Jingwei Cai, Ire Ju, Samuel Madden, Rylan Jones, Franklin Garcia-Godoy, Udochukwu Oyoyo, So Ran Kwon
{"title":"Assessment of correlation between the Modified Schirmer Test and unstimulated salivary flow testing.","authors":"Jingwei Cai, Ire Ju, Samuel Madden, Rylan Jones, Franklin Garcia-Godoy, Udochukwu Oyoyo, So Ran Kwon","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the efficacy and subjects' perception of the Modified Schirmer Test (MST) to the traditional Unstimulated Salivary Flow Test (USFT) when measuring salivary flow rate for screening and monitoring patients' dry mouth.</p><p><strong>Methods: </strong>A total of 100 subjects were enrolled including subjects with and without dry mouth. All subjects answered a brief self-reported survey about dry mouth before and after the two types of saliva tests and their preference for the type of test administered. The order of performing MST and USFT were randomized. MST was conducted by the clinician holding a Schirmer strip paper at the bottom of the subject's mouth for 1 minute. USFT was measured by having the subject spit any accumulating saliva into a medicine cup for 5 minutes. Correlation analyses were conducted to test the relationship between MST and USFT using the Pearson correlation coefficient. All analyses were performed at a P< 0.05.</p><p><strong>Results: </strong>A significant positive correlation existed between the two salivary flow tests (r= 0.556, P< 0.001). Most of the subjects (79%) preferred the MST while 6% preferred USFT; 15% reported no preference. A negative association between MST and USFT with age indicated that as age increased, subjects' salivary flow rate results for both types of tests decreased (r= - 0.287, P= 0.004).</p><p><strong>Clinical significance: </strong>MST provides dental care providers with an effective, economical, easy-to-perform, and patient-preferred method to screen and monitor salivary flow rate.</p>","PeriodicalId":7538,"journal":{"name":"American journal of dentistry","volume":"37 6","pages":"313-316"},"PeriodicalIF":0.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142942602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hardness, roughness, and compressive strength of different filled resin composites after thermal aging and bleaching procedures.","authors":"Seda Ü Aladağ","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the effect of aging and bleaching on the physico-mechanical properties of the different filled resin composites.</p><p><strong>Methods: </strong>Samples of resin composites [Arabesk (A), G-aenial Anterior (G), i-LIGHT N (I) and Palfique Estelite Paste (P) were first divided into two subgroups. Thermal aging was applied to half of the samples. Then, fresh and aged samples were divided into three subgroups (n= 8): control (C) (no treatment), office bleaching (O), home bleaching (H), thermal aging (T), thermal aging +office bleaching (TO) and thermal aging +home bleaching (TH). The microhardness (kg/mm²), surface roughness (µm), and compressive strength (MPa) values were measured. The data were analyzed with 3‑way ANOVA and Bonferroni post hoc pairwise comparison tests (P< 0.05).</p><p><strong>Results: </strong>T significantly decreased the hardness and increased the roughness of all the resin composites (P< 0.05). The compressive strength of all resin composites decreased after aging. O and H increased the roughness of the A, I and P (P< 0.001). H increased the microhardness of the G (P< 0.05).</p><p><strong>Clinical significance: </strong>Thermal aging and bleaching agents adversely affected the hardness, roughness, and compressive strength of the nonaged composites tested. Bleaching agents have less effect on the physico-mechanical properties of aged composites. Therefore, bleaching can be a safe and conservative esthetic treatment plan for patients who have long-standing composite restorations.</p>","PeriodicalId":7538,"journal":{"name":"American journal of dentistry","volume":"37 6","pages":"307-312"},"PeriodicalIF":0.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142942606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The effect of different beverages on the surface characteristics of PEEK and PEKK polymers.","authors":"Nuron Yanikoğlu, Nihan Kaya, Büşra Tosun, Zeynep Yeşil, Kamber Kaşali","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the effects of various beverages on surface roughness and microhardness of PEEK and PEKK polymers.</p><p><strong>Methods: </strong>Rectangular-shaped PEEK and PEKK polymers were fabricated and examined in the study. The specimens were immersed for 28 days at 37°C in red wine, coffee, and distilled water. The surface microhardness (Vickers microhardness tester) and roughness (profilometry) measurements of the polymers were performed before and after immersion. The Kolmogorov test was used to evaluate the normal distribution of the variables. Kruskal Wallis test was used to compare independent groups and Wilcoxon Signed Rank test was used to compare two dependent groups (P< 0.05).</p><p><strong>Results: </strong>Acidic beverages adversely affected the properties of the tested materials. The microhardness of tested materials was significantly decreased after immersion in the various beverages, whereas surface roughness was increased except for distilled water.</p><p><strong>Clinical significance: </strong>Removable partial dentures can be exposed to chemical agents found in acidic beverages either intermittently or continuously, and this may lead to chemical degradation and changes in surface properties of the denture framework. With the developments in dentistry, framework materials are also developing and diversifying. The clinical performance of PEEK and PEKK polymer-based frameworks is still uncertain.</p>","PeriodicalId":7538,"journal":{"name":"American journal of dentistry","volume":"37 6","pages":"293-296"},"PeriodicalIF":0.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142942608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Milk fat globule EGF and factor V/VIII domain containing-mediated osteoimmunology in periodontal disease.","authors":"Ruonan Zhang, Shuang Peng, Lili Chen, Guangxun Zhu","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>To review the literature on the relationship of milk fat globule EGF and factor V/VIII domain containing (MFGE8) in periodontal osteoimmunology and the clinical significance of MFGE8 in periodontal disease.</p><p><strong>Methods: </strong>Two reviewers carried out a computer-based literature search using PubMed, Scopus, and Web of Science to identify papers published up to November 2023. The keywords used in the investigation were \"MFGE8\" and various words related to periodontal disease (periodontal, periodontitis, gingival, gingivitis, gingiva, and periodontium).</p><p><strong>Results: </strong>MFGE8 plays a critical role in the etiology of periodontal disease via regulating pro-inflammatory cytokines and bone cells. In addition, MFGE8 may be applied as a diagnostic biomarker and a therapeutic target in periodontal disease.</p><p><strong>Clinical significance: </strong>MFGE8-mediated periodontal osteoimmunology fills the vacant part of the pathogenesis in periodontal disease. This review provides a comprehensive perspective on the potential of MFGE8 in periodontal disease therapy.</p>","PeriodicalId":7538,"journal":{"name":"American journal of dentistry","volume":"37 5","pages":"237-243"},"PeriodicalIF":0.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142339254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yong-Shin Hong, Soyeon Kim, Franklin Garcia-Godoy, Young-Seok Park
{"title":"Current landscape of research on whitening toothpastes and their effects on dental hard tissue.","authors":"Yong-Shin Hong, Soyeon Kim, Franklin Garcia-Godoy, Young-Seok Park","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>To explore the latest trends in research on whitening toothpaste and to present the issues and future perspectives of these studies.</p><p><strong>Methods: </strong>An initial PubMed search was performed, followed by a meticulous manual review. A total of 543 papers were initially retrieved, and 54 final research papers were selected and analyzed through a manual review.</p><p><strong>Results: </strong>The number of studies on whitening toothpastes has significantly increased, and while initial studies primarily focused on the efficacy of various whitening toothpastes, recent studies have shifted towards investigating the potential effects on dental hard tissues such as enamel and dentin. Common active ingredients used in these whitening toothpastes include hydrogen peroxide, activated charcoal, and blue covarine. Most studies have used commercial toothpastes with fixed ingredients rather than experimentally manufactured toothpaste, and it was noted that toothpastes from specific major manufacturers were frequently used.</p><p><strong>Clinical significance: </strong>Whitening toothpastes should be treated as separate entities based on their active ingredients, and more standardized experimental designs are required for better comparisons. Accurate analysis and labeling of other components of toothpaste are also essential.</p>","PeriodicalId":7538,"journal":{"name":"American journal of dentistry","volume":"37 5","pages":"223-229"},"PeriodicalIF":0.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142339250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ozge Çeliksöz, Hatice Tepe, Batu C Yaman, Zeynep Dikmen, Fusun Ozer
{"title":"The effect of a universal cleaning agent on the bonding performance of a self-adhesive cement to contaminated dentin surfaces.","authors":"Ozge Çeliksöz, Hatice Tepe, Batu C Yaman, Zeynep Dikmen, Fusun Ozer","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>This study examined the effect of using KATANA Cleaner (KC) containing 10-methacryloyloxydecyl dihydrogen phosphate (MDP) salt on the micro-shear bond strength (µSBS) of a self-adhesive cement to uncontaminated and contaminated dentin.</p><p><strong>Methods: </strong>Dentin samples were categorized into four contamination conditions (no contamination, saliva, blood, saliva/blood mixed) and subjected to two decontamination methods (water rinse and KC use), forming eight groups. Scanning electron microscope images representing each group were obtained. One sample representing each group was analyzed by Raman Spectroscopy. Composite resin was bonded to the sample dentin surfaces with a self-adhesive resin cement. After 5,000 thermal cycles, the µSBS test was performed. The data were analyzed statistically (α= 0.05).</p><p><strong>Results: </strong>The lowest µSBS value was observed in the water-rinsed mixed contamination group, while the highest was in the KC-treated uncontaminated group. KC-treated groups exhibited significantly higher µSBS values compared to water-rinsed groups for each contamination type (P< 0.05), indicating the efficacy of KC in enhancing bond strength.</p><p><strong>Clinical significance: </strong>There are limited studies using the new MDP salt-containing cleaner on dentin. In this study, contamination of dentin tissue with saliva, blood, and saliva/blood mixture was simulated and the effects of water rinsing and MDP salt-containing cleaner (KATANA Cleaner) on bond strength were tested as decontamination methods. The results showed that the use of a cleaner containing MDP salt increased the bond strength to dentin tissue under both non-contaminated and contaminated conditions.</p>","PeriodicalId":7538,"journal":{"name":"American journal of dentistry","volume":"37 5","pages":"230-236"},"PeriodicalIF":0.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142339255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ashley N Bowers, Christina M Tyrakowski, Yukiko Koizumi, Rayhan Shah, Prerna Gopal, Simone Duarte
{"title":"Charcoal dentifrices: A laboratory study of their safety and efficacy.","authors":"Ashley N Bowers, Christina M Tyrakowski, Yukiko Koizumi, Rayhan Shah, Prerna Gopal, Simone Duarte","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>To compare charcoal-containing dentifrices (CDs) to non-charcoal containing dentifrices (NCDs) through the following experiments: potentially available fluoride, 1-minute fluoride release, pH, cytotoxicity, heavy metals, enamel fluoride uptake (EFU) and relative dentin abrasivity (RDA).</p><p><strong>Methods: </strong>Nine fluoride dentifrices; six CDs and three NCDs were tested (n= 3) for available fluoride, the amount of fluoride released within 1 minute, pH cytotoxicity, heavy metals, EFU and RDA. Four CDs and 1 NCD contained sodium fluoride (NaF) as the active ingredient whereas two dentifrices contained stannous fluoride (SnF₂; 1 CD and 1 NCD), and two dentifrices contained disodium monofluorophosphate (Na₂FPO₃, or Na₂MFP; 1 CD and 1 NCD). Available samples were homogenized and diluted to 1-in-100 in deionized water (DIW). Release samples were prepared as 1-in-4 homogenized dilutions by mass in DIW. Available and release samples were measured in triplicate (n= 3) via fluoride ion-selective electrode (F-ISE) and ion chromatography (IC). ANSI/ADA 130 was followed for pH. L929 cells were cultured using the lactate dehydrogenase (LDH) assay and ISO 10993-5 Annex C MTT cytotoxicity test. Heavy metals testing was performed using a hydrofluoric acid digestion sample preparation method followed by inductively coupled plasma mass spectrometry (ICP-MS) detection. EFU was performed on enamel specimens that underwent treatment with a CD slurry (1-in-4 dilution) following Test Method #40 of FDA Monograph 21. RDA was performed following ISO 11609 Annex A and the Hefferren method. Data was analyzed using one-way ANOVA followed by post-hoc tests (α= 0.05).</p><p><strong>Results: </strong>Available fluoride for all nine dentifrices was between ~93-102% of the labeled amount. The amount of fluoride released after 1 minute of homogenous mixing ranged between 75-107% of the labeled amount. The pH values of the nine dentifrices ranged from 6.5 to 7.7. Charcoal did not significantly contribute to cytotoxicity in L929 cells. The concentrations of each heavy metal (Hg, Cd, As and Pb) present in each of the nine dentifrices were < 1 ppm, indicating trace amounts. The CDs were not significantly more abrasive than the NCDs. The SnF₂ CD had the highest EFU value (644.2 ±131.7 ppm) followed by the NaF CD and the Na₂MFP CD at 492.2± 69.5 ppm and 140.1± 28.1 ppm, respectively.</p><p><strong>Clinical significance: </strong>Charcoal-containing dentifrices were not found to be significantly more abrasive or cytotoxic than non-charcoal-containing dentifrices. Charcoal and non-charcoal-containing dentifrices were also found to be comparable through experiments determining their fluoride content, pH, enamel fluoride uptake and heavy metals.</p>","PeriodicalId":7538,"journal":{"name":"American journal of dentistry","volume":"37 5","pages":"255-262"},"PeriodicalIF":0.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142339249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gleica D Savegnago, Youdeline J Jacques, Gabriela B Ortigara, Mariana B Vizzotto, Gabriela S Liedke
{"title":"Influence of file compression on radiographic diagnosis of periodontal bone loss on smartphones.","authors":"Gleica D Savegnago, Youdeline J Jacques, Gabriela B Ortigara, Mariana B Vizzotto, Gabriela S Liedke","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the influence of imaging compression on radiographic diagnosis of periodontal bone loss on smartphones.</p><p><strong>Methods: </strong>45 digital periapical radiographs with diverse periodontal bone loss patterns were selected. All radiographs were performed with a CMOS-type sensor and were exported from the acquisition software with two compressions: JPEG with a 10% compression rate and JPEG with a 90% compression rate. Images were shared using the WhatsApp application and three examiners evaluated all radiographs on the smartphone. The examiners' diagnostic agreement was evaluated using the Kappa index. The McNemar and Cochran's Q statistical tests were used to compare the impact of the image compression, examiner, and type of periodontal bone defect on the diagnosis. Statistical analysis was performed using the SPSS software.</p><p><strong>Results: </strong>Kappa values were greater than 0.7 for all examiners and no statistically significant difference for the periodontal diagnosis, regardless of the image compression, the examiner background, and the type of periodontal bone defect.</p><p><strong>Clinical significance: </strong>The use of smartphones to analyze and share images has become very common in dentistry. This study shows that images can be shared and analyzed on smartphones without compromising periodontal diagnosis, regardless of their spatial resolution.</p>","PeriodicalId":7538,"journal":{"name":"American journal of dentistry","volume":"37 5","pages":"244-246"},"PeriodicalIF":0.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142339253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ingrid C C Souto, Otavio M Dos Santos Neto, Livia Florin, Ana Paula Macedo, Rossana P De Almeida
{"title":"Framework's marginal adaptation evaluation of fixed partial denture using conventional and digital impression techniques.","authors":"Ingrid C C Souto, Otavio M Dos Santos Neto, Livia Florin, Ana Paula Macedo, Rossana P De Almeida","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the marginal and internal misfit of fixed partial denture zirconia frameworks developed from conventional impression and intraoral scanning, before and after being subjected to the thermal cycle of the covering ceramic.</p><p><strong>Methods: </strong>A three-elements fixed partial denture was prepared, molded, and poured with polyurethane. Group CI (n= 7) was impressed by the conventional technique with polyvinyl siloxane material, and the plaster models scanned on the inEosX5 bench scanner. Group DI (n=07) was scanned using the CEREC Bluecam intraoral scanner. The models and images obtained were sent to the laboratory and the frameworks were made using zirconia blocks. After this, they were subjected to the ceramic thermal cycle, simulating the ceramic application. Marginal and internal misfits of the frameworks were measured before (T1) and after (T2) thermal cycle simulation using the replica technique in an optical microscope. Statistical analysis was performed using the mixed effects of linear model tests and comparisons.</p><p><strong>Results: </strong>There were no statistical differences for axial misfit. Significant differences were found between the groups for occlusal, vertical, horizontal, and absolute misfit, where group CI had higher values than group DI (P< 0.001). At the time, there was a statistical difference only in the absolute misfit, where T1 had lower values than T2. The misfit in group CI was greater than in group DI; however, the average misfit values found are low and considered clinically acceptable.</p><p><strong>Clinical significance: </strong>Knowing marginal and internal misfit is an important step to consolidating digital impressions in fixed partial dentures, implying a secure use of this technique.</p>","PeriodicalId":7538,"journal":{"name":"American journal of dentistry","volume":"37 5","pages":"263-267"},"PeriodicalIF":0.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142339252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sanem Ozaslan, Batu C Yaman, Ozge Çeliksöz, Hatice Tepe, Begum Tavas
{"title":"A comparison of polishing systems and thermal cycling on the surface roughness and color stability of a single-shade resin composite.","authors":"Sanem Ozaslan, Batu C Yaman, Ozge Çeliksöz, Hatice Tepe, Begum Tavas","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the surface roughness and color stability of a single-shade composite resin after thermal cycling with different finishing and polishing systems.</p><p><strong>Methods: </strong>A total of 91 specimens were prepared with standard molds using a single-shade resin composite Omnichroma. The specimens were randomly separated into seven groups: Control (Mylar strip only), grit (600 grit SiC abrasive paper), OneGloss, Clearfil Twist Dia, Sof-Lex Diamond Polishing System, EVE Diacomp Plus Twist, and OptiDisc. The top surface of each specimen was polished per the manufacturers' directions. After initial measurements, 10,000 and 50,000 thermal cycles were performed. After each thermal cycling, the measurements were retaken. A generalized linear model analysis was used to compare the values, and multiple comparisons were performed with the Bonferroni correction.</p><p><strong>Results: </strong>Different finishing and polishing systems and thermal cycling significantly affected the surface roughness and color change of the single-shade composite resin (P< 0.001). The smoothest surfaces were obtained with the Sof-Lex Diamond Polishing System, while the group polished with Clearfil Twist Dia showed the least color change.</p><p><strong>Clinical significance: </strong>The surface roughness of the single-shade resin composite exhibited acceptable values for all polishing systems tested. The color change values of the single-shade resin composite were found to be above the acceptable value for all polishing systems, but the two-step spiral polishing systems performed better in terms of color stability.</p>","PeriodicalId":7538,"journal":{"name":"American journal of dentistry","volume":"37 5","pages":"247-254"},"PeriodicalIF":0.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142339248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}