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Acta Universitatis Carolinae. Medica最新文献

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Juvenile chronic arthritis--bone mineral density in relation to corticosteroid therapy. 青少年慢性关节炎——骨密度与皮质类固醇治疗的关系。
Acta Universitatis Carolinae. Medica Pub Date : 1994-01-01
M Bayer, J Stĕpán, D Nĕmcová, S Kutílek, J Hoza
{"title":"Juvenile chronic arthritis--bone mineral density in relation to corticosteroid therapy.","authors":"M Bayer,&nbsp;J Stĕpán,&nbsp;D Nĕmcová,&nbsp;S Kutílek,&nbsp;J Hoza","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Bone demineralization often accompanies juvenile chronic arthritis (JCA). Fourteen patients with confirmed diagnosis of JCA had their bone mineral density (BMD) measured with the use of dual photon X-ray absorptiometry. The results obtained were compared to the Lunar BMD DPXA standards. Seven patients received Prednisone in doses of more than 0.16 mg/kg/day for more than 6 months and 7 patients (sex and age matched) never received any steroids at all. In the first group BMD was decreased in 7 patients (100%), in the second group BMD was mildly decreased in 2 patients (28%). Due to the difference in BMD in both groups, it is obvious that corticosteroids have substantial influence on bone demineralization in JCA.</p>","PeriodicalId":75422,"journal":{"name":"Acta Universitatis Carolinae. Medica","volume":"40 1-4","pages":"33-5"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20285906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cyclosporin in pediatric rheumatology; a seven years experience. 环孢素在小儿风湿病中的应用;七年的经验。
Acta Universitatis Carolinae. Medica Pub Date : 1994-01-01
M Gattinara, C Lomater, V Gerloni, J Mazzotti, F Fantini
{"title":"Cyclosporin in pediatric rheumatology; a seven years experience.","authors":"M Gattinara,&nbsp;C Lomater,&nbsp;V Gerloni,&nbsp;J Mazzotti,&nbsp;F Fantini","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75422,"journal":{"name":"Acta Universitatis Carolinae. Medica","volume":"40 1-4","pages":"105-8"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20287109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Combination therapy of juvenile rheumatoid arthritis with hydroxychloroquine-gold-methotrexate: a pilot study. 羟氯喹-金-甲氨蝶呤联合治疗幼年类风湿性关节炎:一项初步研究。
Acta Universitatis Carolinae. Medica Pub Date : 1994-01-01
G Lomater, M Gattinara, V Gerloni, S Zeni, F Fantini
{"title":"Combination therapy of juvenile rheumatoid arthritis with hydroxychloroquine-gold-methotrexate: a pilot study.","authors":"G Lomater,&nbsp;M Gattinara,&nbsp;V Gerloni,&nbsp;S Zeni,&nbsp;F Fantini","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75422,"journal":{"name":"Acta Universitatis Carolinae. Medica","volume":"40 1-4","pages":"109-12"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20288902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Outlooks of systemic enzyme therapy in rheumatoid arthritis and other immunopathological diseases. 类风湿性关节炎和其他免疫病理疾病的全身酶治疗前景。
Acta Universitatis Carolinae. Medica Pub Date : 1994-01-01
K Nouza
{"title":"Outlooks of systemic enzyme therapy in rheumatoid arthritis and other immunopathological diseases.","authors":"K Nouza","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Systemic enzyme therapy (SET) represents a specific therapeutic approach consisting in peroral application of blends of animal and plant hydrolytic enzymes. A significant part of the swallowed enzymes (about 25%) is resorbed in the intestine in functionally active form. After being complexed with natural antiproteases, enzymes set concentrated in wounds, inflammation sites and immunopathological foci. SET has many important indications in traumatologic, thrombotic, infectious, inflammatory, immunopathologic and even tumorous processes. Rheumatoid arthritis, Bechterew's disease, activated arthrosis and extraarticular rheumatism represent important and sensitive targets of SET. In situ and in vivo studies continue to elucidate selective interferences of absorbed proteolytic enzymes with the crucial pathogenic mechanisms of rheumatoid processes.</p>","PeriodicalId":75422,"journal":{"name":"Acta Universitatis Carolinae. Medica","volume":"40 1-4","pages":"101-4"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20287108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Monitoring bone mineralization in chronic rheumatic children on steroid treatment. 慢性风湿病儿童类固醇治疗的骨矿化监测。
Acta Universitatis Carolinae. Medica Pub Date : 1994-01-01
F Fantini, M Gallazzi, M Gattinara, V Gerloni, C Lomater, J Mazzotti
{"title":"Monitoring bone mineralization in chronic rheumatic children on steroid treatment.","authors":"F Fantini,&nbsp;M Gallazzi,&nbsp;M Gattinara,&nbsp;V Gerloni,&nbsp;C Lomater,&nbsp;J Mazzotti","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75422,"journal":{"name":"Acta Universitatis Carolinae. Medica","volume":"40 1-4","pages":"17-22"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20285903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolic bone status in young women with JCA. 年轻女性JCA的骨代谢状况。
Acta Universitatis Carolinae. Medica Pub Date : 1994-01-01
S Havelka, P Vavrincová, J Stĕpán, M Hladíková
{"title":"Metabolic bone status in young women with JCA.","authors":"S Havelka,&nbsp;P Vavrincová,&nbsp;J Stĕpán,&nbsp;M Hladíková","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The study was based on clinical, densitometric and biochemical evaluations and on a life-style questionnaire, applied in a cohort of 41 individuals. The mean age of the young women was 24.2 (18-36) years. The main point was to compare subgroups with (CS) an without (NCS) corticosteroid treatment (19 and 22 patients, respectively). There was no significant difference in age, weight and duration of JCA. Of the densitometric examinations, spine DXA (DPX-L LUNAR apparatus) yielded values significantly lower in CS than in NCS individuals (p = 0.05). Much more apparent was the difference in stiffness measurements in the calcanei performed by Achilles-LUNAR ultrasound instrument, again with lower values in CS women (p = 0.001) (Fig. 1, 2, 3). No significant differences were found between the two subgroups as regards blood levels of bone alkaline phosphatase, osteocalcin and tartrate-resistant acidic phosphatase, and urine hydroxyproline output. Menarche occurred at a mean age of 14.37 years in the CS subgroup (p = 0.01, against healthy population) and of 13.32 years in the NCS subgroup (not significant). The prevalence of fractures was enconsiderable in both subgroups. These findings are to be understood from the viewpoint of combined influences of both disease activity and corticotherapy in the CS patients with JCA.</p>","PeriodicalId":75422,"journal":{"name":"Acta Universitatis Carolinae. Medica","volume":"40 1-4","pages":"65-7"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20287101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemiluminescence of peripheral blood leukocytes and activity of an inflammatory process in juvenile chronic arthritis (JCA). 青少年慢性关节炎(JCA)中外周血白细胞的化学发光和炎症过程的活性。
Acta Universitatis Carolinae. Medica Pub Date : 1994-01-01
A Sikora, H Brózik, J P Sikora, M Gołebiowska
{"title":"Chemiluminescence of peripheral blood leukocytes and activity of an inflammatory process in juvenile chronic arthritis (JCA).","authors":"A Sikora,&nbsp;H Brózik,&nbsp;J P Sikora,&nbsp;M Gołebiowska","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The oxidative metabolites have been implicated in the aetiology and pathology of rheumatoid arthritis. In our work we endeavoured to deal with polymorphonuclear leukocytes (PMNLs) ability to generate oxygen free radicals (OFRs). PMNLs metabolic activity was assessed by the means of chemiluminescence (CL) method. We observed significantly higher PMNLs metabolic activity in children suffering from JCA in comparison to the healthy group. Greater activity of the rheumatoid process was accompanied by an increased PMNLs activity. The results constitute another piece of evidence confirming the role of PMNLs in the pathogenesis of JCA.</p>","PeriodicalId":75422,"journal":{"name":"Acta Universitatis Carolinae. Medica","volume":"40 1-4","pages":"75-9"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20287103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigations of bone density in patients with juvenile chronic arthritis by a sonographie method. 儿童慢性关节炎患者骨密度的超声检查。
Acta Universitatis Carolinae. Medica Pub Date : 1994-01-01
H H Thiemann, M John, V John
{"title":"Investigations of bone density in patients with juvenile chronic arthritis by a sonographie method.","authors":"H H Thiemann,&nbsp;M John,&nbsp;V John","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75422,"journal":{"name":"Acta Universitatis Carolinae. Medica","volume":"40 1-4","pages":"37-41"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20285907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Arthroscopic synovectomy of the knee joint in the treatment of patients with juvenile chronic arthritis. 关节镜下膝关节滑膜切除术治疗青少年慢性关节炎。
Acta Universitatis Carolinae. Medica Pub Date : 1994-01-01
M Gattinara, C Lomater, E Paresce, R Minola, R Vigano, F Fantini
{"title":"Arthroscopic synovectomy of the knee joint in the treatment of patients with juvenile chronic arthritis.","authors":"M Gattinara,&nbsp;C Lomater,&nbsp;E Paresce,&nbsp;R Minola,&nbsp;R Vigano,&nbsp;F Fantini","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75422,"journal":{"name":"Acta Universitatis Carolinae. Medica","volume":"40 1-4","pages":"113-5"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20288903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of some factors on the indication for surgical treatment of gastroduodenal ulcer disease. 一些因素对胃十二指肠溃疡手术适应证的影响。
Acta Universitatis Carolinae. Medica Pub Date : 1993-01-01
I Hritz
{"title":"Effects of some factors on the indication for surgical treatment of gastroduodenal ulcer disease.","authors":"I Hritz","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The author of the present communication collected a variety of important information on 2,173 patients living permanently in Prague 4. In all of them the diagnosis of gastroduodenal ulcer disease was established between 1979 and 1988 incl. The results obtained by the currently applied therapy were not designated as satisfactory both by the patient and by his doctor. The predomination of conservative therapy was due to the introduction of new drugs which reduce markedly gastric secretion of HCl. On the basis of strict indications elective surgery was advised in some patients. In the acute stage of the disease (bleeding, perforation, stenosis) clearly defined criteria allowed to establish the indication for elective surgery. The answer to this question provides the author in the form of a scheme of the regimen which should be observed after a definite diagnosis. It was devised on the basis of the results of the present study, of reports in the Czech and international literature, as well as of our own experience. For the indication of surgical treatment is of great importance a high degree of responsibility of the doctor. This is reflected by the correct choice of the optimum surgical procedure. Good results obtained in the management of ulcer disease were due to the fact that attention was paid to the often neglected aspect of the psychosomatic character of this disease.</p>","PeriodicalId":75422,"journal":{"name":"Acta Universitatis Carolinae. Medica","volume":"39 1-4","pages":"57-107"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20286598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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