Stress biology最新文献

{"title":"Integrative bioinformatics analysis of potential convergent evolution in tardigrade stress-response proteins.","authors":"Sawar Khan, Ayesha Nisar, Abdul Qadeer, Sijie Liu, Sardar Azhar Mehmood, Lingqiang Zhang, Zanxian Xia","doi":"10.1007/s44154-026-00286-5","DOIUrl":"10.1007/s44154-026-00286-5","url":null,"abstract":"<p><p>Tardigrades, known for their extraordinary resilience to extreme environmental conditions, employ specialized stress-response proteins to maintain cellular integrity under stress. These proteins, including SAHS, CAHS, MAHS, and Dsup, play critical roles in protecting cells from dehydration, radiation, and other environmental stressors. Previous work has characterized many of these proteins in Ramazzottius varieornatus, but the taxonomic breadth, copy-number variation, and structural diversity of these families across other tardigrade lineages remain poorly understood. The recent expansion of genomic resources for additional species motivated a comprehensive multi-species analysis to map ortholog diversity and structural features across tardigrade taxa. We investigated the genetic, structural, and evolutionary features of these stress-response proteins using an integrative bioinformatics approach, analyzing gene structure, orthologous clustering, molecular phylogeny, conserved motifs, and 3D protein structures across four tardigrade species-R. varieornatus, Hypsibius exemplaris, Paramacrobiotus metropolitanus, and H. henanensis. Our results reveal significant variation in predicted gene copy numbers and sequence conservation that reflect species-specific adaptations to environmental stress. Orthologous clustering showed shared evolutionary patterns across species, and conserved motifs were identified within the SAHS, CAHS, and MAHS families. Notably, we identified a new Dsup protein (H.Henanensis.Chr5.66), a potential ortholog in H. henanensis, thereby expanding the known diversity of Dsup proteins. The Dsup protein family exhibited notable sequence diversity across species, yet structural analyses revealed conserved α-helix regions and hydrophobicity patterns, suggesting a flexible conformation that aids DNA protection during extreme stress. Phylogenetic analyses revealed patterns consistent with parallel clustering patterns among stress-response proteins. This study advances our understanding of the molecular adaptations that underpin tardigrades' resilience and offers insights into potential applications for enhancing stress tolerance in other organisms.</p>","PeriodicalId":74874,"journal":{"name":"Stress biology","volume":"6 1","pages":""},"PeriodicalIF":6.4,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13006486/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147501021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The phytohormone indole-3-acetic acid induces quorum sensing signal DSF turnover via a positive feedback biosynthetic loop in the phytopathogen Xanthomonas campestris.","authors":"Si-Nan Li, Ming-Lei Zhang, Ying Cui, Lin Li, Chitti Thawai, Lian Jiang, Dong-Lan Tian, Yu-Cheng Gu, Ya-Wen He, Lian Zhou, Kai Song","doi":"10.1007/s44154-026-00298-1","DOIUrl":"10.1007/s44154-026-00298-1","url":null,"abstract":"<p><p>Indole-3-acetic acid (IAA) accumulates in host plants following infection by Xanthomonas campestris pv. campestris (Xcc), the causal agent of cruciferous black rot. How exposure to IAA affects the invading Xcc remains unclear. Here, we demonstrate that either exogenous addition of IAA or endogenous production of IAA induced turnover of the quorum sensing (QS) signal diffusible signaling factor (DSF) in a RpfB-dependent manner. IAA addition prevented the cytoplasmic and culture pH decline. Transcriptomic analyses revealed four IAA-regulated gene clusters. Specifically, IAA induced the expression of trpB-A, enhancing tryptophan biosynthesis and intracellular IAA accumulation, and thereby establishing a self-reinforcing synthesis loop. IAA upregulated F₀F₁ ATP synthases and a resistance-nodulation-cell division (RND)-family efflux pump HepABCD to induce a pH-dependent DSF turnover. Moreover, IAA downregulated another RND family efflux pump IaepABCDE to induce a pH-independent DSF turnover. Finally, the IAA-regulated gene clusters were transcribed during the XC1 infection of cabbage. Collectively, these findings reveal a previously unrecognized role of IAA in modulating bacterial QS, underscoring the importance of IAA in the molecular dialogue between the pathogen and its host.</p>","PeriodicalId":74874,"journal":{"name":"Stress biology","volume":"6 1","pages":""},"PeriodicalIF":6.4,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13009335/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147505639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enemy's arsenal backfires: pathogen proteases detonate broad-spectrum plant immunity via engineered NLRs.","authors":"Shan Liu, Yanping Jing, Jian Chen","doi":"10.1007/s44154-026-00296-3","DOIUrl":"10.1007/s44154-026-00296-3","url":null,"abstract":"","PeriodicalId":74874,"journal":{"name":"Stress biology","volume":"6 1","pages":""},"PeriodicalIF":6.4,"publicationDate":"2026-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12963559/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147357961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanoparticles based interventions for metal(loid) stress mitigation in plants.","authors":"Anuj Sharma, Vaibhav Sharma, Mahipal Singh Sankhla, Kumud Kant Awasthi, Anjali Awasthi, Garima Awasthi","doi":"10.1007/s44154-024-00194-6","DOIUrl":"10.1007/s44154-024-00194-6","url":null,"abstract":"<p><p>Metal(loid) stress is one of the key constraints limiting plant growth and productivity, thus threatening agricultural yields and ecosystem health. This review elaborates on the mechanisms through which metal(loid) stress acts on plants, with a special focus on disturbances to key physiological and biochemical aspects. Drawing on global research findings, the review then systematically discusses the interactions between various metal(loid)s and plant components, clarifying the specifity of stress responses across different plant-metal(loid) systems. A central focus of this review is the application of nanoparticles (NPs) as a mitigation strategy to enhance plant growth and improve tolerance to metal(loid) stress. Specifically, it summarizes the multifaceted roles of NPs in this context: promoting plant growth and development, inducing the activity of antioxidant enzymes, and mitigating oxidative stress. This review confirms that metal(loid) stress can strongly inhibit plant growth and physiological functions, but such adverse effects can be significantly alleviated by NPs-based interventions ultimately facilitating the cultivation of more robust and healthy plants. These findings highlight the potential of NPs-mediated strategies as a practical and effective approach to counteract metal(loid) toxicity in plants, providing valuable insights for the development of sustainable agricultural system.</p>","PeriodicalId":74874,"journal":{"name":"Stress biology","volume":"6 1","pages":""},"PeriodicalIF":6.4,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12946573/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147292059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated proteomic and phosphoproteomic analysis reveals the MAPK cascade as a key regulator of ethylene-induced latex production in Hevea brasiliensis.","authors":"Linling Yang, Boxuan Yuan, Fengyan Fang, Minmin He, Wei Li, Shugang Hui, Xiaoyu Du, Lixia He, Huijiao Lui, Tian Sang, Xuchu Wang","doi":"10.1007/s44154-026-00290-9","DOIUrl":"10.1007/s44154-026-00290-9","url":null,"abstract":"<p><p>Natural rubber is a crucial industrial raw material globally, with wide applications in industries such as automotive and healthcare. Application of ethylene promotes latex production in the Hevea rubber tree (Hevea brasiliensis). However, its potential protein-regulation mechanism remains unclear. To elucidate the role of ethylene in latex production, we employed high-resolution proteomics and phosphoproteomics to determine the global changes in protein abundance and phosphorylation during ethylene-stimulated latex production. Using latex samples collected from ethephon-treated rubber tree, we identified more than 3,700 quantifiable proteins and 2,000 phosphorylated proteins with over 6,000 phosphorylation sites. Proteins involved in the mitogen-activated protein kinase (MAPK) cascade, metabolic pathways, and vesicular trafficking, like rubber elongation factors (REFs), small rubber particle proteins (SRPPs), and 14-3-3 proteins, exhibit pronounced robust phosphorylation dynamics upon ethephon application. Interestingly, the serine/threonine-proline (S/T-P) motif, which could be recognized by MAPKs, was highly enriched in REFs, 14-3-3, and ubiquitin-associated DENN (UDENN) domain-containing proteins, suggesting a potential role of MAPKs in ethylene-induced rubber biosynthesis. Consistently, the MAPKs show altered activation in ethephon-treated Hevea rubber trees, compared to water-treated controls. Additionally, activation of UDENN domain proteins implicated Ras-related Rab GTPases in membrane trafficking and rubber particle formation. These results provide comprehensive information on global changes in protein abundance and phosphorylation upon ethephon application in latex production, and may provide valuable clues for understanding the molecular basis of ethephon-regulated natural rubber biosynthesis in Hevea rubber trees.</p>","PeriodicalId":74874,"journal":{"name":"Stress biology","volume":"6 1","pages":"18"},"PeriodicalIF":6.4,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12920992/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146230054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A viral protein disrupts rice cell wall integrity and modulates interactions with viruses and insects.","authors":"Jialin Zhang, Wenyang Ye, Shanshan Li, Chaoyi Dong, Fanrong Peng, Ci Wang, Jiaqi Qin, Qun Hu, Jie Zhang, Jianguo Wu, Shanshan Zhao","doi":"10.1007/s44154-026-00287-4","DOIUrl":"10.1007/s44154-026-00287-4","url":null,"abstract":"<p><p>The plant cell wall provides structural support and serves as a barrier against pathogen invasion. Rice grassy stunt virus (RGSV) infection suppresses genes involved in cell wall biosynthesis, but the underlying mechanism remains unclear. To further investigate this phenomenon, we generated transgenic rice lines overexpressing the RGSV-encoded p2 protein. These transgenic lines exhibited a brittle phenotype with reduced plant height, thinner sclerenchyma cell walls, decreased cellulose and increased lignin contents. Biochemical and microscopic analyses confirmed that mechanical strength of the cell wall was significantly weakened in p2-expressing plants. Notably, immunoblotting and in situ hybridization revealed partial localization of p2 to the cell wall, suggesting potential structural association. Transcriptome analysis revealed that p2 expression significantly altered the expression of genes involved in cell wall organization, hormone signaling, and pathogen interactions, suggesting a mechanistic basis for the observed phenotypes. Additionally, p2 transgenic lines exhibited increased susceptibility to multiple viruses, but unexpectedly showed enhanced resistance to the brown planthopper (BPH, Nilaparvata lugens), a major phloem-feeding pest. These findings reveal that a single viral protein can remodel the cell wall to influence both pathogen susceptibility and insect resistance, highlighting the broader ecological impacts of virus-induced cell wall remodeling in plants.</p>","PeriodicalId":74874,"journal":{"name":"Stress biology","volume":"6 1","pages":"17"},"PeriodicalIF":6.4,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12921124/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146230113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydrogen sulfide promotes wheat immunity against stripe rust through TaATG6c persulfidation.","authors":"Ying Ma, Fangfang Peng, Ran Zhao, YuPing Li, Jiayu Qian, Yizhe Wang, Guozhi Sun, Jiayu Meng, Jisheng Li, Zhensheng Kang, Xiaojing Wang","doi":"10.1007/s44154-026-00292-7","DOIUrl":"10.1007/s44154-026-00292-7","url":null,"abstract":"<p><p>Hydrogen sulfide (H₂S) is a key gaseous signaling molecule involved in plant growth and stress responses, yet its role in wheat resistance to stripe rust remains poorly understood. Here, we show that exogenous H₂S enhances resistance of wheat (Triticum aestivum L.) to Puccinia striiformis f. sp. tritici (Pst), the causative agent of stripe rust. Comparative persulfidation proteomics identified the autophagy-related protein TaATG6c as a Pst-responsive H₂S target. Site-specific mass spectrometry and a modified biotin-switch assay demonstrated that Cys177 and Cys180 of TaATG6c undergo H₂S-induced persulfidation. Structural modeling based on AlphaFold predicted that these two site mutations reduced the binding activity of ATG6c to ATG14. Functional characterization using virus-induced gene silencing (VIGS) revealed that TaATG6 positively regulates wheat immunity against Pst, as silencing TaATG6 promoted fungal growth. Moreover, TaATG6 expression was markedly induced during Pst infection. Notably, the resistance-promoting effect of NaHS was compromised in TaATG6-silenced plants. Conversely, transient overexpression of TaATG6 enhanced wheat resistance to stripe rust, whereas mutation of Cys177 and Cys180 attenuated this effect. Endogenous biotin-switch assays further showed that TaATG6c persulfidation exhibits pathogen-responsive and dynamic characteristics, which were abolished in the TaATG6^C177A/C180A mutant. Consistently, H₂S treatment and Pst infection stimulated the accumulation of lipidated ATG8 (ATG8-PE), indicating activation of autophagy, while this response was largely abolished in TaATG6-silenced plants. Together, these results suggest that H₂S promotes autophagy initiation through persulfidation of TaATG6c, thereby enhancing wheat resistance to stripe rust and highlighting a redox-regulated mechanism underlying plant stress adaptation.</p>","PeriodicalId":74874,"journal":{"name":"Stress biology","volume":"6 1","pages":"16"},"PeriodicalIF":5.8,"publicationDate":"2026-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12905053/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146183148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genomic structural variation underlies cell type-specific betacyanin variegation in Chenopodium quinoa.","authors":"Zheting Zhang, Yuwei Wang, Xiangwei Hu, Tiansheng Yu, Yaozu Feng, Jungao Zhang, Ting Zhang, Guojun Feng, Heng Zhang","doi":"10.1007/s44154-025-00284-z","DOIUrl":"10.1007/s44154-025-00284-z","url":null,"abstract":"<p><p>The allotetraploid crop quinoa (Chenopodium quinoa) accumulates red/violet betacyanins, which function as vital stress-mitigating antioxidants. We investigated the genetic basis of red/green variegation observed in the aerial organs of the P0429 accession. We demonstrated that this color mosaic is primarily localized to epidermal bladder cells (EBCs), with red EBCs accumulating betacyanin levels ~ 50-fold higher than colorless EBCs. Cell-type-specific RNA-sequencing of EBCs identified the cytochrome P450 gene Cqu0091301 (CYP76ADα) as the dominant and rate-limiting factor, exhibiting strong upregulation in red EBCs. This high pigmentation requires a specific structural variation in the P0429 accession: a ~ 4-kb genomic insertion that restores the full functionality of Cqu0091301, which is otherwise truncated and non-functional in common reference genomes. Genomic analysis reveals that Cqu0091301 is part of a multicopy CYP76ADα-DODA gene cluster. Notably, expression analysis revealed functional divergence between the quinoa subgenomes, with B-subgenome CYP76ADα genes highly dominant in EBCs, while A-subgenome homologs were preferentially expressed in other tissues. Our results establish a clear link between structural genomic variation and cell-type-specific betalain biosynthesis, providing molecular insight into pigment regulation and subgenome specialization in allotetraploid quinoa.</p>","PeriodicalId":74874,"journal":{"name":"Stress biology","volume":"6 1","pages":"15"},"PeriodicalIF":5.8,"publicationDate":"2026-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12894481/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146159509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A conserved Lsm8-exosome module maintains RNA splicing fidelity to control fungal stress adaptation and virulence.","authors":"Yiyi Ren, Haolan Cheng, Xingmin Han, Meiling Guo, Chenghui Xu, Jiayue Yan, Zhiwei Ge, Zhonghua Ma, Yun Chen","doi":"10.1007/s44154-026-00285-6","DOIUrl":"10.1007/s44154-026-00285-6","url":null,"abstract":"<p><p>Fusarium graminearum, the causal agent of Fusarium head blight (FHB), poses a major threat to global food security by contaminating cereals with the mycotoxin deoxynivalenol (DON). Although transcriptional and protein-level regulation of its stress response and virulence has been extensively studied, the functional significance of mRNA processing in these critical processes remains largely unexplored. Here, we identify Lsm8, a highly conserved core subunit of the nuclear Lsm2-8 complex, as a pivotal regulator linking RNA splicing fidelity to fungal growth, stress adaptation, and virulence. Deletion of LSM8 disrupted Lsm2-8 assembly and nuclear localization, resulting in widespread intron retention in genes essential for stress signaling (HOG1, ATF1), development (GPA1, STE12), and trichothecene biosynthesis. Consequently, osmoadaptation was impaired, sexual reproduction was abolished, and both DON production and virulence were drastically reduced. We further demonstrate that intron-retained transcripts are predominantly degraded by the RNA exosome, revealing a conserved Lsm8-exosome module that maintains splicing fidelity and RNA surveillance. Given the deep evolutionary conservation of Lsm8 across eukaryotes, these findings uncover a fundamental post-transcriptional regulatory layer governing fungal stress response, virulence, and mycotoxin biosynthesis, and highlight RNA-processing factors as universal determinants of virulence and promising antifungal targets across eukaryotic pathogens.</p>","PeriodicalId":74874,"journal":{"name":"Stress biology","volume":"6 1","pages":"14"},"PeriodicalIF":5.8,"publicationDate":"2026-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12886710/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146151300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The bark latent fungus Botryosphaeria dothidea exacerbates branch dieback following the infection with Verticillium dahliae.","authors":"Ruifeng Guo, Yicheng Li, Chen Tang, Yize Zhao, Mohan Wang, Guanghang Qiao, Steven J Klosterman, Yonglin Wang","doi":"10.1007/s44154-026-00288-3","DOIUrl":"10.1007/s44154-026-00288-3","url":null,"abstract":"<p><p>Verticillium wilt, caused by the soilborne fungus Verticillium dahliae, has resulted in high mortality of Cotinus coggygria (smoke tree) in China. Symptoms of this disease are complex, many infected smoke trees exhibit wilting or dieback on some branches but no other branches. Whether other microbial taxa act synergistically to contribute to symptom development is unknown. Here, we investigated the microbial community assembly features associated with different branches of smoke trees with or without Verticillium wilt symptoms and established linkages between symptomatic branches and putative keystone taxa. Amplicon data analyses revealed that V. dahliae significantly affected the microbiota structure within tree branches. Microbial network connectivity indicated that Verticillium wilt destabilized the network, and fungal communities were more sensitive to Verticillium wilt than the bacterial communities. Based on taxonomic level information, the fungus Botryosphaeria dothidea was significantly enriched in diseased branches and positively correlated with the abundance of V. dahliae. Through microbial isolations, pathogen co-inoculations, histopathological assays, and RNA-seq analyses, the results indicated that plants infected with V. dahliae showed significantly increased susceptibility to B. dothidea and downregulated expression of defense-related genes. Overall, the results revealed that Verticillium wilt provokes changes in the structure of the smoke tree microbiome and that these changes likely influence symptom development in some but not all tree branches. The synergistic interplay between the commensal fungus B. dothidea and the soil-borne fungus V. dahliae promotes wilt progression in smoke trees, offering new insights into developing effective control strategies through fungicides plus enhancing host vigor.</p>","PeriodicalId":74874,"journal":{"name":"Stress biology","volume":"6 1","pages":"13"},"PeriodicalIF":5.8,"publicationDate":"2026-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12886702/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146151412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}