Acta medica Scandinavica. Supplementum最新文献

{"title":"Effect of acute and long-term beta-adrenergic blockade with alprenolol in definite or suspected myocardial infarction. Study design, patient characteristics and conduct of the study.","authors":"H J Jürgensen, M P Andersen, P Bechsgaard, J Frederiksen, D A Hansen, P B Nielsen, F Pedersen, O Pedersen-Bjergaard, S L Rasmussen","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75385,"journal":{"name":"Acta medica Scandinavica. Supplementum","volume":"680 ","pages":"8-17"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17434903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The diabetic gangrene: research and clinical practice. Proceedings of a symposium in Umeå, Sweden, October 14-15, 1982.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75385,"journal":{"name":"Acta medica Scandinavica. Supplementum","volume":"687 ","pages":"1-114"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17647972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sodium and blood pressure. Studies in young and middle-aged men with a positive family history of hypertension.","authors":"O Gudmundsson","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>To study the relationship between family history of hypertension and the response to increased salt intake, normotensive 50-year-old men with (n = 11) and without (n = 26) and younger men (mean age 30 years) with (n = 17) and without (n = 15) a family history of hypertension were studied on habitual and increased salt intake (ordinary intake + 12 g NaCl/day for four weeks). No difference in blood pressure was seen in either age group between the familial groups during habitual salt intake. The older group increased blood pressure and weight during high salt intake, whilst the younger group did not, indicating that age is important for the handling of sodium. Family history had no impact on the changes in blood pressure. Echocardiography in the younger group showed no haemodynamic differences between the familial groups during habitual salt but after three days of high salt an increased cardiac output and a decreased total peripheral resistance was seen in the group with a family history of hypertension while the control group showed no such changes. This difference disappeared during the course of the study. Plethysmography in the younger group showed no structural vascular changes in the familially predisposed group. At rest they had however an increased resistance and vascular tone indicating a higher contractile state in their calf muscle resistance vessels. Increased salt intake did not influence any of these variables in neither group. Both the younger and older familially predisposed men had higher levels of intraerythrocyte sodium during habitual salt intake compared to the control groups. In the younger group this increase was probably due to a significant decrease in the sodium efflux rate constant. During high salt the intraerythrocyte sodium decreased in the familially predisposed groups, and the efflux rate constant in the younger group increased significantly, the initial difference between the familial groups thereby disappeared. These findings do not support the existence of a circulating sodium transport inhibitor. No difference in catecholamine excretion was seen between the familial groups during habitual salt intake. An increase in urine catecholamines was seen during increased salt intake in the older group whilst a slight decrease was seen in the younger groups mainly during the first 10 days. The reason for this discrepancy is not clear. During ordinary salt intake a higher plasma renin activity was noted in the younger familially predisposed group.(ABSTRACT TRUNCATED AT 400 WORDS)</p>","PeriodicalId":75385,"journal":{"name":"Acta medica Scandinavica. Supplementum","volume":"688 ","pages":"1-65"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17649264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"39th Nordic Congress of Internal Medicine and annual spring meeting for the Danish Societies of Internal Medicine, Clinical Chemistry and Clinical Physiology and Nuclear Medicine. Copenhagen, June 7-9, 1984. Proceedings and abstracts.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75385,"journal":{"name":"Acta medica Scandinavica. Supplementum","volume":"685 ","pages":"1-55"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17649263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemophilia in Sweden. Studies on demography of hemophilia and surgery in hemophilia and von Willebrand's disease.","authors":"S A Larsson","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Demography: All known hemophiliacs in Sweden, 564 cases, were subjected to a demographic survey in 1980. The ratio of hemophilia A/B was 81/19. The severe cases constituted 30% and the mild 54%. Mean and median ages for mild and moderate hemophiliacs did not differ from those of Swedish males but were approximately 10 years lower in the severe cases. The prevalence was 7 per 100,000 population. The incidence remained constant at 1.7 (+/- 0.1) per 10,000 live-born males in the period 1957-1978. Mortality: In the period 1957-1980, there was a substantial increase in the median age at death among 118 deceased hemophiliacs. This increase was most pronounced in severe hemophilia, from 19 to 50.5 years. Intracranial hemorrhage accounted for one third of the deaths. Six deaths were attributed to hepatic dysfunction caused by hepatitis. Age related deaths (ischemic heart disease and malignancy) increased from 8 % to 32 %. Longevity: Median life expectancy of hemophiliacs in Sweden increased faster than the median life expectancy of the male population. In the beginning of the century, severe hemophiliacs faced a median life expectancy of about 11 years which had increased to 58 years by 1969-1980. Median life expectancy in mild and moderate hemophilia was 72 years, only three and a half years less than the corresponding age for Swedish males. Surgery in hemophilia and von Willebrand's disease: Three hundred and twelve operations (225 in hemophilia and 87 in von Willebrand's disease) were performed on 180 patients (121 hemophiliacs) in the period 1956-1983 at the General Hospital in Malmö. During the first years reconstructive orthopedic surgery dominated among young, severely affected, hemophiliacs but in recent years surgical diseases unrelated to the bleeding disorders increased. Ninety-seven operations were indicated by ailments caused by the bleeding disorders, mainly hemophilic arthropathy and pseudotumours. In another 72 operations the bleeding disorders were considered a contributing factor, mainly gastric surgery for ulcers, hysterectomy indicated by menometrorrhagia and subdural hematomas. Reconstructive orthopedic surgery was almost exclusively performed in hemophilia but gastric surgery was more common in von Willebrand's disease. The operations claimed three fatalities. It was considered essential to extend the substitution therapy to at least two weeks, especially in orthopedic surgery and in severe hemophilia. Furthermore, it was of the utmost importance to have access to laboratory facilities for repeated determinations of VIII:C/IX:C in hemophilia, Duke bleeding time in von Willebrand's disease, and to exclude the presence of inhibitors.</p>","PeriodicalId":75385,"journal":{"name":"Acta medica Scandinavica. Supplementum","volume":"684 ","pages":"1-72"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17666712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of acute and long-term beta-adrenergic blockade with alprenolol in definite or suspected myocardial infarction. Causes of death and post-mortem findings with special reference to early deaths.","authors":"D A Hansen,&nbsp;H J Jürgensen,&nbsp;O Pedersen-Bjergaard","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75385,"journal":{"name":"Acta medica Scandinavica. Supplementum","volume":"680 ","pages":"50-8"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17434902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetic macroangiopathy. Medial calcifications, narrowing, rugosities, stiffness, norepinephrine depletion and reduced blood flow capacity in the leg arteries.","authors":"B Neubauer,&nbsp;N J Christensen,&nbsp;T Christensen,&nbsp;H J Gundersen,&nbsp;J Jørgensen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Five quantitative studies performed to disclose and measure diabetic abnormalities in the leg arteries are reported and briefly discussed. A medial as well as an intimal disease was found in the diabetic leg arteries. Thus roentgenological medial calcification correlated to glucose intolerance in older non-diabetics and to diabetes duration in young insulin dependent diabetics. An intimal roughness was disclosed by arteriography in young insulin-dependent diabetic patients. The roughness grew worse the longer the diabetes persisted. The development of this abnormality did not take place simultaneous with the medial calcification, but was closely connected with another disclosed abnormality, a uniform arterial narrowing, quite unlike the well known abrupt narrowing in older patients. The existence of a uniform arterial narrowing in diabetic patients was confirmed by ultrasonography and the use of this technique further revealed arterial stiffness as a long-term diabetic phenomenon. A functional abnormality of the leg arteries of diabetic patients was disclosed by measurement of the postischemic peak blood flow in the leg in a 45 degree feet-down position. A vast destruction of the autonomic nerves of the peripheral arteries was demonstrated by measurement of the norepinephrine content post mortem in long-term diabetic patients. The results reported suggest a specific element in the large-vessel disease of diabetic patients.</p>","PeriodicalId":75385,"journal":{"name":"Acta medica Scandinavica. Supplementum","volume":"687 ","pages":"37-45"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17647854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wound assessment in clinical practice. A critical review of methods and their application.","authors":"R D Forrest,&nbsp;P Gamborg-Nielsen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This review describes the methods that may be used clinically for the assessment of open wounds and indicates potential limitations in their usefulness. None of the methods available for the appraisal of wounds in human subjects measures healing directly but a number of objective variables may be used to shed light on the healing process. Research methods have been suggested that may be clinically useful in assessing healing but are not generally available at present.</p>","PeriodicalId":75385,"journal":{"name":"Acta medica Scandinavica. Supplementum","volume":"687 ","pages":"69-74"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17647855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"On the normal scalar ECG. A new classification system considering age, sex and heart position.","authors":"B Lundh","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>472 randomly selected men and women from the city of Lund were examined for disease in the heart, lungs and for hypertension. 163 men and 194 women who had no symptom or sign of disease were accepted for the further study. The prevalence of various exclusion criterias, such as symptoms and signs of heart disease, lung disease and other diseases which may possibly affect the ECG are reported as well as the distribution of blood pressures in the sample. A computer-averaged standard 12-lead ECG (leads aVL, I, -aVR, II, aVF, III, V1-V6) was recorded. All measurements of ECG-deflections have been made visually using a magnifying glass (6 times). ST-segments were classified according to the Punsar code by independent visual observers as well as by the computer. The mean frontal QRS-axis shifted to the left with advancing age, but the shift was statistically significant only in men. In both men and women there was a leftward shift of the mean frontal QRS-axis with increased weight, increased chest circumference and increased obesity index. The normal range of axis was found to be 0 degrees to 90 degrees in men and +15 degrees to 90 degrees in women. The problems concerning the definition of the electrical heart position is discussed. The concept of a Q-axis is introduced as an alternative way to indicate electrical heart position. There is a statistical significant relationship between the Q-axis and the QRS-axis in the frontal plane, although this relationship is not always apparent in the individual ECG. The presence or absence of a Q-wave in an individual lead was used to denote a lead as being a left ventricular lead or not. Using the Q-wave as a marker of heart position in the individual lead is more practical than to use the QRS-axis or the transitional zone. Duration and amplitude of the Q-wave have been measured. The upper limit of normal duration exceeded 0.03 s in leads aVL and aVF in men but not in women. The R-wave amplitudes proved to vary with age and heart position in men. In women variation of the R-wave amplitude was found with heart position but not with age.(ABSTRACT TRUNCATED AT 400 WORDS)</p>","PeriodicalId":75385,"journal":{"name":"Acta medica Scandinavica. Supplementum","volume":"691 ","pages":"1-147"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17303571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extremes in drug utilization patterns. Low prescribing of antihypertensives in the District of Novi Sad, Yugoslavia.","authors":"V Jakovljević,&nbsp;M Stanulović","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>According to data expressed in defined daily doses (DDD), the utilization of antihypertensives is lower in the district of Novi Sad (Yugoslavia) than in other settings studied so far. The number of actually treated persons is even lower than that indicated by the DDD value, which in 1981 was 23.4 DDD/1 000 inhabitants/day. Currently, the participating members in the WHO coordinated MONICA-project are considering the possibility to incorporate the defined daily dose approach to evaluate drug usage in relation to morbidity data. This offers a realistic prospect for identifying the medical consequences of the regional differences in prescribing patterns.</p>","PeriodicalId":75385,"journal":{"name":"Acta medica Scandinavica. Supplementum","volume":"683 ","pages":"67-9"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17644352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}