Uirusu最新文献

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[The current situation of H5 high pathogenicity avian influenza viruses in wild birds and mammals]. [H5高致病性禽流感病毒在野生鸟类和哺乳动物中的现状]。
Uirusu Pub Date : 2024-01-01 DOI: 10.2222/jsv.74.107
Takahiro Hiono, Norikazu Isoda, Yoshihiro Sakoda
{"title":"[The current situation of H5 high pathogenicity avian influenza viruses in wild birds and mammals].","authors":"Takahiro Hiono, Norikazu Isoda, Yoshihiro Sakoda","doi":"10.2222/jsv.74.107","DOIUrl":"https://doi.org/10.2222/jsv.74.107","url":null,"abstract":"<p><p>H5 high pathogenicity avian influenza viruses, which emerged in Guangdong Province, China, in 1996, has now been persistently transmitted among various wild birds due to the \"silent spreading\" of the viruses among vaccinated poultry and domestic waterfowl. These viruses traveled long distances along with bird migration; therefore, the threat of H5 high pathogenicity avian influenza viruses is now a global issue. Furthermore, infection in wild mammals has become more prominent since 2020. The contamination of the wild bird population by the virus is considered to be an irreversible situation, and thus, the reduction of virus levels in the environment is an urgent issue to prevent further deterioration of the situation. This review will describe the history and current situations of influenza virus infection in wild birds and mammals, and discuss the research and countermeasures that are required to stop the damage caused by this virus.</p>","PeriodicalId":75275,"journal":{"name":"Uirusu","volume":"74 2","pages":"107-116"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143538218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Data-Driven Research for Understanding and Predicting Viral Epidemics and Evolution]. [了解和预测病毒流行和进化的数据驱动研究]。
Uirusu Pub Date : 2024-01-01 DOI: 10.2222/jsv.74.49
Jumpei Ito
{"title":"[Data-Driven Research for Understanding and Predicting Viral Epidemics and Evolution].","authors":"Jumpei Ito","doi":"10.2222/jsv.74.49","DOIUrl":"10.2222/jsv.74.49","url":null,"abstract":"<p><p>The era of big data has begun in life sciences, and virology is no exception. Especially since COVID-19, virology has become one of the most genome data-rich fields in life sciences. In this article, I will introduce the new paradigm of \"understanding and predicting viral epidemics and evolution, \" made possible by the emergence of vast amounts of genome data, focusing on my research to date. Additionally, I would like to introduce our efforts toward advancing the field of viral informatics.</p>","PeriodicalId":75275,"journal":{"name":"Uirusu","volume":"74 1","pages":"49-56"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Creation of enveloped viral replica equipped with SARS-CoV2 spike protein]. [制造带有SARS-CoV2刺突蛋白的包膜病毒复制品]。
Uirusu Pub Date : 2024-01-01 DOI: 10.2222/jsv.74.159
Kazunori Matsuura, Hiroto Furukawa
{"title":"[Creation of enveloped viral replica equipped with SARS-CoV2 spike protein].","authors":"Kazunori Matsuura, Hiroto Furukawa","doi":"10.2222/jsv.74.159","DOIUrl":"https://doi.org/10.2222/jsv.74.159","url":null,"abstract":"","PeriodicalId":75275,"journal":{"name":"Uirusu","volume":"74 2","pages":"159-164"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143538196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Study of practical biorisk management in microbiological containment laboratories]. 微生物控制实验室实际生物风险管理研究
Uirusu Pub Date : 2024-01-01 DOI: 10.2222/jsv.74.131
Yohei Kurosaki, Ken-Ichi Hanaki, Shuetsu Fukushi, Masayuki Shimojima, Yasuhiro Kawai, Asuka Nanbo, Katuaki Shinohara, Shintaro Shichinohe
{"title":"[Study of practical biorisk management in microbiological containment laboratories].","authors":"Yohei Kurosaki, Ken-Ichi Hanaki, Shuetsu Fukushi, Masayuki Shimojima, Yasuhiro Kawai, Asuka Nanbo, Katuaki Shinohara, Shintaro Shichinohe","doi":"10.2222/jsv.74.131","DOIUrl":"10.2222/jsv.74.131","url":null,"abstract":"<p><p>Biosafety Level 4 facilities have been established in our country to promote research and development and national capacity of diagnostic test systems for infectious diseases, including highly pathogenic viruses. In particular, the operation of a suit-type laboratory requiring positive pressure protective suits is a first for our country, and it is necessary to establish unique safety management technology. With the support of the Research Program on Emerging and Re-emerging Infectious Diseases of the Japan Agency for Medical Research and Development (AMED), we conducted research entitled \"Study of Practical Biorisk Management in the Microbiological Containment Laboratories\" from 2021 to 2023, with the aim of improving biosafety management technology in Japan. We have summarized our research project and its results obtained for the future direction of biorisk management research in Japan.</p>","PeriodicalId":75275,"journal":{"name":"Uirusu","volume":"74 2","pages":"131-140"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143538216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Analysis of RNA virus pathogenicity and development of novel prevention methods.] RNA病毒致病性分析及新型预防方法的发展
Uirusu Pub Date : 2024-01-01 DOI: 10.2222/jsv.74.57
Ryuta Uraki
{"title":"[Analysis of RNA virus pathogenicity and development of novel prevention methods.]","authors":"Ryuta Uraki","doi":"10.2222/jsv.74.57","DOIUrl":"10.2222/jsv.74.57","url":null,"abstract":"<p><p>In the first quarter of the 21st century, infectious diseases caused by RNA viruses such as SARS, pandemic influenza viruses, MERS, Zika virus, and SARS-CoV-2 have spread. When such emerging and re-emerging viruses occur and spread, it is important for public health to quickly analyze the characteristics of these viruses and develop preventive measures. We found that the Zika virus causes damage to the testes, leading to testicular atrophy; that a vaccine based on mosquito salivary gland proteins suppresses mosquito-borne Zika virus transmission/infection; that the pathogenicity of SARS-CoV-2 Omicron variants BA.2, BA.4, and BA.5 isolated from patients is comparable to that of Omicron BA.1; and that a strategy targeting regulatory T cells to enhance vaccine efficacy is effective. Here, I would like to briefly discuss these findings.</p>","PeriodicalId":75275,"journal":{"name":"Uirusu","volume":"74 1","pages":"57-66"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Uirusu Pub Date : 2023-01-01 DOI: 10.2222/jsv.73.45
{"title":"","authors":"","doi":"10.2222/jsv.73.45","DOIUrl":"https://doi.org/10.2222/jsv.73.45","url":null,"abstract":"","PeriodicalId":75275,"journal":{"name":"Uirusu","volume":"73 1","pages":"45-48"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142334066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Integrase and reversetranscriptase: New insights into the HIV genome replication system in line.] [整合酶和逆转录酶:对艾滋病毒基因组复制系统的新认识]
Uirusu Pub Date : 2023-01-01 DOI: 10.2222/jsv.73.139
Takao Masuda, Gota Kawai
{"title":"[Integrase and reversetranscriptase: New insights into the HIV genome replication system in line.]","authors":"Takao Masuda, Gota Kawai","doi":"10.2222/jsv.73.139","DOIUrl":"https://doi.org/10.2222/jsv.73.139","url":null,"abstract":"<p><p>Reverse transcriptase (RT) and integrase (IN) are retrovirus enzymes to convert virus genomic RNA into provirus DNA state in host cells. The RT and IN encoded tandemly in the pol gene, are translated as a fused form and incorporated into the virus particles. Recently, we discovered the potential role of HIV-1 IN to regulate the reverse transcription through the fused state with RT (RT-IN). On the other hand, analysis of HIV-1 transcripts have revealed the variations in number of guanine residue at the 5' end (5'G) due to fluctuations in the transcription initiation point within HIV-1 provirus DNA. Importantly, the number of 5'G dictates the packaging of HIV genome RNA into virus particles serving as a template for the reverse transcription reaction. In this review, we provide new insights into the mechanism of HIV genome replication based on our recent findings of the structural-functional correlation of HIV enzymes (RT and IN) and virus genomic RNA.</p>","PeriodicalId":75275,"journal":{"name":"Uirusu","volume":"73 2","pages":"139-146"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142334090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Neutralizing antibodies against SARS-CoV-2]. [针对 SARS-CoV-2 的中和抗体]。
Uirusu Pub Date : 2023-01-01 DOI: 10.2222/jsv.73.153
Saya Moriyama
{"title":"[Neutralizing antibodies against SARS-CoV-2].","authors":"Saya Moriyama","doi":"10.2222/jsv.73.153","DOIUrl":"https://doi.org/10.2222/jsv.73.153","url":null,"abstract":"<p><p>Severe acute respiratory syndrome (SARS) corona virus 2 (SARS-CoV-2) is a novel coronavirus that infects humans and causes respiratory symptoms, resulting in a global pandemic since its appearance in 2019. Neutralizing antibody production is an important immune response following SARS-CoV-2 infection, and a great deal of research has been performed regarding the immune response against SARS-CoV-2 infection. However, SARS-CoV-2 is constantly changing and multiple amino acid reconstitutions accumulated in the spike protein enabled viruses to escape from immune responses, especially from neutralizing antibodies. In this review, the antibody responses to SARS-CoV-2 and the emergence of escape variants, and the development of broadly neutralizing antibodies will be introduced.</p>","PeriodicalId":75275,"journal":{"name":"Uirusu","volume":"73 2","pages":"153-162"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142334091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Uirusu Pub Date : 2023-01-01 DOI: 10.2222/jsv.72.167
Tomotaka Okamura, Yasuhiro Yasutomi
{"title":"","authors":"Tomotaka Okamura, Yasuhiro Yasutomi","doi":"10.2222/jsv.72.167","DOIUrl":"10.2222/jsv.72.167","url":null,"abstract":"","PeriodicalId":75275,"journal":{"name":"Uirusu","volume":"72 2","pages":"167-170"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139467422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Uirusu Pub Date : 2023-01-01 DOI: 10.2222/jsv.73.67
{"title":"","authors":"","doi":"10.2222/jsv.73.67","DOIUrl":"https://doi.org/10.2222/jsv.73.67","url":null,"abstract":"","PeriodicalId":75275,"journal":{"name":"Uirusu","volume":"73 1","pages":"67-70"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142334071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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