Aktuelle Gerontologie最新文献_第4页

[Histology of the pineal gland in the elderly human]. [老年人松果体组织学研究]。

Aktuelle Gerontologie Pub Date : 1983-05-01

W Gusek

{"title":"[Histology of the pineal gland in the elderly human].","authors":"W Gusek","doi":"","DOIUrl":"","url":null,"abstract":"2700 Non-selected pineal bodies from autopsied infants and subjects up to the 9th decade were weighted and studied histologically. The results show, that post-pubertal atrophy does not occur. Histologically, no sex-specific difference exists. Variations in weight are present only. In the first decade the mean weight is 80-100 mg, rising steadily to reach a maximum of 150-160 mg in the fifth decade. Later on the pineal, on an average, is larger and heavier in women. Pineal weight relationship to the hypophysis and the brain remains constant throughout adult life. In advanced age a general increase in the amount of supporting tissue is observed corresponding to structural fibrosis also occurring in other organs. This shows no age-dependent distribution pattern, does not occur at the expense of the parenchymal cells and is not related to calcification or weight. Calcifications, fibroses glioses and cysts are already found in neonates, statistically only being more frequently present in the higher age groups. A true, general, selective senile atrophy of the pineal does not occur, even in relation to the weight of the brain in the same decade. The quantitative and qualitative analysis of the elements, based on radiofluorescence and radiorefraction, will be discussed in detail. The causes of the recently reported depression of reagibility are still in discussion.","PeriodicalId":75459,"journal":{"name":"Aktuelle Gerontologie","volume":"13 3","pages":"111-4"},"PeriodicalIF":0.0,"publicationDate":"1983-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17201331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Need for therapy and target groups for therapy in nursing homes]. [疗养院治疗需求和治疗目标群体]。

Aktuelle Gerontologie Pub Date : 1983-05-01

H P Tews

引用次数: 0

[Calcification of the arterial wall in the aging process. Electron microscopic and biochemical studies of a model of vitamin D3 overdose]. 衰老过程中动脉壁的钙化。维生素D3过量模型的电镜和生化研究]。

Aktuelle Gerontologie Pub Date : 1983-05-01

V Seydewitz, J Staubesand

引用次数: 0

Nuclear-envelope nucleoside triphosphatase: stimulation by poly(A) (+)mRNA and modulation by microtubule protein. 核膜核苷三磷酸酶:聚(A) (+)mRNA的刺激和微管蛋白的调节。

Aktuelle Gerontologie Pub Date : 1983-05-01

A Bernd, H C Schröder, R K Zahn, W E Müller

{"title":"Nuclear-envelope nucleoside triphosphatase: stimulation by poly(A) (+)mRNA and modulation by microtubule protein.","authors":"A Bernd, H C Schröder, R K Zahn, W E Müller","doi":"","DOIUrl":"","url":null,"abstract":"Nuclear envelopes contain a nucleoside triphosphatase which is thought to be involved in the supply of energy for nucleo-cytoplasmic RNA transport. This enzyme is stimulated most efficiently by poly(A) and to a lesser extent by poly(G) and poly(dT). Half-maximal stimulation of the enzyme from rat liver nuclei, which was associated with the poly(A)-specific Endoribonuclease IV and was free from poly(A) polymerase and Endoribonuclease V activity, was determined to occur at a concentration of 1.1 X 10(6) poly(A) molecules/nuclear ghost. Double-reciprocal plot analysis revealed a 2.8-fold stimulation of the enzyme by poly(A). Poly(A) in the hybrid form had no influence on the activity of the nucleoside triphosphatase. Stimulation by oligo(A) required a minimal chain length of 18 nucleotide units. Naturally occurring RNA species enhanced the nucleoside triphosphatase activity, provided they contained a poly(A) segment. Using poly(A)(+)mRNA, half-maximal stimulation was determined to proceed at 0.5 X 10(6) molecules/nuclear ghost. Removal of the poly(A) segment from mRNA mRNA abolished the stimulatory effect on the enzyme. Microtubule protein was found to inhibit the nucleoside triphosphatase efficiently. At a concentration of 2.0 mg/ml, polymerized microtubule protein reduced the enzyme activity by 96%. Dimeric tubulin was less inhibitory, while actin was without any significant effect. From these findings it is suggested that a possible nucleoside triphosphatase-mediated transport of poly(A)(+) mRNA through nuclear envelope is controlled firstly, by the poly(A) segment of this RNA species and secondly, by cytoplasmic microtubules.","PeriodicalId":75459,"journal":{"name":"Aktuelle Gerontologie","volume":"13 3","pages":"119-21"},"PeriodicalIF":0.0,"publicationDate":"1983-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17201228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Ginkgolip, a new geriatric drug. Results of a double-blind study]. 银杏，一种新的老年药物。一项双盲研究的结果]。

Aktuelle Gerontologie Pub Date : 1983-05-01

H Schenker

引用次数: 0

[Phagocytosis activity of the isolated perfused rat liver]. [离体灌注大鼠肝脏的吞噬活性]。

Aktuelle Gerontologie Pub Date : 1983-05-01

T Vömel, D Platt

引用次数: 0

[Therapeutic principles of bronchopulmonary infections in the aged]. 老年人支气管肺感染的治疗原则。

Aktuelle Gerontologie Pub Date : 1983-05-01

F Kummer

{"title":"[Therapeutic principles of bronchopulmonary infections in the aged].","authors":"F Kummer","doi":"","DOIUrl":"","url":null,"abstract":"Airways and lungs are equipped with a highly effective defense mechanism. These can bei found damaged in the aged: Cough is weaker, mucociliary clearance and mucous production are irregular. This damage can bei caused and increased by smoking, recurrent infection, and some sorts of air pollution (SO2). We call it a primary infection, when the organ has been intact as well as the general condition (immune defense etc), and where the causative agent is a virus or virus-like organism. A secondary infection is conditioned by previous disease, and when the causative agents are bacilli. Finally, a tertiary infection is dependent on a defense failure of the body and on opportunistic organisms. For elderly patients, secondary infections outweight the others (recurrent purulent bronchitits). However, tertiary infections must also bei considered in bedridden or post-operative patients or in those with metabolic disease. Finally, pneumonia in the aged must be differentiated in terms of underlying carcinoma, infarction, aspiration and tuberculosis. Therapy of primary (viral)infection consists mainly in prophylaxis of bacterial secondary infection. The choice of drug, dosage and duration of treatment depends on the degree of previous damage to the organ, of complications and status of the whole body and it's defense mechanisms.","PeriodicalId":75459,"journal":{"name":"Aktuelle Gerontologie","volume":"13 3","pages":"87-9"},"PeriodicalIF":0.0,"publicationDate":"1983-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17201230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Internal medicine aspects in patients with operable carotid lesions]. [颈动脉可手术病变患者的内科方面]。

Aktuelle Gerontologie Pub Date : 1983-05-01

V Enzenhofer, H P Ammerer, H Brenner, J Slany

{"title":"[Internal medicine aspects in patients with operable carotid lesions].","authors":"V Enzenhofer, H P Ammerer, H Brenner, J Slany","doi":"","DOIUrl":"","url":null,"abstract":"Cerebral insufficiency with or without neurological deficits (n.d.) may be treated effectively surgically by carotid artery reconstruction or by extra-intracranial anastomoses. The low mortality of these operations and the favourable results including prevention of new n.d. and amelioration of long standing n.d. suggest consideration of operation in geriatric patients. Noninvasive screening methods for cranial artery pathology such as neck auscultation, direct and indirect Doppler ultrasonic investigations and dynamic and static cerebral scan therefore should be performed not only in all patients with overt cerebrovascular insufficiency whatever degree but also in patients with hypertension, diabetes mellitus, ischemic heart disease and occlusive disease of the extremities on account of the high incidence of multivascular disease in these patients. We compared 60 consecutive patients before and beyond the age of 70 respectively, treated surgically for cerebrovascular insufficiency. The only significant differences apart from age were a higher rate of pathologic findings of the heart on x-ray and on the ecg in the aged. Despite this mortality, major complications and favourable results were not different for both age groups. These results favour an active approach to diagnosis and indication to surgical treatment not only in young patients but also in the symptomatic geriatric patient.","PeriodicalId":75459,"journal":{"name":"Aktuelle Gerontologie","volume":"13 3","pages":"90-1"},"PeriodicalIF":0.0,"publicationDate":"1983-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17201231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Drug compliance of pregeriatric rehabilitation patients. Brief communication on a longitudinal investigation. 老年康复患者药物依从性分析。关于纵向调查的简短通讯。

Aktuelle Gerontologie Pub Date : 1983-05-01

B Fischer, S Lehrl, U Fischer, E Weber

引用次数: 0

[Emergencies in geriatrics]. [老年急症]。

Aktuelle Gerontologie Pub Date : 1983-03-01

R M Schütz

引用次数: 0