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Archives d'anatomie et de cytologie pathologiques最新文献

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[Anaplastic carcinoma of the thyroid]. [甲状腺间变性癌]。
Archives d'anatomie et de cytologie pathologiques Pub Date : 1998-01-01
C Brocheriou
{"title":"[Anaplastic carcinoma of the thyroid].","authors":"C Brocheriou","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Anaplastic carcinoma of the thyroid, also called undifferentiated carcinoma, is a rare variety of thyroid carcinoma observed in elderly subjects, usually female. This tumour presents in the form of a cervical mass and is rapidly fatal, usually within several months. Histologically, anaplastic carcinoma consists of a proliferation of spindle and/or giant cells, more rarely squamous cells, rich in cytonuclear abnormalities and mitotic figures with areas of necrosis. Immunohistochemistry confirms the epithelial nature of the proliferation, as tumour cells are generally labelled by low molecular weight cytokeratins; cytokeratin-vimentin coexpression is not rare. Anaplastic carcinoma can occur de novo or secondary to a pre-existing thyroid lesion, particularly well differentiated papillary or follicular carcinoma; in this latter case, study of p53 can be useful to detect the appearance of anaplastic transformation.</p>","PeriodicalId":75531,"journal":{"name":"Archives d'anatomie et de cytologie pathologiques","volume":"46 1-2","pages":"87-93"},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20667379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Value of a computer-assisted screening method (PAPNET) for the detection of infectious cervico-uterine smears]. [计算机辅助筛查方法(PAPNET)在检测感染性宫颈子宫涂片中的价值]。
Archives d'anatomie et de cytologie pathologiques Pub Date : 1998-01-01
M Bernier, A M Bergemer, C Got, C Marsan
{"title":"[Value of a computer-assisted screening method (PAPNET) for the detection of infectious cervico-uterine smears].","authors":"M Bernier,&nbsp;A M Bergemer,&nbsp;C Got,&nbsp;C Marsan","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>There have been several reports regarding the accuracy of the PAPNET system applied to the screening for cancerous and precancerous lesions. Based on neuronal networks, this computerized tool was initially trained to select atypical cells. It has been approved in the USA for the re-screening of cervical smears for quality assurance. However, its particular behaviour has not been frequently studied when the system is designed to detect frequent infectious organisms. We report the results of re-screening of 42 inflammatory cervico-uterine smears by the PAPNET system. The computerized images were reviewed by two different pathologists, with complete agreement between the two observers in 39 cases. Infectious organisms were detected in only 66% of cases. Trichomonas, mycoses and Gardnerella were diagnosed in 63%, 56% and 87% of cases respectively. No herpetic lesions were identified. The low accuracy of the PAPNET system in the diagnosis of infectious cervico-uterine smears should be taken into account if this system is developed as an exclusive pre-screening method.</p>","PeriodicalId":75531,"journal":{"name":"Archives d'anatomie et de cytologie pathologiques","volume":"46 3","pages":"184-7"},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20667772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Lymphoepithelial tumor of the skin]. [皮肤淋巴上皮肿瘤]。
Archives d'anatomie et de cytologie pathologiques Pub Date : 1998-01-01
J P Dufau, M E Moll, G Lanternier, R Le Vagueresse
{"title":"[Lymphoepithelial tumor of the skin].","authors":"J P Dufau,&nbsp;M E Moll,&nbsp;G Lanternier,&nbsp;R Le Vagueresse","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The authors report an additional case of lympho-epithelial tumor. First described in 1987 by Santa-Cruz et al., this tumor, also called cutaneous lymphadenoma, is rare. The mean age is 44. The lesion is generally located on the face and the clinical diagnosis of basal cell carcinoma is most often evoked. The tumor has a peculiar histological feature with cyst-like cavities composed by an epithelial proliferation and intraepithelial lympho-histiocytic cells. It is considered as a benign tumor. Its origin is still discussed but a pilosebaceous nature seems to be accepted.</p>","PeriodicalId":75531,"journal":{"name":"Archives d'anatomie et de cytologie pathologiques","volume":"46 3","pages":"199-203"},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20667774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Hamartomatous adiposity of the thyroid]. [甲状腺错构瘤性肥胖]。
Archives d'anatomie et de cytologie pathologiques Pub Date : 1998-01-01
J P Terrier, A Bizeau, P Calvet, M Civatte, E Carloz, C Pierre
{"title":"[Hamartomatous adiposity of the thyroid].","authors":"J P Terrier,&nbsp;A Bizeau,&nbsp;P Calvet,&nbsp;M Civatte,&nbsp;E Carloz,&nbsp;C Pierre","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Report of one case of hamartomatous adiposity of the thyroid gland. Only eight cases have been reported. The lesion is composed of thyroid tissue and mature adipose elements. Previously reported cases are reviewed and the pathogenesis is discussed.</p>","PeriodicalId":75531,"journal":{"name":"Archives d'anatomie et de cytologie pathologiques","volume":"46 1-2","pages":"145-8"},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20667918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
XXII International Congress of the International Academy of Pathology and 13th World Congress of Academic and Environmental Pathology. Nice, France, October 18-23, 1998. Abstracts. 第22届国际病理学会国际大会和第13届世界学术与环境病理学大会。尼斯，法国，1998年10月18-23日。摘要。
Archives d'anatomie et de cytologie pathologiques Pub Date : 1998-01-01
{"title":"XXII International Congress of the International Academy of Pathology and 13th World Congress of Academic and Environmental Pathology. Nice, France, October 18-23, 1998. Abstracts.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75531,"journal":{"name":"Archives d'anatomie et de cytologie pathologiques","volume":"46 5-6","pages":"270-647"},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20820036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The RET gene in thyroid pathology]. [RET基因在甲状腺病理中的作用]。
Archives d'anatomie et de cytologie pathologiques Pub Date : 1998-01-01
F M Michiels, M Billaud
{"title":"[The RET gene in thyroid pathology].","authors":"F M Michiels,&nbsp;M Billaud","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The RET proto-oncogene encodes a receptor tyrosine kinase which plays a crucial role during the embryonic development of the enteric nervous system and of the kidney. Cytogenetic analyses of papillary thyroid carcinoma (PTC), a neoplasm which originates from thyrocytes, have revealed that somatic rearrangements of the RET gene are involved in the etiology of a significant proportion of this tumour. Medullary thyroid carcinoma (MTC) which arises from neural-crest derived C-cells is the cardinal disease feature of multiple endocrine neoplasia type 2 (MEN 2), a dominantly inherited cancer syndrome. Recent studies have provided evidence that germline mutations of the RET gene are the underlying genetic events responsible for MEN 2. This review focuses on the role of RET mutations in the pathogenesis of PTC and MTC and summarizes our present knowledge on the consequences of these alterations on the RET tyrosine kinase function. We further describe a transgenic mouse model for hereditary MTC. Mice carrying a MEN 2A allele of RET under the control of the CGRP/calcitonin promoter develop bilateral and multifocal MTC, morphologically and biologically similar to human MTC.</p>","PeriodicalId":75531,"journal":{"name":"Archives d'anatomie et de cytologie pathologiques","volume":"46 1-2","pages":"19-30"},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20667373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Follicular carcinoma]. (滤泡细胞癌)。
Archives d'anatomie et de cytologie pathologiques Pub Date : 1998-01-01
B Caillou
{"title":"[Follicular carcinoma].","authors":"B Caillou","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Thyroid follicular carcinoma are divided in three subgroups: 1) minimally invasive well differentiated encapsulated follicular carcinoma; 2) invasive well differentiated follicular carcinoma; 3) moderately differentiated follicular carcinoma. Usually diagnosis between encapsulated well differentiated follicular carcinoma and atypical adenoma is difficult. Apart the presence of metastases, histologic criteria to separate these entities are often insufficient. Insofar as all these tumours have a very good prognosis, we think that they could be brought together under the same terminology. Actual morphological differences would be expressed, like in some others localizations, in a histologic grading. This way of classifying appears more consistent with reality and could allow to assume in better conditions, diagnostic uncertainty which exists in this field.</p>","PeriodicalId":75531,"journal":{"name":"Archives d'anatomie et de cytologie pathologiques","volume":"46 1-2","pages":"39-44"},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20667375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Fine-needle biopsy and core biopsy in nonpalpable breast lesions. How does one judge with mammography?]. 细针活检和核心活检在不可触及的乳腺病变。如何用乳房x光检查来判断呢?
Archives d'anatomie et de cytologie pathologiques Pub Date : 1998-01-01
A Tardivon, A Corvellec-Rudelli, V Bazile, J M Guinebretière
{"title":"[Fine-needle biopsy and core biopsy in nonpalpable breast lesions. How does one judge with mammography?].","authors":"A Tardivon,&nbsp;A Corvellec-Rudelli,&nbsp;V Bazile,&nbsp;J M Guinebretière","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Techniques for localizing and sampling subclinical lesions seen on mammograms are reviewed. Localization of the lesion, the equipment used (fine-needle aspiration or core biopsy), and harvesting techniques are discussed, with special emphasis on quality criteria that should be satisfied to ensure optimal histologic performance.</p>","PeriodicalId":75531,"journal":{"name":"Archives d'anatomie et de cytologie pathologiques","volume":"46 4","pages":"227-32"},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20667742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Pulmonary lymphangioleiomyomatosis. Immunohistochemical and ultrastructural study of two cases]. (肺lymphangioleiomyomatosis。2例免疫组织化学及超微结构研究。
Archives d'anatomie et de cytologie pathologiques Pub Date : 1998-01-01
V Battaglione, M Piche, J Jourdan, J Mouroux, J F Michiels, C Isetta, P Hofman
{"title":"[Pulmonary lymphangioleiomyomatosis. Immunohistochemical and ultrastructural study of two cases].","authors":"V Battaglione,&nbsp;M Piche,&nbsp;J Jourdan,&nbsp;J Mouroux,&nbsp;J F Michiels,&nbsp;C Isetta,&nbsp;P Hofman","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The authors report two cases of pulmonary lymphangioleiomyomatosis which were diagnosed by surgical biopsies. Immunohistochemical study showed positive staining of the smooth muscle cells using antibodies directed against smooth muscle actin, specific muscle actin, HMB45 and vimentin. Ultrastructural study showed some smooth muscle differentiation features, with numerous myofilaments and some dense bodies near the plasma membrane. In one case, the patient was treated by a double-lung transplantation. LAM is a non-familial disease occurring exclusively in females. The etiology is unknown. This disease can be complicated by chronic respiratory failure. Extrapulmonary sites are not rare, particularly in the uterus. Anti-estrogen treatment can slow the course of the disease. Lung transplantation is actually the only effective treatment at the present time therapy. The differential diagnosis of this disease is discussed.</p>","PeriodicalId":75531,"journal":{"name":"Archives d'anatomie et de cytologie pathologiques","volume":"46 3","pages":"178-83"},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20667770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Transgenic mouse models. Their interest in thyroid tumors]. [转基因小鼠模型。他们对甲状腺肿瘤的兴趣]。
Archives d'anatomie et de cytologie pathologiques Pub Date : 1998-01-01
C Ledent, B Franc, M Parmentier
{"title":"[Transgenic mouse models. Their interest in thyroid tumors].","authors":"C Ledent,&nbsp;B Franc,&nbsp;M Parmentier","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Mouse transgenic models that develop thyroid diseases were generated. All transgenes were driven by the thyroid specific promoter of the thyroglobulin gene. The tissue specificity of the promoter was investigated by using the bacterial chloramphenicol acetyltransferase gene as reporter. The expression of the adenosine A2a receptor resulted in the permanent activation of the cAMP cascade. As a consequence, transgenic mice developed severe hyperthyroidism and a large goiter, demonstrating in vivo the role of the cAMP cascade in the promotion of both function and proliferation of the thyroid cell. These mice constitute a model for autonomous hyperfunctional adenoma and non autoimmune familial hyperthyroidism, where mutant of thyrotropin receptors stimulate the cAMP cascade constitutively. The expression of a mutant of the alpha 1B adrenergic receptor resulted in the constitutive activation of both the cAMP and IP3-CA++ cascades, growth stimulation, hyperfunction, cell degeneracy attributed to the overproduction of free radicals, and development of malignancies. The expression of the SV40 large T antigen promoted the development of aggressive undifferentiated tumors mimicking the phenotype of human anaplastic carcinomas and embryonal tumors. In another transgenic model, the function of the retinoblastoma susceptibility gene product RB1 (and of related proteins) was inhibited by expressing the E7 oncoprotein of human papillomavirus type 16. The result was the development of a differentiated and normofunctional colloid goiter, with progressive development of differentiated malignant lesions. This model suggests the essential role of RB1 and related proteins in the negative control of proliferation that characterizes thyroid cells in the adult. Other transgenic models of thyroid diseases are discussed.</p>","PeriodicalId":75531,"journal":{"name":"Archives d'anatomie et de cytologie pathologiques","volume":"46 1-2","pages":"31-7"},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20667374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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