Thoracic research and practice最新文献

{"title":"Response to: Letter to the Editor Regarding CT-based Prediction of Lung Cancer Histology.","authors":"Fadlan Adima Adrianta, Dini Rachma Erawati, Suryanti Dwi Pratiwi, Nanik Setijowati","doi":"10.4274/ThoracResPract.2026.2026-3-10","DOIUrl":"10.4274/ThoracResPract.2026.2026-3-10","url":null,"abstract":"","PeriodicalId":75221,"journal":{"name":"Thoracic research and practice","volume":"27 3","pages":"196-197"},"PeriodicalIF":0.8,"publicationDate":"2026-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13162295/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147876772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Air Pollution, COVID-19-related Air-quality Changes, and Premature Mortality in Türkiye (2019-2023).","authors":"Didem Han Yekdeş, Ali Cem Yekdeş","doi":"10.4274/ThoracResPract.2025.2025-7-3","DOIUrl":"10.4274/ThoracResPract.2025.2025-7-3","url":null,"abstract":"<p><strong>Objective: </strong>Long-term exposure to fine particulate matter (PM_2.5) contributes to about 8 million premature deaths worldwide annually. In Türkiye, few studies have examined long-term health impacts, particularly during and after the coronavirus disease-2019 (COVID-19) pandemic. This study aimed to estimate premature mortality and the respiratory disease burden attributable to PM_2.5 from 1 January 2019 to 31 December 2023.</p><p><strong>Material and methods: </strong>Premature deaths attributable to PM_2.5 were estimated using the World Health Organization's (WHO) AirQ+ software. Inputs included annual provincial PM_2.5 concentrations (measured directly or at stations without PM_2.5 measurements, converted from PM₁₀ using the WHO-recommended factor of 0.67 for Türkiye), mortality data for individuals aged ≥25 years, and demographic data from Turkish Statistical Institute. The Estimates focused on chronic obstructive pulmonary disease (COPD) and lung cancer. Population attributable fractions were calculated. Temporal comparisons were made across pre-pandemic (2019), pandemic (2020-2021), and post-pandemic (2022-2023) periods to capture potential effects of COVID-19-related reductions in industrial production and traffic. Differences were assessed using one-way ANOVA.</p><p><strong>Results: </strong>An annual average of 85,344 premature deaths (95% confidence interval: 79,129-91,559) was attributable to PM_2.5. COPD and lung cancer accounted for a significant share of PM_2.5-related deaths, with about one in seven linked to COPD. Although temporary improvements in air quality occurred during the COVID-19 pandemic, no statistically significant difference was observed in COPD-attributable mortality across the three study periods (<i>P</i> = 0.687).</p><p><strong>Conclusion: </strong>Air pollution remains a major public health challenge in Türkiye. Sustained, region-specific strategies are needed to reduce the burden of PM_2.5-related mortality. Inadequate monitoring coverage continues to limit precision in exposure and risk assessment.</p>","PeriodicalId":75221,"journal":{"name":"Thoracic research and practice","volume":" ","pages":"77-82"},"PeriodicalIF":0.8,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13002242/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146004918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship Between Peripheral Eosinophilia, Lower Respiratory Tract Pathogens, Age at First Pneumonia, and Malnutrition in Children with Non-cystic Fibrosis Bronchiectasis.","authors":"Esin Gizem Olgun, Gizem Özcan, Fazılcan Zirek, Merve Nur Tekin, Secahattin Bayav, Mahmut Turğut, Mukaddes Ağırtıcı, Semra Küçük Öztürk, Seyhan Çelik Merteşe, Nazan Çobanoğlu","doi":"10.4274/ThoracResPract.2026.2025-9-3","DOIUrl":"10.4274/ThoracResPract.2026.2025-9-3","url":null,"abstract":"<p><strong>Objective: </strong>Non-cystic fibrosis (non-CF) bronchiectasis is a chronic lung disease, primarily characterised by neutrophilic inflammation, with <i>Haemophilus influenzae</i> (HI) frequently isolated from respiratory cultures. Recent adult studies have suggested a potential role for eosinophils in the frequency of pulmonary exacerbations and in lung function decline. This study aimed to evaluate the relationships among peripheral eosinophilia, lower respiratory tract pathogens, age at first pneumonia, and malnutrition in children with non-CF bronchiectasis.</p><p><strong>Material and methods: </strong>In this retrospective study, children who were diagnosed with non-CF bronchiectasis were grouped based on nutritional status, eosinophilia, age at first pneumonia, and the most frequently isolated microorganisms. Clinical outcomes were compared across groups.</p><p><strong>Results: </strong>Among 106 patients (61.3% male), malnutrition was present in 48.1% and eosinophilia in 39.6%. Primary immunodeficiency was the most common etiology (39.6%). HI and <i>Pseudomonas aeruginosa</i> (PA) were isolated in 61.3% and 24.5% of respiratory cultures, respectively. Patients with malnutrition had significantly lower forced expiratory volume in one second and forced vital capacity (FVC) values (<i>P</i> = 0.023 and <i>P</i> = 0.005, respectively). Eosinophilia was more prevalent in patients with PA isolation; was associated with younger ages at first pneumonia and bronchiectasis diagnoses (<i>P</i> = 0.009 and <i>P</i> = 0.017). PA isolation was associated with a higher frequency of aspiration syndromes (<i>P</i> < 0.001) and lower FVC values (<i>P</i> = 0.040). Patients who experienced their first episode of pneumonia before the age of two had more frequent exacerbations and were diagnosed with bronchiectasis at an earlier age.</p><p><strong>Conclusion: </strong>Non-CF bronchiectasis in childhood may be preventable and/or non-progressive when diagnosed early. Clinical features such as malnutrition, eosinophilia, PA isolation, and early-onset pneumonia may help identify children who could benefit from closer clinical monitoring. Further pediatric studies are needed to validate these associations.</p>","PeriodicalId":75221,"journal":{"name":"Thoracic research and practice","volume":" ","pages":"96-102"},"PeriodicalIF":0.8,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13002249/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147313105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emrelis: A New Approach in Treating MET-high Locally Advanced or Metastatic Non-squamous NSCLC; A Mini Review.","authors":"Saim Mahmood Khan, Areeba Naveed, Aleena Amir, Yumna Saifullah, Surraiya Riaz Mahmood Khan","doi":"10.4274/ThoracResPract.2025.2025-6-4","DOIUrl":"10.4274/ThoracResPract.2025.2025-6-4","url":null,"abstract":"<p><p>Non-small cell lung cancer (NSCLC) accounts for 85% of all lung cancers; however, a subset of patients experiences disease progression associated with alterations in the Mesenchymal-Epithelial Transition Factor (c-MET) pathway. These include MET exon 14-skipping mutations, which promote tumor growth, metastasis, and resistance to epidermal growth factor receptor (EGFR)-targeted therapies. Telisotuzumab vedotin (TV-t, Emrelis), a novel first-in-class c-MET inhibitor, is under investigation as a targeted therapy for c-MET-high NSCLC. This article highlights the therapeutic potential of TV-t as a targeted therapy for advanced NSCLC patients with limited post-treatment options. A targeted literature review was conducted using PubMed and ClinicalTrials.gov (2018 and 2025) with terms including \"Telisotuzumab Vedotin,\" \"c-MET,\" \"c-MET-high,\" \"c-MET overexpression,\" \"MET exon 14,\" and \"NSCLC.\" Both clinical and preclinical studies of the efficacy, safety, and pharmacological properties of TV-t were included. Also, those studies reported clinical findings relevant to TV-t in c-MET-altered NSCLC. In the pivotal LUMINOSITY phase II trial, TV-t showed a 28.6% overall response rate (ORR) in EGFR-wildtype, c-MET-overexpressing NSCLC, with 34.6% ORR in c-MET-high patients. Median duration of response was 9.0 months, overall survival 14.5 months, and progression-free survival (PFS) 5.7 months for the c-MET-high subgroup. In phase Ib studies, TV-t combined with osimertinib achieved a 50% ORR and 7.4-month PFS, while TV-t with nivolumab, the median PFS was 7.2 months, but ORR was low (7.4%). Common grade 3 or higher toxicities occurred in 27.9% of patients and included neuropathy, anemia, and pulmonary embolism, with no hepatotoxicity. Remarkable cardiac safety was observed. TV-t demonstrated promising efficacy and tolerability in patients, highlighting its clinical potential. However, further studies are needed to confirm its survival advantage, the durability of response, and safety profile, and to establish its long-term value and support its integration into routine clinical practice.</p>","PeriodicalId":75221,"journal":{"name":"Thoracic research and practice","volume":" ","pages":"114-119"},"PeriodicalIF":0.8,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13002248/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145859099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Underutilization of Bacteriological Testing in Extrapulmonary Tuberculosis: A Retrospective Single-center Study from Mardin, Türkiye.","authors":"Barış Çil, Mehmet Sinan Bodur, Mehmet Kabak","doi":"10.4274/ThoracResPract.2026.2025-10-8","DOIUrl":"10.4274/ThoracResPract.2026.2025-10-8","url":null,"abstract":"<p><strong>Objective: </strong>Extrapulmonary tuberculosis (EPTB) poses diagnostic challenges due to the low bacillus burden of the disease and the limited use of bacteriological tests. The aim of this study was to evaluate bacteriological confirmation rates, diagnostic methods, and sampling practices among patients diagnosed with tuberculosis (TB) in a southeastern province of Türkiye.</p><p><strong>Material and methods: </strong>This retrospective study included a total of 456 TB cases diagnosed between 2014 and 2019. The cases were classified as pulmonary tuberculosis (PTB), EPTB, and cases with both types of involvement. Bacteriological and histopathological confirmation rates were compared between the groups.</p><p><strong>Results: </strong>41.0% of all cases were classified as EPTB. The most commonly involved site was lymph node TB (22.4%). Bacteriological confirmation rates were significantly lower in EPTB cases: acid-fast bacilli (AFB) smear positivity was 3.2% and culture positivity was 4.3%, whereas the histopathological confirmation rate was 88.8%. No bacteriological samples were taken from 63.1% of patients in the EPTB group. Among PTB cases, AFB smear positivity (71.4%) and culture positivity (66.5%) were significantly higher (<i>P</i> < 0.001).</p><p><strong>Conclusion: </strong>The findings suggest that bacteriological tests are both underused and of low diagnostic efficiency in EPTB cases. Most diagnoses are based on histopathology rather than on bacteriological confirmation. Strengthening sampling strategies and promoting the use of rapid molecular testing are critical for enhancing bacteriological validation in EPTB.</p>","PeriodicalId":75221,"journal":{"name":"Thoracic research and practice","volume":" ","pages":"109-113"},"PeriodicalIF":0.8,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13002247/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147313099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Interplay Between Obstructive Sleep Apnea and Respiratory Infections: A Review Article.","authors":"Safy Kaddah, Antonio M Esquinas","doi":"10.4274/ThoracResPract.2025.2025-7-7","DOIUrl":"10.4274/ThoracResPract.2025.2025-7-7","url":null,"abstract":"<p><p>Obstructive sleep apnea (OSA) is a prevalent sleep-related breathing disorder characterized by recurrent upper airway collapse, intermittent hypoxia, and sleep fragmentation. Increasing evidence suggests a bidirectional association between OSA and lower respiratory tract infections (LRTIs), including pneumonia, bronchitis, and exacerbations of chronic lung disease. Multiple mechanisms may underlie this relationship. Intermittent hypoxia and sleep disruption promote systemic inflammation and immune dysregulation. Impaired mucociliary clearance, microaspiration, alterations in airway microbiota, together with obesity and related comorbidities, further contribute to increased susceptibility to and severity of infections. Observational studies demonstrate that individuals with untreated OSA have higher rates of pneumonia, more severe infections, and delayed recovery from infections compared with non-OSA populations. These risks are particularly evident among older adults and patients with cardiopulmonary comorbidities. Continuous positive airway pressure (CPAP) therapy may mitigate infection risk by maintaining airway patency, reducing hypoxemia, and improving mucociliary clearance. However, concerns remain regarding CPAP device-associated microbial colonization, highlighting the importance of strict hygiene practices and equipment maintenance. OSA appears to be an underrecognized risk factor for LRTIs; this association is driven by overlapping pathophysiological mechanisms and is supported by emerging epidemiological data. Recognizing this interplay may guide infection prevention strategies and improve clinical outcomes in high-risk populations.</p>","PeriodicalId":75221,"journal":{"name":"Thoracic research and practice","volume":" ","pages":"120-128"},"PeriodicalIF":0.8,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13002250/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147345586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does Pulmonary Function Testing Affect Autonomic Nervous System Activity?","authors":"Gülay Yalçın, Server Erdoğmuş Gülcan, Erdoğan Kavlak","doi":"10.4274/ThoracResPract.2026.2025-8-1","DOIUrl":"10.4274/ThoracResPract.2026.2025-8-1","url":null,"abstract":"<p><strong>Objective: </strong>The autonomic nervous system (ANS) regulates vital functions such as heart rate (HR) and respiration. Pulmonary function tests (PFTs), which require forced breathing maneuvers, may influence ANS activity, potentially affecting the accuracy of autonomic measurements. This study aimed to investigate the effects of PFT on ANS activity and to assess the reliability of the test order.</p><p><strong>Material and methods: </strong>Forty-eight healthy university students (32 women, 16 men; mean age 19±0.92 years) participated. ANS activity was assessed by heart rate variability (HRV) analysis using the Elite HRV Corsense device. HRV was recorded at rest in a seated position (first measurement), was repeated after a 5-minute rest (second measurement), and was recorded again following PFT performed with a Medwelt SP10 spirometer (third measurement).</p><p><strong>Results: </strong>Comparison of the first and second measurements showed a statistically significant increase only in the root mean square of successive differences (RMSSD) parameter, with no significant changes in other indices. Comparison of the second and third measurements revealed no significant differences in RMSSD or average HR; however, significant changes were observed in the low-frequency (LF) and high-frequency (HF) components and in the LF/HF ratio.</p><p><strong>Conclusion: </strong>Respiratory maneuvers during PFT may temporarily alter ANS activity, particularly affecting parasympathetic-sympathetic balance. The differences between the first and second measurements emphasize the importance of adequate rest periods before HRV assessment. Measurements taken prior to PFT appear to be more reliable for the accurate evaluation of autonomic function.</p>","PeriodicalId":75221,"journal":{"name":"Thoracic research and practice","volume":" ","pages":"83-89"},"PeriodicalIF":0.8,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13002244/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147312680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Household Tobacco Smoke Exposure in Asthmatic Children in Algeria: A Multicenter Study.","authors":"Redouene Sid Ahmed Benazzouz, Massinissa Benyagoub, Azeddine Mekideche, Mohamed Safouane Benazzouz, Faiza Hadjersi","doi":"10.4274/ThoracResPract.2025.2025-8-2","DOIUrl":"10.4274/ThoracResPract.2025.2025-8-2","url":null,"abstract":"<p><strong>Objective: </strong>Passive and active tobacco smoke exposure can worsen asthma outcomes in children, yet data on its prevalence in Algeria are limited. To assess the prevalence and characteristics of tobacco smoke exposure, including prenatal and adolescent active smoking, among asthmatic children in Algeria.</p><p><strong>Material and methods: </strong>A multicenter cross-sectional study was conducted from December 1, 2024, to January 31, 2025, in five pediatric consultation centers across Algeria. A total of 135 children with physician-diagnosed asthma, aged 2 months to 15 years, were enrolled. Data on demographic, clinical, socioeconomic, and environmental factors were collected.</p><p><strong>Results: </strong>Tobacco smoke exposure was documented in 37.8% of participants, most commonly attributable to paternal smoking. In utero exposure was reported in 40% of the study population. Low-income households showed a higher prevalence of exposure compared with higher-income groups (<i>P</i> = 0.009). The geographic distribution of exposure varied significantly (<i>P</i> = 0.001). No significant association was found between tobacco smoke exposure and asthma severity or asthma control. Three adolescent patients reported active smoking.</p><p><strong>Conclusion: </strong>Over one-third of Algerian children with asthma are exposed to tobacco smoke, with a substantial proportion exposed prenatally. These findings highlight the need for family-focused cessation programs and region-specific preventive actions to reduce children's exposure to tobacco smoke in Algeria.</p>","PeriodicalId":75221,"journal":{"name":"Thoracic research and practice","volume":" ","pages":"90-95"},"PeriodicalIF":0.8,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13002243/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146069261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal Trends in the Use of Pulmonary Function Tests Before, During, and After the COVID-19 Pandemic: Experience from a University Hospital in Türkiye.","authors":"Mustafa Ersözlü, Deniz Doğan Mülazimoğlu, Miraç Öz Kahya, Öznur Yıldız, Özlem Özdemir Kumbasar","doi":"10.4274/ThoracResPract.2025.2025-7-6","DOIUrl":"10.4274/ThoracResPract.2025.2025-7-6","url":null,"abstract":"","PeriodicalId":75221,"journal":{"name":"Thoracic research and practice","volume":" ","pages":"129-131"},"PeriodicalIF":0.8,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13002245/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147328534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CT-defined Emphysema Morphology as a Predictor for Histological Subtypes of Lung Cancer: A Single-center Retrospective Study.","authors":"Fadlan Adima Adrianta, Dini Rachma Erawati, Suryanti Dwi Pratiwi, Nanik Setijowati","doi":"10.4274/ThoracResPract.2026.2025-9-6","DOIUrl":"10.4274/ThoracResPract.2026.2025-9-6","url":null,"abstract":"<p><strong>Objective: </strong>Lung cancer and pulmonary emphysema share common risk factors and pathophysiological pathways. Emerging evidence suggests that emphysema morphology, rather than emphysema burden, may influence lung cancer histology. This study evaluated the association between computed tomography (CT)-defined emphysema characteristics and histological subtypes of lung cancer.</p><p><strong>Material and methods: </strong>A retrospective observational cohort study was conducted that included 144 patients with histologically confirmed lung cancer who underwent diagnostic thoracic CT between January 2020 and June 2024 at Dr. Saiful Anwar General Hospital in Indonesia. Emphysema morphology was visually classified as centrilobular emphysema (CLE), paraseptal emphysema, or mixed, and emphysema volume was quantified using 3D Slicer software. Associations with histological subtypes were analyzed using bivariate analyses and multivariate logistic regression, adjusted for age, sex, tumor size, and tumor location. Model performance was assessed using receiver operating characteristic analysis.</p><p><strong>Results: </strong>Adenocarcinoma (ADC) was the most common subtype (65.3%). Emphysema was present in 37.5% of patients and occurred more frequently in non-ADC subtypes. Emphysema morphology was significantly associated with histological subtype (<i>P</i> < 0.001). Multivariate analysis identified CLE as an independent predictor of ADC (adjusted odds ratio: 8.5; 95% confidence interval: 1.24-57.9; <i>P</i> = 0.029), and CLE remained significant after adjustment for tumor size and tumor location. The model demonstrated excellent discrimination (area under the curve: 0.89). Emphysema volume did not differ significantly between groups (<i>P</i> = 0.339).</p><p><strong>Conclusion: </strong>CT-defined CLE is independently associated with lung ADC, whereas emphysema volume is not predictive of lung ADC. Emphysema morphology may serve as a non-invasive imaging biomarker to support histological risk stratification when tissue diagnosis is limited.</p>","PeriodicalId":75221,"journal":{"name":"Thoracic research and practice","volume":" ","pages":"103-108"},"PeriodicalIF":0.8,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13002246/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147345664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}