Acta paediatrica Scandinavica最新文献

{"title":"Efficacy of beclomethasone nasal drops, administered in the Moffat's position for nasal polyposis.","authors":"M Canciani, G Mastella","doi":"10.1111/j.1651-2227.1988.tb10715.x","DOIUrl":"https://doi.org/10.1111/j.1651-2227.1988.tb10715.x","url":null,"abstract":"Nasal obstruction is a common symptom in pediatric age, often with mucopurulent discharge. One of the causes can be nasal polyposis, often occurring in association with some chronic disease, including cystic fibrosis (CF) (1), perennial rhinitis (Z), chronic sinusitis (Z), asthma and aspirin intolerance (3). Nasal polyposis is frequent in CF, occurring in 6 3 6 % of patients, according to different reports (4). The management of nasal polyposis is very difficult (5). In the present study the efficacy of beclomethasone nasal drops in the therapy of nasal polyposis, when administered in Moffat’s position (head down and forwards), was evaluated.","PeriodicalId":75407,"journal":{"name":"Acta paediatrica Scandinavica","volume":"77 4","pages":"612-3"},"PeriodicalIF":0.0,"publicationDate":"1988-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1651-2227.1988.tb10715.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14519740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heparin cofactor II, antithrombin and protein C in plasma from term and preterm infants.","authors":"T R Andersson,&nbsp;H Bangstad,&nbsp;M L Larsen","doi":"10.1111/j.1651-2227.1988.tb10688.x","DOIUrl":"https://doi.org/10.1111/j.1651-2227.1988.tb10688.x","url":null,"abstract":"<p><p>The coagulation inhibitors heparin cofactor II (HC II), antithrombin (AT) and protein C (PC) were measured in healthy term and preterm infants in order to establish reference standards. The mean value for HC II in term infants was found to be about half of the adult values. Values below 25% in healthy infants may suggest hereditary deficiency states. One girl with congenital HC II deficiency was detected. Mean AT and PC levels were somewhat higher than HC II. Healthy preterm infants have significantly lower HC II and AT values than healthy term infants. Serial AT measurements have been used in monitoring seriously ill infants and used as a prognostic indicator. In a small number of unhealthy neonates HC II was reduced to an even greater extent than AT, and on recovery normalized more rapidly than AT.</p>","PeriodicalId":75407,"journal":{"name":"Acta paediatrica Scandinavica","volume":"77 4","pages":"485-8"},"PeriodicalIF":0.0,"publicationDate":"1988-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1651-2227.1988.tb10688.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14520665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High stature in neonatal myotubular myopathy.","authors":"J C LeGuennec,&nbsp;J P Bernier,&nbsp;J Lamarche","doi":"10.1111/j.1651-2227.1988.tb10714.x","DOIUrl":"https://doi.org/10.1111/j.1651-2227.1988.tb10714.x","url":null,"abstract":"A male baby was delivered at 40 weeks of gestation. His birthweight was 3300 g (50th percentile) and length 57 cm (over the 97th percentile). Parents measured 1.70 m and 1.83 m, respectively. The mother later gave birth to two healthy infants, a boy and a girl who measured 53 cm and 47 cm and weighed 3800 g and 2700 g at 40 weeks and 39 weeks of gestation, respectively. In our patients the chest X-ray at birth showed the characteristic thin ribs (Fig. 1). A diagnosis of neuromuscular disease was rapidly made on the basis of persistent generalized hypotonia, muscle atrophy, and feeble respiratory efforts. Muscle biopsies taken from the biceps on the 8th day revealed the characteristic features of myotubular myopathy with predominance of type I fibres and persistence of fetal myotubes in a large proportion of the muscle fibers (Fig. 2). The baby died at 2 months of age from respiratory insufficiency. His mother was clinically normal and her muscle biopsy did not show any abnormality. Because of the high stature observed in this patient, previously published cases of neonatal myotubular myopathy were reviewed and birth length parameters were plotted on Lubchenco growth curves. Only in 6 previously reported cases (14) the height had been recorded. In four of the 6 infants the height was over the 90th percentile, and all had a decreased weight for height (Fig. 3).","PeriodicalId":75407,"journal":{"name":"Acta paediatrica Scandinavica","volume":"77 4","pages":"610-1"},"PeriodicalIF":0.0,"publicationDate":"1988-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1651-2227.1988.tb10714.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14519739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurologic sequelae following interferon therapy of juvenile laryngeal papilloma.","authors":"T Vesikari,&nbsp;A Nuutila,&nbsp;K Cantell","doi":"10.1111/j.1651-2227.1988.tb10718.x","DOIUrl":"https://doi.org/10.1111/j.1651-2227.1988.tb10718.x","url":null,"abstract":"<p><p>Human leukocyte interferon at doses from 2 million units every two days to 3 million units daily was given to a 2-year-old boy for the treatment of recurrent juvenile laryngeal papilloma. After 7 months of treatment the child developed spastic diplegia, which persisted despite the discontinuation of interferon therapy. The clinical picture was consistent with an upper motor neuron lesion; no evidence of peripheral neuropathy was found.</p>","PeriodicalId":75407,"journal":{"name":"Acta paediatrica Scandinavica","volume":"77 4","pages":"619-22"},"PeriodicalIF":0.0,"publicationDate":"1988-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1651-2227.1988.tb10718.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13604263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastric aspirates of newborn infants: pH, volume and levels of gastrin- and somatostatin-like immunoreactivity.","authors":"A M Widström,&nbsp;K Christensson,&nbsp;A B Ransjö-Arvidson,&nbsp;A S Matthiesen,&nbsp;J Winberg,&nbsp;K Uvnäs-Moberg","doi":"10.1111/j.1651-2227.1988.tb10691.x","DOIUrl":"https://doi.org/10.1111/j.1651-2227.1988.tb10691.x","url":null,"abstract":"<p><p>The aim of the present investigation was to study volume, pH and the levels of gastrin- and somatostatin-like immunoreactivity in gastric aspirates obtained immediately after birth from 25 healthy infants. In addition, the same parameters were measured in amniotic fluid collected from 11 of the mothers. The median volume of the gastric contents was 4 ml (range 0-11) and median pH was 6.96 (range 2.77-9.58). Gastrin and somatostatin median concentrations were 8 pM (range 0-52) and 67 pM (range 15- greater than 1,000), respectively. The corresponding levels in amniotic fluid were 8.2 +/- 3.6 pM and 28.4 +/- 5.3 pM, median pH was 9.22 (range 8.05-9.58). There was a significant correlation between volume and pH of gastric contents. The pH of the gastric aspirate was inversely correlated with the somatostatin levels. No correlation could be demonstrated as regards levels in amniotic fluid and gastric content. Gastric content and amniotic fluid were not correlated regarding pH, gastrin and somatostatin. It is suggested that the foetus drinks about 10 ml portions of amniotic fluid which are gradually emptied from the stomach and that these drinking episodes are associated with gastric exocrine and endocrine secretion normally seen following feeding after birth.</p>","PeriodicalId":75407,"journal":{"name":"Acta paediatrica Scandinavica","volume":"77 4","pages":"502-8"},"PeriodicalIF":0.0,"publicationDate":"1988-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1651-2227.1988.tb10691.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14035684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outbreak of infections due to P-fimbriated Escherichia coli O16:K1 in a neonatal intensive care unit.","authors":"K Tullus,&nbsp;G Faxelius,&nbsp;B Fryklund,&nbsp;A Brauner,&nbsp;L G Burman,&nbsp;U Ransjö","doi":"10.1111/j.1651-2227.1988.tb10708.x","DOIUrl":"https://doi.org/10.1111/j.1651-2227.1988.tb10708.x","url":null,"abstract":"In recent years neonatal Escherichiu coli septicemia has been rare in the neonatal intensive care unit (NICU) at the Karolinska Hospital, with only one case diagnosed in 1981-1985 (1). During December 1986, however, an outbreak of severe nosocomial E. coli infections occurred in the NICU. One case each of meningitis, septicemia and pneumonia were diagnosed within a three week period. The three infants were simultaneously nursed in the same room during a period of overcrowding. All three infections were caused by E. coli with identical multiple antibiotic resistance patterns (resistant to ampicillin, piperacillin, cephalotin, trimethoprim-sulphamethoxazole, doxycycline). The isolates from blood and cerebrospinal fluid (CSF) were P-fimbriated and of identical biotype and serotype (016 : K1) whereas the isolate from tracheal secretions was not available for further typing.","PeriodicalId":75407,"journal":{"name":"Acta paediatrica Scandinavica","volume":"77 4","pages":"599-600"},"PeriodicalIF":0.0,"publicationDate":"1988-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1651-2227.1988.tb10708.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14035685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypoglycaemia in childhood diabetes. I. Clinical signs and hormonal counterregulation.","authors":"J Aman,&nbsp;L Wranne","doi":"10.1111/j.1651-2227.1988.tb10697.x","DOIUrl":"https://doi.org/10.1111/j.1651-2227.1988.tb10697.x","url":null,"abstract":"<p><p>Hypoglycaemia (blood glucose 1.3-2.5 mmol/l) was induced in twenty-eight diabetic children by reduction of their morning meal. Fatigue and pallor were the most common signs of hypoglycaemia. Compared to findings during normoglycaemia, plasma concentrations of adrenalin, noradrenalin and cortisol were significantly higher at glucose nadir. Plasma glucagon concentration at glucose nadir was correlated to the fasting C-peptide concentration and inversely to the duration of diabetes. Children who lacked C-peptide also lacked glucagon response to hypoglycaemia. The parents' opinion of the need to give carbohydrates corresponded to the blood glucose level. The presence of adrenergic signs correlated to the plasma adrenalin and the neuroglucopenic signs to blood glucose. The lowest glucose level correlated inversely to the concentration of free insulin. When facilities for glucose infusion are lacking, a rational step in treating the unconscious hypoglycaemic child seems to be the injection of glucagon, considering the blunted or absent glucagon secretion.</p>","PeriodicalId":75407,"journal":{"name":"Acta paediatrica Scandinavica","volume":"77 4","pages":"542-7"},"PeriodicalIF":0.0,"publicationDate":"1988-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1651-2227.1988.tb10697.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14421645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating class II transplantation antigen-expressing T lymphocytes in children with insulin-dependent diabetes mellitus at diagnosis.","authors":"A Karlsson-Parra,&nbsp;M Kobbah,&nbsp;U Ewald,&nbsp;T Tuvemo,&nbsp;U Forsum,&nbsp;L Klareskog","doi":"10.1111/j.1651-2227.1988.tb10699.x","DOIUrl":"https://doi.org/10.1111/j.1651-2227.1988.tb10699.x","url":null,"abstract":"<p><p>The occurrence of circulating class II antigen-expressing T lymphocytes was examined in 25 children with insulin-dependent diabetes mellitus using an indirect double immunofluorescence assay on prefixed cell samples. In order to exclude sensitization to heterologous insulin as a possible factor affecting the results, the patients were investigated at the day of clinical onset, before receiving insulin. An increased percentage of T cells (CD3+ cells) expressing class II antigens was seen in 19 out of 25 patients and class II expression was observed on cells within both the CD4+ and CD8+ T cell subsets. No correlation was found between the levels of class II expressing T cells and the individual degree of metabolic derangement or indicators of recent infection. Re-testing of 16 patients after one year on insulin treatment revealed a significant decrease of class II expressing T cell levels. Our data suggest that the increased levels of class II expressing T cells seen in IDDM of recent onset directly reflects immune reactions that are related to the disease process.</p>","PeriodicalId":75407,"journal":{"name":"Acta paediatrica Scandinavica","volume":"77 4","pages":"554-8"},"PeriodicalIF":0.0,"publicationDate":"1988-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1651-2227.1988.tb10699.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14421646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neonatal campylobacter enteritis with secondary lactose intolerance.","authors":"M A McShane,&nbsp;S H Gillespie,&nbsp;C W Corkey","doi":"10.1111/j.1651-2227.1988.tb10710.x","DOIUrl":"https://doi.org/10.1111/j.1651-2227.1988.tb10710.x","url":null,"abstract":"A five-day-old female infant was admitted to the hospital neonatal unit from the maternity ward with a history of frequent watery stools from shortly after birth. The pregnancy and delivery were uneventful and the birth weight was 3450 g. The baby had been fed on a modified cows milk formula (Osterfeed). Clinical examination was unremarkable, however copious watery stools were produced soon after each feed. Culture of faeces revealed a gram negative organism on Skirrow’s medium which was identified as Campylobacter jejuni biotype I . Culture of the mother’s stool was negative and no other baby in the maternity unit developed symptoms. The pH of the faecal fluid was 6.0 and contained lactose 30 mmol/l, galactose 2.7 mmol/l and glucose 11 mmolil. Lactose, galactose and glucose were detected on urinary sugar chromatography. On day 7 the baby weighed 2 960 g, a weight loss equal to 14% of birth weight. Oral erythromycin and a low lactose feed (Galactomin 17) were commenced. Her diarrhoea resolved completely on this regime and on day 13 she weighed 3630 g. At one month she had a recurrence of symptoms with negative investigations but responded to changing of the feed to a lactose free soya milk preparation (Wysoy) and at 4 months she weighed 6550 g. At this stage, lactose tolerance test produced no diarrhoea and jejunal biopsy demonstrated lactase activity and normal histology. Campylobacter jejuni has recently been recognised as an important cause of enteritis in the community and is now one of the most frequent enteric pathogens reported. Neonatal infection is uncommon, but there have been several case reports in recent years (1 , 2). We present a case of lactose intolerance in a newborn secondary to Campylobacter jejuni gastroenteritis. Lactose intolerance following Campylobacter infection has not previously been reported. The initial presentation could be confused with primary lactase deficiency thus illustrating the importance of using culture techniques suitable for the isolation of Campylobacter species from the faeces of neonates. The probable development of cows milk protein allergy is well recognised in the post enteritis syndrome (3). Galatomin is a low lactose casein containing milk preparation. It would have been more appropriate to use a lactose-free hydrolysed protein milk formula to reduce the risk of development of cow’s milk protein allergy. Reintroduction of a normal cow’s milk protein preparation after development of cow’s milk protein allergy is usually possible after the first year.","PeriodicalId":75407,"journal":{"name":"Acta paediatrica Scandinavica","volume":"77 4","pages":"603"},"PeriodicalIF":0.0,"publicationDate":"1988-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1651-2227.1988.tb10710.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14519736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impaired neutrophil chemotaxis in two patients with mucolipidosis II.","authors":"T Sakaguchi,&nbsp;K Kikuchi,&nbsp;S Ito,&nbsp;H Mikawa","doi":"10.1111/j.1651-2227.1988.tb10713.x","DOIUrl":"https://doi.org/10.1111/j.1651-2227.1988.tb10713.x","url":null,"abstract":"Mucolipidosis I1 (ML 11) is a rare autosomal recessive disorder characterized by coarse facial features, gingival hyperplasia, joint stiffness, skeletal abnormalities and psychomotor retardation. Hasilik e t al. (1) and Reitman et al. (2) found that N-acetyl-glucosaminylphosphotransferase activity was deficient in patients with ML 11. Recently, we have demonstrated that the deficiency of N-acetylglucosaminylphosphotransferase activity is easily detectable by using commercially obtainable UDP-N-ace ty l -~[U-~~c] glucosamine and a-methylmannoside (3). Patients with ML I1 are susceptible to infection, and most of them die between the ages of 3 and 8. Presently, there are only a few reports about immunological functions in patients with ML I1 (4, 5, 6). Neutrophil functions have not yet been investigated in patients with ML 11. In this study, we examined the immunological as well as neutrophil functions in two girls with ML 11.","PeriodicalId":75407,"journal":{"name":"Acta paediatrica Scandinavica","volume":"77 4","pages":"608-9"},"PeriodicalIF":0.0,"publicationDate":"1988-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1651-2227.1988.tb10713.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14519738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}