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[Detection of young female carriers of Duchenne muscular dystrophy]. 年轻女性杜氏肌营养不良症携带者的检测。
Archivos de investigacion medica Pub Date : 1990-07-01
M A Alvarez Leal, A Morales-Aguilera
{"title":"[Detection of young female carriers of Duchenne muscular dystrophy].","authors":"M A Alvarez Leal,&nbsp;A Morales-Aguilera","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>36 females aged through 1 to 16 years were studied. They were sisters or close kin, on the maternal side, of patients with Duchenne's Muscular Dystrophy (DMD). 23 healthy controls were also studied so as to evaluate the usefulness of determining serum creatine phosphokinase (CPK) as means for detecting young carriers of DMD. 18 of 36 girls (50%) who were the daughters of the affected families, showed CPK seric values more than twice the standard deviation of the mean of the witness group (21 +/- 7.9 U/L). The Bayesian analysis performed on the problem group showed a good correspondence. These findings imply a high range of detection in possible carriers under 16 years of age. We believe that the absence of symptomatology in some of these girls does not eliminate the possibility of being a carrier.</p>","PeriodicalId":75554,"journal":{"name":"Archivos de investigacion medica","volume":"21 3","pages":"269-72"},"PeriodicalIF":0.0,"publicationDate":"1990-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13285837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Frequency of sister chromatid exchange in mice treated with gossypol]. [棉酚处理小鼠姐妹染色单体交换频率]。
Archivos de investigacion medica Pub Date : 1990-07-01
C H Leal-Garza, M T González-Garza, G Valenciano-Cedillo
{"title":"[Frequency of sister chromatid exchange in mice treated with gossypol].","authors":"C H Leal-Garza,&nbsp;M T González-Garza,&nbsp;G Valenciano-Cedillo","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>To evaluate the possible mutagenic activity of gossypol, -a male contraceptive , which besides has inhibitory action on some parasites growth. Balb-C mouse received intraesophageally 10, 20 and 30 mg/Kg of gossypol to observe the effect of this drug on the frequency of sister chromatid exchanges (SCE) in bone marrow cells. A dose-response relation was not observed, and a small increase in the frequency of SCE was obtained. As it was not the double among the negative control, the gossypol effect must be classified as \"undetermined\" or \"provisionally positive\" agent. It is important to make more studies to determinate its possible mutagenic potential on humans.</p>","PeriodicalId":75554,"journal":{"name":"Archivos de investigacion medica","volume":"21 3","pages":"217-21"},"PeriodicalIF":0.0,"publicationDate":"1990-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13285985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Virulence factors of Entamoeba histolytica]. [溶组织内阿米巴毒力因子]。
Archivos de investigacion medica Pub Date : 1990-07-01
S Said-Fernández
{"title":"[Virulence factors of Entamoeba histolytica].","authors":"S Said-Fernández","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A panoramic view of the amebiasis concept, its pathogenesis and its epidemiologic importance is presented. Besides, a brief description of the characteristic lesions of the mainly affected organs is done. Then it is proposed a sequential relationship must occur in the amebic lesion production. Finally, the best characterized amoebal infective factors are analyzed. This paper does not pretend to be an exhaustive review, but to offer an image of the pathogenetic mechanisms of amebiasis.</p>","PeriodicalId":75554,"journal":{"name":"Archivos de investigacion medica","volume":"21 3","pages":"253-62"},"PeriodicalIF":0.0,"publicationDate":"1990-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13285990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Growth inhibition of Entamoeba histolytica and E. invadens produced by pomegranate root (Punica granatum L.)]. [石榴根对溶组织内阿米巴和入侵内阿米巴生长的抑制作用]。
Archivos de investigacion medica Pub Date : 1990-07-01
J J Segura, L H Morales-Ramos, J Verde-Star, D Guerra
{"title":"[Growth inhibition of Entamoeba histolytica and E. invadens produced by pomegranate root (Punica granatum L.)].","authors":"J J Segura,&nbsp;L H Morales-Ramos,&nbsp;J Verde-Star,&nbsp;D Guerra","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The purpose of the present work has been to evaluate the biological activity of alkaloids and tannins extracted from roots of Punica granatum L. on axenic cultures from Entamoeba histolytica and E. invadens, strains. Initially, the total aqueous extract and later some of its components obtained by thin layer chromatography were tested. These compounds were identified by chromatography as alkaloids or tannins. The density of amebic cultures was determined with a hemocytometer after 48 and 96 hours of incubation, which was calculated by the difference between number of trophozoites obtained at the times chosen and the number of amoebae inoculated. Two milliliters of aqueous extract had higher activity on cultures from E. histolytica than E. invadens strains, producing growth inhibitions of about 100 and 40 per cent respectively. Alkaloid concentrations of 1 mg/ml had no amebicide activity, however tannins at concentrations of 10 micrograms/ml for E. histolytica, and 100 micrograms/ml for E. invadens were sufficient to produce an growth inhibition about 100 per cent. Tannic acid was also tested on the cultures of E. histolytica observing an high inhibitory activity on the growth, this effect was produced at 0.01 mg/ml was similar to that observed with the tannins mixture.</p>","PeriodicalId":75554,"journal":{"name":"Archivos de investigacion medica","volume":"21 3","pages":"235-9"},"PeriodicalIF":0.0,"publicationDate":"1990-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13285987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Development of a simplified method for the axenic culture of Entamoeba histolytica]. [一种简化的溶组织内阿米巴无菌培养方法的研究]。
Archivos de investigacion medica Pub Date : 1990-07-01
B D Mata-Cárdenas, S Said-Fernández
{"title":"[Development of a simplified method for the axenic culture of Entamoeba histolytica].","authors":"B D Mata-Cárdenas,&nbsp;S Said-Fernández","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Since the TPS-1 medium description, by Diamond, for axenic cultivation of Entamoeba histolytica trophozoites, a spectacular advance in this parasite biology knowledge has been occurred. Recently we described a new medium, called PEHPS, which is as reliable as those of current use, and besides offers a more stable final density. From this latter, we developed, a new simpler medium, after being evaluated the specific contribution of several components of PEHPS. Yields as high as those obtained with the original medium were obtained after the following modifications, incorporated in the new medium formula: Osmolarity 318 +/- 6 mOsm/Kg, pH 6.8, redox potential -130 mV, regulated only with 1.0 g/l of ascorbic acid, glucose 3.75 g/l, instead of the original PEHPS characteristics, which are the following: Osmolarity 340 +/- 42 mOsm/KG, pH 7.0, regulated with both cysteine and ascorbic acid and 6.0 g/l of glucose. As the new medium supplementation with vitamins did not result in significative differences with respect to the non supplemented medium, we eliminated all of these from the final formula.</p>","PeriodicalId":75554,"journal":{"name":"Archivos de investigacion medica","volume":"21 3","pages":"247-51"},"PeriodicalIF":0.0,"publicationDate":"1990-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13285838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Acute pharmacokinetics of the Tl+ ion in the rabbit. 3-compartment model]. Tl+离子在家兔体内的急性药代动力学。3-compartment模型)。
Archivos de investigacion medica Pub Date : 1990-07-01
A Morales-Aguilera, J Careaga Olivares
{"title":"[Acute pharmacokinetics of the Tl+ ion in the rabbit. 3-compartment model].","authors":"A Morales-Aguilera,&nbsp;J Careaga Olivares","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>New Zealand rabbits were used to determine the acute kinetics of the Tl+ ion (0 to 90 minutes) following intravenous administration of two doses of Tl+ (10 mg.kg-1 and 30 mg.kg-1). The rapid disappearance of Tl+ from the blood may be explained by means of an open parallel tricompartmental mamillary model. The most important pharmacokinetic parameters which changed with the dose were Vdl (0.61 +/- 0.08 1.kg-1 for the low dose and 0.59 +/- 0.10 1.kg-1 for the high dose); ABC0-90 (310 +/- 18 mg.ml-1 min-1 for the low dose and 942 +/- 107 Mg.ml-1 min for the high dose; Kd (0.026 +/- 0.005 min-1 for the low dose and 0.037 +/- 0.010 min-1 for the high dose). The importance of the values of the slopes alpha, rho & gamma found by residual methods are discussed and compared with the results reported by other authors working with other species and different times.</p>","PeriodicalId":75554,"journal":{"name":"Archivos de investigacion medica","volume":"21 3","pages":"263-7"},"PeriodicalIF":0.0,"publicationDate":"1990-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13285839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Determination of cytoplasmic glycogen in 4 strains of amoeba of the genus Entamoeba]. [4株内阿米巴属阿米巴原虫细胞质糖原的测定]。
Archivos de investigacion medica Pub Date : 1990-07-01
J J Segura, C Calzado-Flores, J Martínez-Moncivais
{"title":"[Determination of cytoplasmic glycogen in 4 strains of amoeba of the genus Entamoeba].","authors":"J J Segura,&nbsp;C Calzado-Flores,&nbsp;J Martínez-Moncivais","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The purpose of this work was made to determine the cytoplasmic glycogen concentration in trophozoites from four different strains of Entamoeba genus. We used IP-1 and PZ from E. invadens; HM-2 and HK-9 from E. histolytica strains, axenically cultured in TP-S-1 medium. The growth of different strains was determined each 24 hours during 10-days, with the aid of a hemocytometer. The quantification of cytoplasmic glycogen was made by two methods: 1) Montgomery and 2) Krisman. The glycogen concentrations were measured in the four strains during their growing. The results did not show any difference, remained as a constant concentration in each strain. These concentrations quantified by Montgomery method were similar in all strains (35 pg/cell), except in HM-2 strain which showed a less concentration of this polysaccharide (28 pg/cell) than the other strain. These results were different when Krisman method was used, both IP-1 and PZ strains had a similar glycogen concentrations about 19 pg/cell, however HM-2 and HK-9 strains had a higher glycogen concentration (21 pg/cell) than E. invadens strains.</p>","PeriodicalId":75554,"journal":{"name":"Archivos de investigacion medica","volume":"21 3","pages":"241-5"},"PeriodicalIF":0.0,"publicationDate":"1990-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13285992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
N,N-dimethyltryptamine alkaloid in Mimosa tenuiflora bark (tepescohuite). 含羞草树皮中的N,N-二甲基色胺生物碱。
Archivos de investigacion medica Pub Date : 1990-04-01
M Meckes-Lozoya, X Lozoya, R J Marles, C Soucy-Breau, A Sen, J T Arnason
{"title":"N,N-dimethyltryptamine alkaloid in Mimosa tenuiflora bark (tepescohuite).","authors":"M Meckes-Lozoya,&nbsp;X Lozoya,&nbsp;R J Marles,&nbsp;C Soucy-Breau,&nbsp;A Sen,&nbsp;J T Arnason","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75554,"journal":{"name":"Archivos de investigacion medica","volume":"21 2","pages":"175-7"},"PeriodicalIF":0.0,"publicationDate":"1990-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13258701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bone mineral content, 25-hydroxycalciferol and zinc serum levels in insulin-dependent (type I) diabetic patients. 胰岛素依赖型(I型)糖尿病患者骨矿物质含量、25-羟基钙化醇和血清锌水平
Archivos de investigacion medica Pub Date : 1990-04-01
F Arreola, R Paniagua, S Díaz-Bensussen, B Urquieta, E López-Montaño, G Partida-Hernández, S Villalpando
{"title":"Bone mineral content, 25-hydroxycalciferol and zinc serum levels in insulin-dependent (type I) diabetic patients.","authors":"F Arreola,&nbsp;R Paniagua,&nbsp;S Díaz-Bensussen,&nbsp;B Urquieta,&nbsp;E López-Montaño,&nbsp;G Partida-Hernández,&nbsp;S Villalpando","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>To determine the relationship between bone mineral content (BMC), 25-Hydroxycalciferol (25OHD) and zinc serum levels in young insulin-dependent diabetics, we performed photon absorptiometry on a poorly controlled group of 22 patients. Zinc, 25OHD and alkaline phosphatase were measured in fasting serum. Ca, P, Mg, glucose and cAMP were determined in serum and in 24 hours urine collection. The diabetic group showed a significant decrease in BMC (less than 0.001) with raised urinary excretion rate of calcium (p less than 0.001). On the other hand, serum levels of zinc and 25OHD showed a significant decrease (p less than 0.001, both). We found a positive and significant correlation between glycosuria and urinary excretion rate of calcium (r = 0.77; p less than 0.001) and negative one for 25OHD and urinary excretion rate of calcium (r = -0.77; p less than 0.001). We conclude that decreased zinc and 25OHD serum levels in poorly controlled insulin-dependent (Type I) diabetic patients, in addition to raised urinary excretion rate of calcium, as result of the osmotic diuresis, contribute to bone loss in these patients.</p>","PeriodicalId":75554,"journal":{"name":"Archivos de investigacion medica","volume":"21 2","pages":"195-9"},"PeriodicalIF":0.0,"publicationDate":"1990-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13258704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Effect of position with respect to gravitational force on the hydrodynamics of an experimental model of saccular aneurysm]. [位置相对于重力对囊性动脉瘤实验模型流体动力学的影响]。
Archivos de investigacion medica Pub Date : 1990-04-01
I Madrazo, A Noyola, C Piña, A Graef, M Olhagaray, S Gutiérrez, E Ordóñez
{"title":"[Effect of position with respect to gravitational force on the hydrodynamics of an experimental model of saccular aneurysm].","authors":"I Madrazo,&nbsp;A Noyola,&nbsp;C Piña,&nbsp;A Graef,&nbsp;M Olhagaray,&nbsp;S Gutiérrez,&nbsp;E Ordóñez","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We wish to confirm the hypothesis that the hydrodynamics of brain aneurysms depend partially on their position, with respect to the force of gravitation, and so developed an experimental model of latex aneurysms, which was subjected to a pulsatile flow. Four different registers were made with an injection of ink and radioisotopes. A physical model was designed which allowed a quantitative analysis of the results and which allows a mathematical analysis of the aneurysm's hydrodynamics. The results suggest that when an aneurysm is oriented against the force of gravity, it has a very low risk of thrombosis, and the scarce turbulence of the flow condition a lower risk of growth and rupture, in comparison with other conditions. The greatest flow turbulence against the wall is found in the aneurysm oriented downwards, that is parallel to the force of gravity. Due to its hydrodynamics, the downwards aneurysm has the highest probability of complication, since it has; a) higher risk of rupture due to the impact of the stream upon the wall and to the turbulence this impact produces, b) a higher risk of thrombosis produced by the circulatory stasis which has a dome. This combination of factors (rupture and thrombosis) allows these aneurysms to grow more than others.</p>","PeriodicalId":75554,"journal":{"name":"Archivos de investigacion medica","volume":"21 2","pages":"103-13"},"PeriodicalIF":0.0,"publicationDate":"1990-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13258722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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