","DOIUrl":"10.1016/j.ajoc.2025.102373","url":null,"abstract":"<div><h3>Purpose</h3><div>Pyrenochaeta unguis-hominis, also known as Neocucurbitaria unguis-hominis, is a rare fungal pathogen typically isolated from skin and nail infections. Recently, it has been identified as a cause of fungal keratitis, particularly among contact lens wearers. This case report documents the occurrence of Pyrenochaeta unguis-hominis keratitis in Austria and the visualization of changes in the corneal stroma using in vivo confocal microscopy (IVCM).</div></div><div><h3>Observations</h3><div>A 48-year-old female patient presented with severe photophobia and acute pain in her left eye, following extended wear of soft contact lenses. Initial examination revealed a central corneal infiltrate. IVCM was performed prior to corneal scraping, which was then sent for direct staining, culture, and next-generation sequencing (NGS) and identified Pyrenochaeta unguis-hominis and Streptococcus oralis. Treatment included hourly topical voriconazole 2 %, natamycin 5 % and vancomycin 2.5 %, with additional epithelial debridement to enhance drug penetration. IVCM imaging allowed for real-time visualization and tracking of structures with the appearance of fungal hyphae, guiding the treatment course. Over several months, IVCM demonstrated a reduction in these structures, and the patient's condition stabilized, resulting in improved corneal clarity and Best Corrected Distance Visual Acuity from 0.8 to 0.9 (Snellen decimal scale).</div></div><div><h3>Conclusions and importance</h3><div>This case contributes to the limited clinical literature on Pyrenochaeta unguis-hominis-associated keratitis and includes IVCM imaging of a cornea with this rare infection. While IVCM provided early, non-invasive visualization of stromal changes, definitive diagnosis was achieved through molecular testing. A conservative treatment regimen with topical antifungals and epithelial debridement was effective, emphasizing the importance of rapid diagnostics and targeted therapy in managing rare corneal infections.</div></div>","PeriodicalId":7569,"journal":{"name":"American Journal of Ophthalmology Case Reports","volume":"39 ","pages":"Article 102373"},"PeriodicalIF":0.0,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144535223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delayed-onset Moraxella nonliquefaciens endophthalmitis following intravitreal injection","authors":"Paul S. Micevych,&nbsp;Monika Fleckenstein,&nbsp;Paul S. Bernstein","doi":"10.1016/j.ajoc.2025.102370","DOIUrl":"10.1016/j.ajoc.2025.102370","url":null,"abstract":"<div><h3>Purpose</h3><div>To report a case of <em>Moraxella nonliquefaciens</em> endophthalmitis presenting one month after intravitreal injection.</div></div><div><h3>Observations</h3><div>An 84-year-old man presented to the retina clinic with vision loss, pain, and redness in his right eye 28 days after a routine intravitreal injection of faricimab for exudative age-related macular degeneration. The patient had a remote history of cataract surgery, rhegmatogenous retinal detachment repair, and scleral buckle explant for exposure 3 years prior. The patient was found to have endophthalmitis, characterized by a hypopyon and dense vitritis. Broad-spectrum intravitreal antimicrobials and dexamethasone were administered, and a vitreous tap returned sterile. The patient achieved initial quiescence, but he had two recurrences of inflammation in this eye over the next 4.5 months. The patient ultimately underwent pars plana vitrectomy, vitreous biopsy, intraocular lens explant, capsulectomy and repeat intravitreal antimicrobial injections for definitive treatment. Broad-range PCR testing detected <em>Moraxella nonliquefaciens</em>. Inflammation resolved after surgery without further recurrence in the subsequent 7-month post-operative period.</div></div><div><h3>Conclusions and importance</h3><div><em>Moraxella</em> species have been implicated in cases of endophthalmitis associated with glaucoma filtering surgery and trauma, but this report details a delayed-onset <em>Moraxella nonliquefaciens-</em>associated endophthalmitis after intravitreal injection.</div></div>","PeriodicalId":7569,"journal":{"name":"American Journal of Ophthalmology Case Reports","volume":"39 ","pages":"Article 102370"},"PeriodicalIF":0.0,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144570027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corneal pseudomicrocysts following claudin-6 antibody-drug conjugate infusion","authors":"Laura Matuszewska ,&nbsp;Caitlynn Cooper ,&nbsp;Victoria Sattarova ,&nbsp;Wassef Chanbour ,&nbsp;Evan Meyer ,&nbsp;Vania Rashidi","doi":"10.1016/j.ajoc.2025.102375","DOIUrl":"10.1016/j.ajoc.2025.102375","url":null,"abstract":"<div><h3>Purpose</h3><div>To report a case of bilateral corneal pseudomicrocysts associated with infusions of a novel antibody-drug conjugate targeting claudin-6, called TORL-1-23.</div></div><div><h3>Observations</h3><div>A 47-year-old female with a history of advanced recurrent serous ovarian cancer presented to a level 1 tertiary care center with ocular irritation, redness, tearing, and light sensitivity following two infusions of TORL-1-23. Patient's past ocular history was unremarkable. The patient was enrolled in a phase 1 clinical trial for TORL-1-23, an antibody-drug conjugate (ADC). Nine days following the second infusion the patient presented to the ophthalmology clinic complaining of two weeks of bilateral eye discomfort, tearing, and photophobia. On examination, the patient had decreased visual acuity with a surface keratopathy associated with a whorled pattern of epithelial pseudomicrocysts in both eyes. Corneal changes were concentrated between the inferior limbus and central cornea. The remainder of the ophthalmic exam was unremarkable. Collagen and silicone punctal plugs were placed and the patient was started on preservative free artificial tears, topical loteprednol 0.5 %, later replaced with topical prednisolone acetate 1 % drops, and brimonidine 0.2 % in both eyes. The patient developed neuropathy which necessitated a decrease in ADC dosage and the patient's symptoms subsequently improved. However, a decrease in visual acuity and increase in corneal pseudomicrocysts was seen after the fifth infusion. Corneal disease improved with the placement of new collagen punctal plugs and addition of cyclosporine 0.05 % eye drops in both eyes. Ocular symptoms and exam findings waxed and waned with continued infusions of the ADC.</div></div><div><h3>Conclusions and importance</h3><div>This case reports an incidence of corneal pseudomicrocysts associated with TORL-1-23 treatment, which should be recognized as a potential adverse effect of this novel therapy.</div></div>","PeriodicalId":7569,"journal":{"name":"American Journal of Ophthalmology Case Reports","volume":"39 ","pages":"Article 102375"},"PeriodicalIF":0.0,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144548825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrence of hematocornea with intraocular neoplasm","authors":"Oganes Georgievich Oganesyan ,&nbsp;Daria Alexandrovna Gusak ,&nbsp;Svetlana Vladimirovna Saakyan ,&nbsp;Anush Gamletovna Amiryan ,&nbsp;Sergey Victorovich Milash ,&nbsp;Carolina Oganesyan","doi":"10.1016/j.ajoc.2025.102372","DOIUrl":"10.1016/j.ajoc.2025.102372","url":null,"abstract":"<div><h3>Purpose</h3><div>Herein, we report a rare case of recurrent hematocornea due to a non-pigmented adenoma of the ciliary body and its successful management with repeated deep anterior lamellar keratoplasty (DALK).</div></div><div><h3>Observations</h3><div>A 27-year-old man presented with significant visual acuity loss in his only functional eye due to hematocornea. Initial management involved visco-DALK, which restored visual acuity to 0.8. After 6 months, recurrent hematocornea prompted the removal of the underlying neoplasm through a scleral approach, which was histologically confirmed as a non-pigmented adenoma of the ciliary body. A repeat DALK was performed, followed by phacoemulsification with intraocular lens implantation for subsequent cataract development. Postoperative recovery was uneventful, and visual acuity stabilized at 0.8.</div></div><div><h3>Conclusions and importance</h3><div>This case highlights the feasibility and efficacy of visco-DALK in managing hematocornea while preserving endothelial integrity. The approach facilitated subsequent interventions, including neoplasm excision, repeat DALK, and cataract surgery, with favorable visual outcomes.</div></div>","PeriodicalId":7569,"journal":{"name":"American Journal of Ophthalmology Case Reports","volume":"39 ","pages":"Article 102372"},"PeriodicalIF":0.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144518439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal widefield OCT optic nerve thickness measurements in a case of incipient non-arteritic ischemic optic neuropathy","authors":"Winston Z. Lam ,&nbsp;Mengxi Shen ,&nbsp;Qinqin Zhang ,&nbsp;Viet Hoan Le ,&nbsp;Konica Singla ,&nbsp;Marjan Imani Fooladi ,&nbsp;Hong Jiang ,&nbsp;Byron L. Lam ,&nbsp;Ruikang K. Wang ,&nbsp;Giovanni Gregori ,&nbsp;Philip J. Rosenfeld","doi":"10.1016/j.ajoc.2025.102367","DOIUrl":"10.1016/j.ajoc.2025.102367","url":null,"abstract":"<div><h3>Purpose</h3><div>Widefield swept-source optical coherence tomography angiography (SS-OCTA) scans were combined with a semi-automated algorithm for the early detection and resolution of optic nerve edema in a case of incipient non-arteritic anterior ischemic optic neuropathy (NAION).</div></div><div><h3>Observations</h3><div>An incidental case of incipient NAION was identified in a 71-year-old woman enrolled in an ongoing prospective SS-OCTA imaging study using 12 × 12 mm scans that allowed imaging of both the macular and optic disc regions of patients with age-related macular degeneration (AMD). Early intervention with systemic corticosteroids led to the resolution of optic disc edema without subsequent vision loss. A novel semi-automated algorithm was used to quantify the onset and resolution of optic nerve edema and edema in the surrounding retina.</div></div><div><h3>Conclusions and importance</h3><div>This use of 12 × 12 mm SS-OCTA scans and a semi-automated algorithm can significantly improve the detection and management of incipient NAION in clinical practice with the possibility that early detection would facilitate earlier intervention and better vision preservation in this condition. The use of widefield OCT imaging in conjunction with this novel algorithm in eyes at risk for optic nerve and macular edema could have broader implications for other retinal diseases in which optic disc and macular edema might arise such as diabetic retinopathy. Integrating this methodology into routine ophthalmic evaluations will enable clinicians to identify the onset of edema prior to vision loss, thereby improving patient outcomes.</div></div>","PeriodicalId":7569,"journal":{"name":"American Journal of Ophthalmology Case Reports","volume":"39 ","pages":"Article 102367"},"PeriodicalIF":0.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144523448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}