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Translational perioperative and pain medicine最新文献

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A National Survey of Implementation of WHO Surgical Safety Checklist in China 世界卫生组织手术安全检查表在中国实施情况的全国调查
Translational perioperative and pain medicine Pub Date : 2022-06-30 DOI: 10.31480/2330-4871/135
Z. Bin, Eslahpazir Benjamin A, G. Huan, Zhou Xiangyong, Liu Yu, Huang Yuguang, Huang Jeffrey J
{"title":"A National Survey of Implementation of WHO Surgical Safety Checklist in China","authors":"Z. Bin, Eslahpazir Benjamin A, G. Huan, Zhou Xiangyong, Liu Yu, Huang Yuguang, Huang Jeffrey J","doi":"10.31480/2330-4871/135","DOIUrl":"https://doi.org/10.31480/2330-4871/135","url":null,"abstract":"Background: Ten years after implementation of WHO Surgical Safety Checklist (WHO SSC), used as a core item to assess hospital performance in China, an observational study was performed to evaluate level of clinical motivation for routine performance of the surgical safety checklist. Methods: A survey was designed on the basis of three parts of the surgical safety checklist and forming 23 questions. It covers the three main processes of safety check: (1) Before anesthesia induction,","PeriodicalId":75245,"journal":{"name":"Translational perioperative and pain medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46336660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role of Pulmonary Function Test in Perioperative Management of Patients with Cystic Fibrosis 肺功能测试在囊性纤维化患者围手术期治疗中的作用
Translational perioperative and pain medicine Pub Date : 2022-06-06 DOI: 10.31480/2330-4871/155
M. Manzor, G. Asztalos, Koichi Yuki
{"title":"The Role of Pulmonary Function Test in Perioperative Management of Patients with Cystic Fibrosis","authors":"M. Manzor, G. Asztalos, Koichi Yuki","doi":"10.31480/2330-4871/155","DOIUrl":"https://doi.org/10.31480/2330-4871/155","url":null,"abstract":"Cystic fibrosis (CF) is one of chronic illness affecting many different organs. Although the outcome of CF patients undergoing procedures was not favorable more than half a century ago, it showed a continuous improvement based on the previous reports. However, recent outcome report of CF patients’ procedural outcomes is limited. We analyzed CF patients who underwent procedures from 2010 to 2020 in our institution. The mortality of 1,903 procedures performed in 430 CF patients was 0.74%, seen in high-risk procedures such as lung transplantation. We also analyzed the perioperative profiles of CF patients who underwent functional endoscopic sinus surgery (FESS). We identified the preoperative pulmonary function testing result to be predictive of postoperative hospital stay.","PeriodicalId":75245,"journal":{"name":"Translational perioperative and pain medicine","volume":"9 1","pages":"438 - 444"},"PeriodicalIF":0.0,"publicationDate":"2022-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41651950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How Should We Care for Patients with Congenital Heart Diseases Undergoing Surgical Procedures in Ambulatory Settings? 我们应该如何照顾在门诊进行外科手术的先天性心脏病患者?
Translational perioperative and pain medicine Pub Date : 2022-03-31 DOI: 10.31480/2330-4871/150
Hamilton Rebecca, Odegard Kirsten C, Y. Koichi
{"title":"How Should We Care for Patients with Congenital Heart Diseases Undergoing Surgical Procedures in Ambulatory Settings?","authors":"Hamilton Rebecca, Odegard Kirsten C, Y. Koichi","doi":"10.31480/2330-4871/150","DOIUrl":"https://doi.org/10.31480/2330-4871/150","url":null,"abstract":"","PeriodicalId":75245,"journal":{"name":"Translational perioperative and pain medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43845601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dezocine is a Biased Ligand without Significant Beta-Arrestin Activation of the mu Opioid Receptor Dezocine是一种对μ阿片受体没有显著β-抑制激活的偏向性配体
Translational perioperative and pain medicine Pub Date : 2022-03-31 DOI: 10.31480/2330-4871/152
Grothusen John, Lin Wenzhen, Xi Jin, Zanni Giulia, B. Gordon A., Liu Renyu
{"title":"Dezocine is a Biased Ligand without Significant Beta-Arrestin Activation of the mu Opioid Receptor","authors":"Grothusen John, Lin Wenzhen, Xi Jin, Zanni Giulia, B. Gordon A., Liu Renyu","doi":"10.31480/2330-4871/152","DOIUrl":"https://doi.org/10.31480/2330-4871/152","url":null,"abstract":"","PeriodicalId":75245,"journal":{"name":"Translational perioperative and pain medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47701766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Steps to Define Optimal Timing for Elective Surgery after COVID-19 确定新冠肺炎后择期手术最佳时机的步骤
Translational perioperative and pain medicine Pub Date : 2022-03-31 DOI: 10.31480/2330-4871/151
Cates J. Nicholas, Peng Yong G.
{"title":"Steps to Define Optimal Timing for Elective Surgery after COVID-19","authors":"Cates J. Nicholas, Peng Yong G.","doi":"10.31480/2330-4871/151","DOIUrl":"https://doi.org/10.31480/2330-4871/151","url":null,"abstract":"","PeriodicalId":75245,"journal":{"name":"Translational perioperative and pain medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43420003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dezocine: A Totally Different Opioid Dezocine：一种完全不同的阿片类药物
Translational perioperative and pain medicine Pub Date : 2022-03-31 DOI: 10.31480/2330-4871/153
Grothusen John
{"title":"Dezocine: A Totally Different Opioid","authors":"Grothusen John","doi":"10.31480/2330-4871/153","DOIUrl":"https://doi.org/10.31480/2330-4871/153","url":null,"abstract":"compounds that generally are not Most opioids","PeriodicalId":75245,"journal":{"name":"Translational perioperative and pain medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41909825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Perspective: COVID-19 and Its Neurologic Sequelae. 视角:COVID-19及其神经系统后遗症。
Translational perioperative and pain medicine Pub Date : 2022-01-01 DOI: 10.31480/2330-4871/162
Aaron Rothstein, Christopher Favilla, Kelly Sloane, Jens Witsch
{"title":"Perspective: COVID-19 and Its Neurologic Sequelae.","authors":"Aaron Rothstein,&nbsp;Christopher Favilla,&nbsp;Kelly Sloane,&nbsp;Jens Witsch","doi":"10.31480/2330-4871/162","DOIUrl":"https://doi.org/10.31480/2330-4871/162","url":null,"abstract":"<p><p>COVID-19 led to a catastrophic, international, public health crisis after its first detection in 2019 [1]. Though it is primarily a respiratory virus, it impacts the central and peripheral nervous systems leading to further COVID-19-associated disability [2]. This Perspective reviews our current understanding of the neurological sequelae of COVID-19 and the gaps in our understanding of their treatment and epidemiology.</p>","PeriodicalId":75245,"journal":{"name":"Translational perioperative and pain medicine","volume":"9 3","pages":"478-481"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9645563/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10470346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Dezocine is a Biased Ligand without Significant Beta-Arrestin Activation of the mu Opioid Receptor. 地佐辛是一种偏性配体，对μ阿片受体没有明显的β-阿司匹林激活作用。
Translational perioperative and pain medicine Pub Date : 2022-01-01 Epub Date: 2022-03-01
John Grothusen, Wenzhen Lin, Jin Xi, Giulia Zanni, Gordon A Barr, Renyu Liu
{"title":"Dezocine is a Biased Ligand without Significant Beta-Arrestin Activation of the mu Opioid Receptor.","authors":"John Grothusen, Wenzhen Lin, Jin Xi, Giulia Zanni, Gordon A Barr, Renyu Liu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Dezocine is an opioid that was used in clinical practice for acute pain management in the US (1986 to 2011) and is currently in use in China. It is not listed as a controlled substance in the US due to no reported cases of addiction. Dezocine is a partial agonist at the mu opioid receptor (MOR); however, it is unclear whether dezocine can activate both the G protein pathway and the beta-arrestin pathway. In this study we hypothesized that dezocine does not activate the beta-arrestin pathway, which could be the potential molecular mechanism by which dezocine is not addictive or at least less addictive than other classic opioids. Both morphine, a MOR full agonist and buprenorphine, a partial MOR agonist similar to dezocine, were used for comparison purposes. The major side effects of dezocine in clinical usage are its gastrointestinal side effects and first pass effects; therefore, we explored the possibility of administering dezocine intranasally in rodents to demonstrate the feasibility of intranasal administration for new clinical usage purposes. With proper formulation it is possible to administer dezocine intranasally to achieve a high concentration in the brain in the rodent model. The results indicate that dezocine does not activate the beta-arrestin pathway in MOR. Intranasal delivery of dezocine achieves a much higher medication concentration in the blood and brain as compared to intraperitoneal injection. It also persists a longer time before it falls below detection in the blood. This study provides a possible explanation of why dezocine is not addictive or at least less addictive than other commonly used opioids. This study also demonstrates that intranasal administration offers an alternative strategy for its potential clinical applications.</p>","PeriodicalId":75245,"journal":{"name":"Translational perioperative and pain medicine","volume":"9 1","pages":"424-429"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9097853/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142094276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intrathecal administration of the fat-mass and obesity-associated protein inhibitor mitigates neuropathic pain in female rats. 鞘内给药脂肪团和肥胖相关蛋白抑制剂可减轻雌性大鼠的神经性疼痛。
Translational perioperative and pain medicine Pub Date : 2022-01-01 DOI: 10.31480/2330-4871/163
Xiang Li, Yuan-Xiang Tao
{"title":"Intrathecal administration of the fat-mass and obesity-associated protein inhibitor mitigates neuropathic pain in female rats.","authors":"Xiang Li,&nbsp;Yuan-Xiang Tao","doi":"10.31480/2330-4871/163","DOIUrl":"https://doi.org/10.31480/2330-4871/163","url":null,"abstract":"<p><p>Several intracellular signals are involved in the sexual dimorphism of chronic pain. Our previous studies demonstrated that the fat-mass and obesity-associated protein (FTO), a demethylase of RNA <i>N</i>6-methyladenosine, in the injured dorsal root ganglion (DRG) contributed to the development and maintenance of nerve injury-induced nociceptive hypersensitivity in male rats and male mice. However, whether these effects of DRG FTO are in a sex-dependent manner is still unknown. The present study sought to investigate the effect of intrathecal administration of a specific FTO inhibitor, meclofenamic acid (MA), on chronic constriction injury (CCI)-induced nociceptive hypersensitivity in female rats. Intrathecal injection of MA attenuated the CCI-induced mechanical allodynia, heat hyperalgesia, and cold hyperalgesia in both the induction and maintenance periods, without changing acute/basal pain and locomotor function, in female rats. Intrathecal MA also blocked the CCI-induced hyperactivations of neurons and astrocytes in the ipsilateral L4 and L5 dorsal horns of female rats. Mechanistically, intrathecal MA prevented the CCI-induced increase in the histone methyltransferase G9a expression and reversed the G9a-controlled downregulation of mu-opioid receptor and Kv1.2 proteins in the ipsilateral L4 and L5 DRGs of female rats. These findings indicate that the effects of the FTO inhibitor on nerve injury-induced nociceptive hypersensitivity in female rats are similar to those in male rats reported previously. Our data also further confirm the role of DRG FTO in neuropathic pain and suggest potential clinical application of the FTO inhibitors for the prevention and treatment of this disorder in both men and women.</p>","PeriodicalId":75245,"journal":{"name":"Translational perioperative and pain medicine","volume":"9 4","pages":"478-487"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9764434/pdf/nihms-1853228.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10433587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
The Role of Pulmonary Function Test in Perioperative Management of Patients with Cystic Fibrosis. 肺功能检查在囊性纤维化患者围手术期治疗中的作用。
Translational perioperative and pain medicine Pub Date : 2022-01-01 Epub Date: 2022-06-06
Mariel Manzor, Gabor Asztalos, Koichi Yuki
{"title":"The Role of Pulmonary Function Test in Perioperative Management of Patients with Cystic Fibrosis.","authors":"Mariel Manzor,&nbsp;Gabor Asztalos,&nbsp;Koichi Yuki","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Cystic fibrosis (CF) is one of chronic illness affecting many different organs. Although the outcome of CF patients undergoing procedures was not favorable more than half a century ago, it showed a continuous improvement based on the previous reports. However, recent outcome report of CF patients' procedural outcomes is limited. We analyzed CF patients who underwent procedures from 2010 to 2020 in our institution. The mortality of 1,903 procedures performed in 430 CF patients was 0.74%, seen in high-risk procedures such as lung transplantation. We also analyzed the perioperative profiles of CF patients who underwent functional endoscopic sinus surgery (FESS). We identified the preoperative pulmonary function testing result to be predictive of postoperative hospital stay.</p>","PeriodicalId":75245,"journal":{"name":"Translational perioperative and pain medicine","volume":"9 2","pages":"438-444"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9302475/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40622480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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