Acta paediatrica Scandinavica最新文献

{"title":"Examination of infant brain maturation using ultra low field MRI.","authors":"H Suhonen-Polvi,&nbsp;H Määttänen,&nbsp;A Alanen,&nbsp;K Katevuo,&nbsp;A Tenovuo,&nbsp;P Kero,&nbsp;M Kormano","doi":"10.1111/j.1651-2227.1988.tb10692.x","DOIUrl":"https://doi.org/10.1111/j.1651-2227.1988.tb10692.x","url":null,"abstract":"<p><p>The brains of 42 newborn infants were examined with MRI at 0.02 T field, and regional variations of T1 relaxation time were measured from the images. There were three groups: 1. full term infants (9), 2. preterm infants (10) and 3. SGA (= small for gestational age) infants (20). Relaxation times showed a correlation to myelination of the brain. The brain of SGA infants showed a large variation in their T1 values.</p>","PeriodicalId":75407,"journal":{"name":"Acta paediatrica Scandinavica","volume":"77 4","pages":"509-15"},"PeriodicalIF":0.0,"publicationDate":"1988-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1651-2227.1988.tb10692.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14519746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estrogen treatment of excessively tall girls with Marfan syndrome.","authors":"J Knudtzon,&nbsp;D Aarskog","doi":"10.1111/j.1651-2227.1988.tb10696.x","DOIUrl":"https://doi.org/10.1111/j.1651-2227.1988.tb10696.x","url":null,"abstract":"<p><p>Five girls with Marfan syndrome were treated with estrogens for reduction of their final heights. Treatment was started at a chronological age of 12.0 +/- 0.5 years and height of 173.0 +/- 3.1 cm (means +/- SEM). Skeletal age was 12.4 +/- 0.2 years and Bayley-Pinneau final height prediction 186.3 +/- 1.4 cm. Estrogen treatment for 2.0 +/- 0.4 years resulted in final height of 184.1 +/- 0.2 cm (p less than 0.05). The weight increased with 7.8 +/- 2.7 kg during the treatment period. The present results indicate that estrogen treatment may be effective in reducing adult height in girls with Marfan syndrome, but that the effect is probably less than that observed in normally tall girls. This may probably be explained by the rather late start of treatment. No immediate effects on aortic root diameters were observed. Estrogen treatment in Marfan syndrome is discussed with regard to beneficial effects, possible side-effects and optimal age for starting treatment.</p>","PeriodicalId":75407,"journal":{"name":"Acta paediatrica Scandinavica","volume":"77 4","pages":"537-41"},"PeriodicalIF":0.0,"publicationDate":"1988-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1651-2227.1988.tb10696.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14519748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Orocoecal transit time in healthy and constipated children.","authors":"P Vajro,&nbsp;G Silano,&nbsp;D Longo,&nbsp;A Staiano,&nbsp;A Fontanella","doi":"10.1111/j.1651-2227.1988.tb10704.x","DOIUrl":"https://doi.org/10.1111/j.1651-2227.1988.tb10704.x","url":null,"abstract":"<p><p>Orocoecal transit time (OCTT), assessed by means of H2 breath test after lactulose and/or after a semisolid standard meal, was studied in normal and constipated children. Both control subjects and patients with constipation showed a significantly longer OCTT after a standard meal than after lactulose ingestion (p less than 0.01). Whereas the OCTT after lactulose did not differ in the two groups, the constipated patients had a significantly longer transit time after a standard meal when compared to controls (p less than 0.05). No correlation was observed within each group between the OCTT after a standard meal or after lactulose ingestion (r = -0.077; p greater than 0.01). These findings suggest that 1) measurement of the transit of a standard meal instead of a lactulose solution may offer more direct insight into the role of small intestinal transit of food, both in physiological and pathological conditions, 2) gastrointestinal segments other than colon may play a role in chronic non organic constipation of childhood.</p>","PeriodicalId":75407,"journal":{"name":"Acta paediatrica Scandinavica","volume":"77 4","pages":"583-6"},"PeriodicalIF":0.0,"publicationDate":"1988-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1651-2227.1988.tb10704.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14519753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Possible etiological factors in extensive periventricular leukomalacia of preterm infants.","authors":"R S Ikonen,&nbsp;E J Kuusinen,&nbsp;M O Janas,&nbsp;M J Koivikko,&nbsp;A E Sorto","doi":"10.1111/j.1651-2227.1988.tb10689.x","DOIUrl":"https://doi.org/10.1111/j.1651-2227.1988.tb10689.x","url":null,"abstract":"<p><p>During a twelve-month period five cases of extensive periventricular leukomalacia (PVL) in preterm infants with a gestational age of 31-32 weeks were diagnosed by routine ultrasound screening of preterm infants. The perinatal courses and later development of these infants were compared with 12 other infants with a comparable gestational age born during the same time period. PVL babies were delivered more often by the vaginal route (p = 0.0034), and their mean highest serum total bilirubin value was significantly higher (p = 0.0054) than that of the control infants. The mean value of the highest blood pH during the first 72 hours of life was also significantly higher (p = 0.0311) in PVL babies than in control babies. On the basis of these results we speculate that in addition to ischaemia in the periventricular area, bilirubin toxicity may play an additional role in the severe damage seen in extensive periventricular leukomalacia.</p>","PeriodicalId":75407,"journal":{"name":"Acta paediatrica Scandinavica","volume":"77 4","pages":"489-95"},"PeriodicalIF":0.0,"publicationDate":"1988-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1651-2227.1988.tb10689.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14520666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilirubin binding and acid-base equilibrium in newborn infants with low birthweight.","authors":"P Meisel,&nbsp;D Jährig,&nbsp;E Beyersdorff,&nbsp;K Jährig","doi":"10.1111/j.1651-2227.1988.tb10690.x","DOIUrl":"https://doi.org/10.1111/j.1651-2227.1988.tb10690.x","url":null,"abstract":"<p><p>Acidosis is known as a risk factor for the development of bilirubin encephalopathy in neonatal jaundice. However, few attempts have been made to evaluate the influence of acid-base state on bilirubin-albumin binding state in blood of newborn infants. Therefore, in 171 appropriate and 83 small for gestational age newborns (birthweight less than 2,500 g) the acid-base state in blood and bilirubin (BR) binding state in serum was measured at the ages of 3, 4, 5, and 8 days. There is a weak but significant correlation between standard base deficit and the ratio BR/reserve albumin as well as the toxic potential of serum BR. The results suggest that the higher risk in acidosis is not only caused by increased tissue binding of BR but also--at least partially--attributable to decreased BR binding in serum.</p>","PeriodicalId":75407,"journal":{"name":"Acta paediatrica Scandinavica","volume":"77 4","pages":"496-501"},"PeriodicalIF":0.0,"publicationDate":"1988-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1651-2227.1988.tb10690.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13976999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-enzymatic glycation of fetal tissue in diabetic pregnancy. Estimation of the glucitollysine content of umbilical cord extracts.","authors":"A Pollak,&nbsp;H R Salzer,&nbsp;A Lischka,&nbsp;M Hayde","doi":"10.1111/j.1651-2227.1988.tb10687.x","DOIUrl":"https://doi.org/10.1111/j.1651-2227.1988.tb10687.x","url":null,"abstract":"<p><p>Non-enzymatic glycation of fetal tissue was studied by determining the glucitollysine content of umbilical cord extracts from twelve infants of diabetic mothers and fourteen infants of healthy, non-diabetic women (controls). The single, glycated amino-acid glycitollysine, which reflects the extent of glycation processes in biological samples, was measured by a standard amino acid ion exchange chromatography followed by reverse phase high pressure liquid chromatography. Infants of diabetic mothers had significantly higher cord glucitollysine levels than infants of control mothers (14.3 + 4.6 vs. 5.5 + 2.1 ng/mg dry tissue; M + SD, p less than 0.001). Moreover, five infants of diabetic mothers with congenital anomalies had strikingly high glucitollysine levels, higher than the mean +4 SD of the controls. We conclude, that non-enzymatic glycation of fetal tissue does occur as a result of an in utero exposure to cumulative glycemia. Major congenital anomalies in diabetic pregnancies are associated with a greater extent of non-enzymatic glycation of umbilical cord tissue.</p>","PeriodicalId":75407,"journal":{"name":"Acta paediatrica Scandinavica","volume":"77 4","pages":"481-4"},"PeriodicalIF":0.0,"publicationDate":"1988-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1651-2227.1988.tb10687.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14266573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glycogen storage disease type I and III and pyruvate carboxylase deficiency: results of long-term treatment with uncooked cornstarch.","authors":"K Ullrich,&nbsp;H Schmidt,&nbsp;A van Teeffelen-Heithoff","doi":"10.1111/j.1651-2227.1988.tb10695.x","DOIUrl":"https://doi.org/10.1111/j.1651-2227.1988.tb10695.x","url":null,"abstract":"ABSTRACT. Three patients with glycogen storage disease type I (GSD‐I), three with glycogen storage disease type III (GSD‐III) and one with pyruvate carboxylase deficiency (PCD) could be successfully switched over from continuous nocturnal gastric drip feeding (GDF) to nocturnal feeding with uncooked cornstarch in yoghurt or “quark” (CSF) at the age of 4–20 years. The new kind of therapy is much more convenient for the patients. When followed up to 30 months, patients on CSF showed the same clinical and laboratory findings as during the last two years with GDF. CSF was not introduced to three patients with GSD‐I. Two of them refused the permanent starch‐yoghurt meals. In the third patient the morning blood glucose concentrations were too variable.","PeriodicalId":75407,"journal":{"name":"Acta paediatrica Scandinavica","volume":"77 4","pages":"531-6"},"PeriodicalIF":0.0,"publicationDate":"1988-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1651-2227.1988.tb10695.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14266574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antivenom treatment in snake bites.","authors":"V Curro,&nbsp;A Stabile,&nbsp;V Michetti","doi":"10.1111/j.1651-2227.1988.tb10707.x","DOIUrl":"https://doi.org/10.1111/j.1651-2227.1988.tb10707.x","url":null,"abstract":"","PeriodicalId":75407,"journal":{"name":"Acta paediatrica Scandinavica","volume":"77 4","pages":"597-8"},"PeriodicalIF":0.0,"publicationDate":"1988-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1651-2227.1988.tb10707.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14519735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association of supernumerary microtubules and immotile cilia syndrome and defective neutrophil chemotaxis.","authors":"M Canciani,&nbsp;E G Barlocco,&nbsp;G A Cazzola,&nbsp;G Mastella,&nbsp;M M de Santi,&nbsp;C Gardi,&nbsp;G Lungarella","doi":"10.1111/j.1651-2227.1988.tb10712.x","DOIUrl":"https://doi.org/10.1111/j.1651-2227.1988.tb10712.x","url":null,"abstract":"Several ciliary defects are associated with poor motility or immotility of respiratory cilia. The defects include abnormalities in the axonemal structures or in the basal apparatus (1). Patients suffering from immotile cilia syndrome (ICS) show a heterogeneous clinical disease in which respiratory symptoms (viz. bronchiectasis, chronic bronchitis, otitis media) related to the ciliary dysfunction may be associated with other pathological conditions (i.e. situs viscerum inversus and male infertility). Even if numerous studies in humans and in experimental animals provide more information to explain, a t molecular level, the association between ICS and the above mentioned pathological states, to date, the association between ICS and a defective neutrophil chemotaxis is still object of debate (2). This report deals with four unrelated female patients (aged from 7 to 20 years) suffering from ICS in which a peculiar defect in ciliary configuration was found to be associated with a defective neutrophil chemotaxis. ICS was diagnosed by studying the mucociliary clearance and by examining the ultrastructural morphology of nasal cilia. Nasal mucociliary clearance time was tested by the saccharin method, measuring the time between placing saccharin (1 mm diameter particle) on the inferior turbinate and the moment when the subject tasted its sweetness on swallowing (3). Neutrophil chemotaxis was assessed, in symptom-free periods, “in vivo” and “in vitro” according to Senn (4) and Wilkinson ( 5 ) , respectively. In all patients immunological data were normal, whereas “in vivo” (36.1-17.6-15.9-16.1 x 10’ cells/cm2/24 h; normal values 68+ 10) and “in vitro” (chemotactic index: 121-123-119-1 13; normal values 145+ 11) neutrophil chemotaxis was impaired. The saccharin test (two or more different evaluations for each subject) was abnormal in all patients. In particular the clearance time (reference values 8-30 min) was >60 min in 3 patients, and about 50 min in one of the patients (50-52-55 min). The ultrastructural examination of respiratory cilia showed in all patients the presence of additional solitary peripheral microtubules outside or inside the 9+2 complex (Fig. 1). Cilia with axonemal supernumerary microtubules are reported to be associated to a ciliary dyskinesia (actually those cilia are classified as type V dyskinetic cilia) (1). Although data reported by several authors showed that an impairment of neutrophil chemotaxis is not a constant feature in ICS, the data presented here strongly suggest that a defective neutrophil","PeriodicalId":75407,"journal":{"name":"Acta paediatrica Scandinavica","volume":"77 4","pages":"606-7"},"PeriodicalIF":0.0,"publicationDate":"1988-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1651-2227.1988.tb10712.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14519737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Congenital hypothyroid goiter and amiodarone.","authors":"D De Wolf,&nbsp;J De Schepper,&nbsp;H Verhaaren,&nbsp;M Deneyer,&nbsp;J Smitz,&nbsp;L Sacre-Smits","doi":"10.1111/j.1651-2227.1988.tb10717.x","DOIUrl":"https://doi.org/10.1111/j.1651-2227.1988.tb10717.x","url":null,"abstract":"<p><p>Amiodarone is an anti-arrhythmic drug with a content of 39% Iodine. No adverse effects on fetal thyroid function have previously been observed with maternal ingestion of Amiodarone during pregnancy. A case of severe congenital hypothyroidism with goiter, associated with maternal ingestion of 200 mg Amiodarone daily from the 13th week of pregnancy, is described here. No other environmental causes of goiter, nor a congenital organic thyroid disorder could be demonstrated.</p>","PeriodicalId":75407,"journal":{"name":"Acta paediatrica Scandinavica","volume":"77 4","pages":"616-8"},"PeriodicalIF":0.0,"publicationDate":"1988-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1651-2227.1988.tb10717.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14519741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}