The Lancet regional health. Southeast Asia最新文献

{"title":"Mortality among hospitalized children with melioidosis in Thailand: a retrospective national database analysis (2015–2023)","authors":"Phanthila Sitthikarnkha ,&nbsp;Sirapoom Niamsanit ,&nbsp;Leelawadee Techasatian ,&nbsp;Suchaorn Saengnipanthkul ,&nbsp;Kaewjai Thepsuthammarat ,&nbsp;Pope Kosararaksa ,&nbsp;Nattakarn Tantawarak ,&nbsp;Punnathorn Auaboonkanok ,&nbsp;Phenphitcha Pornprasitsakul ,&nbsp;Rattapon Uppala","doi":"10.1016/j.lansea.2025.100707","DOIUrl":"10.1016/j.lansea.2025.100707","url":null,"abstract":"<div><h3>Background</h3><div>Pediatric melioidosis remains under-characterized nationally in Thailand, hindering triage and critical-care planning. We quantified epidemiology, complications, and mortality correlates among hospitalized children.</div></div><div><h3>Methods</h3><div>Retrospective analysis of Thailand's National Health Security Office database from January 2015 to Dec 2023, including patients &lt;18 years with principal melioidosis. Incidence and case-fatality rate were calculated. Mortality-related clinical characteristics were compared using descriptive statistics.</div></div><div><h3>Findings</h3><div>Among 5044 admissions, 58.3% were male and 80.5% from the Northeast; annual incidence ranged 3.7–5.8 per 100,000, peaking in 2023. Median length of hospital stay was 11 days. Lower respiratory tract infection was the commonest localized focus (17.6%), followed by septic shock (2.9%). Organ dysfunction consisted of acute respiratory failure 3.2%, acute renal failure 2.3%, and disseminated intravascular coagulation (DIC) 1.7%. There were 2.3% required intubation with mechanical ventilation &gt;96 h, and 2.2% needed renal replacement therapy. Overall, 84 children died (1.7%); deaths clustered in tertiary hospitals (71.4%). Mortality was markedly higher among children with septic shock, lower respiratory tract infection, and acute respiratory failure compared with children without these complications.</div></div><div><h3>Interpretation</h3><div>National data identify a Northeast-weighted pediatric burden and a high-risk trajectory from pneumonia to acute respiratory failure, shock, and DIC. Embedding pediatric sepsis bundles with early melioidosis-active therapy and seasonal pediatric intensive care unit (PICU) surge/transfer protocols, may shorten time-to-treatment and reduce deaths substantially and equitably.</div></div><div><h3>Funding</h3><div>This study was supported by the <span>Fundamental Fund</span>, <span>Khon Kaen University</span>, Thailand.</div></div>","PeriodicalId":75136,"journal":{"name":"The Lancet regional health. Southeast Asia","volume":"43 ","pages":"Article 100707"},"PeriodicalIF":6.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145790040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methodological issue in a dental neuromelioidosis outbreak investigation","authors":"Bijayini Behera ,&nbsp;Prasanta Raghab Mohapatra","doi":"10.1016/j.lansea.2025.100658","DOIUrl":"10.1016/j.lansea.2025.100658","url":null,"abstract":"","PeriodicalId":75136,"journal":{"name":"The Lancet regional health. Southeast Asia","volume":"43 ","pages":"Article 100658"},"PeriodicalIF":6.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145790020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Lancet Regional Health—Southeast Asia: 2025 year in review","authors":"Shalini Garg,&nbsp;Bhavani Nivetha,&nbsp;Apoorva Dharmendra","doi":"10.1016/j.lansea.2025.100704","DOIUrl":"10.1016/j.lansea.2025.100704","url":null,"abstract":"","PeriodicalId":75136,"journal":{"name":"The Lancet regional health. Southeast Asia","volume":"43 ","pages":"Article 100704"},"PeriodicalIF":6.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145790038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Indonesia leaves SEARO: what it means for regional health and WHO","authors":"Habib Benzian ,&nbsp;Manu Raj Mathur","doi":"10.1016/j.lansea.2025.100660","DOIUrl":"10.1016/j.lansea.2025.100660","url":null,"abstract":"","PeriodicalId":75136,"journal":{"name":"The Lancet regional health. Southeast Asia","volume":"43 ","pages":"Article 100660"},"PeriodicalIF":6.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145790039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tiny lives, big failures: India's drug regulation crisis","authors":"The Lancet Regional Health – Southeast Asia","doi":"10.1016/j.lansea.2025.100705","DOIUrl":"10.1016/j.lansea.2025.100705","url":null,"abstract":"","PeriodicalId":75136,"journal":{"name":"The Lancet regional health. Southeast Asia","volume":"43 ","pages":"Article 100705"},"PeriodicalIF":6.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145790037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nafithromycin in CABP: promise and precaution—authors’ reply","authors":"Himanshu Pophale ,&nbsp;Monica Gupta ,&nbsp;Hariharan Periasamy ,&nbsp;Balaji Veeraraghavan ,&nbsp;Sachin Bhagwat","doi":"10.1016/j.lansea.2025.100696","DOIUrl":"10.1016/j.lansea.2025.100696","url":null,"abstract":"","PeriodicalId":75136,"journal":{"name":"The Lancet regional health. Southeast Asia","volume":"43 ","pages":"Article 100696"},"PeriodicalIF":6.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145529092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delandistrogene Moxeparvovec gene therapy for Duchenne muscular dystrophy: the way forward in South Asian countries","authors":"Priyanka Madaan ,&nbsp;Santosh Kumar Mishra ,&nbsp;Jithangi Wanigasinghe ,&nbsp;Jitendra Kumar Sahu","doi":"10.1016/j.lansea.2025.100699","DOIUrl":"10.1016/j.lansea.2025.100699","url":null,"abstract":"","PeriodicalId":75136,"journal":{"name":"The Lancet regional health. Southeast Asia","volume":"43 ","pages":"Article 100699"},"PeriodicalIF":6.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145624638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concerns on construct validity and contamination in the Lay-CARE study","authors":"Yilin Jiang ,&nbsp;Narina A. Samah ,&nbsp;Heng Zhou","doi":"10.1016/j.lansea.2025.100652","DOIUrl":"10.1016/j.lansea.2025.100652","url":null,"abstract":"","PeriodicalId":75136,"journal":{"name":"The Lancet regional health. Southeast Asia","volume":"43 ","pages":"Article 100652"},"PeriodicalIF":6.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145790019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond immunogenicity in XBB.1.5 subunit COVID-19 boosters focusing on durability, dosing, and target populations: authors reply","authors":"Subhash Thuluva,&nbsp;Vikram Paradkar,&nbsp;SubbaReddy Gunneri,&nbsp;Rammohan Reddy Mogulla,&nbsp;Vijay Yerroju,&nbsp;Siddalingaiah Ningaiah,&nbsp;Mallikarjuna Panchakshari,&nbsp;Chirag Dhar","doi":"10.1016/j.lansea.2025.100678","DOIUrl":"10.1016/j.lansea.2025.100678","url":null,"abstract":"","PeriodicalId":75136,"journal":{"name":"The Lancet regional health. Southeast Asia","volume":"43 ","pages":"Article 100678"},"PeriodicalIF":6.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145790024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pregnancy and neonatal outcomes of term deliveries of singleton pregnancies at different gestations in Sri Lanka: a multicentre prospective study","authors":"Sachith Mettananda ,&nbsp;Himali Herath ,&nbsp;Ranod Madushith ,&nbsp;Tiran Dias ,&nbsp;Rasika Herath ,&nbsp;Sampatha Goonewardena ,&nbsp;Dhammica Rowel ,&nbsp;Abner Elkan Daniel ,&nbsp;Susie Perera","doi":"10.1016/j.lansea.2025.100677","DOIUrl":"10.1016/j.lansea.2025.100677","url":null,"abstract":"<div><h3>Background</h3><div>Delivery at ‘term’ is considered low risk for mothers and neonates. Evidence suggests variable outcomes at different gestations, even within ‘term’. This study aims to compare pregnancy characteristics and neonatal outcomes of delivery at different gestations at ‘term’.</div></div><div><h3>Methods</h3><div>We analysed the data of the island-wide multicentre Sri Lanka Birth Weight Study, which recruited all live-born newborns in 13 hospitals over 2 months in 2023. Only data of singleton pregnancies and term neonates were included. Pregnancy complications and neonatal outcomes of each gestation were analysed by logistic regression.</div></div><div><h3>Findings</h3><div>8053 ‘term’ singleton deliveries (1805, 2367, 2087, 1762, and 32 at 37, 38, 39, 40 and 41 weeks) were included. A higher proportion of mothers delivering at 37 weeks had pregestational diabetes (AOR: 7.84, 95% CI: 4.24–14.37), chronic hypertension (AOR: 4.37, 95% CI: 2.01–9.49), pregnancy-induced hypertension (AOR: 2.65, 95% CI: 1.92–3.66) and gestational diabetes (AOR: 1.96, 95% CI: 1.57–2.44) compared to mothers delivering at 39 weeks. The elective caesarean section rate was highest at 37 weeks (783, 43.4%) compared to 38 weeks (737, 31.1%) or higher gestations. Delivery at 37 weeks was associated with inferior neonatal outcomes of 5-min APGAR &lt;8 (AOR: 3.04, 95% CI: 1.36–6.76), requiring resuscitation (AOR: 1.74, 95% CI: 1.27–2.38) and admission to intensive care (AOR: 1.62, 95% CI: 1.09–2.41) compared to 38 weeks.</div></div><div><h3>Interpretation</h3><div>Neonates born at 38 weeks showed better outcomes than those born at 37 weeks. When elective delivery is necessary, postponing it from 37 weeks to at least 38 weeks would positively impact neonatal outcomes.</div></div><div><h3>Funding</h3><div><span>UNICEF</span>, Sri Lanka, funded the Sri Lanka Birth Weight Study. No funding obtained for this manuscript.</div></div>","PeriodicalId":75136,"journal":{"name":"The Lancet regional health. Southeast Asia","volume":"42 ","pages":"Article 100677"},"PeriodicalIF":6.2,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145222996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}