The Lancet regional health. Southeast Asia最新文献

{"title":"Health insurance in southeast Asia: is it enough for UHC?","authors":"The Lancet Regional Health – Southeast Asia","doi":"10.1016/j.lansea.2025.100653","DOIUrl":"10.1016/j.lansea.2025.100653","url":null,"abstract":"","PeriodicalId":75136,"journal":{"name":"The Lancet regional health. Southeast Asia","volume":"39 ","pages":"Article 100653"},"PeriodicalIF":6.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144827574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Balancing public health priorities and inclusivity in medical education: a clarification on curriculum revisions","authors":"Mirza Jahanzeb Beg , B. Sai Chaitanya Reddy , Manik Inder Singh Sethi","doi":"10.1016/j.lansea.2025.100563","DOIUrl":"10.1016/j.lansea.2025.100563","url":null,"abstract":"","PeriodicalId":75136,"journal":{"name":"The Lancet regional health. Southeast Asia","volume":"39 ","pages":"Article 100563"},"PeriodicalIF":6.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144827575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic accuracy of convolutional neural networks in classifying hepatic steatosis from B-mode ultrasound images: a systematic review with meta-analysis and novel validation in a community setting in Telangana, India","authors":"Akshay Jagadeesh ,&nbsp;Chanchanok Aramrat ,&nbsp;Santosh Rai ,&nbsp;Fathima Hana Maqsood ,&nbsp;Adarsh Kibballi Madhukeshwar ,&nbsp;Santhi Bhogadi ,&nbsp;Judith Lieber ,&nbsp;Hemant Mahajan ,&nbsp;Santosh Kumar Banjara ,&nbsp;Alexandra Lewin ,&nbsp;Sanjay Kinra ,&nbsp;Poppy Mallinson","doi":"10.1016/j.lansea.2025.100644","DOIUrl":"10.1016/j.lansea.2025.100644","url":null,"abstract":"<div><h3>Background</h3><div>Ultrasound is a widely available, inexpensive, and non-invasive modality for evaluating hepatic steatosis (HS). However, the scarcity of radiological expertise limits its utility. Convolutional Neural Networks (CNNs) have potential for automated classification of HS using B-mode ultrasound images. We aimed to assess their diagnostic accuracy and generalisability across diverse study settings and populations.</div></div><div><h3>Methods</h3><div>We systematically reviewed two biomedical databases up to Dec 12, 2023, to identify studies that applied CNNs in the classification of HS using B-mode ultrasound images as input (PROSPERO: CRD42024501483). We supplemented this review with a novel analysis of the community-based Andhra Pradesh Children and Parents’ Study (APCAPS) in India to address the overrepresentation of hospital samples and lack of data on South Asian populations who exhibit a distinct central adiposity phenotype that could influence CNN performance. We quantitatively synthesised diagnostic accuracy metrics for eligible studies using random-effects meta-analyses.</div></div><div><h3>Findings</h3><div>Our search returned 289 studies, of which 17 were eligible. All but one of the 17 studies were based in hospital or clinical outpatient settings with curated cases and controls. Studies were conducted exclusively in East Asian, European, or North American populations. Studies employed varying gold standards: seven studies (41.18%) used liver biopsy, three (17.64%) used MRI proton density fat fraction, and seven (41.18%) used clinician-evaluated ultrasound-based HS grades. The APCAPS sample included 219 participants with radiologist-assigned HS grades. Across the range of study settings and populations, CNNs demonstrated good diagnostic accuracy. Meta-analysis of studies with low risk of bias reporting on five unique datasets showed a pooled area under the receiver operating characteristic curve of 0.93 (95% CI 0.73–0.98) for detecting any severity and 0.86 (95% CI 0.77–0.92) for detecting moderate-to-severe HS severity grades, respectively.</div></div><div><h3>Interpretation</h3><div>CNNs have good diagnostic accuracy and generalisability for HS classification, suggesting potential for real-world application.</div></div><div><h3>Funding</h3><div><span>Medical Research Council</span>, UK (<span><span>MR/T038292/1</span></span>, <span><span>MR/V001221/1</span></span>).</div></div>","PeriodicalId":75136,"journal":{"name":"The Lancet regional health. Southeast Asia","volume":"40 ","pages":"Article 100644"},"PeriodicalIF":6.2,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144749801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urgent need to integrate gender-sensitive financing in Southeast Asia's health insurance expansion","authors":"Schawanya Kaewpitoon Rattanapitoon ,&nbsp;Natnapa Heebkaew Padchasuwan ,&nbsp;Nav La ,&nbsp;Nathkapach Kaewpitoon Rattanapitoon","doi":"10.1016/j.lansea.2025.100645","DOIUrl":"10.1016/j.lansea.2025.100645","url":null,"abstract":"","PeriodicalId":75136,"journal":{"name":"The Lancet regional health. Southeast Asia","volume":"39 ","pages":"Article 100645"},"PeriodicalIF":6.2,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144722540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sample representativeness and temporal comparability in SEAR study","authors":"Jabed Iqbal","doi":"10.1016/j.lansea.2025.100646","DOIUrl":"10.1016/j.lansea.2025.100646","url":null,"abstract":"","PeriodicalId":75136,"journal":{"name":"The Lancet regional health. Southeast Asia","volume":"39 ","pages":"Article 100646"},"PeriodicalIF":6.2,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144722541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinicopathological characteristics and prognostic outcomes of young adult women (aged 18–30 years) with breast cancer in Ahmedabad, India: a single-centre, retrospective observational study","authors":"Ajinkya Pawar,&nbsp;Poojitha Yalla,&nbsp;Mohit Sharma,&nbsp;Ketul Puj,&nbsp;Jebin Aaron,&nbsp;Vikas Warikoo,&nbsp;Abhijeet Salunke,&nbsp;Shashank Pandya","doi":"10.1016/j.lansea.2025.100643","DOIUrl":"10.1016/j.lansea.2025.100643","url":null,"abstract":"<div><h3>Background</h3><div>Breast cancer in young adult women is a rapidly growing group of cancer patients in India which needs to be addressed with urgency. Despite increasing global focus on breast cancer in young women, data from India remain scarce. Considering this gap, we undertook this study to analyse the clinicopathological characteristics and prognostic outcomes of young adult women (aged 18–30 years) with breast cancer in Ahmedabad, India.</div></div><div><h3>Methods</h3><div>This was a retrospective observational study of a prospectively maintained database of 201 patients with breast cancer (aged 18–30 years) treated in a high-volume tertiary centre in Ahmedabad, India, from January 2015 to December 2020. Patients were followed up until June 2023. The demographic parameters, clinicopathological characteristics and survival of all patients were studied. Statistical analyses were done using SPSS and DATAtab.</div></div><div><h3>Findings</h3><div>In this study 49.2% of cases were early breast cancers, 26.8% locally advanced, and 23.8% were metastatic. The proportion of aggressive cancers was higher with 38.8% hormone negative, 39.3% HER2-positive, 26.8% triple-negative and 50.8% grade 3. The median overall survival for all patients was 56 months (95% CI 28–84 months) and the 5-year overall survival was 48% (95% CI 40–56%). The multivariate analysis suggested that clinical stage, grade and luminal A status, significantly affected overall survival. The 5-year overall survival and disease-free survival of patients undergoing surgery were 65% (95% CI 57–74%) and 56% (95% CI 47–65%) respectively.</div></div><div><h3>Interpretation</h3><div>The 5-year overall survival rate of 48% among young adult women with breast cancer included in this study is poor compared to the 77% observed in high-income countries in the western parts of the world. Adoption of appropriate and aggressive treatment strategies may enhance the outcomes in this age group of women with breast cancer.</div></div><div><h3>Funding</h3><div>None.</div></div>","PeriodicalId":75136,"journal":{"name":"The Lancet regional health. Southeast Asia","volume":"40 ","pages":"Article 100643"},"PeriodicalIF":5.0,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144714444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and immunogenicity of booster doses of an XBB.1.5 RBD subunit COVID-19 vaccine among individuals aged 5–80 years in India: a phase 3, single-blind, randomised controlled trial","authors":"Subhash Thuluva ,&nbsp;Vikram Paradkar ,&nbsp;SubbaReddy Gunneri ,&nbsp;Rammohan Reddy Mogulla ,&nbsp;Vijay Yerroju ,&nbsp;Chirag Dhar ,&nbsp;Siddalingaiah Ningaiah ,&nbsp;Mallikarjuna Panchakshari ,&nbsp;Chandrashekhar S. Gillurkar ,&nbsp;Manish Narang ,&nbsp;Shivnitwar Sachin Kisan ,&nbsp;A. Venkateshwar Rao","doi":"10.1016/j.lansea.2025.100642","DOIUrl":"10.1016/j.lansea.2025.100642","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;The SARS-CoV-2 virus continues to evolve with recent variants such as the omicron sub-variants potentially exhibiting increased transmissibility. Of note, the XBB.1.5 variant has been associated with vaccine-breakthrough cases. We utilised the same platform previously used to develop CORBEVAX™, an ancestral Wuhan strain COVID-19 RBD subunit vaccine, to now develop an XBB.1.5 RBD subunit vaccine. We evaluated the safety and immunogenicity of the new XBB.1.5 RBD subunit vaccine compared to an ancestral Wuhan strain RBD subunit vaccine.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;This prospective, single-blind, phase 3 randomised controlled trial was conducted in participants aged 5–80 years. Participants who had not received any other approved COVID-19 vaccine within the last 6 months were enrolled and randomised in a 2:1 ratio to receive two booster doses of either the test vaccine or the control vaccine. The vaccines were administered on Day 0 and Day 28 with immunogenicity assessments on Day 0, Day 28, and Day 42. Safety assessments included the collection of solicited and unsolicited adverse events (AEs) up to Day 56. The primary objective of the study was to demonstrate immunogenic superiority of the test vaccine booster series compared to the control vaccine series. This superiority objective was to be met if the lower limit of the two-sided 95% CI of the anti-XBB.1.5.RBD neutralising antibody (nAb) geometric mean titre (GMT) ratio of test: control was &gt;1.0 on either Day 28 or Day 42. Given the emergence of JN.1 as the prevalent SARS-CoV-2 strain during the conduct of this study, Day 42 anti-JN.1 nAb levels were measured in a &lt;em&gt;post hoc&lt;/em&gt; immunogenicity assessment. In addition, anti-XBB.1.5 RBD protein IgG concentrations were also measured by ELISA on Day 0, Day 28, and Day 42. The trial was registered at Clinical Trials Registry–India as CTRI/2024/01/061423.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Findings&lt;/h3&gt;&lt;div&gt;A total of 360 participants (32.8% female) were enrolled and randomised across seven sites in India. The nAb GMT ratio of test: control participants was 2.08 (95% CI 1.64–2.63) on Day 28 and 2.91 (95% CI 2.38–3.56) on Day 42. The geometric mean fold rise (GMFR) of neutralising antibodies (nAb) was 7.637 (95% CI 6.090–9.578) on Day 28 and 17.02 (95% CI 13.79–21.01) on Day 42 in the test booster series arm. The nAb GMFRs in the control booster series arm at the same time points were 3.033 (95% CI 2.340–3.932) and 4.824 (95% CI 3.731–6.236), respectively. &lt;em&gt;Post hoc&lt;/em&gt; analyses revealed an nAb GMT ratio of 1.90 (95% CI 1.56–2.31) for test: control against the JN.1 SARS-CoV-2 strain. The safety profile of the new XBB.1.5 RBD subunit vaccine was found to be very similar to that of the ancestral strain vaccine with 59 AEs (about 1 AE for every 8 doses administered) and 27 AEs (a little less than 1 AE for every 8 doses administered) respectively during the study. No serious AEs or AEs of special interest were reported in ei","PeriodicalId":75136,"journal":{"name":"The Lancet regional health. Southeast Asia","volume":"40 ","pages":"Article 100642"},"PeriodicalIF":5.0,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144694354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutrients of concern for older infants and young children in packaged food products available in Nepali retail stores","authors":"Nisha Sharma ,&nbsp;Prabhat Lamichhane ,&nbsp;Penelope Love ,&nbsp;Pradeep Kaji Poudel ,&nbsp;Cherie Russell ,&nbsp;Colin Bell","doi":"10.1016/j.lansea.2025.100637","DOIUrl":"10.1016/j.lansea.2025.100637","url":null,"abstract":"<div><h3>Background</h3><div>Nepali older infants and young children (IYC) are increasingly consuming packaged foods. However, energy and nutrients of concern in these products (total sugar, added sugar, total fat, saturated fat, sodium, and non-sugar sweeteners) have not been assessed. This cross-sectional study aimed to assess energy and nutrients of concern in packaged foods available to older IYC in retail stores in Nepal using thresholds from the WHO Southeast Asia Region Nutrient Profile Model (SEAR NPM).</div></div><div><h3>Methods</h3><div>Nutrition labels on packaged food products for sale in a cross-section of 4 large stores (2 supermarkets, 2 departmental stores) and 22 small (corner) stores were photographed by three trained researchers. Ingredients, energy and nutrients of concern were extracted from the labels. Products were categorised into 14 food groups using the SEAR NPM with the primary outcome being the proportion of products exceeding thresholds for one or more nutrients of concern.</div></div><div><h3>Findings</h3><div>We found 2001 unique packaged food products, of which 1525 (76.0%) contained all requisite and readable nutrition information on the labels. Of 1525 products, 1323 products (86.8%) exceeded one or more SEAR NPM thresholds for energy and nutrients of concern and/or contained NSS. Most products exceeded the threshold for total energy (94.9%), followed by 79.7%, 72.5%, 71.4%, 55.3%, and 55.1% of products exceeding the threshold for total sugar, total fat, saturated fat, added sugar, and sodium respectively. By food category, almost all bakery products (99.7%), confectionery (99.6%), savoury snacks (99.2%), and water-based flavoured drinks (98.3%), most frozen dairy based desserts and edible ices (88.4%), approximately three-quarters of instant noodles and soups (75.6%), half of the cereals (54.0%), juices (50.0%), and milk and dairy-based drinks (46.0%) exceeded one or more of the SEAR NPM thresholds for energy and nutrients of concern and/or contained NSS.</div></div><div><h3>Interpretation</h3><div>Our findings suggest that regulatory measures are needed to limit exposure to and consumption of packaged foods by older IYC given the number of products exceeding thresholds for energy and one or more of the nutrients of concern.</div></div><div><h3>Funding</h3><div>NS was supported by <span>Deakin University</span> Postgraduate Research Scholarship and CR was supported by a <span>Deakin University</span> Post-Doctoral Fellowship.</div></div>","PeriodicalId":75136,"journal":{"name":"The Lancet regional health. Southeast Asia","volume":"39 ","pages":"Article 100637"},"PeriodicalIF":5.0,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144685469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Financial vulnerability of the elderly population undergoing cataract surgery within a distributed eye care delivery system in India (2011–2022): a multicentre, retrospective cohort study","authors":"Brijesh Takkar ,&nbsp;Ragukumar Venugopal ,&nbsp;Mehul Mehta ,&nbsp;Anthony Vipin Das ,&nbsp;Varsha Rathi ,&nbsp;Rohit Khanna ,&nbsp;Gudlavalleti V.S. Murthy ,&nbsp;Hemendra Kumar Vaishnav ,&nbsp;Brijesh Kashyap ,&nbsp;Chirantan Chatterjee ,&nbsp;Raja Narayanan","doi":"10.1016/j.lansea.2025.100640","DOIUrl":"10.1016/j.lansea.2025.100640","url":null,"abstract":"<div><h3>Background</h3><div>The health burden of geriatric eye care is expected to rise, yet medical insurance uptake among the elderly population remains low. There is minimal evidence regarding insurance uptake for eye care among the elderly population in the Southeast Asia region. We explored insurance uptake and its impact on visual outcomes among the elderly population who visited an eye care system distributed across four Indian states.</div></div><div><h3>Methods</h3><div>In this retrospective cohort study, we used a browser-based proprietary, Hospital Information Management System (HIMSS) stage six, electronic medical record (EMR) system. Datasets were collected from new patients who visited the four tertiary centres with linked primary and secondary centres of our pyramidal health system (L V Prasad Eye Institute [India]) distributed in four Indian states, Andhra Pradesh, Odisha, Telangana, and Karnataka, between August 2011 and December 2022. The electronic medical records of 38,387 patients aged &gt;70 years who underwent cataract surgery were included (45.5% were females [17,471]). Individuals treated with fully subsidised care were excluded. Data on age, health insurance uptake, type of health insurance (government or private), and mode of payment for cataract surgery were collected. Factors impacting insurance uptake and visual outcomes were studied using logistic regression analysis.</div></div><div><h3>Findings</h3><div>Insurance uptake declined from 17.5% among people aged 70 years to less than 10% among those aged &gt;85 years. Private insurance uptake declined from 13.3% among people aged 70 years to 4.7% among those aged 90 years, while publicly funded insurance remained between 3.3% and 4.2%. Insurance uptake increased during 2018–2022 compared to 2011–2017 (20.61% vs. 10.65%; p &lt; 0.001). A higher proportion of males had insurance uptake compared to females. Median waiting times for surgery among patients with government versus private insurance were 18 and 11 days, respectively. Among patients aged &gt;80 years, surgical outcomes for those without insurance were worse than for those with insurance.</div></div><div><h3>Interpretation</h3><div>Insurance uptake declined dramatically in patients aged above 80 years and was associated with poorer visual outcomes following cataract surgery, as the insurance uptake may impact the quality of eye care received. Policy changes are needed to increase insurance uptake for eye care in this population.</div></div><div><h3>Funding</h3><div><span>DBT Wellcome Trust India Alliance</span>, <span>Clinical Research Centre</span> Grant IA/CRC/19/1/610010; <span>Hyderabad Eye Research Foundation</span> (HERF).</div></div>","PeriodicalId":75136,"journal":{"name":"The Lancet regional health. Southeast Asia","volume":"39 ","pages":"Article 100640"},"PeriodicalIF":5.0,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144685473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transfusion-transmitted Plasmodium spp. infections and safety challenges for malaria in the Indian subcontinent: a systematic review","authors":"Loick P. Kojom Foko ,&nbsp;Shweta Sharma ,&nbsp;Amit Sharma","doi":"10.1016/j.lansea.2025.100641","DOIUrl":"10.1016/j.lansea.2025.100641","url":null,"abstract":"<div><div>Blood transfusion is a globally life-saving intervention, but blood-borne pathogens can threaten its effectiveness. While blood bags are systematically screened for viral and bacterial pathogens, parasite infections are generally overlooked. In this review, we analysed the current literature on transfusion-transmitted malaria (TTM) in India over the past five decades. This analysis is based on 122 studies involving more than 6.5 million individuals. The prevalence of <em>Plasmodium</em> parasitaemia in donors ranged from ∼0% to 0.87% by light microscopy and ∼0% to 2.3% by rapid diagnostic tests. The proportion of post-transfusion malaria (PTM) cases ranged from 0.8% to 6.8% across the studies. The risk of PTM is both time- and diagnosis method-dependent and relatively high in some regions of India. The clinical impacts of PTM range from mild to severe and even fatal outcomes. It is also crucial to address TTM given the often-neglected <em>Plasmodium malariae</em>, in addition to the prevalence of <em>Plasmodium vivax</em> and <em>Plasmodium falciparum</em>. The spread of drug-resistant and/or <em>pfhrp2</em> gene-deleted <em>P. falciparum</em> parasites is another threat in PTM. Blood screening could be achieved through point-of-care nucleic acid amplification techniques to guarantee safer transfusion. If neglected, TTM can become an obstacle to malaria elimination in the coming years.</div></div>","PeriodicalId":75136,"journal":{"name":"The Lancet regional health. Southeast Asia","volume":"40 ","pages":"Article 100641"},"PeriodicalIF":5.0,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144680661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}