Vascular biology (Bristol, England)最新文献

Modeling smooth muscle cell-endothelial cell crosstalk in abdominal aortic aneurysms using 3D microvessels on-chip. 三维微血管芯片模拟腹主动脉瘤平滑肌细胞内皮细胞串扰。

Vascular biology (Bristol, England) Pub Date : 2026-05-07 Print Date: 2026-01-01 DOI: 10.1530/VB-26-0005

Philipp C Hauger, Karlijn B Rombouts, Marc Vila Cuenca, Albert van Wijk, Max C Overboom, Jan Willem Buikema, Kak Khee Yeung, Valeria V Orlova, Peter L Hordijk

{"title":"Modeling smooth muscle cell-endothelial cell crosstalk in abdominal aortic aneurysms using 3D microvessels on-chip.","authors":"Philipp C Hauger, Karlijn B Rombouts, Marc Vila Cuenca, Albert van Wijk, Max C Overboom, Jan Willem Buikema, Kak Khee Yeung, Valeria V Orlova, Peter L Hordijk","doi":"10.1530/VB-26-0005","DOIUrl":"10.1530/VB-26-0005","url":null,"abstract":"Abdominal aortic aneurysms (AAAs) are pathological dilations of the abdominal aorta. To date, surgical intervention has been the only option for managing large AAAs, with no pharmacological therapies to prevent growth of small aneurysms. A current limitation in investigating further pharmacological avenues is the translatability of results from either animal models or patient trials that are limited by co-morbidities and disease severity. To bridge this knowledge gap, we created a novel patient-specific vessel-on-chip (VoC) model of the microcirculation in AAA (AAA-VoC), to specifically address VSMC-EC crosstalk. We found that co-culture of both C (control)-VSMCs and AAA-patient-derived VSMCs with healthy, hiPSC-derived ECs generate lumenized and perfusable microvascular networks. We show that AAA-VoCs are characterized by an enlarged average vascular diameter. We furthermore found that AAA-VSMCs show phenotypical deviations from C-VSMCs after 7 days in co-culture such as increased number and surface area, indicative of a preserved pathological phenotype in our in vitro model. Finally, we demonstrate that AAA-VoCs show an elevated level of pro-inflammatory cytokine expression and an impaired endothelial barrier function, resulting in vascular leakage. With this study, we show that AAA-VSMCs affect microvascular networks formed by healthy hiPSC-ECs and that a AAA-VSMC phenotype is preserved in 3D co-culture, making this model valuable for future studies investigating treatments for AAA.","PeriodicalId":75294,"journal":{"name":"Vascular biology (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13178432/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147791791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trophoblast invasion biology: from normal implantation to accreta spectrum and choriocarcinoma. 滋养细胞侵袭生物学：从正常植入到增生光谱和绒毛膜癌。

Vascular biology (Bristol, England) Pub Date : 2026-04-08 Print Date: 2026-01-01 DOI: 10.1530/VB-25-0016

Mishu Mangla, Rohini Motwani, Seetu Palo, Aparna Setty

{"title":"Trophoblast invasion biology: from normal implantation to accreta spectrum and choriocarcinoma.","authors":"Mishu Mangla, Rohini Motwani, Seetu Palo, Aparna Setty","doi":"10.1530/VB-25-0016","DOIUrl":"10.1530/VB-25-0016","url":null,"abstract":"Trophoblast invasion is a finely regulated physiological process that demonstrates controlled cellular migration and vascular remodeling during human pregnancy. During normal implantation, cytotrophoblasts differentiate into extravillous trophoblasts (EVTs), which enter the maternal decidua and remodel spiral arteries, converting them into low-resistance vessels required for fetal nutrition. This balance of invasion and restraint promotes appropriate vascular adaptation at the maternal-fetal interface. Aberrations in this mechanism result in a range of pathological states, from excessive but non-malignant invasion in placenta accreta spectrum (PAS) to uncontrolled, malignant invasion in choriocarcinoma. In PAS, trophoblasts can infiltrate the myometrium due to dysregulated production of matrix metalloproteinases (MMP-2 and MMP-9), integrins, and angiogenic factors (VEGF and HIF-1α). In choriocarcinoma, trophoblastic cells activate PI3K/AKT, Wnt/β-catenin, and Notch signaling, leading to hyperproliferation, immune evasion through PD-L1, and metastatic potential. Despite differences in clinical behavior, many disorders have molecular mediators that link trophoblast invasion to vascular remodeling, angiogenesis, and immunological regulation. Emerging models, including trophoblast organoids, placental explants, and placenta-on-a-chip technologies, offer enhanced platforms to study such pathways at the cellular and molecular levels. This review highlights trophoblast invasion as a model of controlled angiogenic remodeling, providing mechanistic insight into both obstetric pathology and cancer biology. It underscores how studying placental invasion can inform therapeutic strategies targeting abnormal vascular invasion across diseases.","PeriodicalId":75294,"journal":{"name":"Vascular biology (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13087870/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147596750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endothelial RhoGEF Trio is involved in angiogenesis. 内皮RhoGEF Trio参与血管生成。

Vascular biology (Bristol, England) Pub Date : 2026-03-07 Print Date: 2026-01-01 DOI: 10.1530/VB-25-0020

Jeffrey Kroon, Ilse Timmerman, Ilkka Paatero, Mark Hoogenboezem, Serge A van de Pavert, Ester M Weijers, Pieter Koolwijk, Heinz-Georg Belting, Jaap D van Buul

引用次数: 0

Comparative analysis of BMP signaling in human ECFCs reveals vascular bed-dependent ALK2 expression. 人ecfc中BMP信号的比较分析揭示了血管床依赖性ALK2的表达。

Vascular biology (Bristol, England) Pub Date : 2026-02-11 Print Date: 2026-01-01 DOI: 10.1530/VB-25-0010

Nadine Z Großmann, Nurcan Haştar, Yunyun Xiao, Indigo Brakus, Branka Kampfrath, Harm-Jan Bogaard, Robert Szulcek, Reinhold J Medina, Susanne Hildebrandt, Petra Knaus

{"title":"Comparative analysis of BMP signaling in human ECFCs reveals vascular bed-dependent ALK2 expression.","authors":"Nadine Z Großmann, Nurcan Haştar, Yunyun Xiao, Indigo Brakus, Branka Kampfrath, Harm-Jan Bogaard, Robert Szulcek, Reinhold J Medina, Susanne Hildebrandt, Petra Knaus","doi":"10.1530/VB-25-0010","DOIUrl":"10.1530/VB-25-0010","url":null,"abstract":"Graphical abstract: Abstract: Bone morphogenetic protein (BMP) signaling pathway components play a crucial role in cardiovascular homeostasis and sprouting angiogenesis. Endothelial colony-forming cells (ECFCs) are endothelial progenitor cells with a high proliferative and angiogenic capacity and therefore are valuable candidates for angiogenic therapies and vascular regeneration. Of note, a direct comparative analysis of human umbilical cord blood-derived ECFCs (CB-ECFCs) and peripheral blood-derived ECFCs (PB-ECFCs) with a focus on BMP signaling and potential tissue-dependent effects is lacking. In this study, we characterized the BMP signaling responses in ECFCs derived from the umbilical cord and peripheral blood. Analysis of SMAD1/5 phosphorylation showed that BMP2 stimulation only leads to an activation of the BMP signaling pathway in PB-ECFCs, but not in CB-ECFCs. Analysis of gene expression levels of BMP/TGF-β type I and type II receptors demonstrated an elevated expression of ALK2 in PB-ECFCs. Evaluation of sprouting angiogenesis revealed that si-RNA-mediated silencing of ALK2 in CB-ECFCs results in hypersprouting, while si-RNA-mediated silencing of ALK3 leads to hypersprouting in PB-ECFCs. To conclude, we found a differential BMP signaling pathway activation in CB-ECFCs and PB-ECFCs, which is related to vascular bed-dependent expression of ALK2.","PeriodicalId":75294,"journal":{"name":"Vascular biology (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12899316/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146069246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Myeloid HIF1α has only a minor impact on atherosclerosis development. 髓系HIF-1α对动脉粥样硬化的发展只有很小的影响。

Vascular biology (Bristol, England) Pub Date : 2026-01-24 Print Date: 2026-01-01 DOI: 10.1530/VB-25-0011

Nathalie Dehne, Katrin Schröder

{"title":"Myeloid HIF1α has only a minor impact on atherosclerosis development.","authors":"Nathalie Dehne, Katrin Schröder","doi":"10.1530/VB-25-0011","DOIUrl":"10.1530/VB-25-0011","url":null,"abstract":"Atherosclerosis is a progressive inflammatory disease, of which initiation and progression are potentially mediated by myeloid cells. An imbalance of oxygen supply and, therefore, hypoxic situations in the arterial wall have been hypothesized to be a major driver of development and progression of atherosclerosis. Herein, we analyze the significance of hypoxia-inducible factor (HIF) in myeloid cells in atherosclerosis. Myeloid-specific Hif1α and Hif2α knockout mice were crossed into the ApoE-/- background, and angiotensin II (AngII) infusion was performed to induce accelerated plaque formation. Myeloid Hif1α, but not Hif2α, limited the increase in heart weight after 7 days of AngII infusion, indicating a transient protective effect restricted to early phases of AngII-induced remodeling. With prolonged treatment (4 weeks), these differences were lost, suggesting a protective role for myeloid HIF-1α only in early hypertension-induced cardiac hypertrophy. Macrophages of aged mice (12 months old) showed decreased expression of Hif1α and Hif2α, which did not yield overt differences in classical/alternative polarization markers. Nevertheless, aged ApoE-/- mice with macrophage-specific Hif1α knockout had a higher body weight and developed more aortic plaques compared to wild-type littermates. These observations suggest that activation of Hif1α in macrophages may be protective for plaque formation under chronic hyperlipidemic conditions. Supporting this, a reanalysis of single-cell RNA-sequencing data from human atherosclerotic and normal vessel wall specimens shows that HIF target gene expression is elevated in anti-inflammatory macrophage subsets along pseudotime trajectories. This association suggests that macrophage HIF1α activity may contribute to reparative or stabilizing responses during plaque progression.","PeriodicalId":75294,"journal":{"name":"Vascular biology (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13138601/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145960909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vessels in Middle-Earth: meeting report from the 2025 Australasian Summit on Vascular Biology and Microcirculation. 中土世界的血管：2025年澳大拉西亚血管生物学和微循环峰会会议报告。

Vascular biology (Bristol, England) Pub Date : 2026-01-06 Print Date: 2026-01-01 DOI: 10.1530/VB-25-0017

Kazuhide S Okuda, Amy A Baxter, Christopher P Stanley, Claudine S Bonder

{"title":"Vessels in Middle-Earth: meeting report from the 2025 Australasian Summit on Vascular Biology and Microcirculation.","authors":"Kazuhide S Okuda, Amy A Baxter, Christopher P Stanley, Claudine S Bonder","doi":"10.1530/VB-25-0017","DOIUrl":"10.1530/VB-25-0017","url":null,"abstract":"The 2025 Australasian Summit on Vascular Biology and Microcirculation, jointly hosted by the Australian Vascular Biology Society (AVBS) and the Australian and New Zealand Microcirculation Society (ANZMS), convened in Queenstown, New Zealand, bringing together researchers, clinicians, and trainees across diverse disciplines. The meeting featured plenary lectures, award finalist presentations, and thematic sessions spanning vascular pathology and therapeutic discovery, extracellular matrix dynamics, (lymph) angiogenesis, inflammation, and cerebrovascular biology. Early career researchers and PhD students showcased cutting-edge work, underscoring the vibrancy of the next generation of vascular scientists. A dedicated science communication workshop further enriched the program, promoting effective dissemination and impact of vascular biology research. This report summarises the key scientific advances presented, emerging therapeutic targets, and collaborative opportunities that are shaping the future of vascular biology in Australasia and beyond.","PeriodicalId":75294,"journal":{"name":"Vascular biology (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12820937/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145746112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From mummies to internal mammaries: a historical perspective on the discovery of atherosclerosis. 从木乃伊到内部乳房：动脉粥样硬化发现的历史视角。

Vascular biology (Bristol, England) Pub Date : 2026-01-01 DOI: 10.1530/VB-25-0013

Vincent Q Sier, Ferdi Akca, Paul T Sergeant, Jan M De Raet, Andrew J Nelson, Paul H A Quax, Niels Verberkmoes, Alan Dardik, Margreet R de Vries

{"title":"From mummies to internal mammaries: a historical perspective on the discovery of atherosclerosis.","authors":"Vincent Q Sier, Ferdi Akca, Paul T Sergeant, Jan M De Raet, Andrew J Nelson, Paul H A Quax, Niels Verberkmoes, Alan Dardik, Margreet R de Vries","doi":"10.1530/VB-25-0013","DOIUrl":"10.1530/VB-25-0013","url":null,"abstract":"The aim of this study was to explore the historical evolution of atherosclerosis, from early understanding of the function of the heart and blood vessels to the discovery of arterial occlusive disease. This narrative review draws on historical medical texts, archaeological findings, and recent literature. It synthesizes developments in cardiovascular understanding across ancient, classical, and modern eras, with attention to changing paradigms. Evidence of atherosclerosis has been observed in mummified remains from ancient civilizations, predating any formal understanding of the cardiovascular system. In classical antiquity, the heart and vessels were often assigned symbolic or spiritual meaning, gradually giving way to empirical inquiry and anatomical study. Eventually, atherosclerosis came to be recognized as a multifactorial disease with significant clinical consequences. The understanding of atherosclerosis has evolved through centuries of speculation, anatomical discovery, and technological innovation. These perspectives provide a non-exhaustive overview of historical concepts of the cardiovascular system and atherosclerosis in particular.","PeriodicalId":75294,"journal":{"name":"Vascular biology (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13386238/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148450876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endothelial plasticity as a continuum in the tumor microenvironment. 内皮可塑性在肿瘤微环境中是一个连续体。

Vascular biology (Bristol, England) Pub Date : 2026-01-01 DOI: 10.1530/VB-26-0007

Gunvanti Rathod, Pragnesh Parmar, A Aishwarya Teja

{"title":"Endothelial plasticity as a continuum in the tumor microenvironment.","authors":"Gunvanti Rathod, Pragnesh Parmar, A Aishwarya Teja","doi":"10.1530/VB-26-0007","DOIUrl":"10.1530/VB-26-0007","url":null,"abstract":"The tumor microenvironment (TME) is a dynamic and complex ecosystem, in which endothelial cells (ECs) play a central role beyond their traditional function as passive vascular conduits. Increasing evidence indicates that tumor-associated endothelial cells (TECs) undergo profound phenotypic and functional reprogramming, acquiring plasticity that enables them to adapt to hypoxic, inflammatory, and metabolic stresses. This plasticity encompasses a spectrum of states, including angiogenic activation, immune modulation, metabolic reprogramming, and endothelial-to-mesenchymal transition (EndMT). These transitions contribute to abnormal tumor vasculature, immune evasion, and therapeutic resistance. Advances in single-cell transcriptomics, spatial biology, and molecular pathology have revealed distinct endothelial subpopulations with unique biomarker signatures and functional roles within tumors. Importantly, TEC plasticity is now recognized as a key determinant of response to anti-angiogenic therapies and immune checkpoint inhibitors. This review synthesizes current knowledge on endothelial plasticity in cancer, proposes a conceptual framework for classifying TEC phenotypes, and highlights emerging biomarkers and therapeutic strategies targeting endothelial reprogramming. Understanding the dynamic nature of endothelial cells within the TME may enable the development of precision vascular therapies aimed at normalizing tumor vasculature and improving clinical outcomes.","PeriodicalId":75294,"journal":{"name":"Vascular biology (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13663601/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149013404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From mummies to internal mammaries: a historical perspective on the development of cardiovascular bypass surgery. 从木乃伊到内部乳房：心血管搭桥手术发展的历史视角。

Vascular biology (Bristol, England) Pub Date : 2026-01-01 DOI: 10.1530/VB-26-0006

Vincent Q Sier, Ferdi Akca, Paul T Sergeant, Jan M De Raet, Andrew J Nelson, Paul H A Quax, Niels Verberkmoes, Alan Dardik, Margreet R de Vries

{"title":"From mummies to internal mammaries: a historical perspective on the development of cardiovascular bypass surgery.","authors":"Vincent Q Sier, Ferdi Akca, Paul T Sergeant, Jan M De Raet, Andrew J Nelson, Paul H A Quax, Niels Verberkmoes, Alan Dardik, Margreet R de Vries","doi":"10.1530/VB-26-0006","DOIUrl":"10.1530/VB-26-0006","url":null,"abstract":"The aim of this study was to explore the historical development of contemporary surgical revascularization techniques. This narrative review synthesizes historical medical literature, surgical case reports, and key milestones in (cardiovascular) operative innovation. Developments are traced from early experimental surgery to the establishment of reproducible cardiovascular bypass and off-pump techniques, with emphasis on evolving surgical concepts and operative strategies. Progressive advances in vascular suturing, grafting techniques, and perioperative care enabled the transition from arterial ligation to reconstructive bypass surgery. Early success in peripheral revascularization demonstrated the feasibility of circumventing arterial occlusions, while innovations in coronary visualization and myocardial protection facilitated direct coronary intervention. These developments culminated in the establishment of coronary artery bypass grafting, with the internal mammary artery emerging as the cornerstone conduit for durable surgical revascularization. The history of bypassing atherosclerotic lesions has evolved through years of technological innovation and surgical experimentation. This historical investigation outlines the progression from early concepts to the standardization of contemporary surgical revascularization.","PeriodicalId":75294,"journal":{"name":"Vascular biology (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149082993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Placental syncytial knots in the spectrum of maternal vascular malperfusion: mechanisms and clinical implications. 胎盘合胞结在母体血管灌注不良的频谱：机制和临床意义。

Vascular biology (Bristol, England) Pub Date : 2026-01-01 DOI: 10.1530/VB-26-0004

Seetu Palo, Mishu Mangla, Rohini Motwani

{"title":"Placental syncytial knots in the spectrum of maternal vascular malperfusion: mechanisms and clinical implications.","authors":"Seetu Palo, Mishu Mangla, Rohini Motwani","doi":"10.1530/VB-26-0004","DOIUrl":"10.1530/VB-26-0004","url":null,"abstract":"The human placenta is the nexus of maternal-fetal exchange, with its function reflected in histological features such as syncytial knots. These nuclear aggregations within the syncytiotrophoblast, historically termed Tenney-Parker changes when excessive, serve as critical markers of both placental maturation and maladaptation. This narrative review synthesizes the current understanding of their structural, ultrastructural, and molecular features, emphasizing the biological significance of the syncytial knot index as a quantitative marker of placental function. The syncytial knot index rises progressively with gestation but increases prematurely in conditions such as preeclampsia, fetal growth restriction, maternal vascular malperfusion, and chronic hypoxia, reflecting accelerated syncytiotrophoblast aging and oxidative injury. This review also highlights the mechanistic pathways - apoptosis, senescence, hypoxia-driven signaling, and disturbed trophoblast turnover - that determine knot formation. Emerging evidence on syncytiotrophoblast-derived microparticles illustrates their potential role in mediating maternal endothelial dysfunction and systemic manifestations of placental disease. Despite its diagnostic value, the syncytial knot index remains underutilized due to methodological variability; however, digital pathology, stereology, and 3D imaging now offer promising avenues for standardized assessment.","PeriodicalId":75294,"journal":{"name":"Vascular biology (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13427977/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148458085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0