Vascular biology (Bristol, England)最新文献_第8页

Tumour vessel remodelling: new opportunities in cancer treatment. 肿瘤血管重塑:癌症治疗的新机遇。

Vascular biology (Bristol, England) Pub Date : 2020-01-14 eCollection Date: 2020-01-01 DOI: 10.1530/VB-19-0032

Ruth Ganss

{"title":"Tumour vessel remodelling: new opportunities in cancer treatment.","authors":"Ruth Ganss","doi":"10.1530/VB-19-0032","DOIUrl":"https://doi.org/10.1530/VB-19-0032","url":null,"abstract":"Tumour growth critically depends on a supportive microenvironment, including the tumour vasculature. Tumour blood vessels are structurally abnormal and functionally anergic which limits drug access and immune responses in solid cancers. Thus, tumour vasculature has been considered an attractive therapeutic target for decades. However, with time, anti-angiogenic therapy has evolved from destruction to structural and functional rehabilitation as understanding of tumour vascular biology became more refined. Vessel remodelling or normalisation strategies which alleviate hypoxia are now coming of age having been shown to have profound effects on the tumour microenvironment. This includes improved tumour perfusion, release from immune suppression and lower metastasis rates. Nevertheless, clinical translation has been slow due to challenges such as the transient nature of current normalisation strategies, limited in vivo monitoring and the heterogeneity of primary and/or metastatic tumour environments, calling for more tailored approaches to vascular remodelling. Despite these setbacks, harnessing vascular plasticity provides unique opportunities for anti-cancer combination therapies in particular anti-angiogenic immunotherapy which are yet to reach their full potential.","PeriodicalId":75294,"journal":{"name":"Vascular biology (Bristol, England)","volume":"2 1","pages":"R35-R43"},"PeriodicalIF":0.0,"publicationDate":"2020-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7439841/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38377588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

P53 in lung vascular barrier dysfunction. P53在肺血管屏障功能障碍中的作用。

Vascular biology (Bristol, England) Pub Date : 2020-01-01 Epub Date: 2020-05-20 DOI: 10.1530/vb-20-0004

Nektarios Barabutis

引用次数: 10

Targeting epigenetic mechanisms as an emerging therapeutic strategy in pulmonary hypertension disease. 将表观遗传机制作为肺动脉高压疾病的新兴治疗策略。

Vascular biology (Bristol, England) Pub Date : 2020-01-01 Epub Date: 2020-01-09 DOI: 10.1530/vb-19-0030

Malik Bisserier, Radoslav Janostiak, Frank Lezoualc'h, Lahouaria Hadri

{"title":"Targeting epigenetic mechanisms as an emerging therapeutic strategy in pulmonary hypertension disease.","authors":"Malik Bisserier, Radoslav Janostiak, Frank Lezoualc'h, Lahouaria Hadri","doi":"10.1530/vb-19-0030","DOIUrl":"10.1530/vb-19-0030","url":null,"abstract":"Pulmonary arterial hypertension (PAH) is a multifactorial cardiopulmonary disease characterized by an elevation of pulmonary artery pressure (PAP) and pulmonary vascular resistance (PVR), which can lead to right ventricular (RV) failure, multi-organ dysfunction, and ultimately to premature death. Despite the advances in molecular biology, the mechanisms underlying pulmonary hypertension (PH) remain unclear. Nowadays, there is no curative treatment for treating PH. Therefore, it is crucial to identify novel, specific therapeutic targets and to offer more effective treatments against the progression of PH. Increasing amounts of evidence suggest that epigenetic modification may play a critical role in the pathogenesis of PAH. In the presented paper, we provide an overview of the epigenetic mechanisms specifically, DNA methylation, histone acetylation, histone methylation, and ncRNAs. As the recent identification of new pharmacological drugs targeting these epigenetic mechanisms has opened new therapeutic avenues, we also discuss the importance of epigenetic-based therapies in the context of PH.","PeriodicalId":75294,"journal":{"name":"Vascular biology (Bristol, England)","volume":"2 1","pages":"R17-R34"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/75/69/VB-19-0030.PMC7065685.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37729438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Induced pluripotent stem cell-derived vascular smooth muscle cells. 诱导多能干细胞衍生的血管平滑肌细胞。

Vascular biology (Bristol, England) Pub Date : 2019-12-12 eCollection Date: 2020-01-01 DOI: 10.1530/VB-19-0028

Makeda Stephenson, Daniel H Reich, Kenneth R Boheler

引用次数: 4

New artery of knowledge: 3D models of angiogenesis. 知识的新动脉：血管生成的三维模型。

Vascular biology (Bristol, England) Pub Date : 2019-12-03 eCollection Date: 2019-01-01 DOI: 10.1530/VB-19-0026

Eleonora Zucchelli, Qasim A Majid, Gabor Foldes

引用次数: 0

Revisiting PI3-kinase signalling in angiogenesis. 重温血管生成中的 PI3 激酶信号

Vascular biology (Bristol, England) Pub Date : 2019-11-29 eCollection Date: 2019-01-01 DOI: 10.1530/VB-19-0025

Piotr Kobialka, Mariona Graupera

引用次数: 0

Endothelial connexins in vascular function. 血管功能中的内皮连接素。

Vascular biology (Bristol, England) Pub Date : 2019-11-07 eCollection Date: 2019-01-01 DOI: 10.1530/VB-19-0015

Aurélie Hautefort, Anna Pfenniger, Brenda R Kwak

{"title":"Endothelial connexins in vascular function.","authors":"Aurélie Hautefort, Anna Pfenniger, Brenda R Kwak","doi":"10.1530/VB-19-0015","DOIUrl":"https://doi.org/10.1530/VB-19-0015","url":null,"abstract":"Gap junctions are essential for intercellular crosstalk in blood and lymphatic vasculature. These clusters of intercellular channels ensure direct communication among endothelial cells and between endothelial and smooth muscle cells, and the synchronization of their behavior along the vascular tree. Gap junction channels are formed by connexins; six connexins form a connexon or hemichannel and the docking of two connexons result in a full gap junction channel allowing for the exchange of ions and small metabolites between neighboring cells. Recent evidence indicates that the intracellular domains of connexins may also function as an interaction platform (interactome) for other proteins, thereby regulating their function. Interestingly, fragments of Cx proteins generated by alternative internal translation were recently described, although their functions in the vascular wall remain to be uncovered. Variations in connexin expression are observed along different types of blood and lymphatic vessels; the most commonly found endothelial connexins are Cx37, Cx40, Cx43 and Cx47. Physiological studies on connexin-knockout mice demonstrated the essential roles of these channel-forming proteins in the coordination of vasomotor activity, endothelial permeability and inflammation, angiogenesis and in the maintenance of fluid balance in the body.","PeriodicalId":75294,"journal":{"name":"Vascular biology (Bristol, England)","volume":"1 1","pages":"H117-H124"},"PeriodicalIF":0.0,"publicationDate":"2019-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/bf/0c/VB-19-0015.PMC7439941.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38474438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

The genetics and biomechanics of thoracic aortic diseases. 胸主动脉疾病的遗传学和生物力学。

Vascular biology (Bristol, England) Pub Date : 2019-10-15 eCollection Date: 2019-01-01 DOI: 10.1530/VB-19-0027

Amer Harky, Ka Siu Fan, Ka Hay Fan

{"title":"The genetics and biomechanics of thoracic aortic diseases.","authors":"Amer Harky, Ka Siu Fan, Ka Hay Fan","doi":"10.1530/VB-19-0027","DOIUrl":"https://doi.org/10.1530/VB-19-0027","url":null,"abstract":"Thoracic aortic aneurysms and aortic dissections (TAAD) are highly fatal emergencies within cardiothoracic surgery. With increasing age, thoracic aneurysms become more prevalent and pose an even greater threat when they develop into aortic dissections. Both diseases are multifactorial and are influenced by a multitude of physiological and biomechanical processes. Structural stability of aorta can be disrupted by genes, such as those for extracellular matrix and contractile protein, as well as telomere dysfunction, which leads to senescence of smooth muscle and endothelial cells. Biomechanical changes such as increased luminal pressure imposed by hypertension are also very prevalent and lead to structural instability. Furthermore, ageing is associated with a pro-inflammatory state that exacerbates degeneration of vessel wall, facilitating the development of both aortic aneurysms and aortic dissection. This literature review provides an overview of the aetiology and pathophysiology of both thoracic aneurysms and aortic dissections. With an improved understanding, new therapeutic targets may eventually be identified to facilitate treatment and prevention of these diseases.","PeriodicalId":75294,"journal":{"name":"Vascular biology (Bristol, England)","volume":"1 1","pages":"R13-R25"},"PeriodicalIF":0.0,"publicationDate":"2019-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7e/be/VB-19-0027.PMC7439919.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38377583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Environmental stress influences mitochondrial metabolism in vascular cells: consequences for angiogenesis. 环境应激影响血管细胞的线粒体代谢：血管生成的后果。

Vascular biology (Bristol, England) Pub Date : 2019-10-01 eCollection Date: 2019-01-01 DOI: 10.1530/VB-19-0018

T Scott Bowen, Stuart Egginton

引用次数: 0

Nanotechnology and stem cells in vascular biology. 血管生物学中的纳米技术和干细胞。

Vascular biology (Bristol, England) Pub Date : 2019-09-24 eCollection Date: 2019-01-01 DOI: 10.1530/VB-19-0021

Tomasz Jadczyk, Guido Caluori, Wojciech Wojakowski, Zdenek Starek

引用次数: 0