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Uirusu Pub Date : 2023-01-01 DOI: 10.2222/jsv.73.53
{"title":"","authors":"","doi":"10.2222/jsv.73.53","DOIUrl":"https://doi.org/10.2222/jsv.73.53","url":null,"abstract":"","PeriodicalId":75275,"journal":{"name":"Uirusu","volume":"73 1","pages":"53-56"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142334068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Uirusu Pub Date : 2023-01-01 DOI: 10.2222/jsv.73.77
{"title":"","authors":"","doi":"10.2222/jsv.73.77","DOIUrl":"https://doi.org/10.2222/jsv.73.77","url":null,"abstract":"","PeriodicalId":75275,"journal":{"name":"Uirusu","volume":"73 1","pages":"77-78"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142334074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Uirusu Pub Date : 2023-01-01 DOI: 10.2222/jsv.73.57
{"title":"","authors":"","doi":"10.2222/jsv.73.57","DOIUrl":"https://doi.org/10.2222/jsv.73.57","url":null,"abstract":"","PeriodicalId":75275,"journal":{"name":"Uirusu","volume":"73 1","pages":"57-62"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142334069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Molecular epidemiology and evolution of human noroviruses]. [人类诺罗病毒的分子流行病学和进化]。
Uirusu Pub Date : 2023-01-01 DOI: 10.2222/jsv.73.17
Kentaro Tohma, Hiroshi Ushijima
{"title":"[Molecular epidemiology and evolution of human noroviruses].","authors":"Kentaro Tohma, Hiroshi Ushijima","doi":"10.2222/jsv.73.17","DOIUrl":"https://doi.org/10.2222/jsv.73.17","url":null,"abstract":"<p><p>Noroviruses are the most common viral cause of acute gastroenteritis after the introduction of rotavirus vaccines. Norovirus infection can cause severe symptoms in vulnerable populations including young children and the elderly. Thus, it is still a leading cause of death from diarrhea in children in developing countries. Recent advancement of genomics platforms facilitated understanding of the epidemiology of norovirus, while the whole picture of norovirus diversity is still undetermined. Currently, there are no approved vaccines for norovirus, but state-of-the-art norovirus cultivation systems could elucidate the antigenic diversity of this fast-evolving virus. In this review, we will summarize the historical and latest findings of norovirus epidemiology, diversity, and evolution.</p>","PeriodicalId":75275,"journal":{"name":"Uirusu","volume":"73 1","pages":"17-32"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142334082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Development of an engineered ACE2 decoy for COVID-19 therapy.] [开发用于COVID-19疗法的工程化ACE2诱饵]
Uirusu Pub Date : 2023-01-01 DOI: 10.2222/jsv.73.163
Toru Okamoto, Yumi Itoh, Tatsuya Suzuki
{"title":"[Development of an engineered ACE2 decoy for COVID-19 therapy.]","authors":"Toru Okamoto, Yumi Itoh, Tatsuya Suzuki","doi":"10.2222/jsv.73.163","DOIUrl":"https://doi.org/10.2222/jsv.73.163","url":null,"abstract":"<p><p>It has been passed four years since the pandemic caused by the severe acute respiratory syndrome-2 (SARS-CoV-2) that began in 2019. Since June 2020, we have been working on a project to develop a therapeutic drug using receptor decoys, even though we cannot predict how long the pandemic will last or how long our daily lives will be restricted. This receptor decoy utilizes Angiotensin-converting enzyme 2 (ACE2), which is the receptor for SARS-CoV-2, and involves introducing mutations that enhance its binding ability with the spike protein of SARS-CoV-2. This high-affinity ACE2, acting as a decoy protein, is a strategy to inhibit viral infection and to expect therapeutic effects by replacing the endogeneous ACE2 that SARS-CoV-2 binds to with ACE2 decoy. This paper introduces the development of ACE2 decoys that have progressed through collaborative research with many researchers outside the field of virology.</p>","PeriodicalId":75275,"journal":{"name":"Uirusu","volume":"73 2","pages":"163-172"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142334086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Uirusu Pub Date : 2023-01-01 DOI: 10.2222/jsv.73.63
{"title":"","authors":"","doi":"10.2222/jsv.73.63","DOIUrl":"https://doi.org/10.2222/jsv.73.63","url":null,"abstract":"","PeriodicalId":75275,"journal":{"name":"Uirusu","volume":"73 1","pages":"63-66"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142334070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Identification of a human parechovirus receptor; MYADM]. [人类帕氏病毒受体的鉴定；MYADM]。
Uirusu Pub Date : 2023-01-01 DOI: 10.2222/jsv.73.183
Kanako Watanabe, Masahiro Fujii
{"title":"[Identification of a human parechovirus receptor; MYADM].","authors":"Kanako Watanabe, Masahiro Fujii","doi":"10.2222/jsv.73.183","DOIUrl":"https://doi.org/10.2222/jsv.73.183","url":null,"abstract":"","PeriodicalId":75275,"journal":{"name":"Uirusu","volume":"73 2","pages":"183-188"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142334088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Identification of new host factors supporting the human papillomavirus life cycle]. [确定支持人类乳头瘤病毒生命周期的新宿主因素]。
Uirusu Pub Date : 2023-01-01 DOI: 10.2222/jsv.73.189
Yoshiyuki Ishii, Seiichiro Mori, Iwao Kukimoto
{"title":"[Identification of new host factors supporting the human papillomavirus life cycle].","authors":"Yoshiyuki Ishii, Seiichiro Mori, Iwao Kukimoto","doi":"10.2222/jsv.73.189","DOIUrl":"https://doi.org/10.2222/jsv.73.189","url":null,"abstract":"","PeriodicalId":75275,"journal":{"name":"Uirusu","volume":"73 2","pages":"189-198"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142334089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[RNA Virus Pathogenicity, Evolution, and Intrapopulation Interaction]. [RNA 病毒的致病性、进化和种群内相互作用]。
Uirusu Pub Date : 2023-01-01 DOI: 10.2222/jsv.73.95
Yuta Shirogane
{"title":"[RNA Virus Pathogenicity, Evolution, and Intrapopulation Interaction].","authors":"Yuta Shirogane","doi":"10.2222/jsv.73.95","DOIUrl":"https://doi.org/10.2222/jsv.73.95","url":null,"abstract":"<p><p>Measles virus (MeV), the causative agent of measles, can persist in the brain and cause a fatal neurodegenerative disease, subacute sclerosing panencephalitis (SSPE). Because wild-type MeV is not neurotropic, the virus is thought to evolve and acquire neuropathogenicity to cause SSPE. Our recent studies have shown that MeV acquires hyperfusogenic mutations in the fusion (F) gene that confer the ability to use cell adhesion molecule 1 (CADM1) and CADM2 as cis-acting receptor mimicking molecules and allow MeV to spread in neurons. Furthermore, under these conditions, multiple MeV genomes, rather than a single one, are likely to be transmitted transsynaptically between neurons through cell-cell fusion. Therefore, F proteins encoded by different genomes are co-expressed in infected cells, and positive and negative functional interactions between them can occur. These interactions determine the ability of the virus to spread in neurons as a population. In this article, we describe our studies to understand the mechanism by which MeV acquires neuropathogenicity in SSPE.</p>","PeriodicalId":75275,"journal":{"name":"Uirusu","volume":"73 1","pages":"95-104"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142334084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Changes in rotavirus epidemic strains]. [轮状病毒流行株的变化]。
Uirusu Pub Date : 2023-01-01 DOI: 10.2222/jsv.73.33
Yoshiki Fujii
{"title":"[Changes in rotavirus epidemic strains].","authors":"Yoshiki Fujii","doi":"10.2222/jsv.73.33","DOIUrl":"https://doi.org/10.2222/jsv.73.33","url":null,"abstract":"<p><p>Rotavirus is a major cause of gastroenteritis in infants and is widely prevalent throughout the world regardless of the hygienic environment. However, it is not easy to understand the overall picture of rotavirus epidemic because of the great variety of genotypes and the large inter-seasonal and regional differences in the prevalent strains. Fortunately, the rotavirus vaccines now widely used around the world are highly effective and safe. The number of rotavirus gastroenteritis cases is declining dramatically, especially in high-income countries. In Japan, rotavirus vaccines have been included in the routine vaccination program since October 2020. Additionally, the impact of the SARS-CoV-2 pandemic control measures on the rotavirus epidemic was also very significant. These synergistic effects have resulted in few rotavirus outbreaks in recent years. Nevertheless, rotavirus is unlikely to be completely eradicated, and indeed a small number of sporadic cases continue to be reported. It will continue to be important to maintain high vaccination coverage and to continuously investigate prevalent strains. This review will provide an overview of the rotavirus epidemic situation in Japan and abroad. Annual changes in domestic epidemic strains that have been revealed by steady research to date will also be presented.</p>","PeriodicalId":75275,"journal":{"name":"Uirusu","volume":"73 1","pages":"33-44"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142334078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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