Stress biology最新文献_第4页

Multi-omics of barley Fusarium Head Blight converge on pathogen-triggered biosynthesis of aromatic amino acid derived chemical defense compounds. 大麦枯萎病的多组学研究聚焦于病原菌引发的芳香族氨基酸衍生的化学防御化合物的生物合成。

IF 6.4

Stress biology Pub Date : 2026-06-01 DOI: 10.1007/s44154-026-00313-5

Sophia Hein, Christina E Steidele, Felix Hoheneder, Sarah Brajkovic, Bernhard Kuster, Lisa Kurzweil, Timo D Stark, Corinna Dawid, Ralph Hückelhoven

{"title":"Multi-omics of barley Fusarium Head Blight converge on pathogen-triggered biosynthesis of aromatic amino acid derived chemical defense compounds.","authors":"Sophia Hein, Christina E Steidele, Felix Hoheneder, Sarah Brajkovic, Bernhard Kuster, Lisa Kurzweil, Timo D Stark, Corinna Dawid, Ralph Hückelhoven","doi":"10.1007/s44154-026-00313-5","DOIUrl":"10.1007/s44154-026-00313-5","url":null,"abstract":"Fusarium Head Blight (FHB) is a devastating fungal disease of small grain cereals like wheat and barley, causing substantial yield and quality losses each year worldwide. FHB is caused by Fusarium species that produce mycotoxins such as deoxynivalenol (DON) that impairs protein biosynthesis. Although defense responses in barley to Fusarium infection have been described at the transcriptional level, it remains unclear to what extent these responses are translated into functional changes at the protein and metabolite levels.In this study, we employed comprehensive transcriptomics, proteomics, and metabolomics to dissect the defense responses of barley heads during infection with Fusarium culmorum. Our integrated analyses revealed a set of significantly regulated gene-protein pairs linked to biosynthetic pathways that consistently correspond to upregulated defense-related metabolites. These include tryptophan-derived stress metabolites such as tryptamine and serotonin, as well as barley-specific hydroxycinnamylamides, including conjugates from the trypthophan metabolism, hordatines, and their biosynthetic precursors.Integrating data across multiple omics layers identifies the upregulation of aromatic amino acid derived secondary metabolism as the most consistent barley response to FHB infection across diverse barley varieties that share barley-typical type II resistance to fungal spreading in the head rachis.","PeriodicalId":74874,"journal":{"name":"Stress biology","volume":"6 1","pages":""},"PeriodicalIF":6.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13226754/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148140018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perturbation of mitochondrial Ca²⁺ homeostasis activates cross-compartmental proteostatic response in Arabidopsis. 线粒体Ca2+稳态的扰动激活拟南芥跨区室的蛋白抑制反应。

IF 6.4

Stress biology Pub Date : 2026-05-28 DOI: 10.1007/s44154-026-00314-4

Xiaoyan Zhang, Chongyang Ma, Xinyue Bao, Shenyu Zhang, Omar Zayed, Zhengjing Zhang, Kai Tang, Shaojun Xie, Yunsheng Wang, Dayong Zhang, Huawei Xu, Huifang Jia, Xinying Wang, Qianyan Lei, Xiaocui Wang, Junli Zhang, Savithramma P Dinesh-Kumar, Chun-Peng Song, Jian-Kang Zhu, Xiaohong Zhu

{"title":"Perturbation of mitochondrial Ca2+ homeostasis activates cross-compartmental proteostatic response in Arabidopsis.","authors":"Xiaoyan Zhang, Chongyang Ma, Xinyue Bao, Shenyu Zhang, Omar Zayed, Zhengjing Zhang, Kai Tang, Shaojun Xie, Yunsheng Wang, Dayong Zhang, Huawei Xu, Huifang Jia, Xinying Wang, Qianyan Lei, Xiaocui Wang, Junli Zhang, Savithramma P Dinesh-Kumar, Chun-Peng Song, Jian-Kang Zhu, Xiaohong Zhu","doi":"10.1007/s44154-026-00314-4","DOIUrl":"10.1007/s44154-026-00314-4","url":null,"abstract":"Cross-compartment communication is critical for maintaining cellular homeostasis, which is essential for cell function and survival under stressful conditions. However, the cellular cues that trigger interorganellar communication remain poorly understood. Mitochondrial Ca2+ (mtCa2+) homeostasis is fundamental to mitochondrial function; yet, how mitochondrial Ca2+ (mtCa2+) homeostasis modulates nuclear gene expression to establish and maintain cellular homeostasis remains unclear. Here, we first characterize the critical role of the mitochondrial Ca2+ uniporter (MCU) in control of mtCa2+ uptake and maintaining mtCa2+ homeostasis in planta. Using gain-of-function and sextuple MCU knockdown mutants, we then analyzed the effects of impaired MCU-controlled mtCa2+ homeostasis (iMUCH). We find that iMUCH elicits an interorganellar transcription program that activates multiple compartment-specific unfolded protein responses (UPRs) and genes critical for mitochondrial and cytosolic proteostasis. Additionally, iMUCH induces a post-transcriptional program that selectively represses the synthesis of ribosomes and RNA modification proteins. Furthermore, eukaryotic initiation factor α (eIFα and its phosphorylation likely serve as a protective mechanism under long-term mitochondrial proteotoxic stress induced by iMUCH. Collectively, the data demonstrate that MCU-controlled mtCa2+ homeostasis plays a pivotal role in sustaining mitochondrial and cytosolic proteostasis through an interconnected organelle quality control system, which ultimately determines cell growth and fitness.","PeriodicalId":74874,"journal":{"name":"Stress biology","volume":"6 1","pages":""},"PeriodicalIF":6.4,"publicationDate":"2026-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13219543/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148045122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The multidimensional significance of virus-host protein interactions and their implications in the antiviral defense of plants. 病毒-宿主蛋白相互作用的多维意义及其在植物抗病毒防御中的意义。

IF 6.4

Stress biology Pub Date : 2026-05-14 DOI: 10.1007/s44154-026-00309-1

Juan Zhang, Chunyan Qi, Zengxu Wu, Yuyu Zhang, Jiangbo Shi, Zejun Li, Jun Guo, Xiangping Zhou, Shen Tang, Jian Yang, Peng Liu

引用次数: 0

Mutational analysis of the mitotic exit GTPase MoTem1 reveals its role in development, stress adaptation, pathogenicity and global gene regulation in Magnaporthe oryzae. 水稻有丝分裂出口GTPase MoTem1的突变分析揭示了其在水稻有丝分裂出口GTPase MoTem1的发育、胁迫适应、致病性和全局基因调控中的作用。

IF 6.4

Stress biology Pub Date : 2026-05-09 DOI: 10.1007/s44154-026-00310-8

Mengtian Pei, Xuze Xie, Yingying Cao, Jia Chen, Fan Yang, Zonghua Wang, Stefan Olsson, Guo-Dong Lu, Ya Li

{"title":"Mutational analysis of the mitotic exit GTPase MoTem1 reveals its role in development, stress adaptation, pathogenicity and global gene regulation in Magnaporthe oryzae.","authors":"Mengtian Pei, Xuze Xie, Yingying Cao, Jia Chen, Fan Yang, Zonghua Wang, Stefan Olsson, Guo-Dong Lu, Ya Li","doi":"10.1007/s44154-026-00310-8","DOIUrl":"10.1007/s44154-026-00310-8","url":null,"abstract":"The mitotic exit network (MEN), regulated by the small GTPase Tem1, plays a crucial role in coordinating cytokinesis and cell cycle progression in eukaryotes. In this study, we identified MoTem1, a functional homolog of Saccharomyces cerevisiae Tem1, in the rice blast fungus Magnaporthe oryzae, and investigated its role in mitotic regulation and pathogenesis. Using targeted mutagenesis, we generated a series of mutant strains: ΔMotem1 (knockout), MoTem1-OE (overexpression), as well as MoTem1-CA (constitutively active) and MoTem1-DN (dominant-negative) variants created via single-nucleotide substitutions. Phenotypic characterization revealed that MoTem1's activity states are critical for fungal growth, development, stress tolerance, and pathogenicity. While ΔMotem1 and MoTem1-CA strains showed reduced virulence, the MoTem1-DN mutant exhibited hypervirulence. Transcriptomic profiling and weighted gene co-expression network analysis (WGCNA) identified chitin synthase MoCHS1 as a downstream gene whose expression is directly or indirectly influenced by MoTem1 activity states. Pharmacological inhibition of chitin synthesis using Polyoxin B in MoTem1-CA showed increased sensitivity, confirming a decreased expression of chitin synthase in the MoTem1-CA strain. Subcellular localization studies revealed GTP-dependent spindle pole body (SPB) targeting, with inactive MoTem1 failing to localize to SPBs, while constitutive MEN activation in MoTem1-CA disrupted spindle position checkpoint (SPOC) controls, resulting in multinucleate hyphae and a range of developmental defects. In conclusion, our work establishes MoTem1 not merely as a cell cycle regulator, but as a global upstream factor that influences nuclear division, cell wall integrity, and broadly reshapes the genomic regulatory network to govern development and pathogenesis in M. oryzae.","PeriodicalId":74874,"journal":{"name":"Stress biology","volume":"6 1","pages":""},"PeriodicalIF":6.4,"publicationDate":"2026-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13157382/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147864853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deciphering a pathogen's evolution: a two-decade longitudinal study reveals virulence shifts and identifies durable Pm genes against Himalayan Blumeria graminis f. sp. tritici populations. 破译病原体的进化：一项长达20年的纵向研究揭示了毒力的转变，并确定了针对喜马拉雅蓝灰菌的持久性Pm基因。

IF 6.4

Stress biology Pub Date : 2026-05-09 DOI: 10.1007/s44154-026-00299-0

Amritpal Mehta, Harneet Kaur, Daisy Basandrai, Ashwani Kumar Basandrai, Shafat Ahmad Ahanger, B K Sharma, Rajan Sharma, Sonali Sharma, Umer Basu

{"title":"Deciphering a pathogen's evolution: a two-decade longitudinal study reveals virulence shifts and identifies durable Pm genes against Himalayan Blumeria graminis f. sp. tritici populations.","authors":"Amritpal Mehta, Harneet Kaur, Daisy Basandrai, Ashwani Kumar Basandrai, Shafat Ahmad Ahanger, B K Sharma, Rajan Sharma, Sonali Sharma, Umer Basu","doi":"10.1007/s44154-026-00299-0","DOIUrl":"10.1007/s44154-026-00299-0","url":null,"abstract":"Wheat powdery mildew, caused by the obligate biotrophic fungus Blumeria graminis f. sp. tritici (Bgt), is a devastating disease responsible for substantial global yield reductions. Host resistance offers the most sustainable management strategy, yet its durability is continually undermined by high evolutionary potential of the pathogen, driven by sexual recombination and rapid mutation. To decipher long-term virulence dynamics, we conducted a comparative analysis of Bgt populations in the Northwestern Himalayas over two decades (1994-1998 and 2015-2019). Pathotype profiling of 285 isolates on a common set of nine differential lines revealed a significant shift in virulence structure over time. While the mean virulence complexity per isolate increased in the contemporary population, indicating enhanced pathogenic capability, overall pathotype diversity decreased, suggesting a selective sweep toward fewer, more aggressive lineages. Marked changes in virulence frequency were observed with severe efficacy erosion for Pm1a (virulence increased from 6 to 63%) and Pm8, while virulence against Pm2, Pm3a, and Pm3b declined significantly. Notably, genes Pm2 and Pm4a demonstrated complete and durable effectiveness throughout the study period. Our results identify these as stable resistance donors and underscores the continuous adaptation of Bgt populations. This study provides critical insights for designing durable resistance gene pyramids and underscores the necessity of continuous virulence surveillance to sustain wheat production in the face of evolving pathogen threats.","PeriodicalId":74874,"journal":{"name":"Stress biology","volume":"6 1","pages":""},"PeriodicalIF":6.4,"publicationDate":"2026-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13157376/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147864790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The SPX protein family in plants: from phosphate sensors to multifunctional signaling hubs. 植物SPX蛋白家族：从磷酸盐传感器到多功能信号中枢。

IF 6.4

Stress biology Pub Date : 2026-05-08 DOI: 10.1007/s44154-026-00307-3

Shenghong Ge, Kai Yuan, Mingguang Lei

{"title":"The SPX protein family in plants: from phosphate sensors to multifunctional signaling hubs.","authors":"Shenghong Ge, Kai Yuan, Mingguang Lei","doi":"10.1007/s44154-026-00307-3","DOIUrl":"10.1007/s44154-026-00307-3","url":null,"abstract":"Phosphorus (P) is an essential macronutrient for plant growth and development, yet its limited availability in soil severely constrains crop productivity. To cope with phosphate (Pi) deficiency, plants have evolved a sophisticated signaling network centered on SPX domain proteins, which serve as central regulators of Pi homeostasis. Recent breakthrough structural studies have revolutionized our understanding of these proteins, revealing their function as cellular Pi sensors through binding of the inositol pyrophosphate InsP8. This review synthesizes current knowledge of SPX protein molecular structures, evolution, and functions within the Pi signaling network. We detail their sensing mechanism, focusing on inositol pyrophosphate binding and the subsequent control of PHR activity and phosphate starvation response (PSR) gene expression. Recent cryo-electron microscopy structures of rice SPX1-PHR2, Arabidopsis PHO1;H1, and human XPR1 have provided unprecedented insights into phosphate transport mechanisms and SPX domain regulation. We also discuss emerging functions of SPX proteins in coordinating arbuscular mycorrhizal symbiosis, plant immunity, nitrogen-phosphorus balance, and cold stress responses, highlighting their broad significance in plant biology. Finally, we discuss key challenges and future research directions crucial for translating these mechanistic insights into innovative strategies to enhance phosphorus use efficiency (PUE) in crops, including structure-guided protein engineering approaches.","PeriodicalId":74874,"journal":{"name":"Stress biology","volume":"6 1","pages":""},"PeriodicalIF":6.4,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13153306/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147847333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reversible S-palmitoylation of C4 protein encoded by TYLCCxV orchestrates geminiviral pathogenesis. TYLCCxV编码的C4蛋白可逆s -棕榈酰化调控了双病毒的发病机制。

IF 6.4

Stress biology Pub Date : 2026-05-06 DOI: 10.1007/s44154-026-00308-2

Yan Xie, Min Zhao, Xianan Liu, Junjie Yan, Wanyi Yang, Yiya Chen, Ming Yang, Xiaowei Wang, Shuai Fu, Xueping Zhou

{"title":"Reversible S-palmitoylation of C4 protein encoded by TYLCCxV orchestrates geminiviral pathogenesis.","authors":"Yan Xie, Min Zhao, Xianan Liu, Junjie Yan, Wanyi Yang, Yiya Chen, Ming Yang, Xiaowei Wang, Shuai Fu, Xueping Zhou","doi":"10.1007/s44154-026-00308-2","DOIUrl":"10.1007/s44154-026-00308-2","url":null,"abstract":"Cysteine palmitoylation (S-palmitoylation or S-acylation) is a reversible post-translational modification dynamically controlled by opposing enzymes: palmitoyl acyltransferases (PATs) and depalmitoylases. Despite its established roles in other systems, the mechanistic details of S-acylation in plants, particularly its spatiotemporal regulation during plant-virus interactions, remain poorly understood, largely due to the lack of validated enzyme-substrate pairs. Using the geminivirus tomato yellow leaf curl Chuxiong virus (TYLCCxV) as a model, we show that the viral effector C4 undergoes S-palmitoylation at Cys-4, a modification essential for its plasma membrane anchorage and subsequent mediation of viral pathogenesis. NbPAT4, a palmitoyl acyltransferase from Nicotiana benthamiana, catalyzes C4 S-palmitoylation, promoting its membrane localization, protein stability, and viral infection. Conversely, the C4S substitution (C4C4S) abolishes S-palmitoylation, leading to cytoplasmic redistribution, protein destabilization, and impaired viral pathogenicity. We further identify NbABHD6 as a depalmitoylase that interacts with C4 and catalyzes its S-depalmitoylation, triggering C4 degradation via the 26S proteasome pathway. This study reveals a regulatory axis in plant-geminivirus interactions, identifying NbPAT4 and NbABHD6 as antagonistic enzymes that dynamically regulate the stoichiometry of C4 S-acylation. These findings support a host-pathogen enzymatic tug-of-war model in which competitive S-palmitoylation homeostasis governs viral subcellular trafficking and pathogenicity.","PeriodicalId":74874,"journal":{"name":"Stress biology","volume":"6 1","pages":""},"PeriodicalIF":6.4,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13144479/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147847279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular and physiological adaptations to low-salinity stress in penaeid shrimp: a focus on Litopenaeus vannamei and Penaeus monodon. 对虾对低盐度胁迫的分子和生理适应：以凡纳滨对虾和单对虾为中心。

IF 6.4

Stress biology Pub Date : 2026-04-27 DOI: 10.1007/s44154-026-00295-4

Sheng Huang, Falin Zhou, Shigui Jiang, Erchao Li, Yundong Li

{"title":"Molecular and physiological adaptations to low-salinity stress in penaeid shrimp: a focus on Litopenaeus vannamei and Penaeus monodon.","authors":"Sheng Huang, Falin Zhou, Shigui Jiang, Erchao Li, Yundong Li","doi":"10.1007/s44154-026-00295-4","DOIUrl":"10.1007/s44154-026-00295-4","url":null,"abstract":"Penaeid shrimp are economically important in global aquaculture. Rising demand has expanded shrimp farming and supported coastal economies. Low-salinity (hyposalinity) stress is a major constraint that impairs physiology and reduces growth, survival, and productivity. This review explores the adaptive mechanisms employed by penaeid shrimp in response to salinity stress and the consequent challenges faced by the aquaculture sector. Penaeid shrimp exhibit adaptive responses to salinity stress through a variety of physiological and molecular mechanisms, including ion regulation, osmoregulation, antioxidant defense, and the activation of signaling pathways. While these mechanisms are critical, they necessitate further in-depth investigation. This review synthesizes recent advancements in the understanding of penaeid shrimp adaptation to salinity stress, encompassing salinity signal perception, the activation of calcium and phospholipid signaling, signal transduction, and the regulation of gene expression. Additionally, it provides a comprehensive overview of the physiological and molecular responses of penaeid shrimp to salinity stress. The paper also discusses the potential implications of these findings for the aquaculture industry, particularly for improving climate-change resilience under increasingly frequent and unpredictable salinity fluctuations.","PeriodicalId":74874,"journal":{"name":"Stress biology","volume":"6 1","pages":""},"PeriodicalIF":6.4,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13121679/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147791949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CcAbl1 is required for virulence via regulating NADPH-glutathione-mediated redox balance in Cytospora chrysosperma. CcAbl1通过调节nadph -谷胱甘肽介导的氧化还原平衡来调节黄胚胞孢子的毒力。

IF 6.4

Stress biology Pub Date : 2026-04-24 DOI: 10.1007/s44154-026-00302-8

Wenjun Song, Ruifeng Guo, Jia Zhou, Yonglin Wang

引用次数: 0

Exploiting plant immune "switches" for resistance engineering. 利用植物免疫“开关”进行抗性工程。

IF 6.4

Stress biology Pub Date : 2026-04-24 DOI: 10.1007/s44154-026-00306-4

Bangting Wu, Kaichen Xu, Anum Bashir, Xinyu Han, Qiping Sun, Peng Sun, Guan-Feng Wang, Ricky J Milne, Meixiang Zhang, Leiyun Yang, Guoyong Xu, Guotian Li

{"title":"Exploiting plant immune \"switches\" for resistance engineering.","authors":"Bangting Wu, Kaichen Xu, Anum Bashir, Xinyu Han, Qiping Sun, Peng Sun, Guan-Feng Wang, Ricky J Milne, Meixiang Zhang, Leiyun Yang, Guoyong Xu, Guotian Li","doi":"10.1007/s44154-026-00306-4","DOIUrl":"10.1007/s44154-026-00306-4","url":null,"abstract":"Plant diseases, caused by various pathogens, pose a serious threat to sustainable agriculture. Plants have evolved a sophisticated immune system to detect and mount effective responses against pathogens. The plant immune system contains numerous programmable immune \"switches\" that safeguard plants against pathogens while minimizing energy consumption in the absence of pathogens. The cloning of disease-resistance (R) genes, along with the elucidation of the molecular mechanisms regulating these immune \"switches\", has provided resources and strategies for genetic engineering of novel disease resistance. This review focuses on the resistance engineering through the manipulation of immune \"switches\". It begins by summarizing recent advances in plant immunity, then explores the mechanisms behind plant immune \"switches\", and finally discusses potential strategies for engineering immune genes via these \"switches\". These strategies include engineering promoters to confer precise spatiotemporal regulation at the transcriptional level; engineering mRNA or its regulatory elements to facilitate specific and stable translation of R proteins at the post-transcriptional and translational levels; and engineering proteins at the post-translational level to broaden the pathogen-recognition spectrum of R proteins. Collectively, these strategies will accelerate the development of disease-resistant crop cultivars, thereby enhancing agricultural productivity and global food security.","PeriodicalId":74874,"journal":{"name":"Stress biology","volume":"6 1","pages":""},"PeriodicalIF":6.4,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13109558/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147791913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0