Acta vitaminologica et enzymologica最新文献_第3页

Role of oxygen in myocardial ischaemic and reperfusion damage: effect of alpha-tocopherol. 氧在心肌缺血和再灌注损伤中的作用:α -生育酚的作用。

Acta vitaminologica et enzymologica Pub Date : 1985-01-01

R Ferrari, C Ceconi, S Curello, A Cargnoni, E Condorelli, R Raddino

{"title":"Role of oxygen in myocardial ischaemic and reperfusion damage: effect of alpha-tocopherol.","authors":"R Ferrari, C Ceconi, S Curello, A Cargnoni, E Condorelli, R Raddino","doi":"","DOIUrl":"","url":null,"abstract":"There is evidence that oxygen-derived free radicals may play a role in myocardial ischaemic and reperfusion injury. Major sources of O2 free radicals formation during ischaemia and reperfusion are: the enzyme xanthine oxidase, activated neutrophils and the myocardial mitochondria. However, in the heart there are defense mechanisms against the toxic oxygen metabolites. They include the enzyme superoxide dismutase, catalase and glutathione peroxidase plus endogenous antioxidants like vitamin E, ascorbic acid and cysteine. We have investigated in the isolated rabbit hearts the effects of ischaemia and reperfusion on these defence mechanisms. 90 min of ischaemia and/or hypoxia induced a significant reduction of mitochondrial superoxide dismutase, and of reduced glutathione/oxidized glutathione ratio which was further declined after reperfusion indicating that an oxidative stress has occurred. These alterations are associated with massive tissue and mitochondrial calcium accumulation, loss of mitochondrial function and severe membrane damage. The effects of vitamin E on these parameters have been investigated. Administration of 1.1 mg of dl-alpha-tocopherol acetate showed a protective effect on mitochondrial function but it failed to improve the recovery of mechanical function during reperfusion.","PeriodicalId":75427,"journal":{"name":"Acta vitaminologica et enzymologica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14958485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Clinical use of vitamin A and E in gynecology]. [维生素A和E在妇科的临床应用]。

Acta vitaminologica et enzymologica Pub Date : 1985-01-01

V Pozzi, S Luciani, S Marino, M P Nusiner

{"title":"[Clinical use of vitamin A and E in gynecology].","authors":"V Pozzi, S Luciani, S Marino, M P Nusiner","doi":"","DOIUrl":"","url":null,"abstract":"Dysplasia is an alteration of organ and tissues cellular composition. It means quantitative and qualitative variations (differentiation) of the cells. More recently many Authors have investigated about epithelial neoplasia (breast, cervix, lung, respiratory tract, bladder, colon) and dysplastic epithelial processes and about their medical treatment and prevention of potentially transformative lesions. The view that certain vitamins such as vitamin A (in the form of retinol or its precursor beta-carotene) and vitamin E may protect against the risk of cancer has recently attracted much scientific attention. The potential use of retinoids (and alpha tocopherol) for chemoprevention has been demonstrated by numerous recent experiences. In gynaecology there are no evidence of therapeutical investigations about endometrial and ovarian dysplastic lesions, and then about protective role for consequent neoplasia development. Regarding cervical cancer there are only epidemiological retrospective data about dietary intake of vitamin A. The clinical trial is insufficient, perhaps for technical difficulties of administration, but we hope to obtain satisfactory results in the future. Benign breast disease, instead, so present in woman's life (in particular in fertile phase) is the most common clinical syndrome encompassing several distinct histopathological varieties. BBD is associated with an increase in breast cancer risk, particularly related to the presence of epithelial hyperplasia. In our study (collaborative study; University of L'Aquila--University of Rome) we have treated a group of women (double-blind trial) affected by breast dysplasia, with vitamin A and E association to evaluate the effectiveness of retinoids and alpha-tocopherol in reducing or resolving clinical palpable breast findings (with pain, tension, nodularity and instrumental patterns).(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":75427,"journal":{"name":"Acta vitaminologica et enzymologica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15031106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Preliminary clinical observations on the eutrophic-protective action on the corneal epithelium of combined vitamin A + E]. [复合维生素A + E对角膜上皮富营养化保护作用的初步临床观察]。

Acta vitaminologica et enzymologica Pub Date : 1985-01-01

R Gerhardinger, V Vettori, P Gerhardinger

引用次数: 0

[Contraction of the isolated stomach of the rat as a result of stimulation of postganglionic fibers in the presence of 4-methylesculetol]. [4-甲基己甲醇刺激节后纤维引起的大鼠离体胃的收缩]。

Acta vitaminologica et enzymologica Pub Date : 1985-01-01

R Aragno, V Bettini, G Bruni, F Mayellaro, P Ton

{"title":"[Contraction of the isolated stomach of the rat as a result of stimulation of postganglionic fibers in the presence of 4-methylesculetol].","authors":"R Aragno, V Bettini, G Bruni, F Mayellaro, P Ton","doi":"","DOIUrl":"","url":null,"abstract":"It is known that the bioflavonoids as the Ca++ have an enhancing effect on the transmitter release in different cholinergic nerve-endings. For this reason, it is seemed interesting to study the influence of the separately tested 4-methylesculetin or associated with the ascorbic acid and comparatively the Ca++ concentration increase on the isolated rat stomach response by electrical transmural stimulation achieved in presence or absence of hexamethonium. Both the 4-methylesculetin and the ascorbic acid have always increased the response of the preparation submitted to electrical transmural stimulation. The 4-methylesculetin effect resulted particularly strong if the substance was employed with the ascorbic acid. The enhancing effect of the 4-methylesculetin, obtained with or without the ascorbic acid, is resulted comparatively lesser in presence of hexamethonium. On the basis of the evident analogy between the 4-methylesculetin effects and the ones determined by the increased Ca++ concentration, it can be supposed that the bioflavonoid facilitates the transmitter release in the pre- and postganglionic nerve-endings. The results here reported, confirm other previous observations accomplished on different cholinergic nerve-endings and could substain the hypothesis according to which the 4-methylesculetin increase the Ca++ transport through the biological membranes.","PeriodicalId":75427,"journal":{"name":"Acta vitaminologica et enzymologica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14005469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of reductones on cyclic 3', 5'-adenosine monophosphate phosphodiesterase. 还原剂对环3′，5′-腺苷单磷酸二酯酶的影响。

Acta vitaminologica et enzymologica Pub Date : 1985-01-01

K Shinohara, H Fujiki, Y Hidaka, Y K Tseng, H Murakami, H Omura

引用次数: 0

Multivitamin-mineral supplementation: effects on blood chemistries of college-age women. 补充多种维生素矿物质:对大学年龄妇女血液化学的影响。

Acta vitaminologica et enzymologica Pub Date : 1985-01-01

G A Spiller, T S Pattison, C D Jensen, L G Wong, J H Whittam, J Scala

引用次数: 0

Clinical uses of vitamin E. 维生素E的临床应用。

Acta vitaminologica et enzymologica Pub Date : 1985-01-01

L J Machlin

{"title":"Clinical uses of vitamin E.","authors":"L J Machlin","doi":"","DOIUrl":"","url":null,"abstract":"Early administration of vitamin E to low birth weight (less than 1500 g) infants results in alleviation of the symptoms of retinopathy of prematurity and a lowered incidence of intraventricular hemorrhage. If vitamin E is given to children with cholestatic liver disease (orally or parenterally) before 3 years of age, neurological symptoms such as areflexia, ataxia, and sensory neuropathy are prevented or reversed. Restitution of neurological function is more limited in children ages 5-17 years even after prolonged therapy. Vitamin E is also useful in prevention of neuropathy and retinopathy associated with abetalipoproteinemia and cystic fibrosis. Blood levels of tocopherol are often low in subjects with hemolytic anemias. Administration of vitamin E to G-6-P-D-deficient subjects increased hemoglobin levels, and decreased the number of irreversibly sickled cells in sickle-cell anemia subjects. Most trials have indicated that administration of vitamin E for 6 months or more to subjects with intermittent claudication results in longer walking distance and improved blood flow. Vitamin E reduces platelet aggregation, platelet adhesion to collagen, and platelet thromboxane production. Prostacyclin production is generally enhanced. The significance of these effects to thrombotic diseases. Epidemiological studies have indicated that subjects with higher blood levels of vitamin E have lower risk of death from ischemic heart disease and cancer, a lower risk of breast cancer, and a lower incidence of infections.","PeriodicalId":75427,"journal":{"name":"Acta vitaminologica et enzymologica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15031101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of free radical scavengers on phenylhydrazine induced hemolysis in rat. 自由基清除剂对苯肼致大鼠溶血的作用。

Acta vitaminologica et enzymologica Pub Date : 1985-01-01

H Imanishi, T Nakai, T Abe, T Takino

引用次数: 0

Biochemical and clinical effects of vitamin E administration in homozygous beta-thalassemia. 维生素E对纯合子-地中海贫血的生化及临床影响。

Acta vitaminologica et enzymologica Pub Date : 1985-01-01

O Giardini, A Cantani, A Donfrancesco, F Martino, O Mannarino, P D'Eufemia, C Miano, U Ruberto, R Lubrano

引用次数: 0

[Effects of administration of moderate doses of etretinate (RO 10-9359) on rats deficient in vitamin A]. [中等剂量依维酸酯(ro10 -9359)对维生素A缺乏大鼠的影响]。

Acta vitaminologica et enzymologica Pub Date : 1985-01-01

D Taruoura, P Higueret, C Suberville, D Higueret, H Garcin

引用次数: 0