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Value of inhaled antibiotics in cystic fibrosis patients. 吸入抗生素在囊性纤维化患者中的应用价值。
Acta Universitatis Carolinae. Medica Pub Date : 1990-01-01
P Wunderlich, K D Paul, J Wehner
{"title":"Value of inhaled antibiotics in cystic fibrosis patients.","authors":"P Wunderlich,&nbsp;K D Paul,&nbsp;J Wehner","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The authors give a survey of problems concerning the use of antibiotic aerosols in cystic fibrosis patients. They give recommendations when and how to use this form of treatment. The combination of inhaled antibiotics with the oral or intravenous antibiotic therapy can be recommended best for patients with a chronic lung infection with Pseudomonas aeruginosa.</p>","PeriodicalId":75422,"journal":{"name":"Acta Universitatis Carolinae. Medica","volume":"36 1-4","pages":"34-6"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13284691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Five decades of cystic fibrosis (1938-1988). 五十年的囊性纤维化(1938-1988)。
Acta Universitatis Carolinae. Medica Pub Date : 1990-01-01
L L Kulczycki
{"title":"Five decades of cystic fibrosis (1938-1988).","authors":"L L Kulczycki","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75422,"journal":{"name":"Acta Universitatis Carolinae. Medica","volume":"36 1-4","pages":"7-12"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13284701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Examination of submandibular fluid in cystic fibrosis. 囊性纤维化患者下颌下积液的检查。
Acta Universitatis Carolinae. Medica Pub Date : 1990-01-01
H Davies, J Bagg, M C Goodchild, M A McPherson
{"title":"Examination of submandibular fluid in cystic fibrosis.","authors":"H Davies,&nbsp;J Bagg,&nbsp;M C Goodchild,&nbsp;M A McPherson","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A novel collecting device was used to obtain pure submandibular saliva from control and Cystic Fibrosis (CF) individuals. Vitamin C stimulation induced a 2-fold increase in flow rate relative to resting; CF rates were lower under both conditions. Control and CF saliva differed in that stimulation did not result in increased Na+ and Cl- levels in CF saliva and that elevated levels of Ca2+ and PO4(2-) were observed in CF. The results imply altered electrolyte secretion in CF in response to a stimulus in vivo.</p>","PeriodicalId":75422,"journal":{"name":"Acta Universitatis Carolinae. Medica","volume":"36 1-4","pages":"84-5"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13284707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Autogenic drainage: efficacy of a simplified method. 自体引流:一种简易方法的疗效。
Acta Universitatis Carolinae. Medica Pub Date : 1990-01-01
H Lindemann, A Boldt, R Kieselmann
{"title":"Autogenic drainage: efficacy of a simplified method.","authors":"H Lindemann,&nbsp;A Boldt,&nbsp;R Kieselmann","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A simplified and modified technique of the original autogenic drainage (AD) is described which is supplemented by breathing against an external flow resistance. The new method allows a better teaching and learning. It's efficacy is proven by means of a comparative trial of AD and PEP physiotherapy (i.e. expiration against a defined stenosis). The autogenic drainage (AD) was introduced by a Belgian working group (2). The basic idea was to support the elimination of mucus by deep breathing and by repressing the cough as long as possible. However, a rather sophisticated method impeded teaching and learning of AD (1). Thus, till now, there are only preliminary results which suggest the efficacy of AD (e.g. 3). Therefore, a simplified technique was developed and examined with regard to its sputum eliminating effect.</p>","PeriodicalId":75422,"journal":{"name":"Acta Universitatis Carolinae. Medica","volume":"36 1-4","pages":"210-2"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13285446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevention of cystic fibrosis in Italian families by DNA studies. 通过DNA研究预防意大利家庭囊性纤维化。
Acta Universitatis Carolinae. Medica Pub Date : 1990-01-01
M Ferrari, L Cremonesi, L Ruocco, A Giunta, L Curcio, B Brambati, G Cozzi, S Russo, M Seia, L Piceni Sereni
{"title":"Prevention of cystic fibrosis in Italian families by DNA studies.","authors":"M Ferrari,&nbsp;L Cremonesi,&nbsp;L Ruocco,&nbsp;A Giunta,&nbsp;L Curcio,&nbsp;B Brambati,&nbsp;G Cozzi,&nbsp;S Russo,&nbsp;M Seia,&nbsp;L Piceni Sereni","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We performed a feasibility study of prenatal diagnosis in the Italian population by DNA analysis utilizing the probes: metD, metH, J3.11, KM.19 and XV-2c. With these probes, 118 out of 126 families (93.7%) were fully informative. We also tested part of the families with new additional tightly linked probes, E.9 and W3D1.4. With all the probes feasibility was complete in 44 out of 45 families (97.8%). In particular with a set of only 3 tightly linked probes, KM.19 + XV-2c + W3D1.4, 71% of the families were fully informative. We carried out 8 prenatal diagnoses, 4 of which with the polymerase chain reaction (PCR) for KM.19. These data show that these probes are highly informative and can be used for feasibility studies and prenatal diagnosis of CF in the Italian population.</p>","PeriodicalId":75422,"journal":{"name":"Acta Universitatis Carolinae. Medica","volume":"36 1-4","pages":"105-7"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13285643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of taurine and ursodeoxycholic acid on liver function tests in patients with cystic fibrosis. 牛磺酸和熊去氧胆酸对囊性纤维化患者肝功能检查的影响。
Acta Universitatis Carolinae. Medica Pub Date : 1990-01-01
C Colombo, P M Battezzati, A Crosignani, M Assaisso, M Ronchi, A Giunta
{"title":"Effects of taurine and ursodeoxycholic acid on liver function tests in patients with cystic fibrosis.","authors":"C Colombo,&nbsp;P M Battezzati,&nbsp;A Crosignani,&nbsp;M Assaisso,&nbsp;M Ronchi,&nbsp;A Giunta","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In 9 CF patients with clinical and biochemical evidence of liver disease, taurine (30 mg/kg/day) was administered one month before and during the successive treatment with ursodeoxycholic acid (10-15 mg/kg/day). Standard liver function tests were determined before and after each period of treatment. Taurine administration produced only inconsistent changes of liver function tests from baseline, whereas after the addition of ursodeoxycholic acid a substantial improvement in all abnormal indices was observed. The effects of longer period of treatment are currently investigated, with purpose of establishing their clinical impact and their relationship with changes in bile acid metabolism.</p>","PeriodicalId":75422,"journal":{"name":"Acta Universitatis Carolinae. Medica","volume":"36 1-4","pages":"148-51"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13285653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New restriction fragment length polymorphism (probe E9) reveals the highest linkage disequilibrium in Italian CF patients. 新的限制性片段长度多态性(探针E9)揭示了意大利CF患者中最高的连锁不平衡。
Acta Universitatis Carolinae. Medica Pub Date : 1990-01-01
M Devoto, L De Benedetti, P Ronchetto, L Romano, G Romeo, L C Tsui, M Dean, F Collins, M Seia, L Piceni Sereni
{"title":"New restriction fragment length polymorphism (probe E9) reveals the highest linkage disequilibrium in Italian CF patients.","authors":"M Devoto,&nbsp;L De Benedetti,&nbsp;P Ronchetto,&nbsp;L Romano,&nbsp;G Romeo,&nbsp;L C Tsui,&nbsp;M Dean,&nbsp;F Collins,&nbsp;M Seia,&nbsp;L Piceni Sereni","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We report that the allele distribution for RFLP's flanking the CF gene differs between patients with and without pancreatic insufficiency. The present study confirms this difference. In both classes the linkage disequilibrium (LD) is highest with the RFLP revealed by probe E9. The haplotype distribution identified by these RFLP's can be used for indirect carrier detection.</p>","PeriodicalId":75422,"journal":{"name":"Acta Universitatis Carolinae. Medica","volume":"36 1-4","pages":"102-4"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13142392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
First trimester diagnosis of cystic fibrosis with linked DNA probes. 用DNA连接探针诊断妊娠早期囊性纤维化。
Acta Universitatis Carolinae. Medica Pub Date : 1990-01-01
M Németi, Z Papp
{"title":"First trimester diagnosis of cystic fibrosis with linked DNA probes.","authors":"M Németi,&nbsp;Z Papp","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In late 1985 the cystic fibrosis (CF) gene was located to chromosome 7, at 7q 22/31. Several restriction fragment length polymorphism (RFLP) markers are closely linked to the CF gene. These markers permit accurate first-trimester prenatal diagnosis based on analysis of chorionic villus DNA by studies of families with one or more affected children. In our laboratory 13 families at risk of having a child with CF have been counselled by the use of linked DNA probes: xV-2c; pCS.7; Met H; Met D; pJ3.11; KM 19. In all cases one or more of the mentioned probes were sufficiently informative to allow first-trimester prenatal diagnosis. In four of the 13 families tested prenatal diagnosis have been performed.</p>","PeriodicalId":75422,"journal":{"name":"Acta Universitatis Carolinae. Medica","volume":"36 1-4","pages":"135-8"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13142395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The supporting weekend's meeting of families with CF children. CF儿童家庭周末互助会。
Acta Universitatis Carolinae. Medica Pub Date : 1990-01-01
M Vyhnálek, V Vávrová
{"title":"The supporting weekend's meeting of families with CF children.","authors":"M Vyhnálek,&nbsp;V Vávrová","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Since 1977 3 day-weekend's working meetings have been repeatedly organized for the families with CF children. Several times 97 families comparising 187 parents and 182 children--(of these 101 child patients aged 4-17 years)--took part in them. For one meeting 11 complete families are invited. The working weekend's meeting of complete families (WWM) connects in itself the advantages of parental, thematically oriented discussion group and the principles of psychotherapy by means of modelling. For establishing the program of parents' groups, first of all the level of knowledge on CF was tested by the questionnaires. Other questionnaires contained both the expectation of parents and their evaluation of the psychotherapy. The aim of WWM is: 1. to improve the knowledge of parents about disease, 2. to correct wrong ideas on the disease, 3. to learn both parents the therapeutic rehabilitation, 4. to enable an open discussion between both parents and between parents and health personnel, 5. improving family functions by means of stimulations for free time of the family and 6. to catalyze the reproductive decision of the family if the parents are in fertile age--to inspire the planning of a new family on the basis of the method of prenatal diagnosis. CF is chronic, lethal, genetically conditioned disease. The complex therapy of CF patients enables to prolong their life often up to the adulthood. At the same time the possibility of prenatal diagnosis in CF decreases the risk of birth of another affected child in the family.(ABSTRACT TRUNCATED AT 250 WORDS)</p>","PeriodicalId":75422,"journal":{"name":"Acta Universitatis Carolinae. Medica","volume":"36 1-4","pages":"240-3"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13284687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Survival in cystic fibrosis: preliminary report from an Italian multicenter study. 囊性纤维化的生存:来自意大利多中心研究的初步报告。
Acta Universitatis Carolinae. Medica Pub Date : 1990-01-01
M E Bettinelli, A Civardi, D Costantini, R Padoan, A Giunta, B Cesana, L Greco, D Salvatore, F Santamaria, M Castro
{"title":"Survival in cystic fibrosis: preliminary report from an Italian multicenter study.","authors":"M E Bettinelli,&nbsp;A Civardi,&nbsp;D Costantini,&nbsp;R Padoan,&nbsp;A Giunta,&nbsp;B Cesana,&nbsp;L Greco,&nbsp;D Salvatore,&nbsp;F Santamaria,&nbsp;M Castro","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>An Italian multicenter study has been carried out in order to obtain data on survival and prognostic factors in CF. We report data from four CF Centers: Milan, Neaples, Cagliari, Rome, Anagraphic data, mode of presentation and of diagnosis were collected, using CFDB database, from 536 CF pts. 39 pts had meconium ileus (7.3%); 269 (50%) were diagnosed before 12 months of age. 27 pts were lost to follow-up (5%); and 65 pts died (12%). Statistical analysis was performed by Kaplan-Meier survival curves compared by Logrank test.</p>","PeriodicalId":75422,"journal":{"name":"Acta Universitatis Carolinae. Medica","volume":"36 1-4","pages":"215-6"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13285448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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