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Physiopathology of the inflammation and articular destruction in rheumatology. Symposium at Fribourg, 30-31 March 1979. 风湿病中炎症和关节破坏的生理病理。1979年3月30日至31日在弗里堡举行专题讨论会。
Bulletin der Schweizerischen Akademie der Medizinischen Wissenschaften Pub Date : 1979-09-01
{"title":"Physiopathology of the inflammation and articular destruction in rheumatology. Symposium at Fribourg, 30-31 March 1979.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75639,"journal":{"name":"Bulletin der Schweizerischen Akademie der Medizinischen Wissenschaften","volume":"35 4-6","pages":"273-451"},"PeriodicalIF":0.0,"publicationDate":"1979-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11530998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Regulatory effects of proteases in articular inflammation]. 蛋白酶在关节炎症中的调节作用。
Bulletin der Schweizerischen Akademie der Medizinischen Wissenschaften Pub Date : 1979-09-01
T L Vischer
{"title":"[Regulatory effects of proteases in articular inflammation].","authors":"T L Vischer","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The role of proteases in the stimulation of cells participating in a chronic inflammatory reaction is reviewed. Several neutral proteases stimulate B lymphocytes to produce both specific and unspecific antibodies and such enzymes can replace, at least in vitro, T-helper cells. Proteases might influence macrophages as well, by a MIF-like activity, by increasing spreading in vitro or by liberating from C3 the C3b component which has an activating effect on these cells. Endocytosis of protease - alpha-2 macroglobulin complexes by macrophages induces production of neutral proteases as well. A stimulation of fibroblasts by proteases is possible but not yet clearly proven.</p>","PeriodicalId":75639,"journal":{"name":"Bulletin der Schweizerischen Akademie der Medizinischen Wissenschaften","volume":"35 4-6","pages":"345-50"},"PeriodicalIF":0.0,"publicationDate":"1979-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11601150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Physiopathology of arthroses]. [关节的生理病理学]。
Bulletin der Schweizerischen Akademie der Medizinischen Wissenschaften Pub Date : 1979-09-01
J Villiaumey
{"title":"[Physiopathology of arthroses].","authors":"J Villiaumey","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75639,"journal":{"name":"Bulletin der Schweizerischen Akademie der Medizinischen Wissenschaften","volume":"35 4-6","pages":"355-70"},"PeriodicalIF":0.0,"publicationDate":"1979-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11601151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Experimental arthroses]. [实验性关节]。
Bulletin der Schweizerischen Akademie der Medizinischen Wissenschaften Pub Date : 1979-09-01
R Silberberg
{"title":"[Experimental arthroses].","authors":"R Silberberg","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75639,"journal":{"name":"Bulletin der Schweizerischen Akademie der Medizinischen Wissenschaften","volume":"35 4-6","pages":"379-88"},"PeriodicalIF":0.0,"publicationDate":"1979-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11601152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Arthropathies due to calcium pyrophosphates]. [焦磷酸钙引起的关节病]。
Bulletin der Schweizerischen Akademie der Medizinischen Wissenschaften Pub Date : 1979-09-01
G H Fallet, A Micheli
{"title":"[Arthropathies due to calcium pyrophosphates].","authors":"G H Fallet,&nbsp;A Micheli","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Articular chondrocalcinosis results from the deposits of calcium pyrophosphate microcrystals in the articular hyalin and fibrocartilages, the synovium and at times the tendons. In our area it is seen most frequently as isolated cases in the elderly and may be asymptomatic. When the affected joints present clinical manifestations, they vary from acute to subacute or chronic recurrent arthritis. A marked articular destruction can be observed in some cases. There is a classical radiological picture: linear opacities are most frequently seen localized in the mid-zone layer of the hyalin cartilage running parallel to but at a certain distance from the bone cortex. A part of our research has shown that in contrast to urate gout, articular chondrocalcinosis results from a metabolic disturbance of the calcium pyrophosphate localized almost exclusively in the same articular structures. Precise information is lacking at the present time to explain why calcium pyrophosphate mycrocrystals accumulate in the cartilage, the synovium and at times at the tendons; nor do we understand the precise role played by the pyrophosphate in bone and cartilage destruction.</p>","PeriodicalId":75639,"journal":{"name":"Bulletin der Schweizerischen Akademie der Medizinischen Wissenschaften","volume":"35 4-6","pages":"403-20"},"PeriodicalIF":0.0,"publicationDate":"1979-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11445155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Morphologic indication for the participation of neutrophil granulocytes in rheumatic cartilage destruction]. [中性粒细胞参与风湿性软骨破坏的形态学指征]。
Bulletin der Schweizerischen Akademie der Medizinischen Wissenschaften Pub Date : 1979-09-01
W Mohr, H Menninger, R Putzier
{"title":"[Morphologic indication for the participation of neutrophil granulocytes in rheumatic cartilage destruction].","authors":"W Mohr,&nbsp;H Menninger,&nbsp;R Putzier","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Cartilage destruction in rheumatoid arthritis may be mediated by enzymes of the synovial fluid and by cells of the proliferating pannus tissue. Neutrophilic granulocytes are usually said to affect the cartilage via the synovial fluid, and their local occurrence in the pannus-cartilage border is denied. However, a morphological study on pannus tissue and cartilage by use of histochemistry and immunfluorescence (leucocytes antielastase) exhibited an accumulation of neutrophilic granulocytes in the immediate vicinity of the cartilage in destruction. This result is in contrast to the observation of most investigators reporting studies of the pannus cartilage junction. Experimental datas of the effect of elastase moreover indicate that this enzyme is capable to penetrate into the cartilage and to degrade proteoglycans. Therefore the results show that the occurrence of neutrophilic granulocytes at the pannus-cartilage border is an important phenomenon for understanding the progressive cartilage destruction and that elastase may be at least one enzyme responsible for the degradation of the cartilage matrix.</p>","PeriodicalId":75639,"journal":{"name":"Bulletin der Schweizerischen Akademie der Medizinischen Wissenschaften","volume":"35 4-6","pages":"443-51"},"PeriodicalIF":0.0,"publicationDate":"1979-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11531002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Generalized periarthritis calcarea (generalized hydroxyapatite disease)]. [广泛性周炎钙质(广泛性羟基磷灰石病)]。
Bulletin der Schweizerischen Akademie der Medizinischen Wissenschaften Pub Date : 1979-09-01
W Müller, I Bahous
{"title":"[Generalized periarthritis calcarea (generalized hydroxyapatite disease)].","authors":"W Müller,&nbsp;I Bahous","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The condition of generalized periarthritis calcarea (hydroxyapatite deposition disease) is characterised by multiple periarticular calcification which can be localised around practically any joint and also in proximity to the spine. This calcification consists of hydroxyapatite crystals which are responsible for the episodes of acute, subacute or chronic periarticular or articular inflammation so typical of the condition. Because of this one can classify periarthritis calcarea along with gout and chondrocalcinosis in the group of crystal deposition diseases. The actual cause of the calcification remains unknown but it is probable that, along with hereditary factors, disturbances in metabolism play an important role. The diagnosis of generalised periarthritis is made from the characteristic X-ray picture in conjunction with the clinical findings and, on occasion, the demonstration of hydroxyapatite crystals in the affected tissues. In the differential diagnosis gout, chondrocalcinosis, various inflammatory rheumatic conditions and septic arthritis must be excluded and various calcification processes, particularly interstitial calcinosis and lipocal cinogranulomatosis, must also be considered. Since the etiology of the calcification remains unknown to specific treatment is available. Symptomatic treatment with colchicine is mostly inadequate which is why one often has recourse to the use of non-steroid anti-inflammatory drugs and corticosteroids.</p>","PeriodicalId":75639,"journal":{"name":"Bulletin der Schweizerischen Akademie der Medizinischen Wissenschaften","volume":"35 4-6","pages":"421-42"},"PeriodicalIF":0.0,"publicationDate":"1979-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11601153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immune complexes and complement in rheumatoid arthritis. 类风湿关节炎中的免疫复合物和补体。
Bulletin der Schweizerischen Akademie der Medizinischen Wissenschaften Pub Date : 1979-09-01
P H Lambert, P Casali, U Nydegger
{"title":"Immune complexes and complement in rheumatoid arthritis.","authors":"P H Lambert,&nbsp;P Casali,&nbsp;U Nydegger","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Immune complexes have been shown to occur frequently during rheumatoid arthritis. They have been found in blood, in the synovium and in other extravascular lesions. The recent development of methods for the quantitation of immune complexes provided new tools to evaluate the possible role of immune complexes in rheumatoid arthritis. Immune complexes which appear in synovial fluid are in higher concentration than in serum and have particular physicochemical properties. They likely result from a local formation in the synovium and seem to be directly involved in the generation of the local inflammation. High levels of circulating immune complexes are usually associated with the development of extra-articular vascular lesions. One of the major biological activity of immune complexes is to activate the complement system. There is indeed evidence of complement activation in circulating blood as well as in synovial fluid in patients with rheumatoid arthritis. The presence and the concentration of complement breakdown products in these fluids correlates with the clinical activity. Therefore, the analysis of immune complexes and of complement components appears useful for diagnosis and follow-up, and for the understanding of the pathogenesis of the disease.</p>","PeriodicalId":75639,"journal":{"name":"Bulletin der Schweizerischen Akademie der Medizinischen Wissenschaften","volume":"35 4-6","pages":"301-15"},"PeriodicalIF":0.0,"publicationDate":"1979-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11738741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
General mechanisms of inflammation in rheumatoid arthritis. 类风湿关节炎炎症的一般机制。
Bulletin der Schweizerischen Akademie der Medizinischen Wissenschaften Pub Date : 1979-09-01
M Ziff
{"title":"General mechanisms of inflammation in rheumatoid arthritis.","authors":"M Ziff","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Rheumatoid synovitis is characterized by the simultaneous occurrence of two major types of immunologically-induced inflammation. These usually occur concurrently in the same joint. A cellular immune response is present in the sublining layer of the synovial membrane and an immune complex-induced acute inflammatory reaction is present in the synovial effusion phase of the disease. The two reactions are closely related and mutually interdependent. The cellular immune response is reduced in rheumatoid arthritis, but the chronic inflammatory cells of the synovium are active in the synthesis of IgG and probably considerable amounts of IgG rheumatoid factor. Rheumatoid factor complexes, particularly IgG-RF complexes, appear to be responsible for the exudative, immune complex-induced inflammatory phase of the disease.</p>","PeriodicalId":75639,"journal":{"name":"Bulletin der Schweizerischen Akademie der Medizinischen Wissenschaften","volume":"35 4-6","pages":"275-81"},"PeriodicalIF":0.0,"publicationDate":"1979-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11378376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Chronic polyarthritis: role of polymorphonuclear leukocytes in the destruction of pannus-free articular cartilage]. [慢性多发性关节炎:多形核白细胞在无瘤关节软骨破坏中的作用]。
Bulletin der Schweizerischen Akademie der Medizinischen Wissenschaften Pub Date : 1979-09-01
K Fehr, A Baici, M Velvart, M Knöpfel, M Rauber, G Sommermeyer, P Salgam, G Cohen, A Böni
{"title":"[Chronic polyarthritis: role of polymorphonuclear leukocytes in the destruction of pannus-free articular cartilage].","authors":"K Fehr,&nbsp;A Baici,&nbsp;M Velvart,&nbsp;M Knöpfel,&nbsp;M Rauber,&nbsp;G Sommermeyer,&nbsp;P Salgam,&nbsp;G Cohen,&nbsp;A Böni","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The synovial fluid (SF) of RA patients contains large amounts of PMN which are well equipped with neutral enzymes to degrade articular cartilage: elastase and cathepsin G, which both destroy proteoglycans and native collagen, as well as 2 types of collagenoases. Indirect evidence suggests that PMN might be important in the destruction of RA articular cartilage. In 19 SF of RA patients no free elastase or collagenase was found. Using immune histochemical methods, we observed that PMN and macrophages of SF contain both elastase and alpha 1-anti-trypsin and alpha 2-macroglobulin. Peripheral PMN - but not monocytes - contain elastase, however both types of cells lack alpha 1-antitrypsin and alpha 2-macroglobulin. Elastase is demonstratable in the superficial layer of pannus free RA articular cartilage. These findings suggest that neutral proteinases from PMN in RA SF are generally neutralized by physiologic inhibitors and removed by phagocytes. The enzyme-inhibitor interaction might be bypassed during \"frustrated phagocytosis\" so that enzymes like PMN elastase can damage RA articular cartilage.</p>","PeriodicalId":75639,"journal":{"name":"Bulletin der Schweizerischen Akademie der Medizinischen Wissenschaften","volume":"35 4-6","pages":"317-27"},"PeriodicalIF":0.0,"publicationDate":"1979-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11446067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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