Acta orthopaedica Scandinavica最新文献

{"title":"High local concentrations without systemic adverse effects after impaction of netilmicin-impregnated bone.","authors":"Eivind Witsø,&nbsp;Leif Persen,&nbsp;Pål Benum,&nbsp;Arild Aamodt,&nbsp;Otto Schnell Husby,&nbsp;Kåre Bergh","doi":"10.1080/00016470410001295","DOIUrl":"https://doi.org/10.1080/00016470410001295","url":null,"abstract":"<p><strong>Background: </strong>When cancellous bone is impregnated with antibiotics the subsequent release of antibiotics from the bone shows a high early release. Hence, impaction of large amounts of netilmicin-impregnated bone may cause toxic netilmicin values in serum.</p><p><strong>Patients and methods: </strong>We studied kidney and otovestibular function after impacting 50 g of netilmicin-impregnated cancellous bone during revision hip or knee arthroplasty in 20 patients. The bone was impacted in the acetabulum (n = 8), proximal femur (n = 9) and distal femur/proximal tibia (n = 3). Serum creatinine concentration was measured and audiometry was performed before and after the operation. Netilmicin concentrations in serum, joint fluid, and in urine were recorded postoperatively at regular intervals. We analyzed pharmacokinetics in two study groups receiving bone impregnated with netilmicin (50 mL), at either 50 mg netilmicin/mL (group I) or 100 mg netilmicin/mL (group II).</p><p><strong>Results: </strong>Neither netilmicin-induced renal toxicity, nor otovestibular toxicity was registered. Peak serum netilmicin values in group I and group II were 0.9 (0.5-1.3) mg/L and 1.8 (0.6-4.0) mg/L, respectively (p = 0.04). Peak netilmicin concentrations in wound drainage fluid in group I and group II were 237 (9-647) mg/L and 561 (196-1132) mg/L, respectively (p = 0.01). In both groups, netilmicin was recovered in urine samples for approximately 4 weeks.</p><p><strong>Interpretation: </strong>50 grams of cancellous bone impregnated with 100 mg/mL netilmicin solution was impacted in the hip or knee joint with no adverse effects. Extremely high local concentrations of netilmicin in joint fluid were recorded postoperatively. The use of antibioitic-impregnated cancellous could be an option when performing revision of hip and knee prostheses.</p>","PeriodicalId":75403,"journal":{"name":"Acta orthopaedica Scandinavica","volume":"75 3","pages":"339-46"},"PeriodicalIF":0.0,"publicationDate":"2004-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/00016470410001295","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24620585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new CT method for measuring cup orientation after total hip arthroplasty: a study of 10 patients.","authors":"Henrik Olivecrona,&nbsp;Lars Weidenhielm,&nbsp;Lotta Olivecrona,&nbsp;Mats O Beckman,&nbsp;André Stark,&nbsp;Marilyn E Noz,&nbsp;Gerald Q Maguire,&nbsp;Michael P Zeleznik,&nbsp;Lars Svensson,&nbsp;Torbjörn Jonson","doi":"10.1080/00016470410001169","DOIUrl":"https://doi.org/10.1080/00016470410001169","url":null,"abstract":"<p><strong>Background: </strong>It is difficult to assess the orientation of the acetabular component on routine radiographs. We present a method for determining the spatial orientation of the acetabular component after total hip arthroplasty (THA) using computed tomography.</p><p><strong>Patients and methods: </strong>Two CT-scans, 10 min apart, were obtained from each of 10 patients after THA. Using locally developed software, two independent examiners measured the orientation of the acetabular component in relation to the pelvis. The measurements were repeated after one week. To be independent of the patient position during scanning, the method involved two steps. Firstly, a 3D volumetric image of the pelvis was brought into a standard pelvic orientation, then the orientation of the acetabular component was measured. The orientation of the acetabular component was expressed as operative anteversion and inclination relative to an internal pelvic reference coordinate system. To evaluate precision, we compared measurements across pairs of CT volumes between observers and trials.</p><p><strong>Results: </strong>Mean absolute interobserver angle error was 2.3 degrees for anteversion (range 0-6.6 degrees), and 1.1 degrees for inclination (range 0-4.6 degrees). For interobserver measurements, the precision, defined as one standard deviation, was 2.9 degrees for anteversion, and 1.5 degrees for inclination. A Student's t-test showed that the overall differences between the examiners, trials, and cases were not significant. Data were normally distributed and were not dependent on examiner or trial.</p><p><strong>Interpretation: </strong>We conclude that the implant angles of the acetabular component in relation to the pelvis could be detected repeatedly using CT, independently of patient positioning.</p>","PeriodicalId":75403,"journal":{"name":"Acta orthopaedica Scandinavica","volume":"75 3","pages":"252-60"},"PeriodicalIF":0.0,"publicationDate":"2004-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/00016470410001169","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24619552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Catastrophic failure of an uncemented acetabular component due to high wear and osteolysis: an analysis of 154 omnifit prostheses with mean 6-year follow-up.","authors":"Thord von Schewelov,&nbsp;Lennart Sanzén,&nbsp;Ingemar Onsten,&nbsp;Ake Carlsson","doi":"10.1080/00016470410001213","DOIUrl":"https://doi.org/10.1080/00016470410001213","url":null,"abstract":"<p><strong>Background: </strong>The purposes of this study were (1) to evaluate the wear pattern of the hydroxyapatite-coated \"Dual Radius\" Omnifit cup, (2) to investigate whether wear is correlated to any demographic or prosthesis-related factors, and (3) to describe micromotion of both the cup and the stem.</p><p><strong>Patients and methods: </strong>154 hips were implanted between 1990 and 1996 and followed for an average of 6 years. Wear was measured according to the \"Charnley-duo\" method and, in 79 hips, with radiostereometry IRSA). RSA was also used to evaluate micromotion. We analyzed the femoral heads using scanning electron microscopy, energy dispersive X-ray spectroscopy and an atomic force microscope.</p><p><strong>Result: </strong>66 cups were revised and had a mean annual wear of 0.32 mm compared to 0.12 mm in hips not revised. Osteolytic processes were observed in 35 hips but at revision osteolysis was present in 51 cases. 43/66 sockets were loose. Micromotion evaluated by RSA, weight, age, side, size of cup, screws, polyethylene thickness or shelf-life of the polyethylene did not correlate to wear, whereas male gender did.</p><p><strong>Interpretation: </strong>It is still unclear why about half of our cases had an abnormal wear rate. Annual wear exceeding 0.2 mm is prognostic of late failure and should be considered a warning sign.</p>","PeriodicalId":75403,"journal":{"name":"Acta orthopaedica Scandinavica","volume":"75 3","pages":"283-94"},"PeriodicalIF":0.0,"publicationDate":"2004-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/00016470410001213","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24619557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low accuracy of stem implantation in THR using the CASPAR-system: anteversion measurements in 10 hips.","authors":"Farhad Mazoochian,&nbsp;Christoph Pellengahr,&nbsp;Armin Huber,&nbsp;Jörn Kircher,&nbsp;Hans Jürgen Refior,&nbsp;Volkmar Jansson","doi":"10.1080/00016470410001178","DOIUrl":"https://doi.org/10.1080/00016470410001178","url":null,"abstract":"<p><p>We studied 10 patients by means of pre- and postoperative CT who underwent computer-assisted total hip replacement using the CASPAR-system (OrthoMaquet GmbH, Rastatt, Germany). The anteversion angles of the stem and translational deviations measured after surgery were compared to the preoperatively planned ones as a quality control. We found an average difference of 7.8 degrees (SD 6.3 degrees; 95% CI 3.3 degrees-12.3 degrees) in the angles and an average difference of 1.8 (SD 1.7; 95% CI 0.6-3.0) mm and 1.2 (SD 1.4: 95% CI 0.25-2.2), respectively, in the medial and lateral deviation. In conclusion, we could not confirm the same accuracy of implant position as that claimed by the manufacturer.</p>","PeriodicalId":75403,"journal":{"name":"Acta orthopaedica Scandinavica","volume":"75 3","pages":"261-4"},"PeriodicalIF":0.0,"publicationDate":"2004-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/00016470410001178","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24619553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of polyethylene and TiAlV wear particles on expression of RANK, RANKL and OPG mRNA.","authors":"Bernd Baumann,&nbsp;Christof P Rader,&nbsp;Jochen Seufert,&nbsp;Ulrich Nöth,&nbsp;Olaf Rolf,&nbsp;Jochen Eulert,&nbsp;Franz Jakob","doi":"10.1080/00016470410001222","DOIUrl":"https://doi.org/10.1080/00016470410001222","url":null,"abstract":"<p><strong>Background: </strong>Wear debris has been associated with periprosthetic osteolysis and loosening of total joint arthroplasties. RANKL (receptor activator of NF-kappaB ligand), RANK (receptor activator of NF-kappaB) and OPG (osteoprotegerin) are three key molecules which regulate differentiation, survival, fusion, and activation of osteoclasts.</p><p><strong>Material and methods: </strong>We evaluated the effect of TiAIV and polyethylene particles on expression of RANK, RANKL and OPG mRNA. We used a human monocytic leukemic cell line (THP-1) in this in vitro study. THP-1 monocytes were differentiated into macrophage-like cells and exposed to polyethylene particles and prosthesis-derived TiAIV particles. The supernantant was used for measurement of TNFalpha protein and total RNA was extracted from the cells. Expression of the genes coding for OPG, RANKL and RANK was analysed at the mRNA level using a semiquantitative RT-PCR method.</p><p><strong>Results: </strong>Both polyethylene and TiAIV particles induced a significant release of TNFalpha after 6 h of exposure and a significant upregulation of RANK mRNA. OPG mRNA expression was transiently upregulated after exposure to polyethylene and TiAIV particles. These effects were dependent on particle dose. RANKL mRNA was not detectable in our THP-1 model. In contrast, LPS exhibited a different pattern of RANK/ RANKL/OPG mRNA expression.</p><p><strong>Interpretation: </strong>Our findings provide evidence that both polyethylene and TiAIV particles induce upregulation of RANK expression in cells of the monocytic lineage, which may be important for periprosthetic osteoclastogenesis.</p>","PeriodicalId":75403,"journal":{"name":"Acta orthopaedica Scandinavica","volume":"75 3","pages":"295-302"},"PeriodicalIF":0.0,"publicationDate":"2004-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/00016470410001222","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24620578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Freeze-dried irradiated bone brittleness improves compactness in an impaction bone grafting model.","authors":"Olivier Cornu,&nbsp;Xavier Libouton,&nbsp;Bénédicte Naets,&nbsp;Bernard Godts,&nbsp;John Van Tomme,&nbsp;Christian Delloye,&nbsp;Xavier Banse","doi":"10.1080/00016470410001240","DOIUrl":"https://doi.org/10.1080/00016470410001240","url":null,"abstract":"<p><strong>Background: </strong>Defatted bone chips with or without freeze-drying and irradiation have mechanical advantages as compared to fresh-frozen controls in in vitro models of impaction. These improved results have been ascribed to replacement of viscous bone marrow by saline and embrittlement of the freeze-dried bone by irradiation.</p><p><strong>Material and methods: </strong>To determine which of these hypotheses is correct, we compared the development of stiffness and compactness of morselized bone graft that had been: 1) fat-reduced with saline, and 2) fresh-frozen, solvent-detergent defatted, 3) freeze-dried irradiated and 4) not irradiated. We used 12 osteoarthrotic femoral heads to prepare these four batches of morselized bone, and impacted 18 samples from each batch in a cylinder. The frozen bone grafts were tested after thawing at room temperature for 2 hours and the freeze-dried grafts were tested after 30 minutes of rehydration. We monitored the development of compactness and stiffness of the material during impaction.</p><p><strong>Results: </strong>The stiffness of the freeze-dried irradiated bone was greater than that of the other three series after 10, 50 and 150 impactions. The freeze-dried bone chips that were not irradiated and the chips defatted with saline alone were less stiff than the fresh-frozen control after 150 impactions.</p><p><strong>Interpretation: </strong>The brittleness of freeze-dried irradiated bone, caused by loss of the capacity to absorb energy in a plastic way, increases the compactness and stiffness of the morselized grafts. Washing bone with saline alone or treating bone with solvent-detergent but no irradiation had no similar mechanical advantage and the bone did not impact better than fresh-frozen undefatted bone in our model.</p>","PeriodicalId":75403,"journal":{"name":"Acta orthopaedica Scandinavica","volume":"75 3","pages":"309-14"},"PeriodicalIF":0.0,"publicationDate":"2004-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/00016470410001240","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24620580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic reasonance imaging of the surgically repaired meniscus: a 13-year follow-up study of 13 knees.","authors":"Franky Steenbrugge,&nbsp;Koenraad Verstraete,&nbsp;René Verdonk","doi":"10.1080/00016470410001268","DOIUrl":"https://doi.org/10.1080/00016470410001268","url":null,"abstract":"<p><strong>Background: </strong>This study was initiated to evaluate the long-term outcome of meniscal sutures and to correlate clinical findings with MRI findings. We were interested to see if a clinically healed meniscus also showed as such on MRI and if degenerative changes were present</p><p><strong>Patients and methods: </strong>We studied prospectively 13 patients (7 men) aged between 29 and 50 years, who had undergone closed meniscus repair between 1985 and 1988 using an inside-out technique, clinically and with MRI, with a mean follow-up time of 13 years.</p><p><strong>Results: </strong>Meniscal suture gave good clinical long-term results: all patients got a Hospital for Special Surgery score of more than 75%. In all patients the site of the previous suture was still visible on MRI, mainly from small metal artefacts in the meniscus. 4 of 7 patients with an unrepaired ACL lesion had signs of arthrosis and cartilage degeneration. MRI showed signs of mucoid degeneration or scar tissue in 6/13 of the patients.</p><p><strong>Interpretation: </strong>We believe that asymptomatic meniscal tears produce abnormal MR signals even though they have stable unions, and that MR signals at the site of repair represent edematous scar tissue, not true nonunions.</p>","PeriodicalId":75403,"journal":{"name":"Acta orthopaedica Scandinavica","volume":"75 3","pages":"323-7"},"PeriodicalIF":0.0,"publicationDate":"2004-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/00016470410001268","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24620582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Internet based counseling to remote orthopedic patients.","authors":"G Labiris,&nbsp;G Papadopoulis,&nbsp;G Lentaris,&nbsp;M Kafentzis,&nbsp;A Drakakis","doi":"10.1080/00016470410001349","DOIUrl":"https://doi.org/10.1080/00016470410001349","url":null,"abstract":"Copyright © Taylor & Francis 2004. ISSN 0001–6470. Printed in Sweden – all rights reserved. Sir—Internet-based counseling is a form of telemedicine that uses internet technology to inform or educate patients. We did a prospective study over 8 years to assess the efficiency of this type of counseling to underserved orthopaedic patients (Labiris et al. 2002). The patients could request information and professional advice on orthopedic matters via electronic mail. Their questions were answered by 31 physicians, including 18 consultant orthopaedic surgeons and general practitioners. The patients ̓ age, sex, residence, social situation, and medical/ orthopedic history were noted. The replies were given in everyday language. A quality-gap detection audit system monitored the service (Zeithaml et al. 1990). A seven-member expert committee supervised the scientific and ethical standards (Dyer 2001). Moreover, all cultural and religious differences in the various groups of patients were considered before answering the questions. The advisory role of the service was clarified and the importance of a physical examination and appropriate personal patient-doctor contact was emphasized. Between 1993 and 2001, 1,234 patients asked for advice: 747 were men (43 (18–77) years) and 487 women (55 (32–75) years). Most came from urban areas in USA, EU, Canada, and Australia (Table 1). Inaccessible patients requested counseling for various reasons: 611 wanted to evaluate Internet-based health services; 277 were not satisfied with their physician; 44 explicitly stated that the local medical services were inaccessible/ too expensive. Counseling was given to 1,021 patients (83%) (Table 2). The need for a physical examination and insufficient provision of medical data were the main reasons for failure to answer all requests. Apart from having their medical queries answered, a significant number of the inaccessible subjects participated in interactive educational sessions on common chronic diseases of the musculoskeletal system. During these sessions, groups of patients (i.e., with osteoporosis, rheumatoid arthritis) answered the available questionnaires and actively participated in internet-related “chats” in which the principal details of the relevant diseases were discussed—e.g., in the “osteoporosis” group, the importance of compliance to the physicians instructions and the need for dietary restrictions were strongly emphasized (Bourgon and Maillard 1998, Liel et al. 2001). The quality audit of the service was determined by attaching the electronic mails to predetermined questionnaires, in Likert-scale forms, concerning the quality dimensions of responsiveness, empathy, and reliability. In descending numerical order, these patients complained of the predictable delays of the service, language barriers (the service was available in English and German only), and the local availability of the Internet. However, almost all patients (> 90%) favored this type of counseling an","PeriodicalId":75403,"journal":{"name":"Acta orthopaedica Scandinavica","volume":"75 3","pages":"366-7"},"PeriodicalIF":0.0,"publicationDate":"2004-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/00016470410001349","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24621562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High osteolysis and revision rate with the hydroxyapatite-coated ABG hip prostheses: 65 hips in 56 young patients followed for 5-9 years.","authors":"Jan Blacha","doi":"10.1080/00016470410001204","DOIUrl":"https://doi.org/10.1080/00016470410001204","url":null,"abstract":"<p><strong>Background: </strong>There are few reports on the outcome of uncemented HA-coated cups in young patients.</p><p><strong>Patients: </strong>I evaluated the 7-year (5-9) results of HA-coated hip prosthesis (ABG, Stryker) in a consecutive series of 65 primary arthroplasties on 56 patients (mean age 44 years). 2 patients were lost to follow-up and 3 died.</p><p><strong>Results: </strong>The cumulative survival rate with revision for any reason as endpoint at 9 years was 98% (95% CI, 96-100) for the stem, 69% (61-77) for the acetabular metal backing, and 59% (50-67) for the polyethylene liner. 15 of 65 cups were revised on average 6 years after the primary operation and 3 more are planned. Revisions were done in 3 hips because of loosening and migration of the cup, and in 12 hips because of wear and progressive osteolysis around stable components. Only hips with migration had clinical symptoms. Visual inspection of polyethylene liners revealed wear of the articulation in all cases, loosening of the locking mechanism in 10 cases and nonarticular surface deformity in 7 hips. All original stems are in situ although femoral osteolysis was seen in 12 cases and 1 hip was reoperated because of periprosthetic traumatic fracture. Despite the high revision rate, the clinical improvement was good: the average pre- and postoperative Harris Hip Scores at the most recent follow-up were 41 and 90, respectively.</p><p><strong>Interpretation: </strong>While the results on the femoral side were good, the survival rates of the acetabular cups were poor and we stopped using ABG I hip prostheses.</p>","PeriodicalId":75403,"journal":{"name":"Acta orthopaedica Scandinavica","volume":"75 3","pages":"276-82"},"PeriodicalIF":0.0,"publicationDate":"2004-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/00016470410001204","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24619556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neck fracture femoral heads for impaction bone grafting: evolution of stiffness and compactness during impaction of osteoarthrotic and neck-fracture femoral heads.","authors":"Olivier Cornu,&nbsp;Olivier Manil,&nbsp;Bernard Godts,&nbsp;Bénédicte Naets,&nbsp;John Van Tomme,&nbsp;Christian Delloye,&nbsp;Xavier Banse","doi":"10.1080/00016470410001231","DOIUrl":"https://doi.org/10.1080/00016470410001231","url":null,"abstract":"<p><strong>Background: </strong>The need for safe bone allografts is increasing and preservation of femoral heads from patients being operated on with hip arthroplasty should be encouraged. However, should we preserve femoral heads from patients operated on for neck fracture as tissue mechanical quality may not be satisfactory?</p><p><strong>Material and methods: </strong>We compared the evolution of stiffness and compactness of fresh-frozen morselized bone obtained from osteoarthrotic femoral heads and those from neck fractures. Both materials were also compared after freeze-drying and irradiation. We used 6 osteoarthrotic and 6 neck-fracture femoral heads to prepare 4 batches of morselized bone. 18 samples from each batch were impacted in a contained cylinder. Frozen bone grafts were tested after thawing at room temperature for 2 hours and freeze-dried grafts were tested after 30 minutes of rehydration.</p><p><strong>Results: </strong>The stiffness of fresh-frozen neck fracture bone was lower than that of fresh-frozen osteoarthrotic bone at 150 impactions. The stiffness of freeze-dried irradiated bone was higher than that of the fresh-frozen bone and did not differ between osteoarthrotic and neck-fracture bone.</p><p><strong>Interpretation: </strong>Solvent-treated freeze-dried bone from femoral heads procured during arthroplasty for sub-capital hip fractures represents a valuable source of material for allografts, addressing concerns regarding serological testing, medical history and bone quality.</p>","PeriodicalId":75403,"journal":{"name":"Acta orthopaedica Scandinavica","volume":"75 3","pages":"303-8"},"PeriodicalIF":0.0,"publicationDate":"2004-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/00016470410001231","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24620579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}