Radiochemistry最新文献_第3页

Comparison of Perfluorooctanoic and Alkylbenzenesulfonic Acids in Radionuclide Extraction into Liquefied Freon HFC-134a 全氟辛酸和烷基苯磺酸萃取液化氟利昂HFC-134a中放射性核素的比较

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Radiochemistry Pub Date : 2026-07-17 DOI: 10.1134/S1066362226030069

A. M. Fedotov, A. Yu. Nikolaev, V. A. Babain, A. A. Murzin, N. E. Mishina

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Potential of RadioHPLC for the Purification of [18F]anle138b, a Candidate Radiotracer for PET Diagnostics of Parkinson’s Disease 放射高效液相色谱法纯化帕金森病PET诊断候选示踪剂[18F]anle138b的潜力

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Radiochemistry Pub Date : 2026-07-17 DOI: 10.1134/S1066362226030124

O. S. Fedorova, V. V. Orlovskaya, R. N. Krasikova

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Radiosynthesis and Preclinical Evaluation of [99mTc]Tc-HYNIC-anti-TIGIT for Immuno-SPECT Imaging [99mTc]Tc-HYNIC-anti-TIGIT用于免疫spect成像的放射合成及临床前评价

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Radiochemistry Pub Date : 2026-07-17 DOI: 10.1134/S1066362226030112

F. Amjad, S. Q. Shah, R. Santos-Oliveira

{"title":"Radiosynthesis and Preclinical Evaluation of [99mTc]Tc-HYNIC-anti-TIGIT for Immuno-SPECT Imaging","authors":"F. Amjad, S. Q. Shah, R. Santos-Oliveira","doi":"10.1134/S1066362226030112","DOIUrl":"10.1134/S1066362226030112","url":null,"abstract":"T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is a newly identified immune checkpoint involved in tumor immune evasion; it represents a promising target for cancer immunotherapy. Noninvasive in vivo imaging of TIGIT expression may provide valuable insights into the tumor immune microenvironment and facilitate the evaluation of TIGIT-targeted therapies. In this study, tiragolumab (anti-TIGIT monoclonal antibody) was conjugated with HYNIC and radiolabeled with 99mTc using an EDDA/tricine coligand system under optimized mild conditions. Radiochemical purity and stability were assessed by ITLC and SEC-HPLC, while the chelator-to-antibody ratio (CAR) was determined using MALDI-TOF. In vitro binding was evaluated using saturation binding assays in TIGIT-expressing Jurkat cells, and the immunoreactivity was evaluated by Lindmo analysis. Biodistribution and small-animal SPECT imaging were conducted in a Jurkat tumor-bearing mouse model. The radioconjugate was obtained with a radiochemical yield of 64.2 ± 1.7%. It exhibited high radiochemical purity (>98%) along with good stability under physiological conditions. Saturation binding studies showed concentration-dependent and saturable binding to Jurkat cells, with a dissociation constant of Kd = 0.82 ± 0.11 nM and a maximum binding capacity of Bmax = 18.3 ± 1.6 fmol/106 cells, indicating high-affinity interaction. The immunoreactive fraction was 0.85 ± 0.03. In vivo biodistribution demonstrated progressive tumor accumulation, reaching 11.7 ± 1.4% ID/g at 4 h. SPECT imaging enabled clear visualization of tumors with improving contrast over time. [99mTc]Tc-HYNIC-anti-TIGIT was successfully prepared using a HYNIC-based radiolabeling strategy. It enables visualization of TIGIT expression in a preclinical model, supporting its potential as a radiopharmaceutical platform for immuno-SPECT imaging.","PeriodicalId":747,"journal":{"name":"Radiochemistry","volume":"68 3","pages":"374 - 387"},"PeriodicalIF":0.9,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148459118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Features of Intermolecular Interactions in the Structures of Mn, Tc, and Re Carbonyl Halides Mn、Tc和Re羰基卤化物结构中分子间相互作用的特征

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Radiochemistry Pub Date : 2026-07-17 DOI: 10.1134/S1066362226030033

G. V. Sidorenko, L. B. Serezhkina, S. V. Kondrashkin, V. N. Serezhkin

引用次数: 0

Natural Radioactivity in Core Samples from Titas and Rashidpur Gas Fields, Bangladesh 孟加拉Titas和Rashidpur天然气田岩心样本的天然放射性

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Radiochemistry Pub Date : 2026-07-17 DOI: 10.1134/S1066362226030161

M. Begum, M. M. M. Siraz, M. B. Rashid, S. M. S. Salekin, M. S. Alam, H. Osman, R. Khan, K. Naher, M. U. Khandaker

{"title":"Natural Radioactivity in Core Samples from Titas and Rashidpur Gas Fields, Bangladesh","authors":"M. Begum, M. M. M. Siraz, M. B. Rashid, S. M. S. Salekin, M. S. Alam, H. Osman, R. Khan, K. Naher, M. U. Khandaker","doi":"10.1134/S1066362226030161","DOIUrl":"10.1134/S1066362226030161","url":null,"abstract":"This study presents a comparative analysis of natural radioactivity and radiological hazard parameters in core samples from the Titas and Rashidpur gas fields, Bangladesh, determined using a high-purity germanium (HPGe) detector. Six core samples from Titas (depths: 2713–2784 m) and four from Rashidpur (depths: 1454–2896 m) were analyzed for the activity concentrations of 226Ra, 232Th, and 40K. The radionuclide concentrations in Titas range from 17 ± 2 to 64 ± 4 Bq/kg for 226Ra, 43 ± 3 to 109 ± 4 Bq/kg for 232Th, and 787 ± 47 to 2701 ± 70 Bq/kg for 40K; while in Rashidpur, the concentrations of ²²⁶Ra range from 32 ± 3 to 52 ± 3 Bq/kg; those of 232Th, from 48 ± 3 to 88 ± 4 Bq/kg; and those of 40K, from 660 ± 33 to 1737 ± 63 Bq/kg, both surpassing the global average significantly. Assessment of radiological hazard parameters indicates that some values in the Titas samples and a few in the Rashidpur samples exceed internationally recommended reference levels. These findings highlight the importance of continued monitoring and suggest that caution should be exercised when handling or utilizing materials from these gas fields for any purpose.","PeriodicalId":747,"journal":{"name":"Radiochemistry","volume":"68 3","pages":"430 - 441"},"PeriodicalIF":0.9,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148459127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sorption Equilibria of Cr(VI), Mo(VI), Se(IV), and Re(VII) Oxo Ions with TiO2||C Oxide–Graphene Composite Cr(VI), Mo(VI), Se(IV), Re（VII）氧离子在TiO2 bb| -石墨烯复合材料上的吸附平衡

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Radiochemistry Pub Date : 2026-07-17 DOI: 10.1134/S1066362226030082

E. V. Polyakov, I. V. Volkov, A. A. Ioshin, V. N. Krasil’nikov

{"title":"Sorption Equilibria of Cr(VI), Mo(VI), Se(IV), and Re(VII) Oxo Ions with TiO2||C Oxide–Graphene Composite","authors":"E. V. Polyakov, I. V. Volkov, A. A. Ioshin, V. N. Krasil’nikov","doi":"10.1134/S1066362226030082","DOIUrl":"10.1134/S1066362226030082","url":null,"abstract":"The equilibrium mechanism of sorption interaction of CrO42–, MoO42–, SeO32–, and ReO4– ions with surface functional centers of the graphene–oxide composite TiO2||C was established. The anion sorption isotherms are described by the Langmuir model for a monoenergetic sorbent with the Henry region at concentrations below 1 μM. The pH dependences of the anion distribution coefficient Kd are dome-shaped with a maximum at pH in the range 3–4. At pH in the range 2–6, the composite exhibits the properties of a collective action sorbent for the oxo anions studied with logKd [mL/g] ≈ 2–5. A mechanism of oxo anion sorption based on the 2-pK model of surface complexation of anions by the sorption sites of the composite is proposed. The sorption mechanism suggests that the affinity of the nonprotonated anion for sorption sites in the pH range studied significantly exceeds that of the protonated species. As a result, the parameters of the surface complexation of anions KM(0,1,2) are independent of the protonation constants of anions in the solution and remain constant, but different for the sorption sites Ti–OH2+, Ti–OН, and Ti-O– of the composite. Based on the modeling results, a predictive calculation of the sorption isotherm of the Sb(OH)6– anion by the composite as a function of pH was performed. Qualitative agreement of the calculation results with published data was demonstrated.","PeriodicalId":747,"journal":{"name":"Radiochemistry","volume":"68 3","pages":"350 - 358"},"PeriodicalIF":0.9,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148459130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Technetium Carbonyl Compounds in Chemistry and Nuclear Medicine: Recent Advances 化学和核医学中的锝羰基化合物：最新进展

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Radiochemistry Pub Date : 2026-07-17 DOI: 10.1134/S106636222603001X

G. V. Sidorenko, M. Yu. Tyupina

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Sorption of f-Elements onto Sorbents with Synergistic Interaction of a Phosphorus-Containing Polymer Matrix and TODGA 含磷聚合物基质与TODGA协同作用下f元素在吸附剂上的吸附

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Radiochemistry Pub Date : 2026-07-17 DOI: 10.1134/S1066362226030070

D. A. Lopatin, K. S. Domnikov, S. I. Antonova, M. A. Gerasimov, A. V. Gopin, E. M. Chistyakov, N. E. Borisova, P. I. Matveev

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Radiological Assessment of Gross Alpha and Beta Activities in Groundwater and Associated Health Risks in Central Saudi Arabia 沙特阿拉伯中部地下水中总α和β活性及相关健康风险的放射评估

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Radiochemistry Pub Date : 2026-07-17 DOI: 10.1134/S1066362226030148

S. Alashrah, A. El-Taher

{"title":"Radiological Assessment of Gross Alpha and Beta Activities in Groundwater and Associated Health Risks in Central Saudi Arabia","authors":"S. Alashrah, A. El-Taher","doi":"10.1134/S1066362226030148","DOIUrl":"10.1134/S1066362226030148","url":null,"abstract":"This study presents an assessment of gross alpha and beta radioactivity levels in groundwater samples collected from the Al-Gwaa region in central Saudi Arabia and evaluates the associated radiological health risks. A total of 19 groundwater samples were collected from wells and analyzed using a low-background gas proportional alpha/beta counting system. The measured gross alpha activity concentrations ranged from 0.12 to 1.68 Bq/L with an average value of 0.55 Bq/L, while gross beta activities varied from 0.16 to 2.70 Bq/L with a mean value of 0.86 Bq/L. Several groundwater samples exceeded the World Health Organization (WHO) recommended screening levels of 0.1 Bq/L for gross alpha and 1.0 Bq/L for gross beta activities. Total dissolved solids (TDS) ranged between 312 and 3350 mg/L with an average value of 817 mg/L, indicating elevated mineralization in some groundwater sources. The calculated annual effective dose (AED) and excess lifetime cancer risk (ELCR) values revealed that some sampling locations may pose potential radiological health risks due to long-term groundwater consumption. The elevated radioactivity levels are mainly attributed to naturally occurring radionuclides associated with the geological formations of the aquifer system studied. Continuous radiological monitoring and detailed radionuclide investigations are therefore recommended to ensure groundwater safety in the region.","PeriodicalId":747,"journal":{"name":"Radiochemistry","volume":"68 3","pages":"409 - 415"},"PeriodicalIF":0.9,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148459128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Altitude-Dependent Deposition of 137Cs Radionuclide in Soils of the Mountains of Koya District in the Kurdistan Region, Iraq 伊拉克库尔德斯坦地区Koya山区土壤中137Cs放射性核素的海拔依赖性沉积

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Radiochemistry Pub Date : 2026-07-17 DOI: 10.1134/S1066362226030136

S. Z. Sedeeq, J. M. Smail, S. T. Ahmad

引用次数: 0