WormBook : the online review of C. elegans biology最新文献_第4页

Classical genetic methods. 经典遗传方法。

WormBook : the online review of C. elegans biology Pub Date : 2013-12-30 DOI: 10.1895/wormbook.1.165.1

David S Fay

引用次数: 41

Insulin/insulin-like growth factor signaling in C. elegans. 秀丽隐杆线虫中胰岛素/胰岛素样生长因子的信号传导。

WormBook : the online review of C. elegans biology Pub Date : 2013-12-26 DOI: 10.1895/wormbook.1.164.1

Coleen T Murphy, Patrick J Hu

引用次数: 399

Wnt signaling in C. elegans. 秀丽隐杆线虫中的Wnt信号。

WormBook : the online review of C. elegans biology Pub Date : 2013-12-09 DOI: 10.1895/wormbook.1.7.2

Hitoshi Sawa, Hendrik C Korswagen

引用次数: 96

Microfluidics as a tool for C. elegans research. 微流体技术在秀丽隐杆线虫研究中的应用。

WormBook : the online review of C. elegans biology Pub Date : 2013-09-24 DOI: 10.1895/wormbook.1.162.1

Adriana San-Miguel, Hang Lu

引用次数: 113

The neuronal genome of Caenorhabditis elegans. 秀丽隐杆线虫的神经元基因组。

WormBook : the online review of C. elegans biology Pub Date : 2013-08-13 DOI: 10.1895/wormbook.1.161.1

Oliver Hobert

{"title":"The neuronal genome of Caenorhabditis elegans.","authors":"Oliver Hobert","doi":"10.1895/wormbook.1.161.1","DOIUrl":"https://doi.org/10.1895/wormbook.1.161.1","url":null,"abstract":"The ~100 MB genome of C. elegans codes for ~20,000 protein-coding genes many of which are required for the function of the nervous system, composed of 302 neurons in the adult hermaphrodite and of 383 neurons in the adult male. In addition to housekeeping genes, a differentiated neuron is thought to express many hundreds if not thousands of genes that define its functional properties. These genes code for ion channels, G-protein-coupled receptors, neurotransmitter-synthesizing enzymes, transporters and receptors, neuropeptides and their receptors, cell adhesion molecules, motor proteins, signaling molecules and many others. Collectively such genes have been referred to as \"terminal differentiation genes\" or \"effector genes\". The differential expression of distinct combinations of terminal differentiation genes define different neuron types. This paper provides a compendium of more than 2,800 putative terminal differentiation genes. One pervasive theme revealed by the analysis of many gene families is the nematode-specific expansions of many neuron function-related gene families, including, for example, many types of ion channel families, sensory receptors and neurotransmitter receptors. The gene lists provided here can serve multiple purposes. They can serve as quick reference guides for individual gene families or they can be used to mine large datasets (e.g., expression datasets) for genes with likely functions in the nervous system. They also serve as a starting point for future projects. For example, a comprehensive understanding of the regulation of the often complex expression patterns of these genes in the nervous system will eventually explain how nervous systems are built.","PeriodicalId":75344,"journal":{"name":"WormBook : the online review of C. elegans biology","volume":" ","pages":"1-106"},"PeriodicalIF":0.0,"publicationDate":"2013-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4781646/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31771844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 226

Canonical RTK-Ras-ERK signaling and related alternative pathways. 典型RTK-Ras-ERK信号通路及相关替代通路。

WormBook : the online review of C. elegans biology Pub Date : 2013-07-11 DOI: 10.1895/wormbook.1.80.2

Meera V Sundaram

引用次数: 82

An introduction to the UCSC Genome Browser. 介绍UCSC基因组浏览器。

WormBook : the online review of C. elegans biology Pub Date : 2013-07-11 DOI: 10.1895/wormbook.1.160.1

Raymond Lee

引用次数: 3

TGF-β signaling in C. elegans. 秀丽隐杆线虫TGF-β信号传导。

WormBook : the online review of C. elegans biology Pub Date : 2013-07-10 DOI: 10.1895/wormbook.1.22.2

Tina L Gumienny, Cathy Savage-Dunn

引用次数: 114

A biologist's guide to statistical thinking and analysis. 生物学家的统计思维和分析指南。

WormBook : the online review of C. elegans biology Pub Date : 2013-07-09 DOI: 10.1895/wormbook.1.159.1

David S Fay, Ken Gerow

{"title":"A biologist's guide to statistical thinking and analysis.","authors":"David S Fay, Ken Gerow","doi":"10.1895/wormbook.1.159.1","DOIUrl":"https://doi.org/10.1895/wormbook.1.159.1","url":null,"abstract":"The proper understanding and use of statistical tools are essential to the scientific enterprise. This is true both at the level of designing one's own experiments as well as for critically evaluating studies carried out by others. Unfortunately, many researchers who are otherwise rigorous and thoughtful in their scientific approach lack sufficient knowledge of this field. This methods chapter is written with such individuals in mind. Although the majority of examples are drawn from the field of Caenorhabditis elegans biology, the concepts and practical applications are also relevant to those who work in the disciplines of molecular genetics and cell and developmental biology. Our intent has been to limit theoretical considerations to a necessary minimum and to use common examples as illustrations for statistical analysis. Our chapter includes a description of basic terms and central concepts and also contains in-depth discussions on the analysis of means, proportions, ratios, probabilities, and correlations. We also address issues related to sample size, normality, outliers, and non-parametric approaches. ","PeriodicalId":75344,"journal":{"name":"WormBook : the online review of C. elegans biology","volume":" ","pages":"1-54"},"PeriodicalIF":0.0,"publicationDate":"2013-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3880567/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31625918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Getting into the mind of a worm--a personal view. 进入蠕虫的思想——个人观点。

WormBook : the online review of C. elegans biology Pub Date : 2013-06-25 DOI: 10.1895/wormbook.1.158.1

John G White

{"title":"Getting into the mind of a worm--a personal view.","authors":"John G White","doi":"10.1895/wormbook.1.158.1","DOIUrl":"https://doi.org/10.1895/wormbook.1.158.1","url":null,"abstract":"Ever since I can remember, I liked to take things to bits to see how they work. My parents thought that this trait was not to be encouraged when applied to living animals, so diverted my attention to things mechanical and electronic. I was given the use of a shed in the garden. This became my beloved workshop where I made bombs, rockets, and radios. After one of my bombs caused a local scare, my activities were restricted to electronics. On finishing school, I worked in a factory for a time and then progressed onto a couple of other jobs in industrial development labs on the basis of my self-taught skills in electronics. Eventually, I got a job as an electronics technician in the Medical Research Council's labs in Mill Hill (MRC National Institute for Medical Research, Mill Hill, London, UK). It was here that I got my first (ethical) exposure to biology. I developed a voltage clamp apparatus for neurophysiological research, a project that piqued my curiosity about nervous systems. I also developed a computer system for displaying 3D images of molecular structures. The MRC encouraged and supported me to study for a physics degree at Brunel University. However, after I graduated in 1969, there seemed no good career path where I could pursue my developing interest in computers in the lab where I was working, so I sought and obtained a job offer from industry. However, my boss at the MRC Mill Hill lab encouraged me to check out the MRC Laboratory of Molecular Biology (LMB) in Cambridge where he had heard there was a new research initiative to use computers to study the nervous system of a worm. So, mainly out of a sense of duty to the MRC for having supported me though my undergraduate studies, I donned my best (and only) suit and headed off to Cambridge.","PeriodicalId":75344,"journal":{"name":"WormBook : the online review of C. elegans biology","volume":" ","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2013-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4781474/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31627911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11