M Devoto, L De Benedetti, P Ronchetto, L Romano, G Romeo, L C Tsui, M Dean, F Collins, M Seia, L Piceni Sereni
{"title":"新的限制性片段长度多态性(探针E9)揭示了意大利CF患者中最高的连锁不平衡。","authors":"M Devoto, L De Benedetti, P Ronchetto, L Romano, G Romeo, L C Tsui, M Dean, F Collins, M Seia, L Piceni Sereni","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>We report that the allele distribution for RFLP's flanking the CF gene differs between patients with and without pancreatic insufficiency. The present study confirms this difference. In both classes the linkage disequilibrium (LD) is highest with the RFLP revealed by probe E9. The haplotype distribution identified by these RFLP's can be used for indirect carrier detection.</p>","PeriodicalId":75422,"journal":{"name":"Acta Universitatis Carolinae. Medica","volume":"36 1-4","pages":"102-4"},"PeriodicalIF":0.0000,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"New restriction fragment length polymorphism (probe E9) reveals the highest linkage disequilibrium in Italian CF patients.\",\"authors\":\"M Devoto, L De Benedetti, P Ronchetto, L Romano, G Romeo, L C Tsui, M Dean, F Collins, M Seia, L Piceni Sereni\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>We report that the allele distribution for RFLP's flanking the CF gene differs between patients with and without pancreatic insufficiency. The present study confirms this difference. In both classes the linkage disequilibrium (LD) is highest with the RFLP revealed by probe E9. The haplotype distribution identified by these RFLP's can be used for indirect carrier detection.</p>\",\"PeriodicalId\":75422,\"journal\":{\"name\":\"Acta Universitatis Carolinae. Medica\",\"volume\":\"36 1-4\",\"pages\":\"102-4\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1990-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Acta Universitatis Carolinae. Medica\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta Universitatis Carolinae. Medica","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
New restriction fragment length polymorphism (probe E9) reveals the highest linkage disequilibrium in Italian CF patients.
We report that the allele distribution for RFLP's flanking the CF gene differs between patients with and without pancreatic insufficiency. The present study confirms this difference. In both classes the linkage disequilibrium (LD) is highest with the RFLP revealed by probe E9. The haplotype distribution identified by these RFLP's can be used for indirect carrier detection.
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