Translational perioperative and pain medicine最新文献

{"title":"Emergency Anesthesia in a Patient with Esophageal Foreign Matter Infected with COVID-19: A Case Report","authors":"Tao Huan, Yang Kai, Gan Zheng, O. Fen, Y. Shanglong, Ma Weike, Xia Chengkun","doi":"10.31480/2330-4871/122","DOIUrl":"https://doi.org/10.31480/2330-4871/122","url":null,"abstract":"Anesthetic management for retrieval of the foreign matter has been well reported. But there is still no anesthetic care for patients who suffered from an Esophageal Foreign Matter (EFM) infected with coronavirus disease 2019 (COVID-19). In this case report, we present an emergency EFM patient confirmed COVID-19. Using Propofol Intravenous Anesthesia (PIA) in combination with topical anesthesia (TA), we have successfully retrieved foreign matter in the upper esophagus. Our anesthetic method supports to be an effective strategy for shortening the operation time to avoid the cross-and in-hospital SARS-CoV-2 transmission.","PeriodicalId":75245,"journal":{"name":"Translational perioperative and pain medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44312871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Remote Ischemic Preconditioning for Cardioprotection in Patients Undergoing Cardiac Surgery: A Systemic Review","authors":"W. Sheng, Ye Xiaodong, Wei Jinfeng, Xia Zhengyuan","doi":"10.31480/2330-4871/119","DOIUrl":"https://doi.org/10.31480/2330-4871/119","url":null,"abstract":"A short period of sublethal ischemia can provide cardioprotection against ischemia/reperfusion injury. As direct application of ischemic to the heart is impractical, remote ischemic preconditioning (RIPC) is usually preferred. The mechanism through which the cardioprotective effect is transferred from the remote organ or tissue to the heart remains unclear. Neurogenic, hormonal, and systemic factors have been proposed. Although RIPC has been applied in clinic with different modes, its effect on major cardiac outcomes, especially among diabetic patients, is still controversial. Therefore, further studies are still needed to identify its exact role in clinical practice and also investigate more specific mechanisms. has been considered as more feasible and promising than IPC due to its non-invasiveness. RIPC utilizes transient ischemia and reperfusion of one vascular bed, organ or tissue away from the heart to precondition another vascular bed. It has been applied before the onset of sustained myocardial ischemia [5]. However, the effect of RIPC on clinical outcome among different patients is controversial [6-8]. The differences and complications of patient population involved or differences in the RIPC procedures or the timing of application in different studies may be possible explanations for the controversies observed. However, the major reason for the uncertainty of RIPC cardiopropection is likely the lack of a clear understanding of the mechanism RIPC. Definition and Differences of Conditionings IPC, RIPC and APC that are Applicable during Cardiac Surgery Ischemic preconditioning (IPC), defined as several brief periods of ischemia and reperfusion of the target organ before prolonged ischemia [9], is regarded as a protective means capable of resisting myocardial ischemia-reperfusion injury (IRI). During cardiac surgery such as coronary artery bypass surgery (CABG), coronary artery is inaccessible for IPC [9]. The alternative to IPC is remote ischemic precondition (RIPC), a noninvasive simple method, which is induced by several rounds of short-term remote organ (e.g. upper limbs) ischemia and reperfusion before prolonged myocardial ischemia [6,10-11]. There have been trials confirming that RIPC can significantly reduce cardiac specific enzymes troponin I (cTnI) [10] and cTnT [11] levels in the serum within 72 hours after surgery, as well as decrease myocardium infarct size [7] and promote post-operative patient recovery [12]. However, whether or not it can improve long term cardiovascular outcomes still remains controversial [7,13], despite that the beneficial effect of RIPC on new onset Myocardial Ischemia and Reperfusion Injury Myocardial ischemia is a major cause of myocardial injury and may result in myocardial infarction. Reperfusion therapies or interventions to restore blood flow to ischemic myocardium are needed to limit infarct size, but, return of blood flow can cause additional cardiac damage and complications which is known as reperf","PeriodicalId":75245,"journal":{"name":"Translational perioperative and pain medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41756792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anesthesia Care and Anesthesia Care Providers: Ambiguities in Terminologies","authors":"L. Henry","doi":"10.31480/2330-4871/125","DOIUrl":"https://doi.org/10.31480/2330-4871/125","url":null,"abstract":"","PeriodicalId":75245,"journal":{"name":"Translational perioperative and pain medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48121864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Vitro Model of Stretch-Induced Lung Injury to Study Different Lung Ventilation Regimens and the Role of Sedatives","authors":"Yusuke Mitsui, S. Koutsogiannaki, M. Fujiogi, Koichi Yuki","doi":"10.31480/2330-4871/123","DOIUrl":"https://doi.org/10.31480/2330-4871/123","url":null,"abstract":"Background: Currently lung injury is managed conservatively through supportive care including mechanical ventilation. However, mechanical ventilation can also cause additional lung injury due to over-stretch along with atelectasis and cytokine release. Here we developed an in vitro mechanical ventilation model using cyclic stretch of lung epithelial cells to mimic high and low tidal volume (TV) ventilation strategy, so that we could use this platform for pathophysiology analysis and screening for therapeutic drugs. Method: We subjected MLE-15 cells to the following treatments. 1) No treatment, 2) lipopolysaccharide (100 ng/mL) stimulation for 24 hours, 3) mechanical stretch initiated at 6-hour time point for 18 hours, 4) LPS stimulation at time point 0 hour, and mechanical stretch was added at 6-hour time point for 18 hours. Biaxial cyclic stretch with a triangular wave was given via the Flexcell FX-6000 tension system to mimic low and high TV. Anesthetics dexmedetomidine and propofol were also tested. Result: Our high TV mimic stretch increased cell death, while low TV mimic stretch did not affect the degree of cell death. Using this system, we examined the effect of sedatives commonly used in intensive care units on cell death and found that dexmedetomidine attenuated necrosis associated with stretch. Conclusion: We described the in vitro cyclic stretch system mimicking high and low TV ventilation. High TV mimetic was associated with increased cell death. Dexmedetomidine attenuated the degree of cell death.","PeriodicalId":75245,"journal":{"name":"Translational perioperative and pain medicine","volume":"7 1","pages":"258 - 264"},"PeriodicalIF":0.0,"publicationDate":"2020-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47637647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are we Sure about the Benefits of Opioid Free Anesthesia?","authors":"Zhao Peishan","doi":"10.31480/2330-4871/114","DOIUrl":"https://doi.org/10.31480/2330-4871/114","url":null,"abstract":"overdose and death, the Centers for Disease Control and Prevention (CDC) 2018 report did not differentiate these prescriptions for acute pain or chronic pain management. However, CDC did indicate that “the current epidemic of drug overdoses began in the 1990s with overdose deaths involving prescription opioids being driven by the dramatic increase in prescribing opioids for chronic pain” [9]. Except for prescription opioids, “illicitly manufactured fentanyl” also involved in synthetic opioids overdose deaths [9].","PeriodicalId":75245,"journal":{"name":"Translational perioperative and pain medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46403782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Should we Routinely Reverse Neuromuscular Blockade with Sugammadex in Patients with a History of Heart Transplantation?","authors":"Koichi Yuki, Rebecca Scholl","doi":"10.31480/2330-4871/111","DOIUrl":"https://doi.org/10.31480/2330-4871/111","url":null,"abstract":"Cases of cardiac arrest after administration of neostigmine as a neuromuscular reversal agent have been reported in the literature. Sugammadex is a new neuromuscular reversal agent that acts via a different mechanism than acetylcholinesterase inhibitors. Here we reviewed the currently available literature on the use of sugammadex and potential considerations of using sugammadex in patients with a history of heart transplantation. Based on our currently available information, sugammadex administration in heart transplant patients should warrant similar caution and preparation for cardiovascular collapse as acetylcholinesterase inhibitors.","PeriodicalId":75245,"journal":{"name":"Translational perioperative and pain medicine","volume":"7 1","pages":"185 - 189"},"PeriodicalIF":0.0,"publicationDate":"2020-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48290078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long noncoding RNA H19 in the injured dorsal root ganglion contributes to peripheral nerve injury-induced pain hypersensitivity.","authors":"Jing Wen, Yong Yang, Shaogen Wu, Guihua Wei, Shushan Jia, Stephen Hannaford, Y. Tao","doi":"10.31480/2330-4871/110","DOIUrl":"https://doi.org/10.31480/2330-4871/110","url":null,"abstract":"Peripheral nerve injury-induced changes in gene transcription and translation in the dorsal root ganglion (DRG) play a critical role in the development and maintenance of neuropathic pain. Long noncoding RNAs (lncRNAs) regulate gene expression. Here, we report that peripheral nerve injury caused by ligation of the fourth spinal nerve (SNL) led to a time-dependent increase in the expression in H19, an lncRNA, in the injured DRG. Microinjection of a specific H19 siRNA, but not negative control scrambled siRNA, into the injured DRG 4 days before SNL alleviated mechanical allodynia and thermal hyperalgesia on days 3 and 5 post-SNL. Additionally, DRG microinjection of the H19 siRNA on day 7 after SNL reduced mechanical allodynia and thermal hyperalgesia on days 10 and 12 post-SNL. DRG microinjection of neither siRNA affected locomotor activity and acute basal responses to mechanical and thermal stimuli. Our findings suggest that H19 participates in the peripheral mechanism underlying the development and maintenance of neuropathic pain. H19 may be a potential target for treatment of this disorder.","PeriodicalId":75245,"journal":{"name":"Translational perioperative and pain medicine","volume":"7 2 1","pages":"176-184"},"PeriodicalIF":0.0,"publicationDate":"2020-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44073750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraoperative Laryngeal Mask Airway-Related Hiccup: An Overview.","authors":"Johann Mathew, Shiqian Shen, Henry Liu","doi":"10.31480/2330-4871/103","DOIUrl":"10.31480/2330-4871/103","url":null,"abstract":"<p><p>Hiccup is an involuntary contraction of the diaphragm and intercostal muscles resulting in sudden inspiration and closure of the glottis. The presence of hiccup in the perioperative period can be a challenging problem. Sudden movements of the patient from hiccups can interfere preoperative diagnostic procedures, intraoperative hiccup may delay the beginning of surgery, interfere with the surgical process, and affect intraoperative monitoring, and postoperative hiccup may affect would healing and hemodynamic stability. Hiccup can lead to have increased aspiration risk. Hiccup are is an incompletely understood phenomenon with multiple etiologies. Intraoperative hiccup related to laryngeal mask airway placement has been reported, and it presents unique challenges in diagnosis and management. Both pharmacological and non-pharmacological interventions have been utilized with various level of success. All treatment strategies are primarily aimed at interrupting the hiccup reflex arc.</p>","PeriodicalId":75245,"journal":{"name":"Translational perioperative and pain medicine","volume":"7 1","pages":"145-151"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8048698/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38885687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kappa Opioid Receptor on Pulmonary Macrophages and Immune Function.","authors":"Si Zeng,&nbsp;Yinbo Zhong,&nbsp;Jie Xiao,&nbsp;Jiafu Ji,&nbsp;Jin Xi,&nbsp;Xinchuan Wei,&nbsp;Renyu Liu","doi":"10.31480/2330-4871/117","DOIUrl":"https://doi.org/10.31480/2330-4871/117","url":null,"abstract":"<p><strong>Background: </strong>Respiratory failure significantly increases mortality in critically ill patients. While opioids are often used during the perioperative period and in critically ill situations, little is known about how opioids are involved in pulmonary immune function and the inflammatory response. There is currently no clear information on the role of the kappa opioid receptor (KOR) in pulmonary inflammation. Here we evaluate whether KORs are involved in the modulation of lung macrophages by the use of selective KOR agonists in lipopolysaccharide (LPS) activated alveolar macrophages.</p><p><strong>Method: </strong>The inflammatory response in rat NR8383 macrophages was induced by stimulation with LPS (100 ng/ml) at different time-points. The effects of the KOR agonists Salvinorin A (SA) and U50488 on inflammatory factors such as nitrite, TNF-α, IL-1β, iNOS and COX-2 were investigated. Nor-binaltorphimine, a selective KOR antagonist, was used to investigate the specific role of KOR.</p><p><strong>Results: </strong>Stimulation of NR8383 cells with LPS (100 ng/ml) significantly increased the level of TNF-α at 1h, 2h and 6h compared to un-stimulated cells. SA attenuated the inflammatory response by reducing the levels of TNF-α and IL-1β after LPS treatment. SA co-treatment reduced the elevated levels of NO induced by LPS and also alleviated the over-expression of iNOS and COX-2 within 2 hours after LPS activation, and such effects can be partially blocked by KOR antagonist, nor-binaltorphimine. Similar results from U50488 were observed.</p><p><strong>Conclusion: </strong>Our results indicate that KORs may play a critical role in the modulation of the pulmonary inflammatory process by their activation in macrophages. Selective KOR agonists exert their anti-inflammatory effects acutely on lung macrophages, within 1-2 hours of LPS-stimulated inflammation <i>in vitro</i>.</p>","PeriodicalId":75245,"journal":{"name":"Translational perioperative and pain medicine","volume":"7 3","pages":"225-233"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7668421/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38720817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long noncoding RNA H19 in the injured dorsal root ganglion contributes to peripheral nerve injury-induced pain hypersensitivity.","authors":"Jing Wen,&nbsp;Yong Yang,&nbsp;Shaogen Wu,&nbsp;Guihua Wei,&nbsp;Shushan Jia,&nbsp;Stephen Hannaford,&nbsp;Yuan-Xiang Tao","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Peripheral nerve injury-induced changes in gene transcription and translation in the dorsal root ganglion (DRG) play a critical role in the development and maintenance of neuropathic pain. Long noncoding RNAs (lncRNAs) regulate gene expression. Here, we report that peripheral nerve injury caused by ligation of the fourth spinal nerve (SNL) led to a time-dependent increase in the expression in H19, an lncRNA, in the injured DRG. Microinjection of a specific H19 siRNA, but not negative control scrambled siRNA, into the injured DRG 4 days before SNL alleviated mechanical allodynia and thermal hyperalgesia on days 3 and 5 post-SNL. Additionally, DRG microinjection of the H19 siRNA on day 7 after SNL reduced mechanical allodynia and thermal hyperalgesia on days 10 and 12 post-SNL. DRG microinjection of neither siRNA affected locomotor activity and acute basal responses to mechanical and thermal stimuli. Our findings suggest that H19 participates in the peripheral mechanism underlying the development and maintenance of neuropathic pain. H19 may be a potential target for treatment of this disorder.</p>","PeriodicalId":75245,"journal":{"name":"Translational perioperative and pain medicine","volume":"7 2","pages":"176-184"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041488/pdf/nihms-1066207.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37677219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}