Translational medicine communications最新文献

{"title":"Association of the rs4646994 in <i>ACE</i> gene with susceptibility to tuberculosis in a region of the Brazilian Amazon.","authors":"Débora C R F Porchera, Diana F V B Leal, Ana C O Braga, Pablo D C Pinto, Mayara N Santana da Silva, Lucas C Bezerra Santos, Cintia H Braga da Silva, Giovana E da Costa, Maria Clara da C Barros, Aidalucy do S C de Athayde, Amanda de N Cohen-Paes, Cleonardo A da Silva, Paulo P de Assumpção, Ândrea K C Ribeiro-Dos-Santos, Sidney E B Dos Santos, Marianne R Fernandes, Ney P C Dos Santos","doi":"10.1186/s41231-022-00116-6","DOIUrl":"10.1186/s41231-022-00116-6","url":null,"abstract":"<p><strong>Background: </strong>Tuberculosis (TB) is an infectious disease caused by the bacterium <i>Mycobacterium tuberculosis</i> and represents an important global public health issue. Single-nucleotide polymorphisms and INDELs are common genetic variations that can be located in genes associated with immune response and, therefore, they may have direct implications over the phenotype of susceptibility to infections like tuberculosis. This study aimed to investigate the association between the 17 genetic polymorphisms and susceptibility to tuberculosis in a Brazilian population.</p><p><strong>Methods: </strong>This case-control study enrolled 283 individuals with active tuberculosis and 145 health care workers. Four INDELs and 13 single nucleotide polymorphisms and were genotyped using Multiplex PCR method and TaqMan SNP Genotyping Assays. Group comparisons for categorical variables were performed using the chi-squared test, whilst the t-Student test was used to analyze the continuous variables. Multiple logistic regression analyses were performed to estimate the odds ratio (OR) with 95% confidence intervals (CI). Deviation from Hardy-Weinberg equilibrium was assessed using chi-squared tests with Bonferroni correction. The results were analyzed comparing the genotypic distributions adopting the dominant model and the estimated values ​​of <i>p</i> corrected for multiple tests through FDR (False Discovery Rate) test.</p><p><strong>Results: </strong>The HWE test confirmed that the genotypic frequencies for polymorphisms were balanced. The frequency of Del allele was 73 and 75%, in cases and controls respectively. Frequency of Del allele was significantly higher in the control group than TB group. The homozygous Del/Del genotype was present in 51.6% of cases and 58.6% of controls. The rare Ins/Ins genotype was present in only 7.6% of controls and 6% of cases. The <i>ACE</i> Del/Del genotype was significantly higher in the cases than in controls revealing significant protection for TB in the domain model (OR = 0.465; <i>p</i> < 0.005).</p><p><strong>Conclusions: </strong>The Del/Del genotype of the rs4646994 in <i>ACE</i> gene was associated with susceptibility to tuberculosis. The identification of genetic variants responsible for susceptibility to tuberculosis will allow the development of new diagnostic tools for tuberculosis infection. These studies will help improve control and the future eradication of this disease.</p>","PeriodicalId":75244,"journal":{"name":"Translational medicine communications","volume":"7 1","pages":"10"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9092330/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10249434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunophenotyping of peripheral blood cells allows to discriminate MIS-C and Kawasaki disease.","authors":"Alice Castaldo,&nbsp;Carolina D'Anna,&nbsp;Monica Gelzo,&nbsp;Antonietta Giannattasio,&nbsp;Marco Maglione,&nbsp;Stefania Muzzica,&nbsp;Maddalena Raia,&nbsp;Giulia Scalia,&nbsp;Lorella Tripodi,&nbsp;Giuseppe Castaldo,&nbsp;Vincenzo Tipo,&nbsp;Domenico Grieco,&nbsp;Michela Grieco","doi":"10.1186/s41231-022-00128-2","DOIUrl":"https://doi.org/10.1186/s41231-022-00128-2","url":null,"abstract":"<p><strong>Background: </strong>The pathogenesis of the novel described multisystem inflammatory syndrome in children (MIS-C) and Kawasaki disease (KD) is still debated as it is not clear if they are the same or different nosological entities. However, for both the diseases a rapid and unequivocal diagnosis is mandatory to start the therapy before the onset of severe complications. In this study, we aimed to evaluate the white cell populations in MIS-C and KD as potential markers to discriminate between the two diseases.</p><p><strong>Methods: </strong>We studied white cell populations by flow cytometry in 46 MIS-C and 28 KD patients in comparison to 70 age-matched healthy children.</p><p><strong>Results: </strong>MIS-C patients had a significant lymphopenia that involved both B and T populations while KD patients showed a significant neutrophilia and thrombocythemia. Granulocyte/lymphocyte ratio helped to diagnose both MIS-C and KD with a high diagnostic sensitivity, while a multivariate analysis of granulocyte and T lymphocyte number contributed to discriminate between the two diseases.</p><p><strong>Conclusions: </strong>The relevant lymphopenia observed in MIS-C patients suggests that the disease would be a post-infectious sequel of COVID-19 immunologically amplified by a massive cytokine release, while the significant neutrophilia and thrombocythemia observed in KD confirmed that the disorder has the genesis of a systemic vasculitis. The analysis of a panel of circulating cells may help to early diagnose and to discriminate between the two diseases.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1186/s41231-022-00128-2.</p>","PeriodicalId":75244,"journal":{"name":"Translational medicine communications","volume":" ","pages":"22"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9440857/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33461235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of a composite measure of product adherence, protocol compliance, and semen exposure to a phase III microbicide HIV prevention trial","authors":"T. Jacot, M. Clark, O. Adedipe, S. Godbout, T. Cunningham, Susan Ju, J. Schwartz, S. Delany-Moretlwe, A. Thurman, G. Doncel","doi":"10.1186/s41231-021-00100-6","DOIUrl":"https://doi.org/10.1186/s41231-021-00100-6","url":null,"abstract":"","PeriodicalId":75244,"journal":{"name":"Translational medicine communications","volume":" ","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2021-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44586077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PhiΦBreast & theory of spiral cancer new diagnostic techniques for breast cancer detection","authors":"E. Trapanese, G. Tarro","doi":"10.1186/s41231-021-00105-1","DOIUrl":"https://doi.org/10.1186/s41231-021-00105-1","url":null,"abstract":"","PeriodicalId":75244,"journal":{"name":"Translational medicine communications","volume":"6 1","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2021-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46320013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"StemForte Plus® for stem cell activation and telomerase activity for anti-aging purposes","authors":"V. Chavez","doi":"10.1186/s41231-021-00094-1","DOIUrl":"https://doi.org/10.1186/s41231-021-00094-1","url":null,"abstract":"","PeriodicalId":75244,"journal":{"name":"Translational medicine communications","volume":" ","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2021-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s41231-021-00094-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41615757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of parasitic infection on human gut ecology and immune regulations","authors":"A. Naveed, Sabahat Abdullah","doi":"10.1186/s41231-021-00091-4","DOIUrl":"https://doi.org/10.1186/s41231-021-00091-4","url":null,"abstract":"","PeriodicalId":75244,"journal":{"name":"Translational medicine communications","volume":"6 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2021-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s41231-021-00091-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41608323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intravenous oxygen insufflation (IOI) changes the IL-1-Ra:IL-1β ratio in autologous conditioned serum","authors":"B. König, D. Wiechert","doi":"10.1186/s41231-021-00107-z","DOIUrl":"https://doi.org/10.1186/s41231-021-00107-z","url":null,"abstract":"","PeriodicalId":75244,"journal":{"name":"Translational medicine communications","volume":"7 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2021-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46206542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel method for maintaining the stability of freshly cultured Mesenchymal stem cells in clinical grade injection ready state without cryopreservation","authors":"M. Mohyeddin Bonab, F. Talebian, Aida Borzabadi, Vahideh Nasr, Azam Abedi Kooshlshahi, Fahime Anisie, Ronaz Haghshenas, B. Shalbafan, E. Janzamin, Saeed Shahbeigi","doi":"10.1186/s41231-021-00103-3","DOIUrl":"https://doi.org/10.1186/s41231-021-00103-3","url":null,"abstract":"","PeriodicalId":75244,"journal":{"name":"Translational medicine communications","volume":" ","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2021-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49369510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Behavioural symptoms of mental health disorder such as depression among young people using Instagram: a systematic review","authors":"Gbadebo Collins Adeyanju, Ron Patrick Solfa, T. Tran, Sophia Wohlfarth, J. Büttner, O. Osobajo, Afolabi Otitoju","doi":"10.1186/s41231-021-00092-3","DOIUrl":"https://doi.org/10.1186/s41231-021-00092-3","url":null,"abstract":"","PeriodicalId":75244,"journal":{"name":"Translational medicine communications","volume":" ","pages":"1-13"},"PeriodicalIF":0.0,"publicationDate":"2021-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42068715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scavengers of hemoproteins as potential biomarkers for severe sepsis and septic shock","authors":"M. Verheij, I. Bulder, W. Wuillemin, C. Voermans, S. Zeerleder","doi":"10.1186/s41231-021-00088-z","DOIUrl":"https://doi.org/10.1186/s41231-021-00088-z","url":null,"abstract":"","PeriodicalId":75244,"journal":{"name":"Translational medicine communications","volume":"6 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2021-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s41231-021-00088-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48772305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}