The East African health research journal最新文献

{"title":"Predictors of Smartphone Usage Addiction among Health Sciences Students in Selected Universities in Kampala, Uganda.","authors":"Abdulmujeeb Babatunde Aremu, Ismail Bamidele Afolabi, Naziru Rashid","doi":"10.24248/eahrj.v8i3.811","DOIUrl":"10.24248/eahrj.v8i3.811","url":null,"abstract":"<p><strong>Background: </strong>Globally, smartphone use among university students is expanding at an exponential rate, and its lingering addiction has now become a global issue, causing some emotional comprehension issues that can lead to significant consequences. Hence, this study aimed to assess the magnitude of smartphone addiction (overuse) and its predictors among health sciences students at selected universities in Kampala, Uganda.</p><p><strong>Methodology: </strong>An online-based descriptive cross-sectional study design was employed for this study among 308 students of health sciences in Ugandan universities. A three-sectioned, pretested, and validated questionnaire was used to capture data on socio-demographic attributes and smartphone use habits from the respondents. The data were analysed using IBM SPSS version 26. The outcome variable (i.e., smartphone addiction) was transformed into a weighted aggregate score prior to dichotomisation. Analysis of variance, chi-square test of independence, and binary logistic regression analysis were employed for the study hypotheses, and the significance level was set at <i>P</i> ≤.05.</p><p><strong>Results: </strong>The prevalence of smartphone addiction was found to be 53.9%. Female respondents were predominant, 179 (58.1%), and relatively three-quarters of the respondents, 237 (76.9%), were unmarried. The smartphone addiction score among the respondents was 16.13 (95% confidence interval [CI], 15.49 to 16.78) on a maximum reference scale of 30. At the multivariable model, daily time spent using a smartphone (AOR 0.40; 95% CI, 0.23 to 0.69) and the onset of smartphone use (AOR 0.55, 95% CI, 0.31 to 0.97) were identified as the significant independent predictors of smartphone addiction.</p><p><strong>Conclusion: </strong>This study reported a high prevalence of smartphone addiction among the sampled health sciences students in Ugandan universities. The most significant predictors of smartphone addiction include the number of hours spent on a smartphone daily and the onset of smartphone use. Given the negative health outcomes that this problem may evoke, this study calls for targeted health education intervention to enhance self-control skills, and to effectively tackle smartphone addiction among university students in Uganda.</p>","PeriodicalId":74991,"journal":{"name":"The East African health research journal","volume":"8 3","pages":"409-416"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12083722/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Remote Teaching in a Rwandan Emergency Medicine Residency: A Viable Option with Limited In-person Staff.","authors":"Andrew Beck, Maria Isabel Diaz, Enyonam Odoom, Claudien Niyigirimbabazi, Oriane Longerstaey, Vincent Ndebwanimana, Doris Uwamahoro, Naz Karim","doi":"10.24248/eahrj.v8i3.801","DOIUrl":"10.24248/eahrj.v8i3.801","url":null,"abstract":"<p><p>Low and middle-income countries (LMIC) in Africa face challenges in medical education. Eleven countries have no medical school, 24 countries share one medical school, and few have residency programs. This shortage means that Africa has only 1.7% of the world's physicians, yet bears 27% of the global disease burden. COVID-19 created further educational constraints, especially in emergency medicine (EM). Student and resident education opportunities were limited. Rwanda faced a shortage of available in-person EM residency instructors during the pandemic, and to support learning needs, we designed and implemented a remote teaching model to substitute in-person instruction. The objective of this study was to evaluate whether remote and pre-recorded teaching is positively received by EM learners and if it is a viable supplement in resource limited settings. Pre-recorded lectures were presented to residents, with lecturers remotely available. We evaluated the program using the first-level Kirkpatrick framework (suitability/satisfaction) via a quantitative and qualitative post-lecture survey. The survey was completed by residents in attendance. Responses were analyzed using descriptive statistics. Outcome measures included learner satisfaction, lecture quality, technological quality, and situational suitability. Qualitative and free-response data was An average of 11 Rwandan EM residents attended 18 lectures. Using a Likert scale, the composite learner satisfaction score was 4.25 (σ = 0.1), the lecture quality score was 4.2 (σ = 0.1), the technological quality score was 4.0 (σ = 0.36), and the situational suitability score was 4.25 (σ = 0.07). These results indicated overall satisfaction with the lectures. Lower scores were given regarding lecturer accents and speech rates. Qualitative feedback did not demonstrate significant dissatisfaction with quality or suitability. When in-person lecturers are unavailable, pre-recorded, remote instructional methods may be an appropriate substitute. Future directions may include piloting the project with a larger, multinational cohort or in LMICs with greater technological or resource limitations.</p>","PeriodicalId":74991,"journal":{"name":"The East African health research journal","volume":"8 3","pages":"327-332"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12083723/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sustaining Functionality of Not-for-Profit Health Organisations During Pandemics: Lessons and COVID 19 Experience from Makerere University Walter Reed Project.","authors":"Jude Thaddeus Ssensamba, Brenda Atwijuka, Stephanie Nakimuli, Brenda Kyohangirwe, Gladys Atim, Ezra Musingye, Chrispus Musabe Bakunda, Jackline Namugabo, Prossy Naluyima, Albert Musinguzi, Stephen Mugamba, Betty Mwesigwa, Hannah Kibuuka","doi":"10.24248/eahrj.v8i3.800","DOIUrl":"10.24248/eahrj.v8i3.800","url":null,"abstract":"<p><p>Not for profit health organisations (NPHOs) complement government health response efforts, hence the need for their continued functionality during pandemic situations. In this article we highlight lessons from Makerere University Walter Reed Project's (MUWRP) efforts to ensure continuity of its health mandate during the corona virus disease 2019 (COVID-19) outbreak. Our findings provide cues for other developing world NPHOs as they prepare for the next outbreak. When the first case of COVID-19 was reported in Uganda, MUWRP's leadership identified four strategic pillars of action; minimising the risk of spread of the malady, ensuring continuity of all health activities, early identification and support for casualties, and prevention. An infection prevention and control (IPC) committee was set up to lead response efforts. Innovations per pillar such as adoption of information technology to ensure virtual working and meeting, bringing vaccines to the doorsteps of interested staff, free COVID testing, alternate employee working schedules, introduction of temperature guns, and weekly IPC review meetings were implemented. Routine demographic, testing, positivity, and treatment data was exported to STATA 15.1 for analysis. By the declaration of the end of the pandemic by the WHO, the average positivity rate of COVID-19 among 196 MUWRP staff was 7%, with 95% of all cases being mild, and 94.3% cases managed through home-based care. Only three cases were referred to hospital. Overall, males 30 to 40 years were most affected. Vaccination completion was at 89%, and there were no fatalities reported. Employing the four pillars and related innovations were key to minimising the effects of COVID-19 at MUWRP and are a relevant adaptable tool for other NPHOs in the developing world, as they prepare for the next pandemic.</p>","PeriodicalId":74991,"journal":{"name":"The East African health research journal","volume":"8 3","pages":"315-326"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12083719/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cases of Guinea Worm Disease Among Al Sabah Children Hospital Attendees from January to December 2022, South Sudan.","authors":"Ezbon WApary, Albino G Atak, Jacob Y Awuol, John M Adut, Gai Y Pech, Jackson M Ayii, Philip M Mayar, Akway M Cham","doi":"10.24248/eahrj.v8i3.803","DOIUrl":"10.24248/eahrj.v8i3.803","url":null,"abstract":"<p><strong>Background: </strong>Guinea worm disease carries health risks with potential effects on social and economic wellbeing of an individual and community. Emergence, the fact of manually removing the worm, is slow, painful, and disabling and therefore, it has a serious adverse socioeconomic outcome on the health, agricultural productivity, and school attendance of affected population. This study was conducted to identify case of Guinea worm among children attending Al Sabah Children Hospital, South Sudan.</p><p><strong>Methodology: </strong>The study extracted register data which covered the period from January to December 2022. Using a systematic random sampling, 422 children were selected from the hospital's Statistics Department of Al Sabah Hospital. Descriptive data analysis was performed using SPSS Statistics software.</p><p><strong>Results: </strong>Of the children who received hospital services, the vast majority (76.3%) were children <5 years old, and more than half were females. None of the sampled children had Guinea worm infection.</p><p><strong>Conclusion: </strong>In 2022, none of the attendees of the Al Sabah Children Hospital was diagnosed with Guinea worm infection. But this does not mean that the country is free of the disease as the study design did not allow to establish true prevalence.</p>","PeriodicalId":74991,"journal":{"name":"The East African health research journal","volume":"8 3","pages":"341-345"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12083733/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High Rates of Repeated Caesarean Section Deliveries and its Associated Maternal and Foetal Complications at A Tertiary Hospital in Northern Tanzania.","authors":"Anastazia J Ngao, Joseph Obure, Eusebious William Maro, Damian J Damian","doi":"10.24248/eahrj.v8i1.751","DOIUrl":"10.24248/eahrj.v8i1.751","url":null,"abstract":"<p><strong>Background: </strong>About one-fifth of women undergo repeated caesarean section (RCS) deliveries worldwide. However, an increase in the number of RCS may lead to maternal and foetal morbidity and mortality. This study aimed to determine the rates of RCS deliveries and associated maternal and foetal complications at a tertiary hospital in northern Tanzania.</p><p><strong>Methods: </strong>This was a hospital-based cross-sectional study conducted at Kilimanjaro Christian Medical Centre (KCMC), Northern Tanzania. A total of 253 women who underwent caesarean section (CS) deliveries during the study period were included. Information from patient files was reviewed to abstract specific variables of interest, including maternal demographic and obstetric characteristics, maternal complications such as adhesions, postpartum haemorrhage, infections, anaesthetic complications, hysterectomy, and maternal deaths. Foetal complications related to RCS were also extracted, including the Apgar score, admission to the neonatal unit, neonatal infections, respiratory problems, and perinatal death.</p><p><strong>Result: </strong>A total of 253 women were enrolled in this study. Of these, 133 (52.5%) had RCS delivery. The mean (± standard deviation) age of women at enrolment was 29.9 (±6.5) years. The overall complications rate was 56.5% (32.9% among women having first CS and 67.1% RCS, <i>P<.001</i>). For women who underwent RCS, 37.2% had anaesthesia-related complications, including hypotension, nausea, bradycardia, difficult intubation, aspiration, and respiration. Other complications were sepsis (15%), postpartum haemorrhage (PPH) (11.9%), and wound dehiscence (5.5%). Only sepsis was independently associated with repeated CS delivery (adjusted odds ratio (aOR=11.3, 95% confidence interval [CI], 3.3 to 8.9; <i>P<.001</i>).</p><p><strong>Conclusion: </strong>The reported RCS in this study was high, associated with high CS complications. Necessary measures should be taken by healthcare providers to avoid unnecessary primary CS delivery, and counselling for trial of labour with close monitoring of labour for successful vaginal birth after caesarean section should be emphasised to avoid RCS and its complications.</p>","PeriodicalId":74991,"journal":{"name":"The East African health research journal","volume":"8 1","pages":"74-79"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11371013/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142134679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performance Evaluation of Rapid Test for <i>Schistosoma Mansoni</i> among School Aged Children in Mwanga District Council, Kilimanjaro Tanzania.","authors":"Seif Abdul, Victoria Masue, Magreth A Mlemba, Rafaeli Massawe, Victor Mosha, Beatrice J Leyaro, Sia E Msuya","doi":"10.24248/eahrj.v8i1.743","DOIUrl":"10.24248/eahrj.v8i1.743","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Schistosomiasis is an acute and chronic tropical disease caused by trematodes of the genus Schistosoma. It is a disease of public health concern and mostly affects developing countries of the tropics. According to WHO burden of the disease is as high as 80-85%, principally in sub-Saharan Africa. Although the majority of the infection is often linked with morbidity, it also results in considerable death. The overall annual mortality rate might exceed 200,000 people in Africa due to different complications of urinary and intestinal Schistosomiasis. Children are at a greater risk of acquiring the infection as well as reinfection, and this might cause growth retardation, anemia and low school performance.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;The study aimed at determining the prevalence of &lt;i&gt;Schistosoma mansoni,&lt;/i&gt; associated factors and evaluating the performance of Point of Care Circulating Cathodic Antigen comparison (POC-CCA) against a routine method (formal Ether) of detection methods among school aged children at Mwanga District Council, Kilimanjaro Tanzania.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methodology: &lt;/strong&gt;This was a cross sectional study conducted from April - June 2019 in Mwanga District Council. A minimum of 288 primary school children in Mwanga District were enrolled. Random sampling technique was used to select the participants. Interviews were conducted with study participants followed by single stool and urine sample collection. formal-ether concentration technique, urine dipstick and Point of Care Circulating Cathodic Antigen (POC-CCA) were used for stool and urine analysis. Data were entered and cleaned by using SPSS Version 20. Descriptive statistics were summarised using frequency and proportion for categorical variables and mean and standard dispersion for continuous variables. Logistic regression was used to identify independent factors associated with schistosomiasis. Any association with &lt;i&gt;P value&lt;/i&gt; &lt;.05 was considered significant.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;A total of 288 participants were enrolled. The mean age of participants was 9.8 (±2.4) years. The prevalence of &lt;i&gt;Schistosoma mansoni&lt;/i&gt; among the 288 students was 7.3% by formal ether method and 80.4% by POC-CCA. Social demographic characteristics, and hygiene practice assessed were not associated with &lt;i&gt;Schistosoma mansoni&lt;/i&gt; in this study. Water source was statistically significantly associated with the prevalence of &lt;i&gt;Schistosoma mansoni&lt;/i&gt;.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;The prevalence of &lt;i&gt;Schistosoma mansoni&lt;/i&gt; among school aged children is low by using formal-ether concentration technique (routine method). The annual projects of deworming might have helped decrease the endemicity of the infection. This is due to regular deworming project as recommended by WHO. Despite various efforts which are done to deworm, school aged children are still at risk of acquiring infection, due to poor hygienic practice especially from water sources","PeriodicalId":74991,"journal":{"name":"The East African health research journal","volume":"8 1","pages":"13-19"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11371011/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142134687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experiences and Challenges of Mothers in Caring for Infants with Delayed Developmental Milestones: A Case of Dodoma Region, Tanzania.","authors":"Helena Marco Gemuhay, Saada Ali, Stephen Kibusi","doi":"10.24248/eahrj.v8i1.753","DOIUrl":"10.24248/eahrj.v8i1.753","url":null,"abstract":"<p><strong>Background: </strong>Delayed Developmental Milestones is a physical disability affecting the child development, occurs when the child fails to attain normal milestones compared to other children. Globally, 180-200 million infants have signs of developmental delay, and 86% are from developing countries. In Dar es Salaam, proportion of children with cognitive delay is 12.3%.</p><p><strong>Objectives: </strong>This study explored the experiences and challenges of mothers in caring for infants with delayed developmental milestones.</p><p><strong>Methods: </strong>In-depth interviews with ten mothers explored their experiences and identified challenges they encountered while caring for infants with delayed developmental milestones. NVIVO plus software was used for content analysis.</p><p><strong>Results: </strong>Results showed that parents raising infants with delayed developmental milestones had negative experiences on the cause and types of delayed milestones. They lost hope. They were facing different challenges like lack of specialists, conflict in marriage and stigma.</p><p><strong>Conclusion: </strong>Mothers of infants with delayed developmental milestones had negative experiences about this problem and they face many challenges in caring the infants.</p>","PeriodicalId":74991,"journal":{"name":"The East African health research journal","volume":"8 1","pages":"86-98"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11371068/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142134677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interventions to enhance the use of Evidence Based Decision Making for Quality Care among Nurses: A Systematic Review.","authors":"Safari Agure, Barbara Miyeso, Leyla Abdullahi","doi":"10.24248/eahrj.v8i1.760","DOIUrl":"10.24248/eahrj.v8i1.760","url":null,"abstract":"<p><strong>Background: </strong>Decision-making is the cognitive process that results in the selection of a course of action from several possible alternative options. The complexity of nurses' decisions requires a broad knowledge base and access to reliable sources of information; as well as a supportive working environment therefore requiring that decision making be evidence based with robust knowledge translation platforms to disseminate the evidence. This review aimed to assess interventions for enhancing the use of evidence-based decision making for quality care among nurses.</p><p><strong>Methods: </strong>This study followed the Preferred Reporting Items for Systematic Review and Meta-Analysis review (PRISMA 2020) checklist. This study protocol was registered with PROSPERO number CRD42021262318.</p><p><strong>Results: </strong>The search revealed a total of 143 papers divided as follows: PubMed- 65 papers, CINAHL 25 papers and Cochrane 53 papers. In addition, references of included studies were scanned manually for potential papers and another 46 papers extracted. A total of 133 papers were chosen for detailed extraction following removal of 10 duplicate studies.</p><p><strong>Conclusion: </strong>Results of this review revealed that the interventions that have been used to enhance the use of evidence for decision making are majorly educational. A few interventions have taken the form of modelling, guidelines and programming. Online solutions have also been seen to enhance the use of evidence for clinical practice of nurses.</p>","PeriodicalId":74991,"journal":{"name":"The East African health research journal","volume":"8 1","pages":"148-163"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11371018/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142134682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychosocial Challenges and Coping Strategies Among Adults Living with HIV in Ubungo Municipality, Tanzania: A Qualitative Descriptive Study.","authors":"Masunga K Iseselo, Gift G Lukumay, Idda H Mosha","doi":"10.24248/eahrj.v8i3.812","DOIUrl":"10.24248/eahrj.v8i3.812","url":null,"abstract":"<p><strong>Background: </strong>People living with HIV (PLWH) face numerous psychosocial challenges within the context of healthcare systems and the community where they live. This study aimed to describe psychosocial challenges and individual coping strategies among adults attending Care and Treatment Clinics (CTCs) in Ubungo Municipality, Tanzania.</p><p><strong>Materials and methods: </strong>A qualitative descriptive study was conducted at CTCs in Ubungo Municipality, an urban setting in Dar es Salaam. Data were collected through audio-recorded in-depth interviews with 10 purposively selected participants. Audio files were transcribed verbatim and analyzed using a thematic analysis approach.</p><p><strong>Results: </strong>Difficulty in accepting HIV-positive test results, feeling desperate, fears of HIV disclosure, HIV-related stigma, and financial instability related to HIV infection were the main psychosocial challenges described by the participants. However, their main coping strategies included seeking social support, positive experiences from regular CTC attendance, adaptive coping, disregarding people's comments, and seeking HIV-related information.</p><p><strong>Conclusion: </strong>PLWH encounter various psychosocial challenges. Feeling desperate, fear of HIV disclosure, and HIV-related stigma are the main causes of psychosocial distress among people diagnosed with HIV. Changing the individual perspectives on these challenges through effective coping strategies can improve the quality of life for PLWH. The Ministry of Health, through the National AIDS Control Program, can design interventions focused on addressing these challenges. Future research should be undertaken to quantify the magnitude of these challenges and the coping strategies in similar settings.</p>","PeriodicalId":74991,"journal":{"name":"The East African health research journal","volume":"8 3","pages":"417-425"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12083714/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dolutegravir Associated glycaemia Among Persons with HIV on Treatment at a Kenyan Referral Hospital.","authors":"Judith A Odenyo, George A Mugendi, David G Nyamu, Andew A Okiko","doi":"10.24248/eahrj.v8i3.808","DOIUrl":"10.24248/eahrj.v8i3.808","url":null,"abstract":"<p><strong>Background: </strong>Dolutegravir-based antiretroviral therapy is a clinically proven treatment option for persons living with the human immunodeficiency virus. However, there is emerging clinical evidence that its use may result in hyperglycaemia, but there is limited data in Africa.</p><p><strong>Objectives: </strong>To determine the prevalence of dolutegravir-associated hyperglycaemia and its covariates among Persons Living with HIV on treatment in a tertiary teaching and referral hospital in Kenya.</p><p><strong>Methods: </strong>A cross-sectional study was undertaken among adult patients who had been using dolutegravir-based regimens for at least 3 months at the comprehensive care centre in Kenyatta National Hospital. An interviewer-administered questionnaire was used to collect sociodemographic characteristics while clinical data (viral load, CD4 count) were abstracted from patients' charts. Blood samples were taken to determine random blood sugar and glycated haemoglobin levels. Data were analysed using STATA^® statistical software. Associations between hyperglycaemia and patients' sociodemographic and/or clinical data were determined as appropriate whereas the independent correlates of hyperglycaemia were determined through multivariable logistic regression at <i>P</i>≤.05.</p><p><strong>Results: </strong>We recruited 358 participants all on dolutegravir based therapy and predominantly female (62.0%). Median age was 444 (IQR 38 to 50) years. Prevalence of hyperglycaemia was 55.9%. Age above 40 years (aOR1.7; 95% CI, 1.1 to 2.7; <i>P</i>=.026), being overweight (aOR 1.7; 95% CI, 1.1 to 2.8; <i>P</i>=.026) and obesity (aOR 3.1; 95% CI, 1.7 to 5.5; <i>P</i><.001) were associated with experiencing hyperglycaemia.</p><p><strong>Conclusion: </strong>Dolutegravir-based regimens are associated with hyperglycaemia among patients with advanced age and elevated body mass indices.</p>","PeriodicalId":74991,"journal":{"name":"The East African health research journal","volume":"8 3","pages":"387-393"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12083737/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}