Vascular biology (Bristol, England)最新文献_第9页

Ghrelin and vascular protection. 生长素和血管保护。

Vascular biology (Bristol, England) Pub Date : 2019-09-05 eCollection Date: 2019-01-01 DOI: 10.1530/VB-19-0024

James T Pearson, Mikiyasu Shirai, Vijayakumar Sukumaran, Cheng-Kun Du, Hirotsugu Tsuchimochi, Takashi Sonobe, Mark T Waddingham, Rajesh Katare, Daryl O Schwenke

引用次数: 6

The crosstalk between the cardiovascular and the immune system. 心血管系统和免疫系统之间的相互作用。

Vascular biology (Bristol, England) Pub Date : 2019-08-15 eCollection Date: 2019-01-01 DOI: 10.1530/VB-19-0023

Carlo Dal Lin, Francesco Tona, Elena Osto

引用次数: 14

HMGB1-mediated apoptosis and autophagy in ischemic heart diseases. hmgb1介导的缺血性心脏病细胞凋亡和自噬。

Vascular biology (Bristol, England) Pub Date : 2019-08-12 eCollection Date: 2019-01-01 DOI: 10.1530/VB-19-0013

Eleonora Foglio, Laura Pellegrini, Antonia Germani, Matteo Antonio Russo, Federica Limana

{"title":"HMGB1-mediated apoptosis and autophagy in ischemic heart diseases.","authors":"Eleonora Foglio, Laura Pellegrini, Antonia Germani, Matteo Antonio Russo, Federica Limana","doi":"10.1530/VB-19-0013","DOIUrl":"https://doi.org/10.1530/VB-19-0013","url":null,"abstract":"Acute myocardial infarction (MI) and its consequences are the most common and lethal heart syndromes worldwide and represent a significant health problem. Following MI, apoptosis has been generally seen as the major contributor of the cardiomyocyte fate and of the resultant myocardial remodeling. However, in recent years, it has been discovered that, following MI, cardiomyocytes could activate autophagy in an attempt to protect themselves against ischemic stress and to preserve cardiac function. Although initially seen as two completely separate responses, recent works have highlighted the intertwined crosstalk between apoptosis and autophagy. Numerous researches have tried to unveil the mechanisms and the molecular players involved in this phenomenon and have identified in high-mobility group box 1 (HMGB1), a highly conserved non-histone nuclear protein with important roles in the heart, one of the major regulator. Thus, the aim of this mini review is to discuss how HMGB1 regulates these two responses in ischemic heart diseases. Indeed, a detailed understanding of the crosstalk between apoptosis and autophagy in these pathologies and how HMGB1 regulates them would be of tremendous help in developing novel therapeutic approaches aimed to promote cardiomyocyte survival and to diminish tissue injury following MI.","PeriodicalId":75294,"journal":{"name":"Vascular biology (Bristol, England)","volume":"1 1","pages":"H89-H96"},"PeriodicalIF":0.0,"publicationDate":"2019-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/84/d9/VB-19-0013.PMC7439920.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38474434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

MicroRNAs orchestrating senescence of endothelial and vascular smooth muscle cells. 调控内皮细胞和血管平滑肌细胞衰老的microrna。

Vascular biology (Bristol, England) Pub Date : 2019-08-12 eCollection Date: 2019-01-01 DOI: 10.1530/VB-19-0017

Ornella Colpani, Gaia Spinetti

{"title":"MicroRNAs orchestrating senescence of endothelial and vascular smooth muscle cells.","authors":"Ornella Colpani, Gaia Spinetti","doi":"10.1530/VB-19-0017","DOIUrl":"https://doi.org/10.1530/VB-19-0017","url":null,"abstract":"During organism aging, the process of cellular senescence is triggered by critical stressors such as DNA damage, oncogenes, oxidative stress, and telomere erosion, and vascular cells are not exempted. Senescent cells stop proliferating but remain metabolically active producing pro-inflammatory signals in the environment collectively named senescence-associated secretory phenotype (SASP) that contribute to the amplification of the response to the neighbor and distant cells. Although the shift toward senescence is protective against tumors and needed during wound healing, the accumulation of senescent cells during aging due to an impairment of the immune system deputed to their clearance, can predispose to diseases of the cardiovascular system such as atherosclerosis. In this short review, we describe the main features of senescence of endothelial and smooth muscle cells and focus on the role non-coding RNAs of the microRNAs class in controlling this process. Finally, we discuss the potential of new strategies based on senescence removal in counteracting vascular disease burden.","PeriodicalId":75294,"journal":{"name":"Vascular biology (Bristol, England)","volume":"1 1","pages":"H75-H81"},"PeriodicalIF":0.0,"publicationDate":"2019-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/11/f5/VB-19-0017.PMC7439843.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38474432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

GPCR transactivation signalling in vascular smooth muscle cells: role of NADPH oxidases and reactive oxygen species. 血管平滑肌细胞中GPCR反激活信号:NADPH氧化酶和活性氧的作用。

Vascular biology (Bristol, England) Pub Date : 2019-07-23 eCollection Date: 2019-01-01 DOI: 10.1530/VB-18-0004

Raafat Mohamed, Reearna Janke, Wanru Guo, Yingnan Cao, Ying Zhou, Wenhua Zheng, Hossein Babaahmadi-Rezaei, Suowen Xu, Danielle Kamato, Peter J Little

{"title":"GPCR transactivation signalling in vascular smooth muscle cells: role of NADPH oxidases and reactive oxygen species.","authors":"Raafat Mohamed, Reearna Janke, Wanru Guo, Yingnan Cao, Ying Zhou, Wenhua Zheng, Hossein Babaahmadi-Rezaei, Suowen Xu, Danielle Kamato, Peter J Little","doi":"10.1530/VB-18-0004","DOIUrl":"10.1530/VB-18-0004","url":null,"abstract":"The discovery and extension of G-protein-coupled receptor (GPCR) transactivation-dependent signalling has enormously broadened the GPCR signalling paradigm. GPCRs can transactivate protein tyrosine kinase receptors (PTKRs) and serine/threonine kinase receptors (S/TKRs), notably the epidermal growth factor receptor (EGFR) and transforming growth factor-β type 1 receptor (TGFBR1), respectively. Initial comprehensive mechanistic studies suggest that these two transactivation pathways are distinct. Currently, there is a focus on GPCR inhibitors as drug targets, and they have proven to be efficacious in vascular diseases. With the broadening of GPCR transactivation signalling, it is therefore important from a therapeutic perspective to find a common transactivation pathway of EGFR and TGFBR1 that can be targeted to inhibit complex pathologies activated by the combined action of these receptors. Reactive oxygen species (ROS) are highly reactive molecules and they act as second messengers, thus modulating cellular signal transduction pathways. ROS are involved in different mechanisms of GPCR transactivation of EGFR. However, the role of ROS in GPCR transactivation of TGFBR1 has not yet been studied. In this review, we will discuss the involvement of ROS in GPCR transactivation-dependent signalling.","PeriodicalId":75294,"journal":{"name":"Vascular biology (Bristol, England)","volume":"1 1","pages":"R1-R11"},"PeriodicalIF":0.0,"publicationDate":"2019-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f0/48/VB-18-0004.PMC7439842.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38377582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

NADPH oxidase 4 and its role in the cardiovascular system. NADPH氧化酶4及其在心血管系统中的作用。

Vascular biology (Bristol, England) Pub Date : 2019-07-11 eCollection Date: 2019-01-01 DOI: 10.1530/VB-19-0014

Stephen P Gray, Ajay M Shah, Ioannis Smyrnias

引用次数: 18

Plasticity of vascular resident mesenchymal stromal cells during vascular remodeling. 血管重构过程中血管常驻间充质细胞的可塑性。

Vascular biology (Bristol, England) Pub Date : 2019-07-11 eCollection Date: 2019-01-01 DOI: 10.1530/VB-19-0022

Xuechong Hong, Wenduo Gu

引用次数: 2

Imaging the carotid atherosclerotic plaque. 颈动脉粥样硬化斑块成像。

Vascular biology (Bristol, England) Pub Date : 2019-06-28 eCollection Date: 2019-01-01 DOI: 10.1530/VB-19-0010

Sandra Neumann, Elena G Milano, Chiara Bucciarelli-Ducci, Giovanni Biglino

{"title":"Imaging the carotid atherosclerotic plaque.","authors":"Sandra Neumann, Elena G Milano, Chiara Bucciarelli-Ducci, Giovanni Biglino","doi":"10.1530/VB-19-0010","DOIUrl":"10.1530/VB-19-0010","url":null,"abstract":"This mini review provides a concise overview of imaging techniques that are currently used to image the atheroscletoric plaque in the carotid artery in vivo. The main techniques include ultrasound imaging, X-ray imaging, magnetic resonance imaging and positron emission tomography imaging. Each technique has advantages and limitations and may be chosen depending on the availability, cost and clinical justification for its use. Common to all the imaging techniques presented here is the need for a skilled imaging professional to allow for high reliability and repeatability. While ultrasound-based imaging currently is regarded as a first line technique in clinical practice, the use of other techniques such as computed tomography angiography or magnetic resonance angiography need to be considered in the presence of significant stenosis with or without symptoms. Advancements in these two modalities, as well as in positron emission tomography imaging, are increasingly moving toward a better understanding of the risk-stratification and pre-interventional monitoring of patients at risk of plaque rupture as well as early identification of plaque development and better understanding of plaque composition (e.g. metabolic imaging).","PeriodicalId":75294,"journal":{"name":"Vascular biology (Bristol, England)","volume":"1 1","pages":"H53-H58"},"PeriodicalIF":0.0,"publicationDate":"2019-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7439847/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38377221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MicroRNA regulation of vascular function. MicroRNA对血管功能的调控。

Vascular biology (Bristol, England) Pub Date : 2019-06-10 eCollection Date: 2019-01-01 DOI: 10.1530/VB-19-0009

David Mellis, Andrea Caporali

引用次数: 1

Cellular and molecular mechanisms of PIK3CA-related vascular anomalies. PIK3CA 相关血管异常的细胞和分子机制。

Vascular biology (Bristol, England) Pub Date : 2019-05-28 eCollection Date: 2019-01-01 DOI: 10.1530/VB-19-0016

Timothy D Le Cras, Elisa Boscolo

引用次数: 0