Translational medicine communications最新文献

{"title":"Dietary factors associated with gastric cancer - a review","authors":"Richa, N. Sharma, Geetanjali Sageena","doi":"10.1186/s41231-022-00111-x","DOIUrl":"https://doi.org/10.1186/s41231-022-00111-x","url":null,"abstract":"","PeriodicalId":75244,"journal":{"name":"Translational medicine communications","volume":" ","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46430701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Promises of eukaryotic ribonucleases for cancer treatment: a systematic review","authors":"Y. Siraj","doi":"10.1186/s41231-022-00113-9","DOIUrl":"https://doi.org/10.1186/s41231-022-00113-9","url":null,"abstract":"","PeriodicalId":75244,"journal":{"name":"Translational medicine communications","volume":"7 1","pages":"1-17"},"PeriodicalIF":0.0,"publicationDate":"2022-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42242980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving chronic disease self-management in high-risk patient populations","authors":"Ashruta Patel","doi":"10.1186/s41231-022-00112-w","DOIUrl":"https://doi.org/10.1186/s41231-022-00112-w","url":null,"abstract":"","PeriodicalId":75244,"journal":{"name":"Translational medicine communications","volume":"7 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2022-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47912292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AMP5A modulates Toll-like receptors 7 and 8 single-stranded RNA immune responses in PMA-differentiated THP-1 and PBMC","authors":"Gregory W. Thomas, Kristen N Hirter, E. Frederick, Melissa A. Hausburg, R. Bar-Or, Yetti Mulugeta, M. Roshon, C. Mains, D. Bar-Or","doi":"10.1186/s41231-022-00110-y","DOIUrl":"https://doi.org/10.1186/s41231-022-00110-y","url":null,"abstract":"","PeriodicalId":75244,"journal":{"name":"Translational medicine communications","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44861067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative urine proteomics in pregnant women for the identification of predictive biomarkers for preeclampsia","authors":"S. Joenväärä, Matilda Holm, M. Saraswat, R. Agarwal, T. Tohmola, E. Kajantie, K. Räikkönen, H. Laivuori, P. Villa, E. Hämäläinen, R. Renkonen","doi":"10.1186/s41231-022-00108-6","DOIUrl":"https://doi.org/10.1186/s41231-022-00108-6","url":null,"abstract":"","PeriodicalId":75244,"journal":{"name":"Translational medicine communications","volume":" ","pages":"1-12"},"PeriodicalIF":0.0,"publicationDate":"2022-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49233468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global conserved RBD fraction of SARS-CoV-2 S-protein with T500S mutation in silico significantly blocks ACE2 and rejects viral spike.","authors":"Amrita Banerjee,&nbsp;Mehak Kanwar,&nbsp;Dipannita Santra,&nbsp;Smarajit Maiti","doi":"10.1186/s41231-022-00109-5","DOIUrl":"https://doi.org/10.1186/s41231-022-00109-5","url":null,"abstract":"<p><strong>Background: </strong>SARS-CoV-2 developed global-pandemic with millions of infections/deaths. As it is urgently necessary it is assumed that some blockers/inhibitors of ACE2 could be helpful to resist the binding of viral-spike Receptor-Binding-Domain (RBD).</p><p><strong>Methods: </strong>Here, conserved RBD from 186-countries were compared with WUHAN-Hu-1 wild-type (CLUSTAL-X2/Pymol). The RBD of ACE2-bound nCOV2 crystal-structure 6VW1 was analyzed by Haddock-PatchDock. Extensive structural study/trial to introduce point/double/triple mutations in the different locations of CUT4 (most-effective from total 4 proposed fragments; CUTs) were tested with Swiss-Model-Expacy.</p><p><strong>Results: </strong>Blind-docking of mutated-CUTs in ACE2 completely rejected the nCOV2 binding to ACE2. Further, competitive-docking/binding-analyses (by PRODIGY) demonstrated few more bonding (LYS31-PHE490 and GLN42-GLN498) of CUT4 (than wild) and hindered TYR41-THR500 interaction with ACE2. Moreover, mutated-CUT4 even showed higher blocking effect against spike-ACE2 binding.</p><p><strong>Conclusion: </strong>In summary, CUT4-mutant rejects whole glycosylated-nCoV2 in all pre-dock, post-dock and competitive-docking conditions. The present work strategy is relevant because it could be able to block at the first level entry of the virus to the host cells.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1186/s41231-022-00109-5.</p>","PeriodicalId":75244,"journal":{"name":"Translational medicine communications","volume":" ","pages":"2"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8814807/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39901630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ozone high dose therapy (OHT) improves mitochondrial bioenergetics in peripheral blood mononuclear cells.","authors":"Brigitte König,&nbsp;Johann Lahodny","doi":"10.1186/s41231-022-00123-7","DOIUrl":"https://doi.org/10.1186/s41231-022-00123-7","url":null,"abstract":"<p><strong>Background: </strong>The worldwide increasing number of people with chronic diseases is pushing conventional therapy to its limits. The so-called Major AutoHaemo Therapy (MAH) has been used in many practices for years. Despite suspicions, especially the 10-passes ozone-high-dosis Therapy (OHT) has shown substantial benefits in chronic ailments. However, knowledge of scientifically based effects of high ozone concentrations are still rare. The present investigation focussed on verifying whether OHT may be linked to a beneficial effect on mitochondrial bioenergetics which can be expressed as a bioenergetic health index (BHI).</p><p><strong>Methods: </strong>We report on six patients which received OHT for preventive purposes twice within one week. The BHI in peripheral blood mononuclear cells (PBMC) is calculated from parameters of a cellular mitochondrial function assay, which gives insights into different aspects of mitochondrial function: 1) Basal oxygen consumption rate (OCR); 2) ATP-linked OCR and proton leak; 3) Maximal OCR and reserve capacity; 4) Non-mitochondrial OCR.</p><p><strong>Results: </strong>The results clearly show that the bioenergetic health index in PBMC improves significantly after just 2 OHT applications over a period of 1 week. The overall improvement of the BHI is based primarily on a significant increase in the reserve capacity and the maximum respiration of the mitochondria. The increase in non-mitochondrial oxygen consumption, which has a negative impact on the BHI value, is indicative for the Nrf-2 dependent activation of antioxidant and detoxifying enzymes activated through OHT.</p><p><strong>Conclusion: </strong>These data demonstrate for the first time the beneficial effect of OHT on mitochondrial parameters. Thus, the results of this study suggest that OHT could be a safe and effective therapeutic option alone or as integrative and complementary support for pharmacological therapy in a variety of chronic and acute diseases where mitochondrial dysfunction plays a central role.</p>","PeriodicalId":75244,"journal":{"name":"Translational medicine communications","volume":" ","pages":"17"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9301618/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40625932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comments on the optimal use of medical ozone in clinics versus the Ozone High Dose Therapy (OHT) approach.","authors":"Marianno Franzini,&nbsp;Luigi Valdenassi,&nbsp;Sergio Pandolfi,&nbsp;Giovanni Ricevuti,&nbsp;Umberto Tirelli,&nbsp;Francesco Vaiano,&nbsp;Salvatore Chirumbolo","doi":"10.1186/s41231-022-00132-6","DOIUrl":"https://doi.org/10.1186/s41231-022-00132-6","url":null,"abstract":"","PeriodicalId":75244,"journal":{"name":"Translational medicine communications","volume":"7 1","pages":"26"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9734312/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10750776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19: positive experience with differentiated tactics of mechanical ventilation of the lungs for different phenotypes (L-phenotype).","authors":"Valery Piacherski,&nbsp;Lidziya Muzyka,&nbsp;Dzyanis Zhylynski","doi":"10.1186/s41231-022-00122-8","DOIUrl":"https://doi.org/10.1186/s41231-022-00122-8","url":null,"abstract":"<p><strong>Relevance: </strong>Studies have previously been published on a possible differential approach to respiratory therapy in patients with COVID-19 depending on the L- or H-phenotype.The authors believe that early tracheal intubation reduces the risk of lung injury. The use of deep sedation and low PEEP (6-8 cmH₂O) and early intubation may prevent transition to type H.</p><p><strong>Method and results: </strong>Eleven patients with COVID-19 type L pneumonia received respiratory support based on the proposed guidelines. Eight women and three men (ages 45 to 84) with COVID-19 type L pneumonia were treated in the intensive care unit. Did they all receive oxygen therapy up to 15 L/min. high-flow oxygen therapy up to 60 L/ min, non-invasive ventilation of the lungs. If it was impossible to reduce FiO₂ from 100 to 75% within 2-3 h or if the patient was intolerant to NIV, early tracheal intubation was used.The minute ventilation volume was set to maintain CO₂ <60 mmHg. and pH>7.25 in venous blood. Sedation was performed by intravenous titration of fentanyl and propofol. If deeper sedation was required to synchronize the patient to the ventilator, intravenous muscle relaxants were used over 24-48 hours (bolus or intravenous titration) instead of sedation.</p><p><strong>Conclusion: </strong>All 11 patients were successfully weaned from the mechanical ventilation of the lungs. A differentiated approach to respiratory therapy for COVID-19 L-type pneumonia proved to be an effective approach in these patients.It is probably worth avoiding deep sedation of patients on mechanical ventilation with L-type pneumonia, which would reduce the time spent on mechanical ventilation and reduce the risk of mortality from nosocomial bacterial infection.The new MVL strategy for L-type pneumonia and the problem of deep sedation require more research. But the available data suggests that it probably has benefits.</p>","PeriodicalId":75244,"journal":{"name":"Translational medicine communications","volume":" ","pages":"15"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9263035/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40497729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adoption of telehealth technologies: an approach to improving healthcare system.","authors":"Arpana Sharma,&nbsp;Madhu Pruthi,&nbsp;Geetanjali Sageena","doi":"10.1186/s41231-022-00125-5","DOIUrl":"https://doi.org/10.1186/s41231-022-00125-5","url":null,"abstract":"<p><strong>Background: </strong>Globally, the healthcare industry is well known to be one of the strongest drivers of economic growth and development. The sector has gained substantial attention to deal with the fallout of COVID-19, leading to improvement in the quality observed in developed and developing nations. With the advent of the twenty-first century, globalization an ever-growing populace, and environmental changes prompted the more noteworthy spread of irresistible diseases, highlighting the association between wellbeing and future health security. The massive spread of COVID-19 paralyzed the global economy and took a toll on health governance and wellbeing. The present review aims to map the harrowing impacts of COVID-19 on the QoL (quality of life) observed. Particularly the post-pandemic era is likely to boot-strap the healthcare sector. Hence in post COVID era, there is a dire need to strengthen the healthcare system and understand the evolving challenges to answer calls in recovery in the wake of COVID-19.</p><p><strong>Conclusion: </strong>There is a flurry of research highlighting the implications faced due to the rise of the pandemic, resulting in the wrecking growth and development. However, the massive potential of telehealth is still largely underexplored with scarce research on countless evolving technologies. The current crisis highlighted the need to develop emerging frameworks and facilitate multilateral cooperation. The present research can serve as the baseline for better future strategies to improve global health initiatives. Further, this can help to focus on wider health determinants, redesign strategies and policies for the healthcare industry and to mitigate/deal better with future pandemics.</p>","PeriodicalId":75244,"journal":{"name":"Translational medicine communications","volume":" ","pages":"20"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9361246/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40709760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}