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Translational perioperative and pain medicine最新文献

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Translational Role of Rodent Models to Study Ventilator-Induced Lung Injury. 啮齿动物模型在呼吸机致肺损伤研究中的转化作用。
Translational perioperative and pain medicine Pub Date : 2021-12-01 Epub Date: 2021-11-27
Koichi Yuki, Sophia Koutsogiannaki
{"title":"Translational Role of Rodent Models to Study Ventilator-Induced Lung Injury.","authors":"Koichi Yuki,&nbsp;Sophia Koutsogiannaki","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Mechanical ventilation is an important part of medical care in intensive care units and operating rooms to support respiration. While it is a critical component of medical care, it is well known that mechanical ventilation itself can be injurious to the lungs. Despite a large number of clinical and preclinical studies that have been done so far, there still exists a gap of knowledge regarding how to ventilate patients mechanically without increasing lung injury. Here, we will review what we have learned so far from preclinical and clinical studies and consider how to use preclinical models of ventilation-induced lung injury that better recapitulate the clinical scenarios.</p>","PeriodicalId":75245,"journal":{"name":"Translational perioperative and pain medicine","volume":"8 4","pages":"404-415"},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8729883/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39792589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Microbial Flora in an Experimental Polymicrobial Abdominal Sepsis Model Probed by 16S rRNA Sequencing. 通过 16S rRNA 测序探究实验性多微生物腹腔败血症模型中的微生物菌群。
Translational perioperative and pain medicine Pub Date : 2021-01-01 Epub Date: 2020-12-22
Miho Shibamura-Fujiogi, Sophia Koutsogiannaki, Lifei Hou, Koichi Yuki
{"title":"The Microbial Flora in an Experimental Polymicrobial Abdominal Sepsis Model Probed by 16S rRNA Sequencing.","authors":"Miho Shibamura-Fujiogi, Sophia Koutsogiannaki, Lifei Hou, Koichi Yuki","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Cecal ligation and puncture (CLP) surgery is a widely used preclinical model to induce and study sepsis because it is considered to recapitulate the course of human sepsis the most. This model is highly dependent on the polymicrobial gut flora and represents polymicrobial abdominal sepsis. While the majority of studies using CLP model have focused on the delineation of host immune responses, a limited number of reports have described the composition of microbial strains in this model, although microbial composition can significantly affect the outcome of sepsis in general.</p><p><strong>Methods: </strong>CLP surgery was performed in mice on C57BL6/J from the Jackson laboratory. We examined the composition of microbes at the peritoneal cavity using 16S rRNA sequencing after CLP surgery at 12 and 24 hours. Baseline cecal microbial flora was also analyzed.</p><p><strong>Results: </strong>The bacteria strains from the initial cecum flora consisted of mixed aerobic and anaerobic flora. There was a significant change of bacteria flora from the peritoneal cavity between 12 and 24 hours following CLP surgery. Particularly a significantly increased proportion of anaerobic microbes were noted at 24 hours after CLP surgery. We also tested bacterial composition of cecal flora of mice on the same background from the same vendor 6 months later. Baseline cecal microbial flora was different from earlier mice, showing that baseline cecal flora could be different depending on the batch of mice.</p><p><strong>Conclusion: </strong>There was a dynamical chance of peritoneal microbes during CLP sepsis. Potential difference in baseline cecal flora should be kept in mind upon CLP surgery even when using mice from the same vendor.</p>","PeriodicalId":75245,"journal":{"name":"Translational perioperative and pain medicine","volume":"8 1","pages":"305-311"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7840154/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25316123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How Does the SARS-CoV-2 Pandemic Affect Cardiac Surgery Practice 严重急性呼吸系统综合征冠状病毒2型疫情如何影响心脏外科实践
Translational perioperative and pain medicine Pub Date : 2020-12-31 DOI: 10.31480/2330-4871/134
M. Benjamin, L. Hong, L. David
{"title":"How Does the SARS-CoV-2 Pandemic Affect Cardiac Surgery Practice","authors":"M. Benjamin, L. Hong, L. David","doi":"10.31480/2330-4871/134","DOIUrl":"https://doi.org/10.31480/2330-4871/134","url":null,"abstract":"","PeriodicalId":75245,"journal":{"name":"Translational perioperative and pain medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44468020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Microbial Flora in an Experimental Polymicrobial Abdominal Sepsis Model Probed by 16S rRNA Sequencing 用16S rRNA测序检测实验性多微生物腹腔脓毒症模型中的微生物菌群
Translational perioperative and pain medicine Pub Date : 2020-12-31 DOI: 10.31480/2330-4871/132
Shibamura-Fujiogi Miho, Koutsogiannaki Sophia, Hou Lifei, Y. Koichi
{"title":"The Microbial Flora in an Experimental Polymicrobial Abdominal Sepsis Model Probed by 16S rRNA Sequencing","authors":"Shibamura-Fujiogi Miho, Koutsogiannaki Sophia, Hou Lifei, Y. Koichi","doi":"10.31480/2330-4871/132","DOIUrl":"https://doi.org/10.31480/2330-4871/132","url":null,"abstract":"","PeriodicalId":75245,"journal":{"name":"Translational perioperative and pain medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47070901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The lateral Habenula: Role in Chronic Pain and Depression 侧Habenula在慢性疼痛和抑郁中的作用
Translational perioperative and pain medicine Pub Date : 2020-12-31 DOI: 10.31480/2330-4871/126
Guang-fen Zhang, Guo Jie, Jian-Jun Yang
{"title":"The lateral Habenula: Role in Chronic Pain and Depression","authors":"Guang-fen Zhang, Guo Jie, Jian-Jun Yang","doi":"10.31480/2330-4871/126","DOIUrl":"https://doi.org/10.31480/2330-4871/126","url":null,"abstract":"Pain and depression share common neuroanatomical underpinnings, and the brain area affected by depression is also involved in the perception and processing of pain. The brain areas affected by both pain and depression include the insular cortex, medial prefrontal cortex, anterior cingulate cortex, hippocampus, habenula, amygdala, and thalamus [12-14]. The habenula is an evolutionarily ancient and centrally located nucleus that participates in a series of important biological processes [15]. The neural circuit composed of the habenula, periaqueductal gray, ventral tegmental area (VTA), and dorsal raphe nucleus (DRN) regulates norepinephrine (NE), serotonin (5-HT), dopamine (DA), and other neurotransmitter systems that are closely related to pain and depression [1618]. Recent studies have suggested that the activation of the habenula and the subsequent changes in neurotransmitter activity caused by chronic pain are an important explanation for the promotion of depression-like behavior, and the activation of the habenula might also be a key factor causing pain sensitivity under conditions of depression [19,20]. As a core brain region that transmits information from the forebrain limbic system to the midbrain monoaminergic and dopaminergic neurons, the habenula might be an important region in the pathogenesis of pain-depression comorbidity and might also serve as a therapeutic target. Thus, this article summarizes the structural and functional changes in the habenula in chronic pain and depression, both individually and together, and explores the mechanism of habenular involvement in pain-depression comorbidity. Introduction","PeriodicalId":75245,"journal":{"name":"Translational perioperative and pain medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45597232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
A Case Report of Hemiplegia after Electroconvulsive Therapy and the Management of Subsequent Treatments 电休克治疗偏瘫一例报告及后续治疗的管理
Translational perioperative and pain medicine Pub Date : 2020-12-31 DOI: 10.31480/2330-4871/130
Z. Jack, Seifert Brandon R
{"title":"A Case Report of Hemiplegia after Electroconvulsive Therapy and the Management of Subsequent Treatments","authors":"Z. Jack, Seifert Brandon R","doi":"10.31480/2330-4871/130","DOIUrl":"https://doi.org/10.31480/2330-4871/130","url":null,"abstract":"Upon searching PubMed for transient paralysis and electroconvulsive therapy, there appears to be very little report of this phenomenon in the literature [2-8]. Most reports of transient hemiplegia are in the context of unilateral electrical brain stimulation with resulting contralateral transient hemiplegia. There is no mention of whether subsequent ECT treatments will provoke recurrence of hemiplegia or the risk factors for such. Furthermore, while one study reported subsequent successful ECT treatments following an episode of transient hemiplegia [8], there are limited studies available to help guide recommendations for subsequent ECT treatments.","PeriodicalId":75245,"journal":{"name":"Translational perioperative and pain medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43378932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Efficacy of Dexmedetomidine Infusion to Attenuate Hemodynamic Response and Opioid Sparing Properties During Wide Excision of Carcinoma Tongue 右美托咪定输注对癌舌大范围切除过程中血流动力学反应和阿片保留特性的影响
Translational perioperative and pain medicine Pub Date : 2020-12-31 DOI: 10.31480/2330-4871/128
N. Abhijit, N. H. Hemanth kumar, Gondi Jonathan, Rayani Basanth Kumar
{"title":"Efficacy of Dexmedetomidine Infusion to Attenuate Hemodynamic Response and Opioid Sparing Properties During Wide Excision of Carcinoma Tongue","authors":"N. Abhijit, N. H. Hemanth kumar, Gondi Jonathan, Rayani Basanth Kumar","doi":"10.31480/2330-4871/128","DOIUrl":"https://doi.org/10.31480/2330-4871/128","url":null,"abstract":"status (ASA-PS) I-II patients carcinoma tongue for WLE of tongue lesion for this study. One group was standard intraoperative management (control group) other (Test group) Dexmedetomidine infusion was used. Demography tails (age, gender, ASA-PS) . An was all patients. All patients thorough pre-anesthesia check up and were for proposed surgery once certified fit by the Anesthesiologist. After confirming nothing by mouth status for 6 hrs, patients were shifted to operat ing room. An appropriately sized IV cannula was and essential monitoring was established (pulse oxim eter probe for oxygen saturation, noninvasive blood pressure cuff and electrocardiography using lead Standard general anesthesia was and propofol, all In neuromuscular blockage was","PeriodicalId":75245,"journal":{"name":"Translational perioperative and pain medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41598868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Impact of the COVID-19 Pandemic on Research COVID-19大流行对研究的影响
Translational perioperative and pain medicine Pub Date : 2020-12-31 DOI: 10.31480/2330-4871/133
A. Azeem, Rampes Sanketh, Ma Daqing
{"title":"The Impact of the COVID-19 Pandemic on Research","authors":"A. Azeem, Rampes Sanketh, Ma Daqing","doi":"10.31480/2330-4871/133","DOIUrl":"https://doi.org/10.31480/2330-4871/133","url":null,"abstract":"","PeriodicalId":75245,"journal":{"name":"Translational perioperative and pain medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41750781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ketamine Associated Laryngospasm during Processed EEG Monitored Propofol Sedation 氯胺酮相关喉痉挛在处理脑电图监测异丙酚镇静
Translational perioperative and pain medicine Pub Date : 2020-12-31 DOI: 10.31480/2330-4871/129
Friedberg Barry L
{"title":"Ketamine Associated Laryngospasm during Processed EEG Monitored Propofol Sedation","authors":"Friedberg Barry L","doi":"10.31480/2330-4871/129","DOIUrl":"https://doi.org/10.31480/2330-4871/129","url":null,"abstract":"Opioid-inclusive anesthesia not only fails to prevent postoperative pain but also increases PONV [7]. Postoperative emesis is patients’ number one outcome to avoid [8]. Using MIA, all commonly performed cosmetic surgery cases (i.e. liposuction, breast augmentation, rhytidectomy, and abdominoplasty) have been safely performed with fewer drugs and less pharmacologic/ airway trespass than general endotracheal anesthesia (GA/OET). Retching after surgery is a potential source of hematomas and wound dehiscence [9]. Retching can also rupture abdominoplasty rectus muscle imbrication stitches. Patient as well as surgeon complaints will follow such complications.","PeriodicalId":75245,"journal":{"name":"Translational perioperative and pain medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41983675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nursing Stroke Patients 中风患者的护理
Translational perioperative and pain medicine Pub Date : 2020-12-31 DOI: 10.31480/2330-4871/131
Cluckie Gill, Rudd Anthony G
{"title":"Nursing Stroke Patients","authors":"Cluckie Gill, Rudd Anthony G","doi":"10.31480/2330-4871/131","DOIUrl":"https://doi.org/10.31480/2330-4871/131","url":null,"abstract":"","PeriodicalId":75245,"journal":{"name":"Translational perioperative and pain medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46102945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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