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Erythrocyte superoxide dismutase activity in patients with malignant neoplasms. 恶性肿瘤患者红细胞超氧化物歧化酶活性的研究。
Archivos de investigacion medica Pub Date : 1990-10-01
M E Franco, M C Carrillo, C Hernández, C Medina, B Ibarra, G Vaca, J M Cantú
{"title":"Erythrocyte superoxide dismutase activity in patients with malignant neoplasms.","authors":"M E Franco,&nbsp;M C Carrillo,&nbsp;C Hernández,&nbsp;C Medina,&nbsp;B Ibarra,&nbsp;G Vaca,&nbsp;J M Cantú","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Erythrocyte superoxide dismutase activity was determined in four groups of patients, two with hematologic neoplasms with and without therapy and two others with solid tumors also selected on the basis of therapy. Increased activities were found in the two groups where there was no treatment, whereas those under treatment showed normal levels. In addition, an inverse relationship (r = -0.25 p < 0.02) between superoxide dismutase activities and the time under therapy was observed.</p>","PeriodicalId":75554,"journal":{"name":"Archivos de investigacion medica","volume":"21 4","pages":"285-8"},"PeriodicalIF":0.0,"publicationDate":"1990-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12834696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Qualitative and quantitative determination of urinary glycosaminoglycans in patients with osteochondrodysplasias]. [骨软骨发育不良患者尿糖胺聚糖的定性和定量测定]。
Archivos de investigacion medica Pub Date : 1990-10-01
J Sánchez-Corona, M P Gallegos-Arreola, O Contreras-Sánchez
{"title":"[Qualitative and quantitative determination of urinary glycosaminoglycans in patients with osteochondrodysplasias].","authors":"J Sánchez-Corona,&nbsp;M P Gallegos-Arreola,&nbsp;O Contreras-Sánchez","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A quantitative and qualitative assay of urinary glycosaminoglycans (GAGs) was performed, by means of spectrophotometry and electrophoresis in 37 patients with a suspected diagnosis of osteo-chondrodysplasia. Levels were increased in 70.2% of the cases. One patient showed an electrophoretic pattern which was different and could not be identified in accord with the standard used.</p>","PeriodicalId":75554,"journal":{"name":"Archivos de investigacion medica","volume":"21 4","pages":"353-6"},"PeriodicalIF":0.0,"publicationDate":"1990-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12834639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Experimental testicular fibrosis and atrophy induced by intratesticular propylene glycol injection]. [睾丸内注射丙二醇致实验性睾丸纤维化和萎缩]。
Archivos de investigacion medica Pub Date : 1990-10-01
M A Ramírez-Herrera, G Gabriel Ortíz
{"title":"[Experimental testicular fibrosis and atrophy induced by intratesticular propylene glycol injection].","authors":"M A Ramírez-Herrera,&nbsp;G Gabriel Ortíz","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Fifty-four 15 day old male Wistar rats were given single intratesticular injection of experimental preparations which contained formaldehyde, xylocaine and epinephrine diluted in propylene glycol (FXEP); xylocaine in propylene glycol (XP): epinephrine in propylene glycol (EP) propylene glycol (P); formaldehyde in 0.1 M phosphate buffer solution (F); an one control group. The group of rats that were given FXEP underwent testicular weight reduction; body weight and size were not affected. Also the treatment with P produced atrophy and fibrosis in testis and a more severe testicular weight reduction. The sclerosing effect of P treatment was more satisfactory than treatment with FXEP, and apparently no one affected body weight and size, thus, this could be a safe, easy and inexpensive method for non surgical castration.</p>","PeriodicalId":75554,"journal":{"name":"Archivos de investigacion medica","volume":"21 4","pages":"293-8"},"PeriodicalIF":0.0,"publicationDate":"1990-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12834698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Characterization of SH groups in the membrane proteins of human spermatozoa]. [人精子膜蛋白中SH基团的表征]。
Archivos de investigacion medica Pub Date : 1990-10-01
N M Delgado, R Reyes, L Huacuja, A Carranco, A Rosado
{"title":"[Characterization of SH groups in the membrane proteins of human spermatozoa].","authors":"N M Delgado,&nbsp;R Reyes,&nbsp;L Huacuja,&nbsp;A Carranco,&nbsp;A Rosado","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Membrane proteins rich in SH- groups were identified in human ejaculated spermatozoon, using the alkylation reaction with radioactive iodoacetic acid with a subsequent determination of the electrophoretic characterization of the proteins, as well as their comparison with the proteins in seminal plasma and blood serum of the same individuals. The determination of the incorporated radioactivity shows that out of 20 proteic bands identified by staining with Coomassie Blue, only 9 were alkylated with the iodoacetate. Among these 9 proteic bands, 4 are glycoproteins since they give a PAS positive reaction. All the proteins which incorporated the marked iodoacetate had a molecular weight below 67,000 daltons with a predominance of molecular weight below 25,000 daltons. A comparison of the electrophoresis obtained from the spermatozoon's plasmatic membrane, seminal plasma and blood serum, one finds that among the 9 proteins which were alkylated with the iodoacetate in the plasmatic membranes, two, bands I and IV are also found in the seminal plasma and blood serum, two more, bands VII and IX are found in the membranes and seminal plasma, but not in blood serum, while the rest are only found in the spermatozoon.</p>","PeriodicalId":75554,"journal":{"name":"Archivos de investigacion medica","volume":"21 4","pages":"419-24"},"PeriodicalIF":0.0,"publicationDate":"1990-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12890714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Increase of proliferative and cytotoxic responses to alloantigenic stimulation of mouse spleen cells treated with aclacinomycin]. [阿克拉霉素处理小鼠脾细胞对同种抗原刺激的增殖和细胞毒性反应增加]。
Archivos de investigacion medica Pub Date : 1990-10-01
A Bravo-Cuéllar, J L Martín-Ruíz, R Ramos-Pineda, A M Puebla-Pérez, A Leal-Delgadillo, X H Liu, S Orbach-Arbouys
{"title":"[Increase of proliferative and cytotoxic responses to alloantigenic stimulation of mouse spleen cells treated with aclacinomycin].","authors":"A Bravo-Cuéllar,&nbsp;J L Martín-Ruíz,&nbsp;R Ramos-Pineda,&nbsp;A M Puebla-Pérez,&nbsp;A Leal-Delgadillo,&nbsp;X H Liu,&nbsp;S Orbach-Arbouys","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Aclacinomycin (ACM) is an oncostatic substance on the family of the Anthracyclines, with a proven activity in human and rodents. Splenic cells from C57BL/6 ACM injected mice by intraperitoneal or intravenous route four days before their sacrifice showed a significant increase in the proliferative and cytotoxic response respectively measured by incorporation of 3H-TdR and by the liberation of 51Cr when stimulated in vitro with irradiated mouse DBA/2 splenic cells. This response is doses dependent, and one can clearly observe different effects on the proliferative and cytotoxic responses at high doses. The cultures supernatants of splenic cells from mice treated with ACM during allogeneic stimulation showed a greater activity to induce the proliferation of a line of T cytotoxic cells dependent on Interleukin-2. Finally, the cytotoxic activity of splenic cells induced by the allogeneic stimulation in vitro, of mice treated with ACM, was found in a subpopulation of cells non adherent to plastic, mainly made up of lymphocytes.</p>","PeriodicalId":75554,"journal":{"name":"Archivos de investigacion medica","volume":"21 4","pages":"331-7"},"PeriodicalIF":0.0,"publicationDate":"1990-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12834636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Relative frequency of glucose-6-phosphate dehydrogenase deficiency in jaundiced newborn infants in the metropolitan area of Monterrey, Nuevo León]. [蒙特雷市区黄疸新生儿葡萄糖-6-磷酸脱氢酶缺乏症的相对频率，Nuevo León]。
Archivos de investigacion medica Pub Date : 1990-07-01
G González-Quiroga, J L Ramírez del Río, R Ortíz-Jalomo, R F García-Contreras, R M Cerda-Flores, B D Mata-Cárdenas, R Garza-Chapa
{"title":"[Relative frequency of glucose-6-phosphate dehydrogenase deficiency in jaundiced newborn infants in the metropolitan area of Monterrey, Nuevo León].","authors":"G González-Quiroga,&nbsp;J L Ramírez del Río,&nbsp;R Ortíz-Jalomo,&nbsp;R F García-Contreras,&nbsp;R M Cerda-Flores,&nbsp;B D Mata-Cárdenas,&nbsp;R Garza-Chapa","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In order to estimate the frequency of G6PD deficiency in the icteric population of the Monterrey metropolitan área (MMA), in the state of Nuevo León, there were studied 829 newborn males were studied. It was found that 13 subjects were deficient of this enzyme, that is equivalent to a frequency of 1.57% and when this frequency was compared with the one that was found an a previous study in a random sample of newborn males (0.66%) no statistical difference was observed, but it was estimated that the icteric newborn males have a relative risk of 2.34 times higher than the population in general to be a G6PD deficient, and this fact suggests the necessity to establish this screening test as a routine for all icteric newborn males, in order to have an opportune detection and an appropriate counselling.</p>","PeriodicalId":75554,"journal":{"name":"Archivos de investigacion medica","volume":"21 3","pages":"223-7"},"PeriodicalIF":0.0,"publicationDate":"1990-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13285988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Effect of sodium diphenylhydantoin on sister chromatid exchange frequency in mice]. [二苯肼钠对小鼠姐妹染色单体交换频率的影响]。
Archivos de investigacion medica Pub Date : 1990-07-01
C Leal-Garza, G Valenciano-Cedillo, R Cerda-Flores, R Garza-Chapa
{"title":"[Effect of sodium diphenylhydantoin on sister chromatid exchange frequency in mice].","authors":"C Leal-Garza,&nbsp;G Valenciano-Cedillo,&nbsp;R Cerda-Flores,&nbsp;R Garza-Chapa","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In order to analyze the effect of the anticonvulsant diphenyl hydantoin (DPH) over the frequency of sister chromatid exchanges (SCE) in vivo, Balb-C mouse 8-12 weeks old, males and females, were injected intraperitoneally with a single dose and three different concentrations: 1, 10 and 20 mg/Kg, as negative and positive control, we used physiological serum and mitomycin-C respectively that were injected in the same way. Twenty five metaphases were analyzed per individual in the slide with the differential staining of sister chromatid, we found a light, but significantly increase, in the frequency of SCE in the concentrations of 10 and 20 mg/Kg when they were compared with the ones obtained for the negative control. In the males was observed a positive correlation in the levels of ICH when the doses of DPH were increased.</p>","PeriodicalId":75554,"journal":{"name":"Archivos de investigacion medica","volume":"21 3","pages":"211-5"},"PeriodicalIF":0.0,"publicationDate":"1990-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13285984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Frequency of color blindness and glucose-6-phosphate dehydrogenase enzyme deficiency in non-industrialized populations in the state of Nuevo León, México]. [在Nuevo州非工业化人群中色盲和葡萄糖-6-磷酸脱氢酶缺乏症的频率León, m<s:1> xico]。
Archivos de investigacion medica Pub Date : 1990-07-01
R M Ceda-Flores, G Arriaga-Ríos, J Muñoz-Campos, V A Bautista-Peña, M Angeles Rojas-Alvarado, G González-Quiróga, C H Leal-Garza, R Garza-Chapa
{"title":"[Frequency of color blindness and glucose-6-phosphate dehydrogenase enzyme deficiency in non-industrialized populations in the state of Nuevo León, México].","authors":"R M Ceda-Flores,&nbsp;G Arriaga-Ríos,&nbsp;J Muñoz-Campos,&nbsp;V A Bautista-Peña,&nbsp;M Angeles Rojas-Alvarado,&nbsp;G González-Quiróga,&nbsp;C H Leal-Garza,&nbsp;R Garza-Chapa","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In order to know if there would be genetic structural differences among non industrial and industrial populations, two genetic markers were studied: color-blindness (CPC) and glucose-6-phosphate dehydrogenase deficiency (G6PD), in students, males and females that were resident in five non industrial populations in the State of Nuevo Leon. The results were compared with the information for industrial zone from the Monterrey Metropolitan area (AMM). It was found that the frequencies of CPC and G6PD in non industrial populations (2.57 and 0.00 per cent), were lower than the ones in the industrial AMM (4.0 and 0.66 per cent), probably as a result that in the first populations, with minor urbanization, the main factors that influence are: natural selection, interacial mixed or genetic drift and the second population is the immigration, since 1940 to present time, of Mexican populations with greater influence from the Indians and Africans.</p>","PeriodicalId":75554,"journal":{"name":"Archivos de investigacion medica","volume":"21 3","pages":"229-34"},"PeriodicalIF":0.0,"publicationDate":"1990-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13285986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Mobilization of lead in patients with chronic poisoning by that metal. Oral penicillamine]. 慢性铅中毒患者的铅动员。口服青霉胺)。
Archivos de investigacion medica Pub Date : 1990-07-01
D González-Ramírez, M Zuñiga-Charles, A Narro-Juárez
{"title":"[Mobilization of lead in patients with chronic poisoning by that metal. Oral penicillamine].","authors":"D González-Ramírez,&nbsp;M Zuñiga-Charles,&nbsp;A Narro-Juárez","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Penicillamine was administered, per os, in patients who had been working with lead for several years, showing signs and symptoms suggesting chronic lead intoxication, so as to evaluated the test of lead chelation. A positive response allowed further treatment. Daily elimination of urinary lead, delta-aminolevulinic acid and coproporphyrin were evaluated. Weekly assays of hematic lead, protoporphyrin IX and the activity of the enzyme delta-aminolevulinic acid dehydratase were performed. The result show penicillamine to be an alternative to ethylene diamine tetra acetic acid in the chelatable lead mobilization test and prove that it is an excellent alternative in the treatment of chronic lead intoxication.</p>","PeriodicalId":75554,"journal":{"name":"Archivos de investigacion medica","volume":"21 3","pages":"279-83"},"PeriodicalIF":0.0,"publicationDate":"1990-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13285843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Acute effects of the administration of potassium on the organ uptake of Tl+ in the rabbit]. [给钾对兔器官吸收Tl+的急性影响]。
Archivos de investigacion medica Pub Date : 1990-07-01
J Careaga-Olivares, A Morales-Aguilera
{"title":"[Acute effects of the administration of potassium on the organ uptake of Tl+ in the rabbit].","authors":"J Careaga-Olivares,&nbsp;A Morales-Aguilera","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This paper describes the acute effects produced by administering potassium (2.7 and 5.5 mg.per kg of weight) to rabbits intoxicated with 10 and 30 mg.kg-1 of thallium. Acute capture (90 minutes) of thallium by skeletal muscle, left ventricle, liver and renal medulla and cortex is studied. Different doses of thallium were found to modify the organic capture in the studied organs with quantitative differences. The administering of potassium also modified the magnitude of capture, in different magnitudes, in the various organs. The modification produced depends more upon the studied organ than on the dose of potassium given. The skeletal muscle seems to manage the thallium-potassium interaction depending on the activation of sodium-potassium ATPase. The liver does not seem to be directly affected by the thallium-potassium interaction. The left ventricle captures thallium very rapidly, and also seems to depend on the activation of sodium potassium ATPase, and potassium increases thallium capture. The renal medulla captures 4 to 5 times more thallium than its cortex and the high dose of thallium seems to saturate the medulla's capture. The renal cortex's capture was not renal elimination of thallium is activated by potassium. The renal cortex uptake was not modified by potassium but the renal thallium elimination seems to be activated by potassium. The uptake by the renal medulla is diminished by potassium, suggesting a thallium-potassium interaction similar to the competitive inhibition described by McCall et al. (1985).</p>","PeriodicalId":75554,"journal":{"name":"Archivos de investigacion medica","volume":"21 3","pages":"273-7"},"PeriodicalIF":0.0,"publicationDate":"1990-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13285836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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