Translational medicine communications最新文献

{"title":"A survey on the current status and future perspective of informed consent management in the MIRACUM consortium of the German Medical Informatics Initiative","authors":"Christopher Hampf, Martin Bialke, Lars Geidel, Albert Vass, T. Bahls, Romina Blasini, Arne Blumentritt, M. Boeker, Christian Bruns, B. Jandrig, Maximilian Fünfgeld, Philipp Heinrich, T. Leddig, Achim Michel-Backofen, A. Pirkl, Micha Rautenberg, Fabian Simons, D. Stahl, H. Prokosch, W. Hoffmann","doi":"10.1186/s41231-021-00086-1","DOIUrl":"https://doi.org/10.1186/s41231-021-00086-1","url":null,"abstract":"","PeriodicalId":75244,"journal":{"name":"Translational medicine communications","volume":"6 1","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2021-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s41231-021-00086-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41528940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is the awakening produced by benzodiazepines due to excitatory actions of GABA?","authors":"Y. Ben-Ari","doi":"10.1186/s41231-021-00085-2","DOIUrl":"https://doi.org/10.1186/s41231-021-00085-2","url":null,"abstract":"","PeriodicalId":75244,"journal":{"name":"Translational medicine communications","volume":"6 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2021-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s41231-021-00085-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65780995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging roles of C1Q tumor necrosis factor-related proteins in metabolic diseases","authors":"M. Ramanjaneya, J. Jerobin, I. Bettahi, K. Siveen, A. Abou-Samra","doi":"10.1186/s41231-021-00083-4","DOIUrl":"https://doi.org/10.1186/s41231-021-00083-4","url":null,"abstract":"","PeriodicalId":75244,"journal":{"name":"Translational medicine communications","volume":"6 1","pages":"1-12"},"PeriodicalIF":0.0,"publicationDate":"2021-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s41231-021-00083-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42129178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intra-articular Adenosine, Lidocaine and Magnesium (ALM) solution decreases postoperative joint fibrosis in an experimental knee implant model","authors":"Jodie L. Morris, H. Letson, P. McEwen, E. Biros, C. Dlaska, K. Hazratwala, M. Wilkinson, G. Dobson","doi":"10.1186/s41231-021-00084-3","DOIUrl":"https://doi.org/10.1186/s41231-021-00084-3","url":null,"abstract":"","PeriodicalId":75244,"journal":{"name":"Translational medicine communications","volume":"6 1","pages":"1-13"},"PeriodicalIF":0.0,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s41231-021-00084-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41816264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive model and feature importance for early detection of type II diabetes mellitus","authors":"Eric Adua, Dr. Emmanuel Kolog Awuni, E. Afrifa-Yamoah, Bright Amankwah, C. Obirikorang, E. Anto, E. Acheampong, Wen Wang, A. Tetteh","doi":"10.1186/s41231-021-00096-z","DOIUrl":"https://doi.org/10.1186/s41231-021-00096-z","url":null,"abstract":"","PeriodicalId":75244,"journal":{"name":"Translational medicine communications","volume":"6 1","pages":"1-15"},"PeriodicalIF":0.0,"publicationDate":"2021-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46714877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vivo optical endomicroscopy: two decades of translational research towards next generation diagnosis of eosinophilic esophagitis","authors":"Andreas Wartak, John G. Garber, Qian Yuan, W. Shreffler, P. Hesterberg, A. Katz, Hany Osman, H. Leung, A. Gao, D. O. Otuya, Catriona N. Grant, J. Gardecki, N. Nishioka, G. Tearney, G. Apiou-Sbirlea","doi":"10.1186/s41231-020-00080-z","DOIUrl":"https://doi.org/10.1186/s41231-020-00080-z","url":null,"abstract":"","PeriodicalId":75244,"journal":{"name":"Translational medicine communications","volume":"6 1","pages":"1-19"},"PeriodicalIF":0.0,"publicationDate":"2021-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s41231-020-00080-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46607059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of serotonin and diet in the prevalence of irritable bowel syndrome: a systematic review","authors":"Khushi Bruta, Vanshika, K. Bhasin, Bhawana","doi":"10.1186/s41231-020-00081-y","DOIUrl":"https://doi.org/10.1186/s41231-020-00081-y","url":null,"abstract":"","PeriodicalId":75244,"journal":{"name":"Translational medicine communications","volume":" ","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2021-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s41231-020-00081-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45913428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vaccination against SARS-CoV-2: a human enhancement story.","authors":"Niklas Alexander Döbler,&nbsp;Claus-Christian Carbon","doi":"10.1186/s41231-021-00104-2","DOIUrl":"https://doi.org/10.1186/s41231-021-00104-2","url":null,"abstract":"<p><strong>Background: </strong>Vaccination is an essential strategy for mitigating the COVID-19 pandemic. Besides its significance as a public health measure, vaccination is a sophisticated example of modern biotechnology. Since vaccination gives the human body an ability that it does not naturally possess, the question arises as to its classification as Human Enhancement.</p><p><strong>Main body: </strong>Exemplified on a selection of different definitions, we conclude that vaccinations may indeed be classified and treated as a form of Human Enhancement. This raises some ethical issues that are notorious in the broad field of Human Enhancement. A study with <i>N</i> = 67 participants revealed that vaccinations are perceived neither as a clear nor poor example of Human Enhancement.</p><p><strong>Conclusion: </strong> We argue that qualifying vaccination technology as Human Enhancement does not provide convincing arguments to reject vaccination. By examining the Human Enhancement debate and the similarities to the issue of vaccination shown here, policymakers can learn valuable lessons regarding mass vaccination programs' current and future handling.</p>","PeriodicalId":75244,"journal":{"name":"Translational medicine communications","volume":" ","pages":"27"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8642743/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39810565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Statins in patients with COVID-19: a retrospective cohort study in Iranian COVID-19 patients.","authors":"Payam Peymani, Tania Dehesh, Farnaz Aligolighasemabadi, Mohammadamin Sadeghdoust, Katarzyna Kotfis, Mazaher Ahmadi, Parvaneh Mehrbod, Pooya Iranpour, Sanaz Dastghaib, Ahmad Nasimian, Amir Ravandi, Biniam Kidane, Naseer Ahmed, Pawan Sharma, Shahla Shojaei, Kamran Bagheri Lankarani, Andrzej Madej, Nima Rezaei, Tayyebeh Madrakian, Marek J Los, Hagar Ibrahim Labouta, Pooneh Mokarram, Saeid Ghavami","doi":"10.1186/s41231-021-00082-5","DOIUrl":"10.1186/s41231-021-00082-5","url":null,"abstract":"<p><strong>Background: </strong>The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has profoundly affected the lives of millions of people. To date, there is no approved vaccine or specific drug to prevent or treat COVID-19, while the infection is globally spreading at an alarming rate. Because the development of effective vaccines or novel drugs could take several months (if not years), repurposing existing drugs is considered a more efficient strategy that could save lives now. Statins constitute a class of lipid-lowering drugs with proven safety profiles and various known beneficial pleiotropic effects. Our previous investigations showed that statins have antiviral effects and are involved in the process of wound healing in the lung. This triggered us to evaluate if statin use reduces mortality in COVID-19 patients.</p><p><strong>Results: </strong>After initial recruitment of 459 patients with COVID-19 (Shiraz province, Iran) and careful consideration of the exclusion criteria, a total of 150 patients, of which 75 received statins, were included in our retrospective study. Cox proportional-hazards regression models were used to estimate the association between statin use and rate of death. After propensity score matching, we found that statin use appeared to be associated with a lower risk of morbidity [HR = 0.85, 95% CI = (0.02, 3.93), <i>P</i> = 0.762] and lower risk of death [(HR = 0.76; 95% CI = (0.16, 3.72), <i>P</i> = 0.735)]; however, these associations did not reach statistical significance. Furthermore, statin use reduced the chance of being subjected to mechanical ventilation [OR = 0.96, 95% CI = (0.61-2.99), <i>P</i> = 0.942] and patients on statins showed a more normal computed tomography (CT) scan result [OR = 0.41, 95% CI = (0.07-2.33), <i>P</i> = 0.312].</p><p><strong>Conclusions: </strong>Although we could not demonstrate a significant association between statin use and a reduction in mortality in patients with COVID19, we do feel that our results are promising and of clinical relevance and warrant the need for prospective randomized controlled trials and extensive retrospective studies to further evaluate and validate the potential beneficial effects of statin treatment on clinical symptoms and mortality rates associated with COVID-19.</p>","PeriodicalId":75244,"journal":{"name":"Translational medicine communications","volume":" ","pages":"3"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7829327/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25316998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mesenchymal stem cells in the treatment of severe COVID-19.","authors":"Santosh Kesari,&nbsp;Gregory C Kasper,&nbsp;Lev Verkh,&nbsp;Terese C Hammond,&nbsp;Marla L Matal,&nbsp;Jay W Hammerling,&nbsp;Nikolai Tankovich,&nbsp;Adrianus P Lim,&nbsp;Kevin H Zhao,&nbsp;Tiffany Juarez,&nbsp;Roberta E Redfern,&nbsp;Jaya M Gill,&nbsp;Natsuko Nomura,&nbsp;Audrey Hiemer,&nbsp;Annie Heng,&nbsp;Jessica Shoemaker","doi":"10.1186/s41231-021-00095-0","DOIUrl":"https://doi.org/10.1186/s41231-021-00095-0","url":null,"abstract":"","PeriodicalId":75244,"journal":{"name":"Translational medicine communications","volume":" ","pages":"16"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8350555/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39325664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}