Uirusu最新文献

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[One hundred million years history of bornavirus infection]. [1亿年的冠状病毒感染史]。
Uirusu Pub Date : 2022-01-01 DOI: 10.2222/jsv.72.47
Masayuki Horie
{"title":"[One hundred million years history of bornavirus infection].","authors":"Masayuki Horie","doi":"10.2222/jsv.72.47","DOIUrl":"https://doi.org/10.2222/jsv.72.47","url":null,"abstract":"","PeriodicalId":75275,"journal":{"name":"Uirusu","volume":"72 1","pages":"47-54"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71415860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Uirusu Pub Date : 2022-01-01 DOI: 10.2222/jsv.72.63
Koji Yahara
{"title":"","authors":"Koji Yahara","doi":"10.2222/jsv.72.63","DOIUrl":"https://doi.org/10.2222/jsv.72.63","url":null,"abstract":"","PeriodicalId":75275,"journal":{"name":"Uirusu","volume":"72 1","pages":"63-66"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71415852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Comprehensive understanding of viral diseases by field, molecular, and theoretical studies]. [通过领域、分子和理论研究全面了解病毒性疾病]。
Uirusu Pub Date : 2022-01-01 DOI: 10.2222/jsv.72.87
Yuki Furuse
{"title":"[Comprehensive understanding of viral diseases by field, molecular, and theoretical studies].","authors":"Yuki Furuse","doi":"10.2222/jsv.72.87","DOIUrl":"https://doi.org/10.2222/jsv.72.87","url":null,"abstract":"<p><p>Viral diseases are responsible for substantial morbidity and mortality and continue to be of great concern. To ensure better control of viral infections, I have been tackling the issue as a medical doctor, an academic researcher, and a public health officer. Especially, I have studied respiratory viruses, such as the influenza virus, from the perspectives of molecular virology, theoretical modeling, and field epidemiology. RNA biology and its involvement with viral life-cycle and pathogenicity are central topics of molecular study, while mathematical models of transmission dynamics and phylogenetics are major components of theoretical research. As a field epidemiologist, I work with public health authorities during viral disease outbreaks. I was deployed to West Africa for viral hemorrhagic fever outbreak responses as a WHO consultant, and I have served the Japanese Government as an advisor for COVID-19 countermeasures. I would like to integrate various approaches from clinical medicine to epidemiology, theoretical modeling, evolutionary biology, genetics, and molecular biology in my research. In that way, we could gain a more comprehensive understanding of viral diseases. I hope these findings will help ease the disease burden of viral infections around the world.</p>","PeriodicalId":75275,"journal":{"name":"Uirusu","volume":"72 1","pages":"87-92"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71415854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Reverse genetics systems for Reoviridae viruses]. [呼肠孤病毒科病毒的反向遗传系统]。
Uirusu Pub Date : 2022-01-01 DOI: 10.2222/jsv.72.55
Yuta Kanai, Ryotaro Nouda, Takeshi Kobayashi
{"title":"[Reverse genetics systems for Reoviridae viruses].","authors":"Yuta Kanai,&nbsp;Ryotaro Nouda,&nbsp;Takeshi Kobayashi","doi":"10.2222/jsv.72.55","DOIUrl":"https://doi.org/10.2222/jsv.72.55","url":null,"abstract":"","PeriodicalId":75275,"journal":{"name":"Uirusu","volume":"72 1","pages":"55-62"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71415861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Developing a Biosafety Level 4 Laboratory user training program]. [制定生物安全 4 级实验室用户培训计划]。
Uirusu Pub Date : 2022-01-01 DOI: 10.2222/jsv.72.125
Asuka Nanbo, Shuzo Urata, Yoshimi Tsuda
{"title":"[Developing a Biosafety Level 4 Laboratory user training program].","authors":"Asuka Nanbo, Shuzo Urata, Yoshimi Tsuda","doi":"10.2222/jsv.72.125","DOIUrl":"https://doi.org/10.2222/jsv.72.125","url":null,"abstract":"<p><p>In recent years, numerous emerging and reemerging infectious diseases have occurred worldwide and have seriously threatened our society. As a countermeasure against the pathogens responsible for serious diseases (classified as class 4 pathogens), we are preparing for full operation of the first suit-type biosafety level 4 (BSL-4) facility available for basic and applied research at Nagasaki University. For the safe operation of these facilities, experienced and qualified personnel with appropriate skills and knowledge of biorisk management must be certified. Developing an appropriate training system is a prerequisite for ensuring the safety of users involved in research in a BSL-4 laboratory. Here, we introduce an overview of the content of the training program that we are currently establishing for the BSL-4 facility at Nagasaki University. We are designing this program to follow national and international guidelines and regulations in part by referring to experiences and materials derived from multiple BSL-4 facilities in other countries. The established training program system, including the formulation processes, will serve as a reference and will provide practical materials for other research organizations to develop their own high-containment laboratory training programs.</p>","PeriodicalId":75275,"journal":{"name":"Uirusu","volume":"72 2","pages":"125-130"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139467413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Isolation of anti-SARS-CoV-2 neutralizing monoclonal antibodies cross effective to variants aiming at antibody therapy]. [抗sars - cov -2中和性单克隆抗体与针对抗体治疗的变异交叉有效的分离]。
Uirusu Pub Date : 2021-01-01 DOI: 10.2222/jsv.71.163
{"title":"[Isolation of anti-SARS-CoV-2 neutralizing monoclonal antibodies cross effective to variants aiming at antibody therapy].","authors":"","doi":"10.2222/jsv.71.163","DOIUrl":"https://doi.org/10.2222/jsv.71.163","url":null,"abstract":"<p><p>We isolated five mAbs with potent neutralizing activities against SARS-CoV-2 from two convalescent COVID-19 patients infected with prototype virus. Among them, the 9-105 antibody that have a highest affinity for the receptor-binding domain (RBD), cross-neutralize variants, such as B.1.1.7 (alfa), mink cluster 5 variant, B.1.351 (beta), P.1 (gamma), C.37 (lambda), B.1.617.1 (kappa), B.1.617.2 (delta) and B.1.621 (mu). A single amino acid mutation at K417 of RBD decreased neutralization sensitivity of 9-105. A 9-105 homology model revealed that 9-105 light chain binds to RBD including K417 by the same angle as ACE2.</p>","PeriodicalId":75275,"journal":{"name":"Uirusu","volume":"71 2","pages":"163-168"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9526056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Infectivity-enhancing antibodies against SARS-CoV-2]. [抗SARS-CoV-2感染增强抗体]。
Uirusu Pub Date : 2021-01-01 DOI: 10.2222/jsv.71.169
{"title":"[Infectivity-enhancing antibodies against SARS-CoV-2].","authors":"","doi":"10.2222/jsv.71.169","DOIUrl":"https://doi.org/10.2222/jsv.71.169","url":null,"abstract":"<p><p>Antibodies against the receptor binding domain of the spike protein of SARS-CoV-2 play an important role in preventing infection as neutralizing antibodies. However, antibodies that recognize a specific site on the N-terminal domain of the spike protein induce an open domain of receptor binding that increases the binding of ACE2 and enhances the infectivity of SARS-CoV-2. Furthermore, the presence of the infectivity-enhancing antibodies reduces the neutralizing activity of the neutralizing antibodies. Therefore, when considering the antibody response to SARS-CoV-2, it is necessary to consider not only neutralizing antibodies but also the balance between neutralizing and infectivity-enhancing antibodies. In this article, function and mechanism of infectivity-enhancing antibodies are introduced.</p>","PeriodicalId":75275,"journal":{"name":"Uirusu","volume":"71 2","pages":"169-174"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9533692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
[The latest research findings on Ebola virus]. [埃博拉病毒的最新研究结果]。
Uirusu Pub Date : 2021-01-01 DOI: 10.2222/jsv.71.137
{"title":"[The latest research findings on Ebola virus].","authors":"","doi":"10.2222/jsv.71.137","DOIUrl":"https://doi.org/10.2222/jsv.71.137","url":null,"abstract":"<p><p>013-2016 Ebola virus disease (EVD) outbreak was the largest EVD outbreak ever documented that started earlier in Guinea and later widely spread throughout West Africa, ending up a total of > 28,000 human infections. In this review, we outline research findings on Ebola virus (EBOV) variant Makona, a new EBOV variant isolated from the 2013-2016 EVD outbreak, and introduce the unique biological and pathogenic characteristics of Makona variant. We also discuss about the relevance of persistent infection of EBOV in EVD survivors with resurgence of EVD outbreak in Guinea in 2021. Moreover, this review covers a recent case report of EVD relapse and deliberates new interpretations of EBOV biology and EVD outbreak.</p>","PeriodicalId":75275,"journal":{"name":"Uirusu","volume":"71 2","pages":"137-150"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9526052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Yezo virus and emerging orthonairovirus diseases]. [叶佐病毒和新出现的原鼻病毒疾病]。
Uirusu Pub Date : 2021-01-01 DOI: 10.2222/jsv.71.117
Keita Matsuno
{"title":"[Yezo virus and emerging orthonairovirus diseases].","authors":"Keita Matsuno","doi":"10.2222/jsv.71.117","DOIUrl":"https://doi.org/10.2222/jsv.71.117","url":null,"abstract":"<p><p>A new etiological agent of an acute febrile illness following tick bite has been found in Hokkaido, Japan, in 2019 and designated as Yezo virus. Seven cases of Yezo virus infection were identified from 2014 to 2020 by passive and retrospective surveillance. Yezo virus is classified into the genus Orthonairovirus, family Nairoviridae and forms Sulina genogroup together with Sulina virus, which was identified in ticks in Romania. The Sulina genogroup viruses are closely related to the Tamdy genogroup viruses recently reported as causative agents of febrile illness in China and distant from known orthonairovirus pathogens, such as Crimean-Congo hemorrhagic fever virus. Since only limited information is available for the emerging orthonairovirus diseases, including Yezo virus infection, their occurrence should be carefully monitored.</p>","PeriodicalId":75275,"journal":{"name":"Uirusu","volume":"71 2","pages":"117-124"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9526057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Uirusu Pub Date : 2021-01-01 DOI: 10.2222/jsv.71.185
{"title":"","authors":"","doi":"10.2222/jsv.71.185","DOIUrl":"https://doi.org/10.2222/jsv.71.185","url":null,"abstract":"","PeriodicalId":75275,"journal":{"name":"Uirusu","volume":"71 2","pages":"185-190"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9533691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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