Archives d'anatomie et de cytologie pathologiques最新文献

{"title":"[Contribution of animal models in the understanding of AIDS encephalopathy].","authors":"D Boche,&nbsp;F Gray,&nbsp;E Khatissian,&nbsp;M Hurtrel,&nbsp;L Montagnier,&nbsp;B Hurtrel","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The neuropathology associated with HIV (Human Immunodeficiency Virus) infection is one of the major complications of this disease. The virological and cellular mechanisms by which HIV infection induces motor and cognitive disorders remain unknown. This lack of understanding of the pathophysiology is partly due to the difficulty of experimental analysis in man because only post-mortem samples from terminal phases of the disease and cerebrospinal fluid samples are available. Two animal models, very closely resembling human HIV infection, are available: the cat model infected by FIV (Feline Immunodeficiency Virus) and the macaque model infected by the SIVmac (Simian Immunodeficiency Virus) which have enabled us to conduct a longitudinal study of encephalopathy during primo-infection and the asymptomatic and pre-AIDS (Acquired Immune Deficiency Syndrome) phases. In the cat-FIV model, which presents the advantage of being non-infectious to man, and therefore easier to manipulate, it was shown that infected cats develop behavioural abnormalities and a neuropathology which resemble HIV dementia. Central nervous system lesions induced by FIV are similar to those of HIV infection apart from the absence of multinucleated giant cells. This model was used to analyse the relationship between CNS lesions and the viral load of the brain and showed that the severity of the lesions contrasted with a low viral load. The pathophysiology of SIVmac infection in the rhesus macaque is almost identical to human infection with a more rapid course, since the duration of the asymptomatic phase is 6 months to 5 years, depending on the animal. We studied the relationship between lesions, viral load and cytokine production (IL-1 beta, IL-2, IL-6, TNF alpha, INF gamma, TGF-beta 1) within the CNS. Our results show early, low-grade and constant infection of the brain. The dissociation between the viral load and the lesions observed is our favour of an indirect mechanism for the pathogenesis of these lesions. The relationship between lesions and the cytokine profile studied shows the importance of glial cells in the pathogenesis of the lesions.</p>","PeriodicalId":75531,"journal":{"name":"Archives d'anatomie et de cytologie pathologiques","volume":"45 2-3","pages":"75-85"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20311547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Granular cell tumor of the breast with lymph node neuro-naevic cell inclusions: a double pitfall to avoid].","authors":"A Serrano,&nbsp;A Kanoï,&nbsp;G Tricot,&nbsp;G Contesso","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Aims: </strong>To draw attention to the possibility of simultaneous occurrence of pitfalls in breast pathology.</p><p><strong>Material and methods: </strong>Presentation of a curious case with an association of granular cell tumour of the breast and neuro-naevic inclusions in axillary lymph nodes, first interpreted as metastatic mammary carcinoma.</p><p><strong>Discussion: </strong>Non malignant inclusions in axillary lymph nodes, rare but not unusual, may be erroneously interpreted as metastasis of carcinoma, establishing a wrong diagnosis of malignity in the breast. It is important to recognize this type of lesion and the possibility of their coexistence to correct the diagnosis. An approach to the histogenesis of this lesion is presented.</p>","PeriodicalId":75531,"journal":{"name":"Archives d'anatomie et de cytologie pathologiques","volume":"44 5-6","pages":"254-8"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20270483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Lymph node eosinophilic granuloma. Apropos of 2 cases of Langerhans-cell histiocytosis with isolated lymph node involvement].","authors":"M Robert,&nbsp;C Marty-Double","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The authors report two cases of isolated lymph node involvement by Langerhans' cell histiocytosis which affected two young children. The histologic aspect reveals that lymph nodes have been modified by a proliferation of large histiocyte-like cells, associated with eosinophils. An immunohistochemical study on paraffin sections and for one case on frozen sections, reveals the usual phenotype of Langerhans' cells: these cells stain positively with S 100 protein and CD1 and are negative for both lysozyme and al antichymotrypsine. After a period of two years for one child and four years for the other, these children are in total remission, one spontaneously, the other after chemotherapy.</p>","PeriodicalId":75531,"journal":{"name":"Archives d'anatomie et de cytologie pathologiques","volume":"44 5-6","pages":"237-40"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20270596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cutaneous metastases from gastric adenocarcinoma. Report of two cases and review of the literature.","authors":"A Boscaino,&nbsp;P Orabona,&nbsp;A D'Antonio,&nbsp;S Staibano,&nbsp;G De Rosa","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The skin is rarely involved by metastatic tumors. Breast and pulmonary carcinoma are the most frequent primary lesions that may spread to the skin. Head and neck, chest and abdominal wall are the commonest sites of cutaneous metastases. The authors report two cases of cutaneous metastases from gastric adenocarcinoma, one of which is particularly interesting as it developed on the extremities, a very rare site for skin metastasis. The authors also stress the differential diagnosis with primary cutaneous adenocarcinomas.</p>","PeriodicalId":75531,"journal":{"name":"Archives d'anatomie et de cytologie pathologiques","volume":"44 1","pages":"60-4"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19735159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of factor XIIIa in the mesenchymatogenesis of the human placenta: an immunohistochemical analysis.","authors":"E Agapitos,&nbsp;N Kavantzas,&nbsp;P Paizi-Biza,&nbsp;H Bohn,&nbsp;K Christodoulou,&nbsp;P Davaris","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Human placentas from normal pregnancies [9], interrupted pregnancies due to congenital anomalies of the fetuses [7] and legal abortions [9] were examined immunohistochemically using monoclonal antiserum for factor XIIIa. Hofbauer cells of the chorionic villi were strongly positive for factor XIIIa. Deeper staining in early pregnancy reflects the greater numbers of Hofbauer cells in this period of gestation. Our findings support the hypothesis that the presence of factor XIIIa in the Hofbauer cells promotes the maturation of the chorionic villi.</p>","PeriodicalId":75531,"journal":{"name":"Archives d'anatomie et de cytologie pathologiques","volume":"44 2-3","pages":"83-6"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19765311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Cryoglobulinemia].","authors":"J P Duong,&nbsp;D Nochy","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Cryoglobulinaemias contain seric immunoglobulins which precipitate at low temperatures in some tissues. Based on immunohistochemical analysis of their components (monoclonal or polyclonal), 3 types of cryoglobulinaemias have been identified, and a classification has been proposed. The presence of a paraprotein within the cryoglobulinaemia is due to the proliferation of B cells. Type I is mainly associated with a lymphoproliferative syndrome (myeloma and others...) whereas type II (mixed cryoglobulinaemia) and type III are the result of viral and bacterial infectious diseases, and of autoimmune diseases. Over the last few years, infection by hepatitis C has been found in more than 90% of types II and III cryoglobulinaemias. Cryoprecipitates are pathogenic for kidneys, skin and nervous tissues. In some organs, they are responsible for specific histological lesions, such as necrotizing angeitis with vascular microthrombosis. In kidneys, they occur as endocapillary proliferative glomerulonephrites, accompanied by precipitation of immunoglobulins in the form of intracapillary thrombi. Precipitated immunoglobulins can be identified on frozen specimens. Ultrastructural studies confirm the fibrillar aspect which is characteristic of the cryoprecipitate.</p>","PeriodicalId":75531,"journal":{"name":"Archives d'anatomie et de cytologie pathologiques","volume":"44 2-3","pages":"106-8"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19765253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Diagnostic problems in prostatic pathology: microglandular lesions and intraductal epithelial proliferations].","authors":"N Berger,&nbsp;A Borda","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In this review, the authors discuss the minimal criteria that allow for the distinction of prostatic adenocarcinoma with special emphasis on nuclear and nucleolar aspects and basal cell layer identification by routine and K 903 immunoperoxidase technique. Differential diagnosis are reviewed including microglandular lesions (adenosis, sclerosing adenosis, atrophy) and intraglandular proliferations (basal cell hyperplasia, clear cell cribriform hyperplasia, intraductal dysplasia). The role of dysplasia as a premalignant lesion is also discussed.</p>","PeriodicalId":75531,"journal":{"name":"Archives d'anatomie et de cytologie pathologiques","volume":"44 4","pages":"141-59"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20103970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Glomus tumors. Clinical, histological and immunohistochemical study. Apropos of 29 cases].","authors":"S Arkwright,&nbsp;M Bachar,&nbsp;F Vilde","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This retrospective pathological study, based on twenty-nine glomus tumors, was conducted in order to define the histological or immunohistochemical diagnostic criteria in cases with atypical morphology. The immunohistochemical phenotype of glomus tumors was defined by means of identification of glomus cells, vessels and associated nerve fibres.</p>","PeriodicalId":75531,"journal":{"name":"Archives d'anatomie et de cytologie pathologiques","volume":"44 4","pages":"160-5"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20103971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Neuropathology in France (19th-20th centuries). Semantic and institutional misadventures].","authors":"N Corvisier-Visy,&nbsp;J Poirier","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>At the end of the 19th century (1880-1905), at a time when neuropathology (a science and a word which had just been created by Charcot) was triumphant, recognized, admired, neurology became institutionalized in its place, for the anatomical, physiological and clinical study of diseases of the nervous system. Gradually, emptied of its content, in favour of neurology, neuropathology then entered a period of semantic and institutional uncertainly which only ended with its second \"true-false\" institutionalization, starting in the 1950s, at the cost of its reduction to pathologic anatomy of the nervous system.</p>","PeriodicalId":75531,"journal":{"name":"Archives d'anatomie et de cytologie pathologiques","volume":"44 1","pages":"18-27"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19735900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Malignant rhabdoid tumor of the kidney. A poorly differentiated type with difficult diagnosis].","authors":"M Fabre,&nbsp;M J Terrier-Lacombe","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Rhabdoid tumour of the kidney is a rare, distinct clinico-pathological entity, mostly occurring in children, with an extremely aggressive behaviour. There is a wide range of histologic patterns. We report a case in which the classical \"rhabdoid\" cytology with eosinophilic cytoplasmic inclusions and macronucleoli was scanty and abundant cytoplasm was absent. Immunocytochemical and ultrastructural studies were essential. This poorly differentiated type of rhabdoid tumour must not be confused with Wilms' tumour because it requires an intensive chemotherapy regimen.</p>","PeriodicalId":75531,"journal":{"name":"Archives d'anatomie et de cytologie pathologiques","volume":"44 1","pages":"49-52"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19735906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}