Acta paediatrica Scandinavica最新文献

{"title":"Neonatal cyanosis, methaemoglobinaemia and haemolytic anaemia.","authors":"S Menahem","doi":"10.1111/j.1651-2227.1988.tb10744.x","DOIUrl":"https://doi.org/10.1111/j.1651-2227.1988.tb10744.x","url":null,"abstract":"The early and correct diagnosis of t he cause of neonatal cyanosis is a medical emergency, particularly if t he infant develops increasing acidosis and low arterial oxygenation. Rarely acquired methaemoglobinaemia may be the cause which, once diagnosed, may readily b e treated with the infusion of the reducing agent methylene blue (1). Occasionally, however, the treatment itself may have consequences, namely haemolytic aneamia and/or cyanosis ( 2 4 ) . The former, if severe enough, may entail an exchange transfusion for increasing hyperbilirubinaemia. Two infants are described. They developed methhaemoglobinaemia from an inadvertent injection of prilocaine hydrochloride (Citanest). They responded well t o methylene blue, though one developed severe jaundice. Case I . A boy, delivered normally at term, with an Apgar of 8 at 1 min and 10 at 5 min. By 2 hours he had become pale and dusky and by 3 hours he was quite blue with mild tachypnoea. His pulse was normal, there were no murmurs and his chest was clinically clear. Blood gases done with the infant in air and 90% ambient oxygen revealed a normal pH and Paco, levels and a Pao2 of 55 and 236 mmHg, respectively. Chest X-rays and electrocardiograph were normal and the haemoglobin was 143 gll. The infant remained grey-blue despite oxygen, and a blood spot on filter paper took on a brown-chocolate colour. Methaemoglobinaemia was diagnosed clinically and subsequently confirmed by spectral absorption peaks constituting 39% of the haemoglobin. An echocardiogram showed a structurally normal heart. Four mg of diluted methylene blue (approximately 1 mg/kg-birthweight 3650 g) was given intravenously over 5 min with a dramatic resolution of the cyanosis over the next 15-30 min. The infant did well and was discharged with its mother. Careful examination of the infant’s scalp revealed a tiny abrasion which was thought to be due to a needle prick. It was considered that the baby had inadvertently been injected with prilocaine hydrochloride when the mother’s perineum was injected prior to the episiotomy. Case 2. A boy, Baby A was delivered normally at term with an Apgar of 10 at 1 min and at 5 min. Within an hour he was slightly dusky and was quite blue when seen at 2 hours. He was otherwise normal where examined. Blood gases taken with the infant in air and 90% ambient oxygen revealed a normal pH and Paco, levels and a Pao2 of 86 mmHg, and 372 mmHg, respectively. Chest X-ray and electrocardiograph were normal and a filter paper test was again suggestive of methaemoglobinaemia. Four mg of methylene blue was given slowly i.v. (birthweight 3860 g), the colour of the infant returned to normal within half an hour. By the next day, however, the infant had become increasingly jaundiced. His serum bilirubin measured 309 mmol/l on day 3, at which time phototherapy was commenced. No incompatibility was noted on a direct Coombs’ test and a glucose-6-phosphate dehydrogenase screen was negative. By the 4th day the serum bili","PeriodicalId":75407,"journal":{"name":"Acta paediatrica Scandinavica","volume":"77 5","pages":"755-6"},"PeriodicalIF":0.0,"publicationDate":"1988-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1651-2227.1988.tb10744.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14333082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral biotin treatment is effective for atopic dermatitis in children with low biotinidase activity.","authors":"Y Iikura, Y Odajima, T Nagakura, K Iinuma, K Hayakawa, J Oizumi","doi":"10.1111/j.1651-2227.1988.tb10748.x","DOIUrl":"https://doi.org/10.1111/j.1651-2227.1988.tb10748.x","url":null,"abstract":"Clinical features of biotinidase deficiency in childhood are highlighted by various neurological and cultaneous manifestations (1, 2). The skin changes are indistinguishable from those of atopic dermatitis, however, they respond to biotin treatment (3) . We describe four patients with atopic dermatitis who were found to have low serum biotinidase activity and in whom oral biotin led to a dramatic improvement of the skin lesions.","PeriodicalId":75407,"journal":{"name":"Acta paediatrica Scandinavica","volume":"77 5","pages":"762-3"},"PeriodicalIF":0.0,"publicationDate":"1988-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1651-2227.1988.tb10748.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14333086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain atrophy with intracranial calcification following congenital HIV infection.","authors":"P A Tovo,&nbsp;C Gabiano,&nbsp;S Favro-Paris,&nbsp;E Palomba,&nbsp;G Gajno","doi":"10.1111/j.1651-2227.1988.tb10752.x","DOIUrl":"https://doi.org/10.1111/j.1651-2227.1988.tb10752.x","url":null,"abstract":"<p><p>An 18-month-old girl with AIDS related complex following congenital HIV infection suffered since the first days of life from severe neurological disturbances. The extensive congenital brain atrophy and the diffuse intracranial calcification which were found were strongly reminiscent of intrauterine infection. Since the agents usually responsible for congenital infections were excluded an HIV embryopathy appears likely.</p>","PeriodicalId":75407,"journal":{"name":"Acta paediatrica Scandinavica","volume":"77 5","pages":"776-9"},"PeriodicalIF":0.0,"publicationDate":"1988-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1651-2227.1988.tb10752.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14332095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Iatrogenic intraspinal epidermoid tumour.","authors":"V Ersbak,&nbsp;N Hobolth","doi":"10.1111/j.1651-2227.1988.tb10746.x","DOIUrl":"https://doi.org/10.1111/j.1651-2227.1988.tb10746.x","url":null,"abstract":"","PeriodicalId":75407,"journal":{"name":"Acta paediatrica Scandinavica","volume":"77 5","pages":"759"},"PeriodicalIF":0.0,"publicationDate":"1988-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1651-2227.1988.tb10746.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14333084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low plasma levels of vitamin A and E during weight reduction.","authors":"K Zwiauer,&nbsp;K Widhalm,&nbsp;G Brubacher","doi":"10.1111/j.1651-2227.1988.tb10747.x","DOIUrl":"https://doi.org/10.1111/j.1651-2227.1988.tb10747.x","url":null,"abstract":"Current knowledge and the growing awareness of adverse consequences of human obesity to health has resulted in a frequent use of different weight reducing regimes within the last years. Much attention has been paid in the past to the effect of weight reduction on atherosclerotic risk factors and numerous reports have been published regarding protein and carbohydrate metabolism in obese subjects. Very few studies have evaluated the vitamin status of patients undergoing rapid and/or longterm weight reduction, particularly in grossly obese children and adolescents (1, 2).","PeriodicalId":75407,"journal":{"name":"Acta paediatrica Scandinavica","volume":"77 5","pages":"760-1"},"PeriodicalIF":0.0,"publicationDate":"1988-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1651-2227.1988.tb10747.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14333085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Venous thrombosis associated with lupus anticoagulant and anticardiolipin antibodies.","authors":"P Pelkonen,&nbsp;O Simell,&nbsp;V Rasi,&nbsp;O Vaarala","doi":"10.1111/j.1651-2227.1988.tb10750.x","DOIUrl":"https://doi.org/10.1111/j.1651-2227.1988.tb10750.x","url":null,"abstract":"<p><p>We describe deep vein thrombosis associated with lupus anticoagulant and anticardiolipin antibodies in three children aged 10 to 14 years. One of them also had arterial thromboses. None of the patients had systemic lupus erythematosus when the thrombosis first occurred, but one fulfilled the criteria for systemic lupus erythematosus 3 years later. At presentation all had symptoms suggestive of pulmonary embolism and evidence of an autoimmune disease: Addison's disease in one, anti-DNA or antinuclear antibodies in all three, and a positive Coombs' test in two. Two of the three gave a false-positive test for syphilis. In the patient with systemic lupus erythematosus recurrent thrombocytopenia and severe haemolytic anaemia necessitated splenectomy. A child should be tested for lupus anticoagulant or anticardiolipin antibody if venous or arterial occlusion occurs without a known predisposing cause, or if there is pulmonary embolism or symptoms or laboratory findings suggestive of a connective tissue disease.</p>","PeriodicalId":75407,"journal":{"name":"Acta paediatrica Scandinavica","volume":"77 5","pages":"767-72"},"PeriodicalIF":0.0,"publicationDate":"1988-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1651-2227.1988.tb10750.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14276155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A double-blind clinical trial on diphenhydramine in pertussis.","authors":"A Danzon,&nbsp;J Lacroix,&nbsp;C Infante-Rivard,&nbsp;L Chicoine","doi":"10.1111/j.1651-2227.1988.tb10716.x","DOIUrl":"https://doi.org/10.1111/j.1651-2227.1988.tb10716.x","url":null,"abstract":"Patients were prospectively included in the study if they were younger than 12 months of age, if nurses noted characteristic whooping spells, and if the cases were not treated with steroids. Randomization and allocation of treatment followed a double-blind pattern, according to a list determined by the ParkeDavis Company from a table of random numbers. The hospital pharmacy was responsible for the assignment of patients to the treatment groups. The following baseline data were measured: age at entry, previous vaccination for pertussis, interval between the first paroxysm and hospitalization, concomitant administration of erythromycin, and presence of an opacity on chest radiography. Since patients were included in the trial at different stages of their disease, the number of fits during the 24 hours preceding the introduction of drug or placebo was measured as an indicator of the severity of disease at time zero. Systematic laboratory tests included white blood cell count, lymphocyte count, glycemia, chest radiography, viral serology, and three nasopharyngeal cultures for B. pertussis. Paired serum specimen, obtained at least two-weeks apart, were tested for complement fixing antibody to adenovirus, influenza, parainfluenza and respiratory syncitial virus. Appearance, smell, and taste of active and placebo syrups were similar. Patients in the experimental group received 5 mg/kg/day of the active drug in three doses. The outcome was the frequency of paroxysms between the 25th and the 48th hour after initiation of treatment. Monitoring was similar for all patients. Coughs were monitored around the clock with a system of microphones set up in each room. All patients were fed with frequent small meals. None received sedatives or humidity. The average number of fits per day was compared with a Student's t-test. A dummy regression analysis was used to test the hypothesis that the slopes for the compared groups were parallel (no interaction between prognostic factors and treatment). Having accepted that the slopes were parallel, the mean number of fits per day was compared in the two groups, adjusting for baseline data and the number of fits during the 24 hours preceding entry into the trial. Results were considered as significant for p<0.05. The smallest detectable difference between the two groups, given the sample size, was estimated using a formula suggested by Lachin (1). Informed consent was obtained from a parent or a guardian for each patient. The study was approved by the Ethics Committee of Sainte-Justine Hospital.","PeriodicalId":75407,"journal":{"name":"Acta paediatrica Scandinavica","volume":"77 4","pages":"614-5"},"PeriodicalIF":0.0,"publicationDate":"1988-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1651-2227.1988.tb10716.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14421648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal analysis of infantile growth in children with celiac disease.","authors":"J Karlberg,&nbsp;J I Henter,&nbsp;E Tassin,&nbsp;B S Lindblad","doi":"10.1111/j.1651-2227.1988.tb10693.x","DOIUrl":"https://doi.org/10.1111/j.1651-2227.1988.tb10693.x","url":null,"abstract":"<p><p>The aim of the present study was to describe linear growth of infants with celiac disease, using the \"ICP-growth model\". Supine length during the first three years of life was studied longitudinally in 63 infants with diagnosed celiac disease. \"Undisturbed\" linear growth was seen during the first six postnatal months followed by reduced growth during the second half of the first year. After 1.5 years of age a pattern of catch-up growth was observed, leading to an average attained length at 3 years of age similar to that of the controls. According to the \"ICP-growth model\", normal linear growth can mathematically be represented during the first 3 years of life by an Infancy component with the addition of a Childhood component, the latter acting from the second half of the first postnatal year. The onset of the Childhood component (assumed to represent the age at which growth hormone begins to influence linear growth significantly) was delayed by about an average of 3 months, which is in agreement with the observed reduction in gain during the second half of the first year of life. Children suffering from celiac disease and with \"late\" onset of the Childhood component were shorter at 1, 2 and 3 years of age than those with \"normal\" onset. The results of this investigation show that ICP-based growth charts are helpful in detecting and monitoring growth for children with celiac disease, and indicate a possible mechanism whereby malabsorption (and perhaps secondary malnutrition) leads to reduced growth velocity.</p>","PeriodicalId":75407,"journal":{"name":"Acta paediatrica Scandinavica","volume":"77 4","pages":"516-24"},"PeriodicalIF":0.0,"publicationDate":"1988-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1651-2227.1988.tb10693.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14519747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma lipid and apolipoprotein levels in children hereditarily predisposed to coronary heart disease.","authors":"N Perova,&nbsp;H Aingorn,&nbsp;V Metelskaya,&nbsp;T Dorofeeva,&nbsp;N Belokonj","doi":"10.1111/j.1651-2227.1988.tb10700.x","DOIUrl":"https://doi.org/10.1111/j.1651-2227.1988.tb10700.x","url":null,"abstract":"<p><p>Plasma lipids and apoproteins A-I, A-II and B levels were measured in 125 children whose fathers had coronary atherosclerosis (paternal coronary heart disease group), in 172 children with blood pressure lability and in 154 children selected at random from a representative subsample (reference). The paternal coronary heart disease group had, compared with the reference group, lower levels of high density lipoprotein cholesterol and apoprotein A-I, higher levels of low density lipoprotein cholesterol, triglycerides and apoprotein B, and also a higher ratio of apoprotein B to apoprotein A-I. The paternal coronary heart disease group subjects with blood pressure lability had the most pronounced changes in the lipoprotein spectrum, which were similar to atherogenic changes in the lipoprotein profile, characteristic of patients with coronary atherosclerosis.</p>","PeriodicalId":75407,"journal":{"name":"Acta paediatrica Scandinavica","volume":"77 4","pages":"559-62"},"PeriodicalIF":0.0,"publicationDate":"1988-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1651-2227.1988.tb10700.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14519750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulmonary resection for localized bronchiectasis in cystic fibrosis. Report of three cases and review of the literature.","authors":"G Steinkamp,&nbsp;H von der Hardt,&nbsp;H J Zimmermann","doi":"10.1111/j.1651-2227.1988.tb10702.x","DOIUrl":"https://doi.org/10.1111/j.1651-2227.1988.tb10702.x","url":null,"abstract":"<p><p>Three children with cystic fibrosis and localized bronchiectasis were treated by surgical removal of the affected lobe, after attempts to clear the obstructed bronchus by medical therapy and bronchoscopy with suction and lavage had been unsuccessful. Three to six years after surgery, the results are excellent. Pulmonary disease is mild in all patients, shown by chest radiographs and pulmonary function tests. A review of 102 cases reported in the literature demonstrates that pulmonary surgery is effective and can be performed safely in selected patients.</p>","PeriodicalId":75407,"journal":{"name":"Acta paediatrica Scandinavica","volume":"77 4","pages":"569-75"},"PeriodicalIF":0.0,"publicationDate":"1988-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1651-2227.1988.tb10702.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14519752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}