AIDS Research and Therapy最新文献_第8页

Epidemic of multiple Treponema pallidum strains in men who have sex with men in Japan: efficient multi-locus sequence typing scheme and indicator biomarkers. 日本男男性行为者中多种苍白螺旋体菌株的流行：高效的多焦点序列分型方案和指示性生物标记物。

IF 2.1 4区医学

AIDS Research and Therapy Pub Date : 2024-10-16 DOI: 10.1186/s12981-024-00663-y

Wakana Sato, Ayako Sedohara, Michiko Koga, Yu Nakagama, Hiroshi Yotsuyanagi, Yasutoshi Kido, Eisuke Adachi

{"title":"Epidemic of multiple Treponema pallidum strains in men who have sex with men in Japan: efficient multi-locus sequence typing scheme and indicator biomarkers.","authors":"Wakana Sato, Ayako Sedohara, Michiko Koga, Yu Nakagama, Hiroshi Yotsuyanagi, Yasutoshi Kido, Eisuke Adachi","doi":"10.1186/s12981-024-00663-y","DOIUrl":"https://doi.org/10.1186/s12981-024-00663-y","url":null,"abstract":"Background: The challenges in culturing Treponema pallidum have hindered molecular-biological analysis. This study aims to establish a molecular epidemiological analysis of syphilis among Japanese men who have sex with men (MSM) and to investigate the relationship between bacteremia and associated pathophysiology.Methods: We used whole blood specimens from syphilis-diagnosed individuals in Tokyo, collected between February 2019 and June 2022. All individuals were MSM, and most were people with HIV (97.2%). We used a multi-locus sequence typing (MLST) scheme for epidemiological analysis. Sequences for MLST (TP0136, TP0548, and TP0705) were obtained.Results: Out of 71 whole blood samples, 26 samples (36.6%) were positive for TP0136, and we sequenced three loci for MLST in 22 samples (31.0%). The most frequently detected sequence type (ST) was ST3 (n = 9), followed by ST6 (n = 6). Phylogenetic analysis revealed that 12 samples belonged to the SS14-like group (60%), and 8 samples belonged to the Nichols-like group (40%). Treponema pallidum subsp. endemicum (TEN), the cause of bejel was detected in three samples (12%). There was a significant association between TP0136 detection rate and C- reactive protein (CRP) (77.0% at a cut-off:0.5 mg/dL).Conclusion: Both SS14-like and Nichols-like strains were circulating concurrently, and TEN could have been sexually transmitted among MSM with HIV. Elevated CRP may indicate the presence of the pathogen in the blood.","PeriodicalId":7503,"journal":{"name":"AIDS Research and Therapy","volume":"21 1","pages":"71"},"PeriodicalIF":2.1,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11484458/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142455902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Uptake of early infant HIV diagnosis and its associated factors in Tanzania: an analytical cross-sectional study. 坦桑尼亚婴儿艾滋病早期诊断的接受率及其相关因素：一项横断面分析研究。

IF 2.1 4区医学

AIDS Research and Therapy Pub Date : 2024-10-10 DOI: 10.1186/s12981-024-00652-1

Esther Gaudence Kiurugo, Saada Ali Seif, Walter Cleo Milanzi

引用次数: 0

Missed opportunity: low awareness of undetectable equals untransmittable (U = U) among adolescents living with HIV. 错失良机：感染艾滋病毒的青少年对检测不到等于不能传播（U = U）的认识不足。

IF 2.1 4区医学

AIDS Research and Therapy Pub Date : 2024-10-08 DOI: 10.1186/s12981-024-00659-8

Sonal Swain, Elizabeth Inman, Deirdre Josipovic, Avy Violari, Rachel Kidman

引用次数: 0

Association of ART regimen and adherence to viral suppression: an observational study of a clinical population of people with HIV. 抗逆转录病毒疗法与坚持病毒抑制的关系：一项针对艾滋病临床人群的观察性研究。

IF 2.1 4区医学

AIDS Research and Therapy Pub Date : 2024-10-08 DOI: 10.1186/s12981-024-00657-w

Jasmine A Manalel, Jennifer E Kaufman, Yiyi Wu, Ethan Fusaris, Arlene Correa, Jerome Ernst, Mark Brennan-Ing

{"title":"Association of ART regimen and adherence to viral suppression: an observational study of a clinical population of people with HIV.","authors":"Jasmine A Manalel, Jennifer E Kaufman, Yiyi Wu, Ethan Fusaris, Arlene Correa, Jerome Ernst, Mark Brennan-Ing","doi":"10.1186/s12981-024-00657-w","DOIUrl":"10.1186/s12981-024-00657-w","url":null,"abstract":"Adherence to antiretroviral therapy (ART) is essential for the effective management of HIV, which includes keeping the HIV viral load undetectable. This study aimed to determine whether certain ART medications are more \"forgiving\" of poor adherence in achieving viral suppression. We identified subgroups of ART medication usage and determined the extent to which ART adherence is associated with viral suppression across those subgroups. Data came from claims and clinical records (2017-2019) of 3,552 HIV-positive adult members of a Medicaid managed care plan. Pharmacy fill data were examined to characterize ART medications using latent class analysis (LCA), which captures the complexity of real-world ART usage (i.e., multiple medications, ART switching). LCA yielded five ART medication patterns over three years, mostly characterized by recent medications and formulations of ART, though they varied in number of tablets and in medication class. Mixed effects logistic regression models were estimated to determine whether odds of viral suppression differed by ART adherence level. After adjusting for covariates, those with at least 90% adherence (i.e., 90 to < 95%) did not significantly differ from those with 95% adherence or greater in terms of viral suppression, which corroborates existing clinical recommendations. These findings can inform provider-patient communication for people with HIV, especially those who have difficulty maintaining adherence. This includes those experiencing unstable housing, mental health conditions, or substance use.","PeriodicalId":7503,"journal":{"name":"AIDS Research and Therapy","volume":"21 1","pages":"68"},"PeriodicalIF":2.1,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11460157/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142387248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A matters arising: a structural equation modeling approach to investigate HIV testing willingness for men who have sex with men. 出现的问题：采用结构方程模型法调查男男性行为者的 HIV 检测意愿。

IF 2.1 4区医学

AIDS Research and Therapy Pub Date : 2024-10-04 DOI: 10.1186/s12981-024-00656-x

Jafar Hassanzadeh, Aboubakr Jafarnezhad

{"title":"A matters arising: a structural equation modeling approach to investigate HIV testing willingness for men who have sex with men.","authors":"Jafar Hassanzadeh, Aboubakr Jafarnezhad","doi":"10.1186/s12981-024-00656-x","DOIUrl":"10.1186/s12981-024-00656-x","url":null,"abstract":"This is a Matters Arising about an article titled \"A structural equation modeling approach to investigate HIV testing willingness for men who have sex with men in China\" in the issue of AIDS Res Ther 20, 64 (2023) \" of this journal has been published. While thanking and appreciating the good authors of this article, we would like to explain some of the methodological issues of this study in order to clarify and disambiguate the methodology part of this article and other articles submitted in this style. First of all, it should be known that the concept and definition of structural equation modeling, the reason and method of doing it, specifying the observable and latent variables in the model, the exogenous and endogenous variables of the model, the correct way to draw the SEM graph, should be properly considered. The authors of this Matters Arising do not seek to refute or confirm the authors of this article. Our final opinion is that the methodology section should be written better and scientific clarification should be made in the methodology section for readers and interested parties.","PeriodicalId":7503,"journal":{"name":"AIDS Research and Therapy","volume":"21 1","pages":"67"},"PeriodicalIF":2.1,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11453081/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142374978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Safety of different amphotericin B formulations among AIDS patients with invasive fungal disease: a retrospective observational study. 侵袭性真菌病艾滋病患者使用不同两性霉素 B 制剂的安全性：一项回顾性观察研究。

IF 2.1 4区医学

AIDS Research and Therapy Pub Date : 2024-09-29 DOI: 10.1186/s12981-024-00649-w

Yuting Tan, Yanan Mo, Songjie Wu, Miao Tan, Shihui Song, Jie Liu, Hongying Yu, Ke Liang

{"title":"Safety of different amphotericin B formulations among AIDS patients with invasive fungal disease: a retrospective observational study.","authors":"Yuting Tan, Yanan Mo, Songjie Wu, Miao Tan, Shihui Song, Jie Liu, Hongying Yu, Ke Liang","doi":"10.1186/s12981-024-00649-w","DOIUrl":"10.1186/s12981-024-00649-w","url":null,"abstract":"We conducted a retrospective, observational study among acquired immune deficiency syndrome (AIDS) patients with cryptococcal meningitis or talaromycosis to assess AmB formulations-related adverse events (AEs). Total 205 eligible patients were enrolled. Of them, 139 received AmB therapy, 51 received liposomal AmB (L-AmB) therapy, and 15 received AmB cholesteryl sulfate complex (ABCD) therapy. The incidences of total AEs between the AmB, L-AmB and ABCD group had no significant differences. The ABCD group had significantly higher incidences of hepatotoxicity and hematological toxicity than the AmB and L-AmB groups. The incidence of grade 3-4 hematological toxicity in the ABCD group was significantly higher than that in the AmB and L-AmB groups. Multinomial logistic regression models showed that compared with AmB, ABCD had a higher risk for the occurrence of grade 3-4 hematological toxicity (aOR = 43.924, 95%CI 6.296-306.418; p < 0.001). We demonstrated that ABCD was more prone to hepatotoxicity and hematological toxicity than AmB and L-AmB among AIDS patients, which is worth noting.","PeriodicalId":7503,"journal":{"name":"AIDS Research and Therapy","volume":"21 1","pages":"66"},"PeriodicalIF":2.1,"publicationDate":"2024-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11441144/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142339233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Public health response to Mpox: Safeguarding vulnerable Key Populations and People Living with HIV in Zanzibar. 应对麻风病的公共卫生措施：保护桑给巴尔的重点弱势群体和艾滋病毒感染者。

IF 2.1 4区医学

AIDS Research and Therapy Pub Date : 2024-09-29 DOI: 10.1186/s12981-024-00658-9

Mansour Maulid Mshenga, Issa Abeid Mussa, Shaaban Hassan Haji

{"title":"Public health response to Mpox: Safeguarding vulnerable Key Populations and People Living with HIV in Zanzibar.","authors":"Mansour Maulid Mshenga, Issa Abeid Mussa, Shaaban Hassan Haji","doi":"10.1186/s12981-024-00658-9","DOIUrl":"10.1186/s12981-024-00658-9","url":null,"abstract":"Mpox, caused by the Monkeypox virus (MPXV), has emerged as a significant global public health concern, particularly affecting vulnerable populations. The recent outbreak in the Democratic Republic of the Congo (DRC) is the largest recorded, driven by the highly virulent clade 1 strain. Transmission has shifted from animal contact to primarily sexual contact among Key Populations (KPs) such as Sex Workers (SW) and Men who have Sex with Men (MSM). In Zanzibar, where HIV prevalence is significantly higher among Key Populations, People Living with Human Immunodeficiency Virus (PLHIV) are at increased risk of Mpox infection due to socioeconomic challenges and immunosuppression. Despite no reported cases in Zanzibar, the spread of Mpox in non-endemic areas highlights the need for proactive measures. Leveraging Zanzibar's strengthened public health infrastructure, key strategies include tailored awareness campaigns, improved vaccine access through existing COVID-19 vaccination models, healthcare infrastructure enhancement, and mental health support. These targeted actions aim to protect Zanzibar's most vulnerable populations and bolster preparedness against Mpox, emphasizing the importance of resource-appropriate interventions to mitigate potential outbreaks.","PeriodicalId":7503,"journal":{"name":"AIDS Research and Therapy","volume":"21 1","pages":"65"},"PeriodicalIF":2.1,"publicationDate":"2024-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11440885/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142339232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: Adverse events of inactivated COVID-19 vaccine in HIV-infected adults. 更正：感染艾滋病毒的成人接种 COVID-19 灭活疫苗的不良反应。

IF 2.1 4区医学

AIDS Research and Therapy Pub Date : 2024-09-28 DOI: 10.1186/s12981-024-00654-z

Songjie Wu, Yubin Zhang, Fangzhao Ming, Shi Zou, Mengmeng Wu, Wei Guo, Weiming Tang, Ke Liang

引用次数: 0

Correction: Immune response and safety to inactivated COVID-19 vaccine: a comparison between people living with HIV and HIV-naive individuals. 更正：COVID-19 灭活疫苗的免疫反应和安全性：HIV 感染者与 HIV 病毒免疫者之间的比较。

IF 2.1 4区医学

AIDS Research and Therapy Pub Date : 2024-09-23 DOI: 10.1186/s12981-024-00655-y

Shi Zou, Mengmeng Wu, Fangzhao Ming, Songjie Wu, Wei Guo, Gifty Marley, Zhongyuan Xing, Zhiyue Zhang, Minxia Zeng, Chao Sun, Jianfeng Zhang, Weiming Tang, Ke Liang

引用次数: 0

HIV drug resistance: analysis of viral genotypes and mutation loci in people living with HIV in Chongqing, China (2016–2023) 艾滋病毒耐药性：中国重庆艾滋病毒感染者的病毒基因型和变异位点分析（2016-2023 年）

IF 2.2 4区医学

AIDS Research and Therapy Pub Date : 2024-09-13 DOI: 10.1186/s12981-024-00646-z

Wenwan Gao, Gang Zhou, Mei Li, Pengsen Wang, Jungang Li, Renni Deng

{"title":"HIV drug resistance: analysis of viral genotypes and mutation loci in people living with HIV in Chongqing, China (2016–2023)","authors":"Wenwan Gao, Gang Zhou, Mei Li, Pengsen Wang, Jungang Li, Renni Deng","doi":"10.1186/s12981-024-00646-z","DOIUrl":"https://doi.org/10.1186/s12981-024-00646-z","url":null,"abstract":"Large-scale HIV genotype drug resistance study has not been conducted in Chongqing. A retrospective study was conducted on people living with HIV(PLWH) who received HIV-1 genotype resistance testing at Chongqing Public Health Medical Center from May 2016 to June 2023. The HIV-1pol gene was amplified through RT-PCR and analyzed in terms of genotypic drug resistance. Of the 3015 PLWH tested for HIV-1 drug resistance, 1405 (46.6%) were resistant to at least one antiviral drug. Among non-nucleoside reverse transcriptase inhibitors (NNRTIs), 43.8% were resistant, compared to 29.5% for nucleoside reverse transcriptase inhibitors (NRTIs) and 3.4% for protease inhibitors (PIs). V179D/E and K103N/S were identified as the common mutation sites in the NNRTIs class of drugs, M184V/I and K65R/N were reported as the most common mutation sites in NRTIs, while thymidine analogue mutation (TAM) group was identified in 373 samples. L10FIV was the most common mutation in PIs. The dominant HIV-1 subtype was CRF07_BC. The high prevalence of HIV-1 drug resistance in Chongqing underscores the imperative for rigorous surveillance of the local HIV epidemic. Furthermore, TAMs are associated with HIV-1 multidrug resistance, and timely detection of drug resistance is helpful to reduce the emergence and spread of such drug-resistant strains.","PeriodicalId":7503,"journal":{"name":"AIDS Research and Therapy","volume":"1 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142221019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0